Metabolism And Metabolomics Of Liver In Health And Disease

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Metabolism and Metabolomics of Liver in Health and Disease

Walter Wahli,Hervé Guillou
Metabolism and Metabolomics of Liver in Health and Disease Book PDF

Author : Walter Wahli,Hervé Guillou
Publisher : MDPI
Page : 268 pages
File Size : 49,5 Mb
Release : 2021-02-19
Category : Science
ISBN : 9783039436354

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Metabolism and Metabolomics of Liver in Health and Disease by Walter Wahli,Hervé Guillou Pdf

Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

Metabolism and Metabolomics of Liver in Health and Disease

Walter Wahli,Hervé Guillou
Metabolism and Metabolomics of Liver in Health and Disease Book PDF

Author : Walter Wahli,Hervé Guillou
Publisher : Unknown
Page : 268 pages
File Size : 52,6 Mb
Release : 2021
Category : Electronic
ISBN : 3039436368

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Metabolism and Metabolomics of Liver in Health and Disease by Walter Wahli,Hervé Guillou Pdf

Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

Metabolomics in Health and Disease Biology

Anonim
Metabolomics in Health and Disease Biology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 248 pages
File Size : 40,9 Mb
Release : 2024-02-26
Category : Science
ISBN : 9780443137266

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Metabolomics in Health and Disease Biology by Anonim Pdf

Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions Provides the latest insights into our understanding of diseases using metabolomics-based approaches Includes graphical material for metabolomics application that provide useful information for ease of reading of audience

Liver Metabolism and Diseases

Joseph Curtis
Liver Metabolism and Diseases Book PDF

Author : Joseph Curtis
Publisher : Murphy & Moore Publishing
Page : 0 pages
File Size : 40,5 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1639877851

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Liver Metabolism and Diseases by Joseph Curtis Pdf

Liver is an integral part of the process of metabolism. It helps in the preservation and regulation of the lipid and glucose levels in the body, as well as in energy metabolism. The most common metabolic diseases which can affect the liver are Wilson disease, hereditary hemochromatosis, and Alpha-I antitrypsin deficiency (AATD). Some of the other types of disorders which affect the liver are infections, immune system issues, cancers, and heritable conditions. One of the upcoming methods of study which is used to study the cell metabolism within the liver is metabolomics. It refers to the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Metabolomics has a very high potential to detect biomarker candidates for the prospective advancement of new therapeutics. The book aims to shed light on some of the unexplored aspects of liver metabolism and the recent researches in this field with respect to liver diseases. It will provide comprehensive knowledge to both medical students and professionals.

Metabolism of Human Diseases

Eckhard Lammert,Martin Zeeb
Metabolism of Human Diseases Book PDF

Author : Eckhard Lammert,Martin Zeeb
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 51,6 Mb
Release : 2014-06-02
Category : Medical
ISBN : 9783709107157

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Metabolism of Human Diseases by Eckhard Lammert,Martin Zeeb Pdf

“Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. “Metabolism of Human Diseases” is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.

Cancer Metabolomics 2018

Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Cancer Metabolomics 2018 Book PDF

Author : Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Publisher : MDPI
Page : 184 pages
File Size : 51,8 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9783039213450

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Cancer Metabolomics 2018 by Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto Pdf

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Biomarkers in Liver Disease

Victor R. Preedy,Vinood B. Patel
Biomarkers in Liver Disease Book PDF

Author : Victor R. Preedy,Vinood B. Patel
Publisher : Springer
Page : 0 pages
File Size : 53,6 Mb
Release : 2017-07-14
Category : Medical
ISBN : 9400776748

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Biomarkers in Liver Disease by Victor R. Preedy,Vinood B. Patel Pdf

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Metabolomics and Its Impact on Health and Diseases

Veronica Ghini,Kathleen A. Stringer,Claudio Luchinat
Metabolomics and Its Impact on Health and Diseases Book PDF

Author : Veronica Ghini,Kathleen A. Stringer,Claudio Luchinat
Publisher : Springer Nature
Page : 384 pages
File Size : 44,5 Mb
Release : 2023-03-03
Category : Medical
ISBN : 9783031268595

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Metabolomics and Its Impact on Health and Diseases by Veronica Ghini,Kathleen A. Stringer,Claudio Luchinat Pdf

This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.

