Molecular Approaches To Drug Abuse Research

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Methods in Drug Abuse Research

Barry D. Waterhouse
Methods in Drug Abuse Research Book PDF

Author : Barry D. Waterhouse
Publisher : CRC Press
Page : 296 pages
File Size : 50,8 Mb
Release : 2002-11-25
Category : Science
ISBN : 0849323452

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Methods in Drug Abuse Research by Barry D. Waterhouse Pdf

The field of drug addiction and substance abuse, which was initially confined to behavioral studies, has broadened dramatically. It now includes a vast array of cellular and molecular approaches as well as sophisticated electrophysiological and neurochemical methodologies that bridge the gap between cellular/molecular events and behavior. In many cases, these techniques are used to clarify and characterize specific dimensions of the addictive process or actions of potential abuse. Methods of Drug Abuse Research: Cellular and Circuit Level Analyses assembles this information in one volume. It bridges the gap between cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. The book presents state-of-the-art technical information and critical reviews of the experimental strategies used to dissect the problem of compulsive drug use and addiction at the systems or whole brain level. Chapters provide examples of the use of neurochemical and delectrophysiological the techniques in drug studies, as well as insight into the pros and cons of these various experimental strategies. Focusing on neurochemical and neurophysiological techniques that assess drug actions on neural circuits and neural networks in intact animals, this state-of-the-art reference provides detailed descriptions of procedures as well as methods and equipment used in experiments that often employ multiple technical approaches. Methods of Drug Abuse Research brings together pertinent issues in drug abuse research and systems level investigative techniques, thus allowing you to effectively grasp the critical conceptual and technical issues associated with modern drug abuse studies.

Molecular Biology of Drug Addiction

Rafael Maldonado
Molecular Biology of Drug Addiction Book PDF

Author : Rafael Maldonado
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 54,9 Mb
Release : 2002-09-12
Category : Medical
ISBN : 9781592593439

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Molecular Biology of Drug Addiction by Rafael Maldonado Pdf

A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.

Substance Use Disorders

Michael A. Nader,Yasmin L. Hurd
Substance Use Disorders Book PDF

Author : Michael A. Nader,Yasmin L. Hurd
Publisher : Springer Nature
Page : 503 pages
File Size : 44,7 Mb
Release : 2020-05-19
Category : Medical
ISBN : 9783030336790

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Substance Use Disorders by Michael A. Nader,Yasmin L. Hurd Pdf

The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.

Chemistry and Molecular Aspects of Drug Design and Action

E. A. Rekka,P. N. Kourounakis
Chemistry and Molecular Aspects of Drug Design and Action Book PDF

Author : E. A. Rekka,P. N. Kourounakis
Publisher : CRC Press
Page : 384 pages
File Size : 41,9 Mb
Release : 2008-04-28
Category : Medical
ISBN : 9781420008272

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Chemistry and Molecular Aspects of Drug Design and Action by E. A. Rekka,P. N. Kourounakis Pdf

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve

Drug Repurposing

Farid A. Badria
Drug Repurposing Book PDF

Author : Farid A. Badria
Publisher : BoD – Books on Demand
Page : 236 pages
File Size : 53,6 Mb
Release : 2020-12-02
Category : Medical
ISBN : 9781839685200

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Drug Repurposing by Farid A. Badria Pdf

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Meta-analysis of Drug Abuse Prevention Programs

William J. Bukoski
Meta analysis of Drug Abuse Prevention Programs Book PDF

Author : William J. Bukoski
Publisher : DIANE Publishing
Page : 266 pages
File Size : 43,9 Mb
Release : 1997
Category : Electronic
ISBN : 9780788172151

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Meta-analysis of Drug Abuse Prevention Programs by William J. Bukoski Pdf

Illustrates the value of combining findings from specific high-quality primary research studies into a cohesive summary that better defines what the science of drug abuse prevention offers to guide future program decisionmaking. Presents a current overview of the efficacy of drug abuse prevention programs (DAPG) and related measurement systems. Defines the techniques employed in meta-analysis of DAPG. Provides guidance in the application of research findings from meta-analysis. Discusses key technical procedures that should be considered in conducting future meta-analysis of drug abuse prevention research.

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman
The Organic Chemistry of Drug Design and Drug Action Book PDF

Author : Richard B. Silverman
Publisher : Elsevier
Page : 617 pages
File Size : 43,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080513379

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman Pdf

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization