Nmr Metabolomics In Cancer Research

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NMR Metabolomics in Cancer Research

Miroslava Čuperlović-Culf
NMR Metabolomics in Cancer Research Book PDF

Author : Miroslava Čuperlović-Culf
Publisher : Elsevier
Page : 446 pages
File Size : 55,5 Mb
Release : 2012-12-17
Category : Medical
ISBN : 9781908818263

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NMR Metabolomics in Cancer Research by Miroslava Čuperlović-Culf Pdf

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

NMR-based Metabolomics

Hector C Keun
NMR based Metabolomics Book PDF

Author : Hector C Keun
Publisher : Royal Society of Chemistry
Page : 384 pages
File Size : 41,8 Mb
Release : 2018-01-17
Category : Science
ISBN : 9781849736435

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NMR-based Metabolomics by Hector C Keun Pdf

This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.

Cancer Metabolomics

Shen Hu
Cancer Metabolomics Book PDF

Author : Shen Hu
Publisher : Springer Nature
Page : 317 pages
File Size : 49,5 Mb
Release : 2021-04-01
Category : Medical
ISBN : 9783030516529

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Cancer Metabolomics by Shen Hu Pdf

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

NMR-Based Metabolomics

G. A. Nagana Gowda,Daniel Raftery
NMR Based Metabolomics Book PDF

Author : G. A. Nagana Gowda,Daniel Raftery
Publisher : Humana
Page : 489 pages
File Size : 41,9 Mb
Release : 2020-08-29
Category : Science
ISBN : 1493996924

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NMR-Based Metabolomics by G. A. Nagana Gowda,Daniel Raftery Pdf

This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, NMR-Based Metabolomics: Methods and Protocols serves as a wealth of information for beginners as well as advanced practitioners and also as stepping stones for further advances in the field of metabolomics.

Colon Cancer Diagnosis and Therapy

Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
Colon Cancer Diagnosis and Therapy Book PDF

Author : Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
Publisher : Springer Nature
Page : 374 pages
File Size : 41,5 Mb
Release : 2021-06-10
Category : Medical
ISBN : 9783030633691

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Colon Cancer Diagnosis and Therapy by Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma Pdf

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Cancer Metabolomics 2018

Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Cancer Metabolomics 2018 Book PDF

Author : Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Publisher : MDPI
Page : 184 pages
File Size : 51,5 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9783039213450

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Cancer Metabolomics 2018 by Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto Pdf

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Methodologies for Metabolomics

Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Methodologies for Metabolomics Book PDF

Author : Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Publisher : Cambridge University Press
Page : 641 pages
File Size : 40,7 Mb
Release : 2013-01-21
Category : Medical
ISBN : 9780521765909

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Methodologies for Metabolomics by Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers Pdf

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 55,5 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Kakoli Bose,Pradip Chaudhari
Unravelling Cancer Signaling Pathways A Multidisciplinary Approach Book PDF

Author : Kakoli Bose,Pradip Chaudhari
Publisher : Springer Nature
Page : 587 pages
File Size : 51,7 Mb
Release : 2019-11-25
Category : Medical
ISBN : 9789813298163

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Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach by Kakoli Bose,Pradip Chaudhari Pdf

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

Metabolomics: From Fundamentals to Clinical Applications

Alessandra Sussulini
Metabolomics From Fundamentals to Clinical Applications Book PDF

Author : Alessandra Sussulini
Publisher : Springer
Page : 350 pages
File Size : 55,8 Mb
Release : 2017-01-28
Category : Science
ISBN : 9783319476568

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Metabolomics: From Fundamentals to Clinical Applications by Alessandra Sussulini Pdf

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Haleem J. Issaq,Timothy D. Veenstra
Proteomic and Metabolomic Approaches to Biomarker Discovery Book PDF

Author : Haleem J. Issaq,Timothy D. Veenstra
Publisher : Academic Press
Page : 504 pages
File Size : 53,5 Mb
Release : 2019-10-24
Category : Science
ISBN : 9780128197882

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Proteomic and Metabolomic Approaches to Biomarker Discovery by Haleem J. Issaq,Timothy D. Veenstra Pdf

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Cancer Cell Lines Part 1

John Masters,Bernhard Ø Palsson
Cancer Cell Lines Part 1 Book PDF

Author : John Masters,Bernhard Ø Palsson
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 54,7 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306468728

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Cancer Cell Lines Part 1 by John Masters,Bernhard Ø Palsson Pdf

Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Pancreatic Cancer

Sanjay Srivastava
Pancreatic Cancer Book PDF

Author : Sanjay Srivastava
Publisher : BoD – Books on Demand
Page : 328 pages
File Size : 54,6 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9789535103943

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Pancreatic Cancer by Sanjay Srivastava Pdf

This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.

Tumor Microenvironment

Jacinta Serpa
Tumor Microenvironment Book PDF

Author : Jacinta Serpa
Publisher : Springer Nature
Page : 430 pages
File Size : 42,8 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9783030340254

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Tumor Microenvironment by Jacinta Serpa Pdf

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

The Handbook of Metabonomics and Metabolomics

John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
The Handbook of Metabonomics and Metabolomics Book PDF

Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
Publisher : Elsevier
Page : 573 pages
File Size : 42,8 Mb
Release : 2011-08-11
Category : Science
ISBN : 9780080468006

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The Handbook of Metabonomics and Metabolomics by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes Pdf

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies* aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification* covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.