Molecular And Cellular Aspects Of Erythropoietin And Erythropoiesis

Author : Ivan N. Rich
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 50,5 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642726521

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Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis by Ivan N. Rich Pdf

Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.

Author : Graham Molineux,Mary A. Foote,Steven Elliott
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 54,5 Mb
Release : 2005-11-17
Category : Medical
ISBN : 3764375426

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Erythropoietins and Erythropoiesis by Graham Molineux,Mary A. Foote,Steven Elliott Pdf

A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators. This softcover volume is an unchanged second printing of the hardcover edition published in 2003.

Author : Ivan N. Rich,Terence R. J. Lappin
Publisher : Unknown
Page : 400 pages
File Size : 40,9 Mb
Release : 1994
Category : Medical
ISBN : UVA:X002493307

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Molecular, Cellular, and Developmental Biology of Erythropoietin and Erythropoiesis by Ivan N. Rich,Terence R. J. Lappin Pdf

Recombinant DNA technology has allowed the cloning, sequencing and large-scale production of human erythropoietin, which is now used in therapy for the anaemia of renal disease. In addition, there are many ongoing clinical trials in which recombinant human erythropoietin is being investigated. The availability of the recombinant reagent has added great impetus to all areas of erythropoetin and erythropoiesis research. This multidisciplinary work brings together investigators from many fields who discuss past, present and future research in this area. The science here is primarily experimental and should be of interest to biochemists, experimental haematologists, pharmacologists, clinical haematologists and nephrologists.

Author : Steven G. Elliott,MaryAnn Foote,Graham Molineux
Publisher : Springer Science & Business Media
Page : 337 pages
File Size : 45,6 Mb
Release : 2009-06-05
Category : Medical
ISBN : 9783764386986

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Erythropoietins, Erythropoietic Factors, and Erythropoiesis by Steven G. Elliott,MaryAnn Foote,Graham Molineux Pdf

A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.

Author : Allan J. Erslev
Publisher : Unknown
Page : 504 pages
File Size : 43,8 Mb
Release : 1991
Category : Anemia
ISBN : UOM:39015022030350

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Erythropoietin by Allan J. Erslev Pdf

The aim of this monograph is to provide an account of the events that led to the transformation of a concept of red cell regulation into an effective treatment of many anemias. Each chapter is authored by investigators who were involved in this transformation and who are still at work on elucidating the origin, kinetics, action, and regulation of this growth hormone. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Joao L. Ascensao
Publisher : Springer
Page : 256 pages
File Size : 44,6 Mb
Release : 1989
Category : Medical
ISBN : UCAL:B5036154

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Molecular Biology of Erythropoiesis by Joao L. Ascensao Pdf

The 22 papers provide a broad coverage of the rapid advances in the study of erythropoiesis. Discusses how heme and its derivatives contribute to the proliferation, differentiation, and maturation of the eurythron, the use of genetic engineering to correct globin gene derangements, various regulators of erythropoiesis as analyzed both in vivo and in vitro, and other topics.

Author : Anonim
Publisher : Elsevier
Page : 867 pages
File Size : 49,8 Mb
Release : 2004-05-10
Category : Science
ISBN : 9780080497198

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Oxygen Sensing by Anonim Pdf

The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.

Author : Mohammad Resa Nowrousian
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709176580

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Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology by Mohammad Resa Nowrousian Pdf

Anemia is a frequent complication of cancer and its treatment. A number of clinical studies shows that the impact of anemia is much greater than previously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anemia in cancer and its treatment with rhEPO is presented. Future developments are also discussed. Based on a broad spectrum of topics, the book describes the scientific and clinical aspects of anemia in various fields of oncology and gives diagnostic and therapeutic recommendations on when and how to use rhEPO.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : A. Victor Hoffbrand,Daniel Catovsky,Edward G. D. Tuddenham
Publisher : John Wiley & Sons
Page : 1091 pages
File Size : 41,6 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405143530

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Postgraduate Haematology by A. Victor Hoffbrand,Daniel Catovsky,Edward G. D. Tuddenham Pdf

