Microtechnology For Cell Manipulation And Sorting

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Microtechnology for Cell Manipulation and Sorting

Wonhee Lee,Peter Tseng,Dino Di Carlo
Microtechnology for Cell Manipulation and Sorting Book PDF

Author : Wonhee Lee,Peter Tseng,Dino Di Carlo
Publisher : Springer
Page : 281 pages
File Size : 42,9 Mb
Release : 2016-10-05
Category : Technology & Engineering
ISBN : 9783319441399

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Microtechnology for Cell Manipulation and Sorting by Wonhee Lee,Peter Tseng,Dino Di Carlo Pdf

This book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientists working in the biotechnology industry.

Medical and Industrial Applications of Microfluidic-based Cell/Tissue Culture and Organs-on-a-Chip: Advances in Organs-on-a-Chip and Organoids Technologies

Qasem Ramadan,Massimo Alberti,Martin Dufva,Yi-Chung Tung
Medical and Industrial Applications of Microfluidic based Cell Tissue Culture and Organs on a Chip Advances in Organs on a Chip and Organoids Technologies Book PDF

Author : Qasem Ramadan,Massimo Alberti,Martin Dufva,Yi-Chung Tung
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 47,9 Mb
Release : 2019-10-16
Category : Electronic
ISBN : 9782889631148

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Medical and Industrial Applications of Microfluidic-based Cell/Tissue Culture and Organs-on-a-Chip: Advances in Organs-on-a-Chip and Organoids Technologies by Qasem Ramadan,Massimo Alberti,Martin Dufva,Yi-Chung Tung Pdf

Recent developments in microfluidics have demonstrated enormous potential of microscale cell culture for biology studies and recognized as instrumental in performing rapid and efficient experiments on small-sample volumes. Microfluidic-based cell culture is an area of research that keeps growing and gaining importance as a prominent technology, able to link scientific disciplines with industrial and clinical applications. In particular, organotypic cell culture and its integration in microfluidic devices would enable the realization of “in vivo-like” cell microenvironment within systems that are more amenable to automation and integration. Such remarkable advancement forms the foundation and motivation to transfer research from the laboratory to the field. Although the microfluidics and cell culture technologies have influenced many areas of science, significant research efforts are currently focus on finding methods to transform drug screening and toxicity testing from a system reliant on high-dose animal studies to one based primarily on human-relevant in vitro models. In line with regulatory developments precluding the use of animal testing, as well as fundamental differences in animal versus human, human in vitro methodologies are required to replace the animal-based testes while permitting physiologically relevant model equivalents for superior prediction. Organs-on-a-chip is an ambitious and rapidly growing technology that promise to bridge the gap between in vivo and in vitro studies and open wide possibilities in medical and industrial applications. However, many challenges are still ahead. This eBook present recent state-of-the-art works and critical reviews in organs-on-a-chip technology which highlight the new advances in this growing field with an emphasis on the interface between technological advancements and high impact applications.

Microfluidic Cell Culture Systems

Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Microfluidic Cell Culture Systems Book PDF

Author : Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Publisher : Elsevier
Page : 396 pages
File Size : 43,8 Mb
Release : 2018-09-12
Category : Science
ISBN : 9780128136720

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Microfluidic Cell Culture Systems by Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest Pdf

Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Microfluidics for Cells and Other Organisms

Danny van Noort
Microfluidics for Cells and Other Organisms Book PDF

Author : Danny van Noort
Publisher : MDPI
Page : 200 pages
File Size : 49,8 Mb
Release : 2019-10-23
Category : Technology & Engineering
ISBN : 9783039215621

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Microfluidics for Cells and Other Organisms by Danny van Noort Pdf

Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.

Particles Separation in Microfluidic Devices

Takasi Nisisako ,Naotomo Tottori
Particles Separation in Microfluidic Devices Book PDF

Author : Takasi Nisisako ,Naotomo Tottori
Publisher : MDPI
Page : 230 pages
File Size : 48,5 Mb
Release : 2020-12-10
Category : Technology & Engineering
ISBN : 9783039366941

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Particles Separation in Microfluidic Devices by Takasi Nisisako ,Naotomo Tottori Pdf

Microfluidic platforms are increasingly being used for separating a wide variety of particles based on their physical and chemical properties. In the past two decades, many practical applications have been found in chemical and biological sciences, including single cell analysis, clinical diagnostics, regenerative medicine, nanomaterials synthesis, environmental monitoring, etc. In this Special Issue, we invited contributions to report state-of-the art developments in the fields of micro- and nanofluidic separation, fractionation, sorting, and purification of all classes of particles, including, but not limited to, active devices using electric, magnetic, optical, and acoustic forces; passive devices using geometries and hydrodynamic effects at the micro/nanoscale; confined and open platforms; label-based and label-free technology; and separation of bioparticles (including blood cells), circulating tumor cells, live/dead cells, exosomes, DNA, and non-bioparticles, including polymeric or inorganic micro- and nanoparticles, droplets, bubbles, etc. Practical devices that demonstrate capabilities to solve real-world problems were of particular interest.

