Mitochondrial Function In Vivo Evaluated By Nadh Fluorescence

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Mitochondrial Function In Vivo Evaluated by NADH Fluorescence

Avraham Mayevsky
Mitochondrial Function In Vivo Evaluated by NADH Fluorescence Book PDF

Author : Avraham Mayevsky
Publisher : Springer
Page : 276 pages
File Size : 42,5 Mb
Release : 2015-06-20
Category : Science
ISBN : 9783319166827

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Mitochondrial Function In Vivo Evaluated by NADH Fluorescence by Avraham Mayevsky Pdf

This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate students interested in learning the biomedical applications of NADH fluorescence. This book also: Covers multisite monitoring of NADH, as well as multiparametric responses of NADH to physiological and pathophysiological conditions, and monitoring of various organs in various animal models Describes the relationship between brain activation (i.e. epileptic activity and cortical spreading depression) and NADH redox state Presents the effects of hypoxia,hyperbaric hyperoxia, and ischemia on brain NADH fluorescence and other tissue physiological parameters About the Author Avraham Mayevsky, Ph.D. is a Professor Emeritus in theFaculty of Life Sciences and the Brain Research Center at Bar Ilan University, Israel. He has published more than two hundred papers in the field of mitochondrial function and tissue physiology in vivo under pathophysiological conditions.

In Vivo Optical Imaging of Brain Function, Second Edition

Ron D. Frostig
In Vivo Optical Imaging of Brain Function Second Edition Book PDF

Author : Ron D. Frostig
Publisher : CRC Press
Page : 428 pages
File Size : 44,8 Mb
Release : 2009-05-06
Category : Science
ISBN : 9781420076851

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In Vivo Optical Imaging of Brain Function, Second Edition by Ron D. Frostig Pdf

These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.

Cortical Spreading Depression of Leao

Avraham Mayevsky,Judith Sonn
Cortical Spreading Depression of Leao Book PDF

Author : Avraham Mayevsky,Judith Sonn
Publisher : Springer Nature
Page : 429 pages
File Size : 42,7 Mb
Release : 2022-10-19
Category : Medical
ISBN : 9783031080685

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Cortical Spreading Depression of Leao by Avraham Mayevsky,Judith Sonn Pdf

This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions. This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field.

Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

Anonim
Conceptual Background and Bioenergetic Mitochondrial Aspects of Oncometabolism Book PDF

Author : Anonim
Publisher : Elsevier
Page : 565 pages
File Size : 46,9 Mb
Release : 2014-05-23
Category : Science
ISBN : 9780124166578

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Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism by Anonim Pdf

Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Provides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo

Natural Biomarkers for Cellular Metabolism

Vladimir V. Ghukasyan,Ahmed A. Heikal
Natural Biomarkers for Cellular Metabolism Book PDF

Author : Vladimir V. Ghukasyan,Ahmed A. Heikal
Publisher : CRC Press
Page : 404 pages
File Size : 51,8 Mb
Release : 2014-09-26
Category : Medical
ISBN : 9781466509993

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Natural Biomarkers for Cellular Metabolism by Vladimir V. Ghukasyan,Ahmed A. Heikal Pdf

From the Lab to Clinical Settings-Advances in Quantitative, Noninvasive Optical DiagnosticsNoninvasive fluorescence imaging techniques, novel fluorescent labels, and natural biomarkers are revolutionizing our knowledge of cellular processes, signaling and metabolic pathways, the underlying mechanisms for health problems, and the identification of n

Biomarkers

Vishal S. Vaidya,Joseph V. Bonventre
Biomarkers Book PDF

Author : Vishal S. Vaidya,Joseph V. Bonventre
Publisher : John Wiley & Sons
Page : 632 pages
File Size : 51,7 Mb
Release : 2010-10-28
Category : Science
ISBN : 0470918551

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Biomarkers by Vishal S. Vaidya,Joseph V. Bonventre Pdf

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

Multiphoton Microscopy and Fluorescence Lifetime Imaging

Karsten König
Multiphoton Microscopy and Fluorescence Lifetime Imaging Book PDF

Author : Karsten König
Publisher : Walter de Gruyter GmbH & Co KG
Page : 450 pages
File Size : 43,8 Mb
Release : 2018-01-22
Category : Science
ISBN : 9783110430073