"Most hematologists need a revised and practical textbook in whichthey can rapidly search on the morning of a consultation...Thisbook will be an important resource in suchsituations." New England Journal of Medicine A well established and respected review ofhematology Postgraduate Haematology is a practical, readable text whichwill give trainees, residents and practising hematologistsup-to-date knowledge of the pathogenesis, clinical and laboratoryfeatures and management of blood disorders. Postgraduate Haematology is ideal for: Trainees and residents in hematology Hematologists in practice Why Buy This Book? A well established and respected review ofhematology Practical and readable text Essential information for everyday use as well as thescientific background Up-to-date knowledge of the pathogenesis, clinical andlaboratory features and management of blood disorders Complete revision of all chapters and the addition of newchapters to reflect latest advances in the speciality

Author : Volker Neuhoff,John Friend
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 50,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642764707

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Cell to Cell Signals in Plants and Animals by Volker Neuhoff,John Friend Pdf

Summarizing research progress achieved in 32 areas of cell biology covered in this series, this volume places special emphasis on the following topics: recognition in parasitic and symbiotic systems - the molecular biology and genetics of susceptibility and resistance of plants and animals to pathogens, parasites and symbionts - the cell to cell recognition and differentiation - the most challenging problems in developmental biology of plants and animals - the plasticity in cell to cell communication which plays a major role in cell differentiation and function.

Author : Michael B. Sporn,Anita B. Roberts
Publisher : Springer Science & Business Media
Page : 811 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642492952

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Peptide Growth Factors and Their Receptors I by Michael B. Sporn,Anita B. Roberts Pdf

This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony stimulating factors," was quite artifactual; they are in fact the basis of a com mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.

Author : Helmut Acker
Publisher : Springer Science & Business Media
Page : 214 pages
File Size : 47,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783642834448

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Oxygen Sensing in Tissues by Helmut Acker Pdf

This book covers a wide biological range of problems regarding oxygen sensing in tissues. Oxygen sensing is defined as a process in which 02 reacts with different cellular components to avoid hypoxic cell damages. Oxygen sensing contributes to auxiliary mechanisms which help bacteria, invertebrates, vertebrates, and mammalians to survive and withstand hypoxic sensations. For the first time, experts from different disciplines have cooperated in examining various biological systems exhibiting this phenomenon.

Author : Wolfgang Jelkmann,Andreas J. Gross
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642837456

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Erythropoietin by Wolfgang Jelkmann,Andreas J. Gross Pdf

The book contains a series of up-to-date review articles on the physiology and pathophysiology of the control of the production of red cells by the hormone erythropoietin. In addition, the results are reported of initial clinical trials using recombinant human erythropoietin (rhuEpo) in the treatment of the anemia of renal failure. The introductory chapter briefly recalls the history of erythropoietin research. The following section on the chemistry and physiology covers details of the structure of the hormone, assay methods, the identification of renal and extrarenal sites of the production of erythropoietin by in situ hybridization and the hypoxic stimulation of its production. A special chapter is devoted to the regulation of erythropoiesis in the neonatal period. There follows a section on pathophysiology, which includes respiratory, renal and malignant diseases in humans. In the final section the pharmacology of rhuEpo is considered. The strategy of the cloning and in vitro expression of the erythropoietin gene is described. Four chapters summarize clinical observations of the effects of rhuEpo in the correction of the anemia of renal failure, including the rise in hematocrit, blood viscosity and possibly hypertension, and the increased physical work capacity of the patients. The monograph will prove useful not only to investigators working in the basic fields of physiology, pharmacology and endocrinology, but also to practising physicians, especially hematologists and nephrologists, who are interested in erythropoietin for diagnostic or therapeutic purposes.

Author : Ajay K. Singh,Gordon H. Williams
Publisher : Academic Press
Page : 534 pages
File Size : 50,5 Mb
Release : 2009-01-12
Category : Medical
ISBN : 9780080920467

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Textbook of Nephro-Endocrinology by Ajay K. Singh,Gordon H. Williams Pdf

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field