Microglial Polarization In The Pathogenesis And Therapeutics Of Neurodegenerative Diseases

Author : Yu Tang,Isidre Ferrer
Publisher : Frontiers Media SA
Page : 327 pages
File Size : 52,7 Mb
Release : 2018
Category : Electronic
ISBN : 9782889455256

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Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases by Yu Tang,Isidre Ferrer Pdf

Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 45,8 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368431374

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Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases by Anonim Pdf

Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization.

Author : Jamal Akhtar,Maryam Sarwat,Fouzia Bashir
Publisher : CRC Press
Page : 586 pages
File Size : 48,8 Mb
Release : 2024-06-17
Category : Science
ISBN : 9781040030318

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Medicinal Plants for the Management of Neurodegenerative Diseases by Jamal Akhtar,Maryam Sarwat,Fouzia Bashir Pdf

Ageing is the main reason for most neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). About 10% of individuals aged ≥65 years develop AD, which continuously increases with growing age. Medicinal plants have been used for age-related neurodegenerative disorders for a long time. These plants are rich in terms of various phytochemical constituents such as flavonoids, sterols, alkaloids, saponins, and terpenoids. Different scientific studies have been carried out on these medicinal herbs, e.g., anti-inflammatory, antioxidant, and neuro-regenerative activities that may be used in the treatment of AD and other age-related diseases. These medicinal plants, e.g., Curcuma longa, Bacopa monniera, Glycyrrhiza glabra, Commiphora whighitti, and Acorus calamus L., have anti-inflammatory properties that may decrease swelling of the brain tissue in AD. Despite this, there is currently no book available in the market that provides full information on the phytochemical and medicinal uses of the medicinal plants exclusively used for the management of neurodegenerative diseases in the elderly. This book aims to provide some important and evidence-based information on the plants used for neurodegenerative diseases in the elderly, especially AD and PD, in a planned manner so the academicians, researchers, and students working in the fields of medicinal plants, plant science, chemistry, biotechnology, pharmacognosy, pharmaceuticals, biochemistry, and many other interdisciplinary subjects may benefit. This book will also be useful in identifying a few medicinal plants and their prospects for the synthesis or preparation of new drugs for neurodegenerative diseases. Features: · An overview of the medicinal plants that can be helpful for neurodegenerative disorders. · Recent research results and some pointers for the management of neurodegenerative diseases. This book serve as comprehensive information about the description, phytochemistry, actions, and medicinal use of plants that are used in neurodegenerative diseases. In addition, this book will also ease the understanding and interaction of medicinal plants used in neurodegenerative diseases.

Author : Ishan Patro,Pankaj Seth,Nisha Patro,Prakash Narain Tandon
Publisher : Springer Nature
Page : 763 pages
File Size : 52,8 Mb
Release : 2022-04-09
Category : Medical
ISBN : 9789811683138

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The Biology of Glial Cells: Recent Advances by Ishan Patro,Pankaj Seth,Nisha Patro,Prakash Narain Tandon Pdf

This book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease. ​

Author : Sergey Kasparov
Publisher : MDPI
Page : 422 pages
File Size : 44,9 Mb
Release : 2019-06-17
Category : Medical
ISBN : 9783038979906

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Neuroglia by Sergey Kasparov Pdf

Neuroglia is now published as part of Brain Sciences with a new section Editor-in-Chief Prof. Sergey Kasparov.

Author : Hardy J. Rideout
Publisher : Springer
Page : 271 pages
File Size : 41,5 Mb
Release : 2017-03-28
Category : Medical
ISBN : 9783319499697

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Leucine-Rich Repeat Kinase 2 (LRRK2) by Hardy J. Rideout Pdf

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Author : Sikha Saha,Sriharsha Kantamneni
Publisher : Frontiers Media SA
Page : 317 pages
File Size : 53,6 Mb
Release : 2020-01-30
Category : Electronic
ISBN : 9782889634422

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Cerebrovascular and Neurodegenerative Diseases – New Insights into Molecular Cell Biology and Therapeutic Targets by Sikha Saha,Sriharsha Kantamneni Pdf

Author : Guanghui Wang,Gerald Muench,Yong-Jing Gao,Haigang Ren,Subashchandrabose Chinnathambi
Publisher : Frontiers Media SA
Page : 189 pages
File Size : 42,6 Mb
Release : 2022-05-26
Category : Science
ISBN : 9782889762361

