Metal Chelation In Medicine

Author : Robert R Crichton,Roberta J Ward,Robert C Hider
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 41,9 Mb
Release : 2016-10-18
Category : Science
ISBN : 9781782623892

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Metal Chelation in Medicine by Robert R Crichton,Roberta J Ward,Robert C Hider Pdf

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Author : Jan Aaseth,Guido Crisponi,Ole Anderson
Publisher : Academic Press
Page : 388 pages
File Size : 52,8 Mb
Release : 2016-04-18
Category : Medical
ISBN : 9780128030738

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Chelation Therapy in the Treatment of Metal Intoxication by Jan Aaseth,Guido Crisponi,Ole Anderson Pdf

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 53,6 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Author : Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD
Publisher : BoD – Books on Demand
Page : 122 pages
File Size : 53,5 Mb
Release : 2020-06-02
Category : Medical
ISBN : 9783750428676

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Evidence-Based Clinical Chelation by Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD Pdf

This is an easy-to-read manual about chelation therapy. It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. Expert chemists and chelation therapists have contributed invaluable knowledge and experience to this book. Most importantly, this is not a book promoting personal views or preferences. In fact, the information presents and explains different approaches, and allows the reader to draw his own conclusion. All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous treatment plans. The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the detoxification of certain organ system. Also discussed is the importance and effect of treatment pauses. Diagnostic tests are discussed, and which are useful under certain conditions. Shown are tables comparing the average metal binding ability of the various EDTAs, DMPS, DMSA and other chelating agents. Detailed information explains which chelator binds which metal and why, all of which aids the therapist in finding optimal treatment schedules. Novel chelating agents are presented such as MIADMSA, a new oral chelator specifically designed for arsenic intoxication, or how natural Pectin may be used an alternative for gadolinium intoxication, which metals are bound by lipoic acid and why a slightly alkaline environment supports metal binding, even preventing the often-feared metal redistribution. All in all, this evidence-based chelation "cookbook" should be in medical libraries and on the bookshelf of every physician treating environmental disease.

Author : F Dwyer
Publisher : Elsevier
Page : 546 pages
File Size : 51,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323146418

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Chelating Agents and Metal Chelates by F Dwyer Pdf

Chelating Agents and Metal Chelates focuses on the structure and properties of metal chelates, as well as bond types, stereochemistry, and optical phenomena. The selection first offers information on historical background and fundamental concepts and the nature of metal-ligand bond. Discussions focus on the structure and stability of metal chelates, bond types and characteristic properties, classes of acceptor metal atoms, and metal-metal bonds in complex compounds. The text also touches on bidentate chelates, design and stereochemistry of multidentate chelating agents, and optical phenomena in metal chelates. The publication ponders on oxidation-reduction potentials as functions of donor atom and ligand and metal chelates of ethylenediaminetetraacetic acid and related substances. Topics include liquid junction potentials, reversibility, measurement of redox potentials, ethylenediaminetetraacetato chelate couples, and metal chelates of ethylenediaminetetraacetic acid. The text also takes a look at metal chelates in biological systems and physical and coordination chemistry of tetrapyrrole pigments. The manuscript is a vital reference for senior students, research workers, biologists, and medical scientists interested in the chemistry of metal chelates.

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 48,9 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Author : David R Williams,David M Taylor
Publisher : Royal Society of Chemistry
Page : 136 pages
File Size : 40,6 Mb
Release : 2007-10-31
Category : Medical
ISBN : 9781847552198

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Trace Elements Medicine and Chelation Therapy by David R Williams,David M Taylor Pdf

This book discusses, in relatively simple language, the importance of even minute amounts of certain trace elements for the protection of human health and how insufficiency or excess may produce serious diseases. It also examines the use of metal chelators in the treatment of such diseases.

Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938

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Iron Chelation Therapy by Chaim Hershko Pdf

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Author : Swaran Jeet Singh Flora
Publisher : Academic Press
Page : 752 pages
File Size : 44,6 Mb
Release : 2014-12-26
Category : Medical
ISBN : 9780124199552

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Handbook of Arsenic Toxicology by Swaran Jeet Singh Flora Pdf

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasure

Author : Katja A. Strohfeldt
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 48,9 Mb
Release : 2015-02-16
Category : Science
ISBN : 9780470665589

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Essentials of Inorganic Chemistry by Katja A. Strohfeldt Pdf

A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.

