Molecular And Cellular Pathways In Nk Cell Development

Author : Ewa Sitnicka,Yenan Bryceson,Aharon Freud,Emily Mace
Publisher : Frontiers Media SA
Page : 177 pages
File Size : 54,6 Mb
Release : 2020-09-02
Category : Medical
ISBN : 9782889639779

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Molecular and Cellular Pathways in NK Cell Development by Ewa Sitnicka,Yenan Bryceson,Aharon Freud,Emily Mace Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Kerry S. Campbell,Marco Colonna
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 46,6 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592590445

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Natural Killer Cell Protocols by Kerry S. Campbell,Marco Colonna Pdf

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial migration, in vivo detection of cells migrating into tumors, immunofluorescence staining of intracellular cytokines, and in vitro NK cell development. Valuable techniques for specific applications include vaccinia virus protein expression, soluble KIR-Fc fusions for HLA class I binding assays, calcium mobilization in cell conjugates, and identification of heterodimeric receptor complexes using cDNA library expression cloning. No less important are accounts of such classic methods as hybrid resistance, ADCC, viral defense, target cell cytotoxicity assays, cloning and culturing, tumor immunotherapy, and generation of HLA class I transfected target cells. Natural Killer Cell Protocols: Cellular and Molecular Methods offers immunologists, cancer researchers, virologists, and cell biologists today's most comprehensive collection of both established and cutting-edge techniques, methods that will contribute significantly to advancing our understanding of this fascinating and critically important class of cells.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Covadonga Alonso
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 44,6 Mb
Release : 2008-03-27
Category : Medical
ISBN : 3540742638

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Viruses and Apoptosis by Covadonga Alonso Pdf

Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.

Author : Srinivas S. Somanchi
Publisher : Humana Press
Page : 365 pages
File Size : 48,9 Mb
Release : 2016-05-13
Category : Medical
ISBN : 1493936824

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Natural Killer Cells by Srinivas S. Somanchi Pdf

This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.

Author : Anna Ohradanova-Repic,Marianne Boes,Hannes Stockinger
Publisher : Frontiers Media SA
Page : 224 pages
File Size : 54,9 Mb
Release : 2020-05-26
Category : Electronic
ISBN : 9782889637218

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Role of Metabolism in Regulating Immune Cell Fate Decisions by Anna Ohradanova-Repic,Marianne Boes,Hannes Stockinger Pdf

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Author : Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier
Publisher : Frontiers Media SA
Page : 245 pages
File Size : 45,8 Mb
Release : 2017-11-29
Category : Electronic book
ISBN : 9782889453504

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NK Cell Subsets in Health and Disease: New Developments by Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier Pdf

Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 48,5 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Sybille Mazurek,Maria Shoshan
Publisher : Springer
Page : 374 pages
File Size : 52,7 Mb
Release : 2015-01-19
Category : Medical
ISBN : 9783709118245

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Tumor Cell Metabolism by Sybille Mazurek,Maria Shoshan Pdf

The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.

Author : Armin Ghobadi,John F. DiPersio
Publisher : Springer Nature
Page : 371 pages
File Size : 43,9 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030878498

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Gene and Cellular Immunotherapy for Cancer by Armin Ghobadi,John F. DiPersio Pdf

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Author : Loredana Cifaldi,Daniel Olive,James Di Santo
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2020
Category : Electronic
ISBN : OCLC:1368436979

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Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer by Loredana Cifaldi,Daniel Olive,James Di Santo Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Tim F. Greten
Publisher : Springer
Page : 167 pages
File Size : 42,5 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319649580

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Immunotherapy of Hepatocellular Carcinoma by Tim F. Greten Pdf

In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Author : Chaim Putterman,David Cowburn,Steven Almo
Publisher : Academic Press
Page : 192 pages
File Size : 40,7 Mb
Release : 2018-05-14
Category : Medical
ISBN : 9780128033708

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Structural Biology in Immunology by Chaim Putterman,David Cowburn,Steven Almo Pdf

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles

Author : Magdalena Klink,Izabela Szulc-Kielbik
Publisher : Springer Nature
Page : 358 pages
File Size : 43,8 Mb
Release : 2022-02-14
Category : Medical
ISBN : 9783030913113

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Interaction of Immune and Cancer Cells by Magdalena Klink,Izabela Szulc-Kielbik Pdf

Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Author : Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona
Publisher : Frontiers Media SA
Page : 224 pages
File Size : 50,8 Mb
Release : 2016-09-08
Category : Immunologic diseases. Allergy
ISBN : 9782889199341

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NK Cell-Based Cancer Immunotherapy by Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona Pdf

Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.