Cancer Metabolomics

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Cancer Metabolomics

Shen Hu
Cancer Metabolomics Book PDF

Author : Shen Hu
Publisher : Springer Nature
Page : 317 pages
File Size : 44,6 Mb
Release : 2021-04-01
Category : Medical
ISBN : 9783030516529

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Cancer Metabolomics by Shen Hu Pdf

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

Cancer Metabolomics 2018

Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Cancer Metabolomics 2018 Book PDF

Author : Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Publisher : MDPI
Page : 184 pages
File Size : 49,7 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9783039213450

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Cancer Metabolomics 2018 by Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto Pdf

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

NMR Metabolomics in Cancer Research

Miroslava Čuperlović-Culf
NMR Metabolomics in Cancer Research Book PDF

Author : Miroslava Čuperlović-Culf
Publisher : Elsevier
Page : 446 pages
File Size : 54,5 Mb
Release : 2012-12-17
Category : Medical
ISBN : 9781908818263

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NMR Metabolomics in Cancer Research by Miroslava Čuperlović-Culf Pdf

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Correlation-based network analysis of cancer metabolism

Emily G. Armitage,Helen L. Kotze,Kaye J. Williams
Correlation based network analysis of cancer metabolism Book PDF

Author : Emily G. Armitage,Helen L. Kotze,Kaye J. Williams
Publisher : Springer
Page : 61 pages
File Size : 50,5 Mb
Release : 2014-05-12
Category : Science
ISBN : 9781493906154

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Correlation-based network analysis of cancer metabolism by Emily G. Armitage,Helen L. Kotze,Kaye J. Williams Pdf

With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.

Cancer Metabolomics 2018

Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Cancer Metabolomics 2018 Book PDF

Author : Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Publisher : Unknown
Page : 1 pages
File Size : 40,9 Mb
Release : 2019
Category : Electronic books
ISBN : 3039213466

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Cancer Metabolomics 2018 by Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto Pdf

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Tumor Metabolome Targeting and Drug Development

Steven Kanner
Tumor Metabolome Targeting and Drug Development Book PDF

Author : Steven Kanner
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 40,5 Mb
Release : 2014-01-07
Category : Medical
ISBN : 9781461495451

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Tumor Metabolome Targeting and Drug Development by Steven Kanner Pdf

In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.

The Handbook of Metabonomics and Metabolomics

John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
The Handbook of Metabonomics and Metabolomics Book PDF

Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
Publisher : Elsevier
Page : 573 pages
File Size : 54,7 Mb
Release : 2011-08-11
Category : Science
ISBN : 9780080468006

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The Handbook of Metabonomics and Metabolomics by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes Pdf

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies* aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification* covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Metabolomics in Health and Disease Biology

Anonim
Metabolomics in Health and Disease Biology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 248 pages
File Size : 51,6 Mb
Release : 2024-02-26
Category : Science
ISBN : 9780443137266

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Metabolomics in Health and Disease Biology by Anonim Pdf

Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions Provides the latest insights into our understanding of diseases using metabolomics-based approaches Includes graphical material for metabolomics application that provide useful information for ease of reading of audience

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 51,6 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Metabolomics

Vijay Soni,Travis E. Hartman
Metabolomics Book PDF

Author : Vijay Soni,Travis E. Hartman
Publisher : Springer Nature
Page : 527 pages
File Size : 45,8 Mb
Release : 2023-10-24
Category : Science
ISBN : 9783031390944

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Metabolomics by Vijay Soni,Travis E. Hartman Pdf

This book Introduces the extensive applications of metabolomics from all possible areas of research and development so that not only an undergraduate can understand the advancement of metabolomics, but an entrepreneur can harness the knowledge to address possible problems to make a perfect tool to address their research question. Topics covered include the role of metabolomics in the development of agriculture, plant pathology, and their applications; the generalized application of the metabolomics and use of related technologies in various sectors of industries; and the future of metabolomics and upcoming related technologies that can fill the gap between different -omics and their applications for the betterment of humankind. This is an ideal book for university professors, researchers, and advanced-level scientists who are exploring different avenues in metabolomics. Availability of this concise information in one place will aid scientists by expanding their arsenal of techniques and can be helpful to bring more collaborations and to identify the expert at the global level.