Author : Mahendra Rai,Avinash P. Ingle,Serenella Medici
Publisher : Springer
Page : 325 pages
File Size : 55,6 Mb
Release : 2018-02-24
Category : Medical
ISBN : 9783319748146

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Biomedical Applications of Metals by Mahendra Rai,Avinash P. Ingle,Serenella Medici Pdf

Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.

Author : David Jay Brown,Gary Gordon
Publisher : Unknown
Page : 0 pages
File Size : 41,9 Mb
Release : 2007-11
Category : Health & Fitness
ISBN : 1890572209

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Detox with Oral Chelation by David Jay Brown,Gary Gordon Pdf

EDTA chelation therapy has been shown to improve blood circulation, lower blood pressure, and remove toxic heavy metals from the body. In a day and age where astonishing new advances in medicine are made almost daily, and our vision of the future of medicine borders on the miraculous, this overlooked, inexpensive, and often misunderstood form of therapy offers us the hope that we can all live longer, healthier, and happier lives right now.

Author : Gary Greenberg
Publisher : Humanix Books
Page : 175 pages
File Size : 54,5 Mb
Release : 2020-08-04
Category : Health & Fitness
ISBN : 9781630061203

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The Chelation Revolution by Gary Greenberg Pdf

The Medical Breakthrough of Chelation Therapy: A treatment that uses medicine to remove toxic metals from the body so they don't make you sick. Chelation has long been approved by the FDA to rid the body of lead by using a synthetic amino acid (ethylene diamine tetraacetic acid), which binds to toxic metals and minerals in the bloodstream, allowing a patient to excrete them. When metals like lead, mercury, iron, and arsenic build up in your body, they can be toxic. Alternative medical practitioners have used chelation for nearly 60 years, especially to treat heavy metal contamination that causes or contributes to heart disease. Chelation rids the body of deposits that can lead to atherosclerosis, which causes coronary arteries to narrow, leading to heart attacks. Patients have also found relief through chelation for improving the symptoms of autism. One of the most promising areas of research is in the treatment of Alzheimer’s disease. Because the buildup of metals like copper, iron, and zinc are thought to play a role in Alzheimer's disease, Chelation Therapy might have a place in treating it. Full of hope-inspiring case histories, expert findings and where to find treatment, The Chelation Revolution: Breakthrough Detox Therapy shows how Chelation Therapy can alleviate suffering in numerous medical conditions and lead to a healthier, happier, and longer life. Includes a Foreword by Tammy Born Huizenga, D.O., owner of the internationally recognized Born Clinic in Grand Rapids, MI, an internationally respected organization in preventive medicine with a speciality in Chelation Therapy.

Author : John Parks Trowbridge
Publisher : Unknown
Page : 68 pages
File Size : 50,5 Mb
Release : 1996-06
Category : Medical
ISBN : 0945498012

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Healing Powers of Chelation Therapy by John Parks Trowbridge Pdf

Author : Philippe Collery
Publisher : John Libbey Eurotext
Page : 852 pages
File Size : 54,8 Mb
Release : 2000
Category : Medical
ISBN : 2742002944

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Metal Ions in Biology and Medicine by Philippe Collery Pdf

The objective of the 6th ISMIBM is to foster exchange of opinions between professionals and specialists working on analysis, research and applications of metal ions, trace elements and minerals in biological, biochemical, medical sciences, toxicology and environmental health. The scientific program, composed of plenary and concurrent sessions, and poster presentations is designed to promote intensive and productive dialogue among experts in these fields. A special program with short courses and mini-symposia have also been organised, featuring specialised areas including toxicology, analysis, pathology, remediation strategies, and environmental medicine. Original contributions (oral and/or poster presentations) are invited on the following themes: Metals and Environmental Health; Molecular Toxicology of Metals; Carcinogenicity of Metals; Speciation of Metals and Other Elements; Uses of Metals in Clinical Applications; Metals and Disease: Environmental and Toxicologic Pathology; Epidemiology and Occupational Health; Metals and Aging; Metals and Homeostasis; Effects of Low and High Nutritional Trace Element Status; Metals and Hormone Actions; Metals and Enzyme Activity; Metals and Chelation Therapy; Health Effects of Arsenic; Risk Assessment of Trace Element Status and Health; Advanced Methods for the Analysis of Trace Elements and Metal Ions.