Nonmagnetic and Magnetic Quantum Dots

Vasilios N. Stavrou
Nonmagnetic and Magnetic Quantum Dots Book PDF

Author : Vasilios N. Stavrou
Publisher : BoD – Books on Demand
Page : 248 pages
File Size : 53,5 Mb
Release : 2018-04-04
Category : Science
ISBN : 9789535139591

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Nonmagnetic and Magnetic Quantum Dots by Vasilios N. Stavrou Pdf

The book entitled Nonmagnetic and Magnetic Quantum Dots is divided into two sections. In Section 1, the chapters are related to nonmagnetic quantum dots and their applications. More specifically, exact models and numerical methods have been presented to describe the analytical solution of the carrier wave functions, the quantum mechanical aspects of quantum dots, and the comparison of the latter to experimental data. Furthermore, methods to produce quantum dots, synthesis techniques of colloidal quantum dots, and applications on sensors and biology, among others, are included in this section. In Section 2, a few topics of magnetic quantum dots and their applications are presented. The section starts with a theoretical model to describe the magnetization dynamics in magnetic quantum dot array and the description of dilute magnetic semiconducting quantum dots and their applications. Additionally, a few applications of magnetic quantum dots in sensors, biology, and medicine are included in Section 2.

Microfluidics for Single-Cell Analysis

Jin-Ming Lin
Microfluidics for Single Cell Analysis Book PDF

Author : Jin-Ming Lin
Publisher : Springer Nature
Page : 261 pages
File Size : 55,8 Mb
Release : 2019-08-28
Category : Science
ISBN : 9789813297296

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Microfluidics for Single-Cell Analysis by Jin-Ming Lin Pdf

This book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor’s laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.

Pulsed Electric Fields Technology for the Food Industry

Javier Raso,Volker Heinz,Ignacio Alvarez,Stefan Toepfl
Pulsed Electric Fields Technology for the Food Industry Book PDF

Author : Javier Raso,Volker Heinz,Ignacio Alvarez,Stefan Toepfl
Publisher : Springer Nature
Page : 558 pages
File Size : 48,7 Mb
Release : 2022-01-01
Category : Technology & Engineering
ISBN : 9783030705862

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Pulsed Electric Fields Technology for the Food Industry by Javier Raso,Volker Heinz,Ignacio Alvarez,Stefan Toepfl Pdf

Many novel technologies have been proposed in the attempt to improve existing food processing methods. Among emerging nonthermal technologies, high intensity pulsed electric fields (PEF) is appealing due to its short treatment times and reduced heating effects. This book presents information accumulated on PEF during the last 15 years by experienced microbiologists, biochemists, food technologists, and electrical and food engineers.

Processing of Foods and Biomass Feedstocks by Pulsed Electric Energy

Eugene Vorobiev,Nikolai Lebovka
Processing of Foods and Biomass Feedstocks by Pulsed Electric Energy Book PDF

Author : Eugene Vorobiev,Nikolai Lebovka
Publisher : Springer Nature
Page : 422 pages
File Size : 42,9 Mb
Release : 2020-04-10
Category : Technology & Engineering
ISBN : 9783030409173

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Processing of Foods and Biomass Feedstocks by Pulsed Electric Energy by Eugene Vorobiev,Nikolai Lebovka Pdf

This book presents a comprehensive range of research on pulsed electric energy used in food processing, including sections on the fundamentals of electroporation and important techniques for the estimation of electroporation effects in various foods and biomass feedstocks. By focusing on application over theory, this book presents researchers with practical steps for processing techniques such as solid-liquid extraction, pressing, osmotic dehydration, drying, freezing and cooking. Special interest is given to the selective recovery and extraction of sugar, inulin, starch, proteins, polysaccharides, polyphenols, pigments, flavor compounds, phytochemicals and other of high-value components from food biomasses such as fruits and vegetables, leaves, herbs, mushrooms, microalgae and suspensions of cells. Processing of Foods and Biomass Feedstocks by Pulsed Electric Energy presents a singular overview of the biorefinery applications of pulsed electric energy for the processing of wastes and non-food biomasses such as root and tuber crops, grape waste, lignocellulosic biomass, oil crops and residues and seeds and peels of exotic and citrus fruits. The book begins by presenting general information on the fundamentals of electroporation and information on the procedures and protocols involved. Further chapters focus on the specific food processing operations involved and biorefinery applications for the processing of wastes and non-food biomasses. All of the relevant and up-to-date information any researcher needs on pulsed electric energy in food processing is presented here in this text.