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Multiphoton Microscopy and Fluorescence Lifetime Imaging by Karsten König Pdf

This monograph focuses on modern femtosecond laser microscopes for two photon imaging and nanoprocessing, on laser tweezers for cell micromanipulation as well as on fluorescence lifetime imaging (FLIM) in Life Sciences. The book starts with an introduction by Dr. Wolfgang Kaiser, pioneer of nonlinear optics and ends with the chapter on clinical multiphoton tomography, the novel high resolution imaging technique. It includes a foreword by the nonlinear microscopy expert Dr. Colin Sheppard. Contents Part I: Basics Brief history of fluorescence lifetime imaging The long journey to the laser and its use for nonlinear optics Advanced TCSPC-FLIM techniques Ultrafast lasers in biophotonics Part II: Modern nonlinear microscopy of live cells STED microscopy: exploring fluorescence lifetime gradients for super-resolution at reduced illumination intensities Principles and applications of temporal-focusing wide-field two-photon microscopy FLIM-FRET microscopy TCSPC FLIM and PLIM for metabolic imaging and oxygen sensing Laser tweezers are sources of two-photon effects Metabolic shifts in cell proliferation and differentiation Femtosecond laser nanoprocessing Cryomultiphoton imaging Part III: Nonlinear tissue imaging Multiphoton Tomography (MPT) Clinical multimodal CARS imaging In vivo multiphoton microscopy of human skin Two-photon microscopy and fluorescence lifetime imaging of the cornea Multiscale correlative imaging of the brain Revealing interaction of dyes and nanomaterials by multiphoton imaging Multiphoton FLIM in cosmetic clinical research Multiphoton microscopy and fluorescence lifetime imaging for resection guidance in malignant glioma surgery Non-invasive single-photon and multi-photon imaging of stem cells and cancer cells in mouse models Bedside assessment of multiphoton tomography

Sports Performance and Health

Matej Supej,Jörg Spörri
Sports Performance and Health Book PDF

Author : Matej Supej,Jörg Spörri
Publisher : MDPI
Page : 252 pages
File Size : 48,6 Mb
Release : 2021-08-30
Category : Medical
ISBN : 9783036512587

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Sports Performance and Health by Matej Supej,Jörg Spörri Pdf

Sports performance is primarily associated with elite sport, however, recreational athletes are increasingly attempting to emulate elite athletes. Performance optimization is distinctly multidisciplinary. Optimized training concepts and the use of state-of-the-art technologies are crucial for improving performance. However, sports performance enhancement is in constant conflict with the protection of athletes’ health. Notwithstanding the known positive effects of physical activity on health, the prevention and management of sports injuries remain major challenges to be addressed. Accordingly, this Special Issue on "Sports Performance and Health" consists of 17 original research papers, one review paper, and one commentary, and covers a wide range of topics related to fatigue, movement asymmetries, optimization of sports performance by training, technique, and/or tactics enhancements, prevention and management of sports injuries, optimization of sports equipment to increase performance and/or decrease the risk of injury, and innovations for sports performance, health, and load monitoring. As this Special Issue offers several new insights and multidisciplinary perspectives on sports performance and health, readers from around the world who work in these areas are expected to benefit from this Special Issue collection.

Mitochondria: Hubs of Cellular Signaling, Energetics and Redox Balance

Miguel A. Aon,Amadou K. S. Camara
Mitochondria Hubs of Cellular Signaling Energetics and Redox Balance Book PDF

Author : Miguel A. Aon,Amadou K. S. Camara
Publisher : Frontiers Media SA
Page : 230 pages
File Size : 44,5 Mb
Release : 2017-08-11
Category : Electronic book
ISBN : 9782889452392

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Mitochondria: Hubs of Cellular Signaling, Energetics and Redox Balance by Miguel A. Aon,Amadou K. S. Camara Pdf

