Methodologies For Metabolomics

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Methodologies for Metabolomics

Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Methodologies for Metabolomics Book PDF

Author : Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Publisher : Cambridge University Press
Page : 641 pages
File Size : 49,8 Mb
Release : 2013-01-21
Category : Medical
ISBN : 9780521765909

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Methodologies for Metabolomics by Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers Pdf

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Metabolomics

Wolfram Weckwerth
Metabolomics Book PDF

Author : Wolfram Weckwerth
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 41,5 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597452441

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Metabolomics by Wolfram Weckwerth Pdf

Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Haleem J. Issaq,Timothy D. Veenstra
Proteomic and Metabolomic Approaches to Biomarker Discovery Book PDF

Author : Haleem J. Issaq,Timothy D. Veenstra
Publisher : Academic Press
Page : 504 pages
File Size : 43,7 Mb
Release : 2019-10-24
Category : Science
ISBN : 9780128197882

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Proteomic and Metabolomic Approaches to Biomarker Discovery by Haleem J. Issaq,Timothy D. Veenstra Pdf

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Chromatographic Methods in Metabolomics

Tuulia Hyotylainen,Susanne Wiedmer
Chromatographic Methods in Metabolomics Book PDF

Author : Tuulia Hyotylainen,Susanne Wiedmer
Publisher : Royal Society of Chemistry
Page : 350 pages
File Size : 41,9 Mb
Release : 2013-09-06
Category : Science
ISBN : 9781849737272

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Chromatographic Methods in Metabolomics by Tuulia Hyotylainen,Susanne Wiedmer Pdf

The concept of a metabolic profile was introduced in 1971, when gas chromatography demonstrated a range of compounds present in human samples. Now termed metabolomics, the field is still emerging, and chromatography remains an essential tool for determining metabolites in a living system. This is the first book to present the chromatographic techniques used in metabolomics in a fundamental way. Sample preparation and quality control are described in detail, and all forms of chromatography applied to metabolomics are included. The editors present guidelines on selecting the most appropriate methodology, making the book an accessible guide to anyone entering the field. Handling data and applications are also described. This is an essential handbook for any laboratory looking to embark on a metabolomics research programme and includes the fundamentals of chromatography alongside the latest developments in the field.

Methodologies for Metabolomics

Norbert Lutz
Methodologies for Metabolomics Book PDF

Author : Norbert Lutz
Publisher : Unknown
Page : 642 pages
File Size : 45,9 Mb
Release : 2012
Category : Mass spectrometry
ISBN : 1139615335

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Methodologies for Metabolomics by Norbert Lutz Pdf

Methodologies for Metabolomics provides comprehensive descriptions of the newest methodological strategies and techniques in metabolomic research.

Computational Methods and Data Analysis for Metabolomics

Shuzhao Li
Computational Methods and Data Analysis for Metabolomics Book PDF

Author : Shuzhao Li
Publisher : Humana
Page : 491 pages
File Size : 44,7 Mb
Release : 2021-02-01
Category : Science
ISBN : 1071602411

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Computational Methods and Data Analysis for Metabolomics by Shuzhao Li Pdf

This book provides a comprehensive guide to scientists, engineers, and students that employ metabolomics in their work, with an emphasis on the understanding and interpretation of the data. Chapters guide readers through common tools for data processing, using database resources, major techniques in data analysis, and integration with other data types and specific scientific domains. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, practical guidance of methods and techniques, useful web supplements, and connect the steps from experimental metabolomics to scientific discoveries. Authoritative and cutting-edge, Computational Methods and Data Analysis for Metabolomics to ensure successful results in the further study of this vital field.

Methodologies for Metabolomics

Norbert Lutz,Jonathan V. Sweedler,Ron Wevers
Methodologies for Metabolomics Book PDF

Author : Norbert Lutz,Jonathan V. Sweedler,Ron Wevers
Publisher : Unknown
Page : 642 pages
File Size : 46,8 Mb
Release : 2013
Category : SCIENCE
ISBN : 1139624636

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Methodologies for Metabolomics by Norbert Lutz,Jonathan V. Sweedler,Ron Wevers Pdf

Methodologies for Metabolomics provides comprehensive descriptions of the newest methodological strategies and techniques in metabolomic research.

Metabolomics

Xianquan Zhan
Metabolomics Book PDF

Author : Xianquan Zhan
Publisher : BoD – Books on Demand
Page : 170 pages
File Size : 45,6 Mb
Release : 2021-09-01
Category : Science
ISBN : 9781839690839

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Metabolomics by Xianquan Zhan Pdf

Metabolomics is the methodology and theory to study the metabolome, including targeted approaches based on selected/multiple reaction monitoring (SRM/MRM) and untargeted approaches based on nuclear magnetic resonance (NMR) or mass spectrometry (MS). The metabolome contains all metabolites derived from sugars, lipids, proteins, and nucleic acids in a given biological system, tissue, cell, or body fluid in a metabolic network system. Metabolomic variations directly link to molecular mechanisms of a disease, reliable therapeutic targets, and effective biomarkers for prediction, diagnosis, and prognostic assessment of disease. This book presents new advances in the concept and methodology of metabolomics, as well as applications of metabolomics in the research and practice of medical and life sciences.