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Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders by Guanghui Wang,Gerald Muench,Yong-Jing Gao,Haigang Ren,Subashchandrabose Chinnathambi Pdf

Author : Guoqiang Xing,John Wesson Ashford,Yu Zhang,Yumin Zhang,Maheen Mausoof Adamson,Ansgar J. Furst
Publisher : Frontiers Media SA
Page : 202 pages
File Size : 44,5 Mb
Release : 2021-09-30
Category : Medical
ISBN : 9782889714322

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Advances in Diagnosis and Treatment of TBI-Induced Neurodegeneration and Cognitive Deficits by Guoqiang Xing,John Wesson Ashford,Yu Zhang,Yumin Zhang,Maheen Mausoof Adamson,Ansgar J. Furst Pdf

Author : Francesco Marotta
Publisher : Springer Nature
Page : 440 pages
File Size : 42,5 Mb
Release : 2023-01-01
Category : Medical
ISBN : 9783031140235

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Gut Microbiota in Aging and Chronic Diseases by Francesco Marotta Pdf

This edited volume studies gut microbiota peculiarities in elderly, in senescence-related and environmental-related alterations of gut microbiota in chronic diseases. Aging, as a physiological process mediated through several regulatory pathways and transcription factors, is generally speaking associated to a relentless functional decline and increasing risk of chronic diseases. Growing data on gut microbiota quali-quantitative changes in aging gut, and the opportunity to study by advanced NGS and metabolomic technologies, now offers novel horizons to link such changes to disease risks and to theoretically the weapons for gut microbiota intervention as an effective therapeutic tool. Chapters are divided into clear sections, starting with the aging perspective, then moving from chronic diseases to neurodegenerative diseases and cancer. The final parts focusses on interventions. Contributors are well-reputed and dedicated scientists in clinics and experimental medicine from 4 different continents who have provided their contribution keeping the polar star on aging as a guide while investigating their gut microbiota in occurrence and progression of disease together with proposed preventing, monitoring and therapeutic interventions. In the wide offer of books on gut microbiota, this age-thematic volume will be a valuable source of updated information for a wide group of readership including gerontologists, geriatricians, medical specialists of several fields, PhDs, basic scientists and public/private research entities focused on potential intervention in and through gut ecosystem. This book will stimulate a large number of basic scientists and clinicians to review their once organ (or cellular line)-specific knowledge and widen either their pathophysiological mechanisms understanding while providing novel ways to prevent, monitor and treat diseases from eyes to bones.

Author : Chengjin Gao,Shuming Pan,Kun Xiong
Publisher : Frontiers Media SA
Page : 355 pages
File Size : 49,8 Mb
Release : 2024-03-19
Category : Medical
ISBN : 9782832546529

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Characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases by Chengjin Gao,Shuming Pan,Kun Xiong Pdf

The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and γδ T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases.

Author : Marie-Ève Tremblay,Amanda Sierra
Publisher : Springer
Page : 490 pages
File Size : 44,7 Mb
Release : 2014-09-22
Category : Medical
ISBN : 9781493914296

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Microglia in Health and Disease by Marie-Ève Tremblay,Amanda Sierra Pdf

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Author : Victoria Campos-Peña,Oscar Rosas-Carrasco,Karla Guadalupe Carvajal,Rocío Martínez De Pablos
Publisher : Frontiers Media SA
Page : 213 pages
File Size : 45,6 Mb
Release : 2022-01-24
Category : Science
ISBN : 9782889741496

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Neurodegeneration: From Genetics to Molecules, Volume II by Victoria Campos-Peña,Oscar Rosas-Carrasco,Karla Guadalupe Carvajal,Rocío Martínez De Pablos Pdf

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Page : 320 pages
File Size : 47,9 Mb
Release : 2017-08-23
Category : Medical
ISBN : 9789535134510

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Mechanisms of Neuroinflammation by Gonzalo Emiliano Aranda Abreu Pdf

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Author : Jian-Sheng Lin,Pertti Panula,Maria Beatrice Passani
Publisher : Frontiers Media SA
Page : 100 pages
File Size : 50,7 Mb
Release : 2015-03-18
Category : Brain
ISBN : 9782889194346

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Histamine in the brain by Jian-Sheng Lin,Pertti Panula,Maria Beatrice Passani Pdf

Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.