Modelling The Toxicity Of Nanoparticles

Author : Lang Tran,Miguel A. Bañares,Robert Rallo
Publisher : Springer
Page : 360 pages
File Size : 41,6 Mb
Release : 2017-02-06
Category : Medical
ISBN : 9783319477541

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Modelling the Toxicity of Nanoparticles by Lang Tran,Miguel A. Bañares,Robert Rallo Pdf

In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.

Author : Busi Siddhardha,Madhu Dyavaiah,Kaviyarasu Kasinathan
Publisher : Springer Nature
Page : 466 pages
File Size : 49,9 Mb
Release : 2020-03-28
Category : Medical
ISBN : 9789811517020

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Model Organisms to Study Biological Activities and Toxicity of Nanoparticles by Busi Siddhardha,Madhu Dyavaiah,Kaviyarasu Kasinathan Pdf

This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.

Author : Baoshan Xing,Chad D. Vecitis,Nicola Senesi
Publisher : John Wiley & Sons
Page : 506 pages
File Size : 48,6 Mb
Release : 2016-10-10
Category : Science
ISBN : 9781119275824

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Engineered Nanoparticles and the Environment by Baoshan Xing,Chad D. Vecitis,Nicola Senesi Pdf

Details the source, release, exposure, adsorption, aggregation, bioavailability, transport, transformation, and modeling of engineered nanoparticles found in many common products and applications Covers synthesis, environmental application, detection, and characterization of engineered nanoparticles Details the toxicity and risk assessment of engineered nanoparticles Includes topics on the transport, transformation, and modeling of engineered nanoparticles Presents the latest developments and knowledge of engineered nanoparticles Written by world leading experts from prestigious universities and companies

Author : Namita Agrawal,Prasanna Shah
Publisher : Springer Nature
Page : 128 pages
File Size : 48,5 Mb
Release : 2020-08-24
Category : Medical
ISBN : 9789811555220

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Toxicology of Nanoparticles: Insights from Drosophila by Namita Agrawal,Prasanna Shah Pdf

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Author : Suresh C. Pillai,Yvonne Lang
Publisher : CRC Press
Page : 246 pages
File Size : 43,5 Mb
Release : 2021-03-31
Category : Nanostructured materials
ISBN : 0367779757

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Toxicity of Nanomaterials by Suresh C. Pillai,Yvonne Lang Pdf

This book, edited by two leading experts in nanotoxicology with contributions from a global team of specialists, provides a comprehensive overview of the risks and environmental and health impacts assosciated with the toxicology of nanomaterials.

Author : Saura C. Sahu,Daniel A. Casciano
Publisher : John Wiley & Sons
Page : 630 pages
File Size : 40,9 Mb
Release : 2009-08-04
Category : Science
ISBN : 9780470747797

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Nanotoxicity by Saura C. Sahu,Daniel A. Casciano Pdf

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessment nanotoxicity assessment by gene expression analysis in vivo and in vitro models for nanotoxicity testing mechanisms of nanotoxicity pharmakokinetics of nanomaterials nanotoxicity of foods including food processing, food packaging and food safety nanotoxicity of drugs including drug development and drug delivery nanotoxicity of cosmetics and consumer products health and environmental impact of nanotoxicity safety evaluation of nanomaterials regulatory impact of nanomaterials Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Author : Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar
Publisher : Springer
Page : 346 pages
File Size : 46,8 Mb
Release : 2018-02-16
Category : Science
ISBN : 9783319720418

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Cellular and Molecular Toxicology of Nanoparticles by Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar Pdf

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”. The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

Author : Vineet Kumar,Nandita Dasgupta,Shivendu Ranjan
Publisher : CRC Press
Page : 654 pages
File Size : 43,6 Mb
Release : 2018-03-12
Category : Medical
ISBN : 9781351138185

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Nanotoxicology by Vineet Kumar,Nandita Dasgupta,Shivendu Ranjan Pdf

As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.

Author : Vineet Kumar,Nandita Dasgupta,Shivendu Ranjan
Publisher : CRC Press
Page : 603 pages
File Size : 45,6 Mb
Release : 2018-04-17
Category : Medical
ISBN : 9781351252942

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Environmental Toxicity of Nanomaterials by Vineet Kumar,Nandita Dasgupta,Shivendu Ranjan Pdf

Environmental Toxicity of Nanomaterials focuses on causes and prevention of environmental toxicity induced by various nanomaterials. In sixteen chapters it describes the basic principles, trends, challenges, and future directions of nanoecotoxicity. The future acceptance of nanomaterials in various industries depends on the impacts of nanomaterials on the environment and ecosystem. This book analyzes the safe utilization of nanotechnology so the tremendous prospect of nanotechnology can be achieved without harming either living beings or the environment. Environmental Toxicity of Nanomaterials introduces nanoecotoxicity, describes various factors affecting the toxicity of nanomaterials, discusses various factors that can impart nanoecotoxicity, reviews various studies in the area of nanoecotoxicity evaluation, and describes the safety and risk assessment of nanomaterials. In addition, the book discusses strategies for mitigating nanoecotoxicity. Lastly, the authors provide guidelines and protocols for nanotoxicity evaluation and discuss regulations for safety assessment of nanomaterials. In addition to environmental toxicologists, this book is aimed at policy makers, industry personnel, and doctoral and postdoctoral scholars.