Metabolomics Tools for Natural Product Discovery

Ute Roessner,Daniel Anthony Dias
Metabolomics Tools for Natural Product Discovery Book PDF

Author : Ute Roessner,Daniel Anthony Dias
Publisher : Humana
Page : 0 pages
File Size : 48,8 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493963015

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Metabolomics Tools for Natural Product Discovery by Ute Roessner,Daniel Anthony Dias Pdf

Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.

Cancer Metabolomics

Shen Hu
Cancer Metabolomics Book PDF

Author : Shen Hu
Publisher : Springer Nature
Page : 317 pages
File Size : 50,9 Mb
Release : 2021-04-01
Category : Medical
ISBN : 9783030516529

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Cancer Metabolomics by Shen Hu Pdf

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

Plant Metabolomics

Carla António
Plant Metabolomics Book PDF

Author : Carla António
Publisher : Humana
Page : 355 pages
File Size : 47,9 Mb
Release : 2019-05-29
Category : Science
ISBN : 1493992945

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Plant Metabolomics by Carla António Pdf

This detailed book aims to address the need for standardizing key steps in plant metabolomics research that is still considered a critical issue in the field. The collection unites diverse mass spectrometry (MS)-based protocols, from sample preparation and extraction of plant primary and secondary metabolites (e.g. a range of sugars, lipids, phytohormones and volatile organic compounds) to metabolite analysis, using exclusively highly sensitive MS-based methodologies, followed by frontline bioinformatics and/or mathematical modeling approaches to produce reliable biological data interpretation. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Metabolomics: Methods and Protocols serves both new and well-established researchers in the plant metabolomics field in finding helpful guidelines and useful laboratory-based protocols for setting up their routine plant metabolomics experiments.

Metabolomics: From Fundamentals to Clinical Applications

Alessandra Sussulini
Metabolomics From Fundamentals to Clinical Applications Book PDF

Author : Alessandra Sussulini
Publisher : Springer
Page : 350 pages
File Size : 54,6 Mb
Release : 2017-01-28
Category : Science
ISBN : 9783319476568

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Metabolomics: From Fundamentals to Clinical Applications by Alessandra Sussulini Pdf

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Clinical Metabolomics

Martin Giera
Clinical Metabolomics Book PDF

Author : Martin Giera
Publisher : Humana
Page : 389 pages
File Size : 54,7 Mb
Release : 2019-06-04
Category : Science
ISBN : 1493985302

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Clinical Metabolomics by Martin Giera Pdf

This detailed volume presents a comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. The methodologies explored here form the core of several very promising initiatives evolving around personalized health care and precision medicine, which can be seen as complimentary to the field of clinical chemistry and aid the aforementioned field with novel disease markers and diagnostic patterns. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Metabolomics: Methods and Protocols aims to serve as the basis for successful communication between scientists from several fields, including chemists, biologist, bioinformaticians, and clinicians, ultimately leading to effective study design and completion.

Metabolome Analysis

Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali
Metabolome Analysis Book PDF

Author : Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali
Publisher : John Wiley & Sons
Page : 339 pages
File Size : 54,7 Mb
Release : 2007-02-16
Category : Science
ISBN : 9780470105504

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Metabolome Analysis by Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali Pdf

Providing information on the main approaches for the analysis of metabolites, this textbook: Covers basic methodologies in sample preparation and separation techniques, as well as the most recent techniques of mass spectrometry. Differentiates between primary and secondary metabolites. Includes four chapters discussing successful metabolome studies of different organisms. Highlights the analytical challenges of studying metabolites. Illustrates applications of metabolome analysis through the use of case studies.

Processing Metabolomics and Proteomics Data with Open Software

Robert Winkler
Processing Metabolomics and Proteomics Data with Open Software Book PDF

Author : Robert Winkler
Publisher : Royal Society of Chemistry
Page : 460 pages
File Size : 53,9 Mb
Release : 2020-03-19
Category : Science
ISBN : 9781788017213

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Processing Metabolomics and Proteomics Data with Open Software by Robert Winkler Pdf

Metabolomics and proteomics allow deep insights into the chemistry and physiology of biological systems. This book expounds open-source programs, platforms and programming tools for analysing metabolomics and proteomics mass spectrometry data. In contrast to commercial software, open-source software is created by the academic community, which facilitates the direct interaction between users and developers and accelerates the implementation of new concepts and ideas. The first section of the book covers the basics of mass spectrometry, experimental strategies, data operations, the open-source philosophy, metabolomics, proteomics and statistics/ data mining. In the second section, active programmers and users describe available software packages. Included tutorials, datasets and code examples can be used for training and for building custom workflows. Finally, every reader is invited to participate in the open science movement.