Obesity, Fatty Liver and Liver Cancer

Jun Yu
Obesity Fatty Liver and Liver Cancer Book PDF

Author : Jun Yu
Publisher : Springer
Page : 157 pages
File Size : 49,6 Mb
Release : 2018-06-28
Category : Science
ISBN : 9789811086847

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Obesity, Fatty Liver and Liver Cancer by Jun Yu Pdf

This volume covers a state-of-the-art illustration of recent discoveries concerning obesity-related fatty liver diseases and liver cancer. The contents are extensive and comprehensive. It brings important topics in the field all together under one umbrella, from epidemiology and etiology, molecular pathogenesis, cellular biology, epigenetics, immunology, microbiology, animal models to therapeutic approaches and treatments. All the book contributors are leading experts in the field. It will appeal to researchers, clinicians and graduate students in obesity, fatty liver diseases, GI/Liver cancer field. It may also yield benefits for pharmaceutical companies with regard to drug discovery.

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines

Aihua Zhang,Wanying Wang
Mass Spectrometry Based Metabolomics in Clinical and Herbal Medicines Book PDF

Author : Aihua Zhang,Wanying Wang
Publisher : John Wiley & Sons
Page : 292 pages
File Size : 43,6 Mb
Release : 2021-08-20
Category : Science
ISBN : 9783527835744

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Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines by Aihua Zhang,Wanying Wang Pdf

Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Tumor Organoids

Shay Soker,Aleksander Skardal
Tumor Organoids Book PDF

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 55,7 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Nutricines and Derivatives of Nutrients in Animal Health and Disease Prevention

Tao Wang,HongGu Lee
Nutricines and Derivatives of Nutrients in Animal Health and Disease Prevention Book PDF

Author : Tao Wang,HongGu Lee
Publisher : Frontiers Media SA
Page : 195 pages
File Size : 44,9 Mb
Release : 2024-03-20
Category : Science
ISBN : 9782832546574

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Nutricines and Derivatives of Nutrients in Animal Health and Disease Prevention by Tao Wang,HongGu Lee Pdf

Good animal health is of great importance for the efficient production of animal-derived foods at a low cost. The demand for solutions for animal health maintenance and disease prevention is a major global challenge in animal production, food safety, and public health. The animal body has a complete self-defense system, including oxidation and anti-oxidation balance, immune activation and suppression balance, pro- and anti-inflammatory balance, which can help the host against various factors that endanger normal life activities. Nowadays, the strategy of nutrition-based health has become an increasingly important solution for animal health maintenance and disease prevention. Nutrients (carbohydrates, fats, proteins, minerals, vitamins, et al.) and nutricines (carotenoids, enzymes, fatty acids, flavors, oligosaccharides, organic acids, phospholipids, polyphenols, et al.) are two major categories of components in feeds. Nutricines and some derivatives of nutrients (vitamin derivatives, amino acid derivatives, et al.) have been intensively studied in animal and cell culture models, and their roles in animal health maintenance and disease prevention are intimately known.

Nutrigenomics and Proteomics in Health and Disease

Yoshinori Mine,Kazuo Miyashita,Fereidoon Shahidi
Nutrigenomics and Proteomics in Health and Disease Book PDF

Author : Yoshinori Mine,Kazuo Miyashita,Fereidoon Shahidi
Publisher : John Wiley & Sons
Page : 413 pages
File Size : 52,6 Mb
Release : 2009-04-13
Category : Technology & Engineering
ISBN : 9780813807171

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Nutrigenomics and Proteomics in Health and Disease by Yoshinori Mine,Kazuo Miyashita,Fereidoon Shahidi Pdf

Part of the Functional Food Science and Technology book series (Series Editor: Fereidoon Shahidi), this book compiles the current science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals (food factors) and their impact on gene interaction and health. Authored by a stellar international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date.

Metabolomics for Biomedical Research

Jerzy Adamski
Metabolomics for Biomedical Research Book PDF

Author : Jerzy Adamski
Publisher : Academic Press
Page : 266 pages
File Size : 48,8 Mb
Release : 2020-03-20
Category : Medical
ISBN : 9780128127858

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Metabolomics for Biomedical Research by Jerzy Adamski Pdf

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research

Management of Dyslipidemia

Wilbert S. Aronow
Management of Dyslipidemia Book PDF

Author : Wilbert S. Aronow
Publisher : BoD – Books on Demand
Page : 176 pages
File Size : 49,6 Mb
Release : 2021-07-21
Category : Medical
ISBN : 9781839685071

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Management of Dyslipidemia by Wilbert S. Aronow Pdf

Dyslipidemia is a major risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. The earlier in life dyslipidemia is treated, the better the prognosis. The current book is an excellent one on dyslipidemia written by experts on this topic. This book includes 12 chapters including 5 on lipids, 4 on hypercholesterolemia in children, and 3 on the treatment of dyslipidemia. This book should be read by all health care professionals taking care of patients, including pediatricians since atherosclerotic cardiovascular disease begins in childhood.