Handbook on Biological Warfare Preparedness

S.J.S. Flora,Vidhu Pachauri
Handbook on Biological Warfare Preparedness Book PDF

Author : S.J.S. Flora,Vidhu Pachauri
Publisher : Academic Press
Page : 306 pages
File Size : 40,7 Mb
Release : 2019-10-05
Category : Medical
ISBN : 9780128120552

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Handbook on Biological Warfare Preparedness by S.J.S. Flora,Vidhu Pachauri Pdf

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins Discusses medical countermeasures, including vaccines and post-exposure therapeutics Includes a comprehensive review of current methods of detection

Imaging Technologies and Transdermal Delivery in Skin Disorders

Chenjie Xu,Xiaomeng Wang,Manojit Pramanik
Imaging Technologies and Transdermal Delivery in Skin Disorders Book PDF

Author : Chenjie Xu,Xiaomeng Wang,Manojit Pramanik
Publisher : John Wiley & Sons
Page : 498 pages
File Size : 41,7 Mb
Release : 2020-03-09
Category : Science
ISBN : 9783527344604

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Imaging Technologies and Transdermal Delivery in Skin Disorders by Chenjie Xu,Xiaomeng Wang,Manojit Pramanik Pdf

Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical presentations, pathophysiological mechanisms, and current clinical practices used to treat diseases affecting the skin are then introduced. Common preclinical models used for studying the mechanisms of diverse skin diseases, validation of novel therapeutic targets, and screening of new drugs to treat these diseases are also covered. The book examines the latest imaging technologies for understanding in vivo skin changes, as well as technologies such as high-resolution ultrasound imaging, quantitative Magnetic Resonance Imaging, high-resolution Optical Coherence Tomography, and emerging hybrid-imaging modalities. It concludes with chapters introducing emerging drug delivery technologies and potential future innovative developments. * Presents up-to-date knowledge of the skin biology and pathologies * Introduces advancements in the topic of imaging technology for tracing the drug delivery process, which is rarely systematically reported by other counterparts * Covers the latest development in three inter-related directions of drug delivery, imaging, and skin disease intersect for skin research * Provides an overview of the latest development of diagnostic and therapeutic technologies for skin diseases Imaging Technologies and Transdermal Delivery in Skin Disorders will be of great interest to analytical chemists, materials scientists, pharmaceutical chemists, clinical chemists, biotechnologists, bioengineers, cosmetics industry, and dermatologists.

Microdevices and Microsystems for Cell Manipulation

Aaron T. Ohta,Wenqi Hu
Microdevices and Microsystems for Cell Manipulation Book PDF

Author : Aaron T. Ohta,Wenqi Hu
Publisher : MDPI
Page : 179 pages
File Size : 52,5 Mb
Release : 2018-07-03
Category : Electronic books
ISBN : 9783038426189

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Microdevices and Microsystems for Cell Manipulation by Aaron T. Ohta,Wenqi Hu Pdf

This book is a printed edition of the Special Issue "Microdevices and Microsystems for Cell Manipulation" that was published in Micromachines

Cell Separation Methods and Applications

Diether Recktenwald
Cell Separation Methods and Applications Book PDF

Author : Diether Recktenwald
Publisher : CRC Press
Page : 352 pages
File Size : 41,6 Mb
Release : 1997-11-04
Category : Medical
ISBN : 9781482273649

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Cell Separation Methods and Applications by Diether Recktenwald Pdf

"Offers complete coverage and assessment of cell separation technologies for analytical and preparative isolations of biological cell populations-demonstrating how to select and devise optimal sorting strategies for applications in biochemistry, immunology, cell and molecular biology, and clinical research. "

Essentials of Single-Cell Analysis

Fan-Gang Tseng,Tuhin Subhra Santra
Essentials of Single Cell Analysis Book PDF

Author : Fan-Gang Tseng,Tuhin Subhra Santra
Publisher : Springer
Page : 414 pages
File Size : 53,5 Mb
Release : 2016-01-21
Category : Technology & Engineering
ISBN : 9783662491188

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Essentials of Single-Cell Analysis by Fan-Gang Tseng,Tuhin Subhra Santra Pdf

This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devices, microfluidic cytometry) and their integration with sensor technology, optical and hydrodynamic stretchers etc., and demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems. It also discusses the future challenges for single-cell analysis, including the advantages and limitations. This book is enjoyable reading material while at the same time providing essential information to scientists in academia and professionals in industry working on different aspects of single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished Professor of Engineering and System Science at the National Tsing Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research Associate at the California Nano Systems Institute, University of California at Los Angeles, USA.

Microscale Acoustofluidics

Thomas Laurell,Andreas Lenshof
Microscale Acoustofluidics Book PDF

Author : Thomas Laurell,Andreas Lenshof
Publisher : Royal Society of Chemistry
Page : 250 pages
File Size : 40,9 Mb
Release : 2014-12-08
Category : Technology & Engineering
ISBN : 9781849737067

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Microscale Acoustofluidics by Thomas Laurell,Andreas Lenshof Pdf

The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves. Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays. Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.