Poised at the convergence of most catabolic and anabolic pathways, mitochondria are the center of heterotrophic aerobic life, representing a hub in the overall metabolic network of cells. The energetic functions performed by mitochondria face the unavoidable redox hurdle of handling huge amounts of oxygen while keeping its own as well as the cellular redox environment under control. Reactive oxygen species (ROS) are produced in the respiratory chain as a result of the energy supplying function of mitochondria. Originally considered an unavoidable by-product of oxidative phosphorylation, ROS have become crucial signaling molecules when their levels are kept within physiological range. This occurs when their production and scavenging are balanced within mitochondria and cells. Mitochondria-generated hydrogen peroxide can act as a signaling molecule within mitochondria or in the cytoplasm, affecting multiple networks that control, for example, cell cycle, stress response, cell migration and adhesion, energy metabolism, redox balance, cell contraction, and ion channels. However, under pathophysiological conditions, excessive ROS levels can happen due to either overproduction, overwhelming of antioxidant defenses, or both. Under oxidative stress, detrimental effects of ROS include oxidation of protein, lipids, and nucleic acids; mitochondrial depolarization and calcium overload; and cell-wide oscillations mediated by ROS-induced ROS release mechanisms. Mitochondrial dysfunction is central in the pathogenesis of numerous human maladies including cardiomyopathies and neurodegeneration. Diseases characterized by altered nutrient metabolism, such as diabetes and cancer, exhibit elevated ROS levels. These may contribute to pathogenesis by increasing DNA mutation, affecting regulatory signaling and transcription, and promoting inflammation. Under metabolic stress, several ionic channels present in the inner and outer mitochondrial membranes can have pro-life and -death effects. In the present E-book, based on the Frontiers Research Topic entitled: "Mitochondria: Hubs of cellular signaling, energetics and redox balance", we address one of the fundamental questions that the field of ROS biology faces today: how do mitochondria accomplish a reliable energy provision and at the same time keep ROS levels within physiological, non-harming, limits but crucial for cellular signaling function? Additionally, and within the perspective of mitochondria as signaling-energetic hubs in the extensive cellular metabolic network, we ask how can their collective dynamics scale from the subcellular to the cellular, tissue and organ levels to affect function in health and disease.

Reviews in Fluorescence 2010

Chris D. Geddes
Reviews in Fluorescence 2010 Book PDF

Author : Chris D. Geddes
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 51,8 Mb
Release : 2011-11-25
Category : Medical
ISBN : 9781441998286

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Reviews in Fluorescence 2010 by Chris D. Geddes Pdf

Reviews in Fluorescence 2010, the seventh volume of the book serial from Springer, serves as a comprehensive collection of current trends and emerging hot topics in the field of fluorescence and closely related disciplines. It summarizes the year’s progress in fluorescence and its applications, with authoritative analytical reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of fluorescence. Reviews in Fluorescence offers an essential reference material for any lab working in the fluorescence field and related areas. All academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of fluorescence will find it an invaluable resource. Key features: Accessible utility in a single volume reference. chapters authored by known leading figures in the fluorescence field, new volume publishes annually, comprehensive coverage of the year's hottest and emerging topics, each Reviews in Fluorescence volume is citable (ISI) and indexed. Reviews in Fluorescence 2010 topics include: Novel Metal-based Luminophores for Biological Imaging. hydration Dynamics of Probes and Peptides in Captivity, how does tobacco etch viral mRNA get translated? A fluorescence study of competition, stability and kinetics, synchronous Fluorescence Spectroscopy and Its Applications in Clinical Analysis and Food Safety Evaluation, quantitative molecular imaging in living cells via FLIM, a Multiparametric Imaging of Cellular Coenzymes for Monitoring Metabolic and Mitochondrial Activities, optimal Conditions for Live Cell Microscopy and Raster Image Correlation Spectroscopy (RICS).

Neural Metabolism In Vivo

In-Young Choi,Rolf Gruetter
Neural Metabolism In Vivo Book PDF

Author : In-Young Choi,Rolf Gruetter
Publisher : Springer Science & Business Media
Page : 1168 pages
File Size : 46,9 Mb
Release : 2012-03-08
Category : Medical
ISBN : 9781461417880

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Neural Metabolism In Vivo by In-Young Choi,Rolf Gruetter Pdf

From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter

Advances in Biomedical Photonics and Imaging

Qingming Luo
Advances in Biomedical Photonics and Imaging Book PDF

Author : Qingming Luo
Publisher : World Scientific
Page : 393 pages
File Size : 50,9 Mb
Release : 2008
Category : Medical
ISBN : 9789812832344

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Advances in Biomedical Photonics and Imaging by Qingming Luo Pdf

This unique volume contains selected papers presented at the 6th International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2007), held on November 4OCo6, 2007 at Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, P R China.PIBM is designed to bring together scientists, engineers and clinical researchers from a variety of disciplines engaged in applying optical science, photonics and imaging technologies to problems in biology and medicine. The scope of this conference ranges from basic research to instrumentation engineering to biological and clinical studies. It is recognized as one of the largest and most comprehensive international conferences in China, and represents the highest level of worldwide research in this field. An increasing number of young researchers are presenting and exchanging their innovative ideas on this friendly and professional platform, thus making PIBM a not-to-be-missed annual meeting in Wuhan."

Redox Regulation in Skeletal Muscle Aging and Exercise

Brian McDonagh
Redox Regulation in Skeletal Muscle Aging and Exercise Book PDF

Author : Brian McDonagh
Publisher : Frontiers Media SA
Page : 103 pages
File Size : 53,5 Mb
Release : 2017-07-05
Category : Electronic book
ISBN : 9782889451968

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Redox Regulation in Skeletal Muscle Aging and Exercise by Brian McDonagh Pdf

Skeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise.

Nanotoxicology

Hemant Kumar Daima,S. L. Kothari,Bhargava Suresh Kumar
Nanotoxicology Book PDF

Author : Hemant Kumar Daima,S. L. Kothari,Bhargava Suresh Kumar
Publisher : CRC Press
Page : 461 pages
File Size : 53,9 Mb
Release : 2021-07-15
Category : Medical
ISBN : 9781000399974

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Nanotoxicology by Hemant Kumar Daima,S. L. Kothari,Bhargava Suresh Kumar Pdf

The field of nanomedicine has risen quickly due to the increasing number of designer-made nanomaterials. These nanomaterials have the potential to manage diseases and change the way medicine is currently studied. However, the increased practice of using nanomaterials has shed light on how many concepts of nanomedicine and nanotoxicity have been overlooked. Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications addresses the existing gaps between nanomedicine and nanotoxicity. This book also brings together up-to-date knowledge on advances toward safe-by-design nanomaterials and existing toxicity challenges. This book delivers a comprehensive coverage in the field with fundamental understanding, serving as a platform to convey essential concepts of nanotoxicology and how these concepts can be employed to develop advanced nanomaterials for a range of biomedical applications. This book is an effort to answer some of the thoughtful nanotoxicological complications and their auspicious probable solutions with new approaches and careful toxicity assessment. Key Features: Reveals novel nanoscale approaches, toxicity assessment, and biomedical applications Includes importance of nanotoxicity concepts in developing smart nanomaterials Highlights unique contributions and "A to Z" aspects on the state-of-the-art from global leaders Offers a complete package to learn fundamentals with recommendations on nanomaterials toxicity and safe-by-design nanomedicines Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications illuminates the high potential of many innovative nanomaterials, ultimately demonstrating them to be promising substitutes for available therapies that can be effectively used in fighting a myriad of biomedical complications. Further, this book reports legal, ethical, safety, and regulatory issues associated with nanomaterials, which have often been neglected, if not overlooked in literature and limiting clinical translation at nanoscale level. It will equip readers with cutting-edge knowledge of promising developments in nanomedicine and nanotoxicology, along with potential future prospects.

Brain Hypoxia-Ischemia Research Progress

Océane M. Roux
Brain Hypoxia Ischemia Research Progress Book PDF

Author : Océane M. Roux
Publisher : Nova Publishers
Page : 314 pages
File Size : 55,7 Mb
Release : 2008
Category : Cerebral anoxia
ISBN : 1604561394

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Brain Hypoxia-Ischemia Research Progress by Océane M. Roux Pdf

Brain hypoxia-ischemia is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain oedema; coma; and other conditions. This book presents the latest research in this field from around the world.