Metabolomics of Bladder Cancer

Vishwajeet Singh,Mukul Kumar Singh
Metabolomics of Bladder Cancer Book PDF

Author : Vishwajeet Singh,Mukul Kumar Singh
Publisher : Elsevier
Page : 0 pages
File Size : 49,6 Mb
Release : 2024-09-01
Category : Science
ISBN : 9780443238826

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Metabolomics of Bladder Cancer by Vishwajeet Singh,Mukul Kumar Singh Pdf

Metabolomics of Bladder Cancer: An Emerging Application provides a unique perspective on the role of metabolomics in identifying new cancer biomarkers and offers insights into the latest research methodologies and potential therapeutic applications. With a strong focus on foundational research of bladder cancer, the book examines how applied research on the discovery of metabolomic biomarkers with prognostic and predictive value is needed to stratify patients into different risk groups, minimizing overtreatment and the risk of drug resistance development. In 8 chapters Metabolomics of Bladder Cancer: An Emerging Application gives an in-depth analysis of recent findings in both fundamental and applied research, with a focus on the metabolomics approach and its potential for identifying major metabolic pathways that characterize various diseases and physiological states. It intuitively leads from the discovery of biomarkers for bladder cancer, to the metabolisms of glutamine and fatty acids and finalizes with a chapter on the metabolic effect of cancer therapy. Overall, this book is a comprehensive and insightful resource for researchers, clinicians, and academic professionals interested in the latest developments in bladder cancer research. Gives an in-depth analysis of the most recent findings in both fundamental and applied research on bladder cancer Focuses on metabolomics and how this type of research strategy identifies biomarkers to understand the disease and identify targetable therapeutic molecules Provides insight into the technological advancements in metabolomic analysis for bladder cancer

Methodologies for Metabolomics

Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Methodologies for Metabolomics Book PDF

Author : Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Publisher : Cambridge University Press
Page : 128 pages
File Size : 51,5 Mb
Release : 2013-01-21
Category : Medical
ISBN : 9781139619059

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Methodologies for Metabolomics by Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers Pdf

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Metabolomics

Anonim
Metabolomics Book PDF

Author : Anonim
Publisher : BoD – Books on Demand
Page : 114 pages
File Size : 49,5 Mb
Release : 2020-07-01
Category : Science
ISBN : 9781789851274

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Metabolomics by Anonim Pdf

This book is mainly for researchers interested in the new developments and applications of metabolomics. It is also important for physicians using metabolomic approaches in the diagnosis of diseases or treatment, and for postgraduate students starting their research projects on metabolomics. The book is divided into two sections as indicated from its title, namely: new insights into biology and new insights into medicine. It gives examples of the different applications of metabolomics from the production of biosurfactants by marine microorganisms to the applications of data from fecal metabolomics, serum metabolomics, and metabolomics of microbiota, as well as the use of Chinese medicines for cancer treatment. Overall, this is a well-written book, containing some very interesting research avenues and cutting-edge approaches. Finally, the editing of this book was of special interest to me and I hope that readers will also find it stimulating.

Metabolomics: From Fundamentals to Clinical Applications

Alessandra Sussulini
Metabolomics From Fundamentals to Clinical Applications Book PDF

Author : Alessandra Sussulini
Publisher : Springer
Page : 350 pages
File Size : 55,7 Mb
Release : 2017-01-28
Category : Science
ISBN : 9783319476568

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Metabolomics: From Fundamentals to Clinical Applications by Alessandra Sussulini Pdf

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Epigenetics and Metabolomics

Paban K. Agrawala,Poonam Rana
Epigenetics and Metabolomics Book PDF

Author : Paban K. Agrawala,Poonam Rana
Publisher : Elsevier
Page : 478 pages
File Size : 45,8 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9780323856539

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Epigenetics and Metabolomics by Paban K. Agrawala,Poonam Rana Pdf

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others Provides guidance in epigenomics and metabolomic research methodology