Mitochondria And Cancer

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Mitochondria and Cancer

Keshav Singh,Leslie Costello
Mitochondria and Cancer Book PDF

Author : Keshav Singh,Leslie Costello
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 52,9 Mb
Release : 2009-04-05
Category : Medical
ISBN : 9780387848358

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Mitochondria and Cancer by Keshav Singh,Leslie Costello Pdf

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Cancer as a Metabolic Disease

Thomas Seyfried
Cancer as a Metabolic Disease Book PDF

Author : Thomas Seyfried
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 55,8 Mb
Release : 2012-05-18
Category : Science
ISBN : 9781118310304

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Cancer as a Metabolic Disease by Thomas Seyfried Pdf

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Mitochondria and Cancer

Keshav Singh,Leslie Costello
Mitochondria and Cancer Book PDF

Author : Keshav Singh,Leslie Costello
Publisher : Springer
Page : 289 pages
File Size : 51,9 Mb
Release : 2008-12-12
Category : Medical
ISBN : 0387848347

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Mitochondria and Cancer by Keshav Singh,Leslie Costello Pdf

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.

Mitochondria: The Anti- cancer Target for the Third Millennium

Jiri Neuzil,Shazib Pervaiz,Simone Fulda
Mitochondria The Anti cancer Target for the Third Millennium Book PDF

Author : Jiri Neuzil,Shazib Pervaiz,Simone Fulda
Publisher : Springer
Page : 382 pages
File Size : 52,9 Mb
Release : 2014-05-26
Category : Medical
ISBN : 9789401789844

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Mitochondria: The Anti- cancer Target for the Third Millennium by Jiri Neuzil,Shazib Pervaiz,Simone Fulda Pdf

This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.

Mitochondrial DNA Mutations in Aging, Disease and Cancer

Keshav K. Singh
Mitochondrial DNA Mutations in Aging Disease and Cancer Book PDF

Author : Keshav K. Singh
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 45,6 Mb
Release : 2013-03-09
Category : Science
ISBN : 9783662125090

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Mitochondrial DNA Mutations in Aging, Disease and Cancer by Keshav K. Singh Pdf

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 55,8 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Mitochondria As Biosynthetic Factories for Cancer Proliferation

Madrid Madrid Press
Mitochondria As Biosynthetic Factories for Cancer Proliferation Book PDF

Author : Madrid Madrid Press
Publisher : Unknown
Page : 38 pages
File Size : 54,5 Mb
Release : 2015-12-15
Category : Electronic
ISBN : 1522769668

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Mitochondria As Biosynthetic Factories for Cancer Proliferation by Madrid Madrid Press Pdf

This open access article by various authors presents key research on Mitochondria as biosynthetic factories for cancer proliferation. Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critical biochemical functions for the synthesis of fundamental cellular components, including fatty acids, amino acids, and nucleotides. Despite the extensive interest in the glycolytic phenotype of many cancer cells, tumors contain fully functional mitochondria that support proliferation and survival. Furthermore, tumor cells commonly increase flux through one or more mitochondrial pathways, and pharmacological inhibition of mitochondrial metabolism is emerging as a potential therapeutic strategy in some cancers. Here, we review the biosynthetic roles of mitochondrial metabolism in tumors and highlight specific cancers where these processes are activated.

Mitochondrial Metabolism

Jalal Pourahmad,Mohsen Rezaei
Mitochondrial Metabolism Book PDF

Author : Jalal Pourahmad,Mohsen Rezaei
Publisher : Academic Press
Page : 316 pages
File Size : 44,8 Mb
Release : 2021-07-28
Category : Science
ISBN : 9780128224090

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Mitochondrial Metabolism by Jalal Pourahmad,Mohsen Rezaei Pdf

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondria in Health and in Sickness

Andrea Urbani,Mohan Babu
Mitochondria in Health and in Sickness Book PDF

Author : Andrea Urbani,Mohan Babu
Publisher : Springer Nature
Page : 277 pages
File Size : 41,6 Mb
Release : 2019-08-26
Category : Science
ISBN : 9789811383670

