Molecular Basis Of Sex Hormone Receptor Function

Author : Hinrich Gronemeyer,Ulrike Fuhrmann,Karsten Parczyk
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 54,9 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662036891

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Molecular Basis of Sex Hormone Receptor Function by Hinrich Gronemeyer,Ulrike Fuhrmann,Karsten Parczyk Pdf

How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.

Author : Hinrich Gronemeyer,Ulrike Fuhrmann,Karsten Parczyk
Publisher : Unknown
Page : 256 pages
File Size : 49,7 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 3662036908

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Molecular Basis of Sex Hormone Receptor Function by Hinrich Gronemeyer,Ulrike Fuhrmann,Karsten Parczyk Pdf

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences
Publisher : National Academies Press
Page : 287 pages
File Size : 47,6 Mb
Release : 2001-07-02
Category : Medical
ISBN : 9780309132978

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Exploring the Biological Contributions to Human Health by Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences Pdf

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Author : Fahri Saatcioglu
Publisher : Humana Press
Page : 0 pages
File Size : 51,5 Mb
Release : 2011-08-09
Category : Science
ISBN : 161779242X

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Androgen Action by Fahri Saatcioglu Pdf

Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.

Author : Stephen S. Wachtel
Publisher : Academic Press
Page : 537 pages
File Size : 47,5 Mb
Release : 2014-07-23
Category : Science
ISBN : 9781483295589

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Molecular Genetics of Sex Determination by Stephen S. Wachtel Pdf

In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field

Author : Andrea Manni,Michael Verderame
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 48,7 Mb
Release : 2002-01-18
Category : Medical
ISBN : 9781592591572

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Selective Estrogen Receptor Modulators by Andrea Manni,Michael Verderame Pdf

Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

Author : Trevor W. Stone
Publisher : CRC Press
Page : 256 pages
File Size : 53,8 Mb
Release : 1996-03-27
Category : Science
ISBN : 0849376335

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CNS Neurotransmitters and Neuromodulators by Trevor W. Stone Pdf

As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference. Well-known international authors have contributed up-to-date reviews covering a wide-range of interdisciplinary aspects of neuroactive steroid function. Specifically, this volume includes chapters dealing with the expression and properties of steroid receptors in the central nervous system (CNS); steroid interactions with amino acids, amines, and growth factors; electrophysiology; hypothalamic and feeding control; and the extremely topical issue of steroid influences on sexual differentiation of the brain. Neuroactive Steroids is an indispensable reference work for any researcher involved with steroids in the CNS, particularly in the areas of physiology, anatomy, neuropharmacology, neurochemistry, psychiatry, and molecular biology. In addition, it provides the perfect one-stop introduction for students.

Author : Gorazd Drevensek
Publisher : BoD – Books on Demand
Page : 360 pages
File Size : 45,6 Mb
Release : 2018-05-02
Category : Medical
ISBN : 9781789230147

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Sex Hormones in Neurodegenerative Processes and Diseases by Gorazd Drevensek Pdf

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Author : O. Hiort,S.F. Ahmed
Publisher : Karger Medical and Scientific Publishers
Page : 312 pages
File Size : 55,8 Mb
Release : 2014-09-15
Category : Medical
ISBN : 9783318025590

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Understanding Differences and Disorders of Sex Development (DSD) by O. Hiort,S.F. Ahmed Pdf

Ten years ago a group of experts assembled in Chicago to develop a consensus on the management of conditions previously described as intersex. The consequences of this consensus have been far reaching, including a change in nomenclature, the development of greater collaboration across geographical boundaries, and a move towards greater involvement of patients and parents. Moreover, an international registry was established, as well as research and clinical networks. This book brings together a thorough overview on all these topics. Furthermore, the major technological advances in diagnostic genetic and biochemical capabilities over the past 10 years are outlined in detail. Offering a comprehensive update on various aspects of disorders of sex development (DSD), this book will be essential reading to all clinicians who are involved in delivering health care to patients with a DSD, as well as scientists involved in biomedical research related to DSD.

Author : Albert Altchek,Liane Deligdisch,Nathan Kase
Publisher : Elsevier
Page : 568 pages
File Size : 52,7 Mb
Release : 2003-09-04
Category : Medical
ISBN : 9780080494517

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Diagnosis and Management of Ovarian Disorders by Albert Altchek,Liane Deligdisch,Nathan Kase Pdf

This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES * Includes updated information on early diagnosis of ovarian cancer * Reviews new diagnostic techniques for ovarian disorders * Discusses latest information on reproductive technology * Presents translational treatment linking laboratory research with clinical medicine

Author : H.B. Croxatto,R. Schürmann,U. Fuhrmann,I. Schellschmidt
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 42,6 Mb
Release : 2005-01-13
Category : Medical
ISBN : 3540230890

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New Mechanisms for Tissue-Selective Estrogen-Free Contraception by H.B. Croxatto,R. Schürmann,U. Fuhrmann,I. Schellschmidt Pdf

Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.

Author : Herbert Waldmann,Marcus Koppitz
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 53,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662053140

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Small Molecule — Protein Interactions by Herbert Waldmann,Marcus Koppitz Pdf

Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.

Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 47,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423

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The Role of Natural Products in Drug Discovery by J. Mulzer,R. Bohlmann Pdf

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Author : Stefan Jaroch,Hilmar Weinmann
Publisher : Springer Science & Business Media
Page : 187 pages
File Size : 43,6 Mb
Release : 2007-05-26
Category : Science
ISBN : 9783540376354

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Chemical Genomics by Stefan Jaroch,Hilmar Weinmann Pdf

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Author : Robert E. Sobol,Kevin J. Scanlon,Eirik Nestaas
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 48,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783662035771

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Gene Therapy by Robert E. Sobol,Kevin J. Scanlon,Eirik Nestaas Pdf

This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and characterized. Several reports describe both approaches currently used in gene therapy: the introduction of a wild-type gene to restore normal gene function in diseased cells, and the use of antisense molecules to hinder abnormal gene expression. Clinical studies detail several different strategies for the treatment of cancer and cardiovascular diseases, using genetic material as therapeutic agents. The regulatory issues governing the use of gene therapy in Europe and the United States are also presented. This book highlights the range of applications and demonstrates the rapid progress being made in the field of gene therapy.