Author : Marcelo Larramendy,Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 224 pages
File Size : 53,9 Mb
Release : 2015-07-15
Category : Science
ISBN : 9789535121435

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Nanomaterials by Marcelo Larramendy,Sonia Soloneski Pdf

This edited book, Nanomaterials - Toxicity and Risk Assessment, is a collection of current research and information on numerous advances on the toxicity and hazardous effects of nanomaterials, including theoretical and experimental approaches as well as nanotechnology applications in the field of medicine, pharmacology, and the manufacture of nanoscale materials. Based on the large number of nanomaterial applications, a careful understanding of the associated systemic and local toxicity is critically required.

Author : Nancy A. Monteiro-Riviere,C. Lang Tran
Publisher : CRC Press
Page : 516 pages
File Size : 52,7 Mb
Release : 2014-03-03
Category : Medical
ISBN : 9781482203875

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Nanotoxicology by Nancy A. Monteiro-Riviere,C. Lang Tran Pdf

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines. Topics include The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies A roadmap for future research The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

Author : Muharrem Ince,Olcay Kaplan Ince,Gabrijel Ondrasek
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 54,6 Mb
Release : 2020-07-29
Category : Medical
ISBN : 9781789846966

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Biochemical Toxicology by Muharrem Ince,Olcay Kaplan Ince,Gabrijel Ondrasek Pdf

Biochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.

Author : Agnieszka Gajewicz,Tomasz Puzyn
Publisher : CRC Press
Page : 570 pages
File Size : 43,7 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9781000680881

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Computational Nanotoxicology by Agnieszka Gajewicz,Tomasz Puzyn Pdf

The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials (ENMs) has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of ENMs, computational methods originally developed for regular chemicals cannot always be applied explicitly in nanotoxicology. This book discusses the current state of the art and future needs in the development of computational modeling techniques for nanotoxicology. It focuses on (i) computational chemistry (quantum mechanics, semi-empirical methods, density functional theory, molecular mechanics, molecular dynamics), (ii) nanochemoinformatic methods (quantitative structure–activity relationship modeling, grouping, read-across), and (iii) nanobioinformatic methods (genomics, transcriptomics, proteomics, metabolomics). It reviews methods of calculating molecular descriptors sufficient to characterize the structure of nanoparticles, specifies recent trends in the validation of computational methods, and discusses ways to cope with the uncertainty of predictions. In addition, it highlights the status quo and further challenges in the application of computational methods in regulation (e.g., REACH, OECD) and in industry for product development and optimization and the future directions for increasing acceptance of computational modeling for nanotoxicology.

Author : Suresh Pillai,Yvonne Lang
Publisher : CRC Press
Page : 259 pages
File Size : 46,6 Mb
Release : 2019-05-16
Category : Science
ISBN : 9780429556012

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Toxicity of Nanomaterials by Suresh Pillai,Yvonne Lang Pdf

Choice Recommended Title, April 2020 This comprehensive book, edited by two leading experts in nanotechnology and bioengineering with contributions from a global team of specialists, provides a detailed overview of the environmental and health impacts associated with the toxicology of nanomaterials. Special attention is given to nanomaterial toxicity during synthesis, production and application, and chapters throughout are focused on key areas that are important for future research and development of nanomaterials. This book will be of interest to advanced students studying biomedical engineering and materials science, PhD researchers, post-docs and academics working in the area of nanotechnology, medicine, manufacturing and regulatory bodies. Features: Collates and critically evaluates various aspects of the toxicology of nanomaterials in one comprehensive text Discusses the various effects of nanocrystals including the morphologies on cytotoxicity, in addition to the environmental and cytotoxicity risks of graphene and 2D nanomaterials Explores practical methods of detection and quantification, with applications in the environmental and healthcare fields

Author : Khan Maaz
Publisher : Unknown
Page : 290 pages
File Size : 50,5 Mb
Release : 2018-07
Category : Electronic
ISBN : 9781789234787

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Silver Nanoparticles by Khan Maaz Pdf