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Mitochondria in Health and in Sickness by Andrea Urbani,Mohan Babu Pdf

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

Mitochondrial Genetics and Cancer

Gabriel D. Dakubo
Mitochondrial Genetics and Cancer Book PDF

Author : Gabriel D. Dakubo
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 50,6 Mb
Release : 2010-03-23
Category : Medical
ISBN : 9783642114168

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Mitochondrial Genetics and Cancer by Gabriel D. Dakubo Pdf

With very few exceptions, eukaryotic cells possess two interdependent genomes, chromosomal and extra-chromosomal. Over the past several decades, cancer - search has focused primarily on deciphering the intricate alterations in the chro- somal genome, with until recently, very little attention to its cytoplasmic counterpart. In spite of the enormous complexity of the nuclear genome, which we now fully appreciate after completion of the human genome project, the efforts of cancer researchers are commendable in terms of the tremendous gains made in unraveling the numerous genetic changes in cancer. These changes include d- coveries of tumor suppressor genes, oncogenes, and caretaker genes that are often mutated in cancer. Recent studies of genomic pro?les are uncovering even more altered and mutated genes in cancer. Besides these ?ndings, several therapeutic targets for chemotherapy are currently made from studies of altered nuclear genetic pathways. Inspite of all these positive efforts, the war on cancer, declared in 1971 by Richard Nixon, is far from being worn. Indeed, the failure of chemotherapy is obvious to clinicians, oncologists, and their patients alike. Moreover, the global incidence and prevalence of cancer continue to rise. What are we missing? Which direction should we be taking? Of course, modern integrated nuclear genomics, proteomics, and metabolomics should provide important clues to carcinogenesis, but the contribution of cytoplasmic genetic alterations to carcinogenesis cannot be neglected.

Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy

Dhyan Chandra
Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy Book PDF

Author : Dhyan Chandra
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 44,7 Mb
Release : 2013-12-11
Category : Science
ISBN : 9781461493266

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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy by Dhyan Chandra Pdf

This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.

Mitochondrial Dysfunction

Lawrence H. Lash,Dean P. Jones
Mitochondrial Dysfunction Book PDF

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 44,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

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Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Advances in Mitochondrial Medicine

Roberto Scatena,Patrizia Bottoni,Bruno Giardina
Advances in Mitochondrial Medicine Book PDF

Author : Roberto Scatena,Patrizia Bottoni,Bruno Giardina
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 43,5 Mb
Release : 2012-02-09
Category : Medical
ISBN : 9789400728684

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Advances in Mitochondrial Medicine by Roberto Scatena,Patrizia Bottoni,Bruno Giardina Pdf

Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Tumor Cell Metabolism

Sybille Mazurek,Maria Shoshan
Tumor Cell Metabolism Book PDF

Author : Sybille Mazurek,Maria Shoshan
Publisher : Springer
Page : 374 pages
File Size : 54,5 Mb
Release : 2015-01-19
Category : Medical
ISBN : 9783709118245

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Tumor Cell Metabolism by Sybille Mazurek,Maria Shoshan Pdf

The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.

Cell Stress, Metabolic Reprogramming, and Cancer

Sergio Giannattasio,Cristina Mazzoni,Mario G. Mirisola
Cell Stress Metabolic Reprogramming and Cancer Book PDF

Author : Sergio Giannattasio,Cristina Mazzoni,Mario G. Mirisola
Publisher : Frontiers Media SA
Page : 68 pages
File Size : 53,5 Mb
Release : 2018-08-31
Category : Electronic
ISBN : 9782889455652

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Cell Stress, Metabolic Reprogramming, and Cancer by Sergio Giannattasio,Cristina Mazzoni,Mario G. Mirisola Pdf

The present eBook presents one review, five mini-reviews, and an opinion article on the achievements and perspectives of studies on important aspects of cancer cell metabolic reprogramming whose mechanisms and regulation are still largely elusive. It also sheds light on certain novel functional components, which rewires cell metabolism in tumor transformation.