Molecular Cardiology For The Cardiologists

Author : Bernard Swynghedauw
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461520191

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Molecular Cardiology for the Cardiologists by Bernard Swynghedauw Pdf

Molecular Cardiology for the Cardiologist provides a short, easily readable summary of what the new biology brings to cardiology. With this in mind, special efforts have been made to present many comprehensive schemes and drawings, as well as teaching tables. The five parts of the book provide a general introduction to the new language of biology; the normal structure of the heart and blood vessels; the physiopathology and the new therapeutic avenues that have been opened up by the new biology. A concise summary of the keys that assist the cardiologist or student who seeks to learn and read more about this field. Provides practical examples to illustrate the clinical interest of the new approach.

Author : Bernard Swynghedauw
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461549697

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Molecular Cardiology for the Cardiologist by Bernard Swynghedauw Pdf

Molecular Cardiology for the Cardiologist, Second Edition provides a short, easily readable summary of what the new biology brings to cardiology. Special efforts have been made to include comprehensive diagrams and drawings, as well as teaching tables, and also to keep the size of the second edition within the modest limits of the first edition. The book remains divided into 5 parts. The first part is a general introduction to the new terminology. The second part is devoted to the normal structure of the heart and vessels. Parts 3 and 4 deal with physiopathology. One of the important contributions of molecular biology to cardiology is a better understanding of the general process of adaptation of the heart and vessels to a permanent mechanical overloading. Such a process is generally called remodeling, and results from coordinate changes in the expression of the genes. The last part of the book includes information on gene and cellular therapy.

Author : Michael R. Sanders,John B. Kostis
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 52,5 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585381411

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Molecular Cardiology in Clinical Practice by Michael R. Sanders,John B. Kostis Pdf

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

Author : Marschall S. Runge,Cam Patterson
Publisher : Springer Science & Business Media
Page : 604 pages
File Size : 54,6 Mb
Release : 2007-11-14
Category : Medical
ISBN : 9781592598786

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Principles of Molecular Cardiology by Marschall S. Runge,Cam Patterson Pdf

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Author : José Marín-García
Publisher : Academic Press
Page : 935 pages
File Size : 43,7 Mb
Release : 2014-05-09
Category : Medical
ISBN : 9780124046429

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Post-Genomic Cardiology by José Marín-García Pdf

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Author : Marianne J. Legato
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461338345

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The Developing Heart by Marianne J. Legato Pdf

Heart disease, despite recent improvements, continues to be the single most im portant cause of death and disability in the United States. It is estimated that the direct cost of medical care for cardiovascular disease is $6 billion dollars per year. Data compiled by the National Center for Health Statistics reveal a dramatic de cline in deaths from cardiovascular disease in the United States (greater than 20% since 1968). This phenomenon has been the subject of in-depth study. It is clear that the decline is real and not a statistical artifact. The decrease in mortality has been noted in all sections of the country, though the onset and rate of decline varies in different regions of the country. Both primary prevention, through changes in risk factors, and basic and applied research leading to earlier recognition and im proved treatment have contributed to the decline. They do not fully explain the decline. Further research is needed to clarify this issue. Clinical cardiologists have been exposed to a veritable explosion of new knowl edge of mechanisms of cardiovascular disease, development of new improved non-invasive diagnostic techniques, and the pharmacodynamics of agents affect ing the cardiovascular system. This new knowledge results from contributions made by individuals from diverse disciplines including cellular and molecular bi ologists, geneticists, hematologists, cardiologists, and cardiovascular surgeons.

Author : Marianne J Legato
Publisher : Unknown
Page : 284 pages
File Size : 50,7 Mb
Release : 1984-11-30
Category : Electronic
ISBN : 1461338352

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The Developing Heart by Marianne J Legato Pdf

Author : Cam Patterson,Monte S. Willis
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 47,8 Mb
Release : 2012-07-04
Category : Medical
ISBN : 9781617798917

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Translational Cardiology by Cam Patterson,Monte S. Willis Pdf

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Author : Victor J. Dzau, MD,Choong-Chin Liew, PhD
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 44,6 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470765944

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Cardiovascular Genetics and Genomics for the Cardiologist by Victor J. Dzau, MD,Choong-Chin Liew, PhD Pdf

Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine. In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand: • how cardiovascular genetics may remodel the way cardiovascular medicine is practiced • what material has immediate relevance to the practicing clinician • how to incorporate genetics and genomics in your practice to ensure up-to-date patient care The book opens with introductory chapters, then discusses: • cardiovascular single gene disorders • cardiovascular polygenic disorders • therapies and applications Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

Author : Zhongjie Sun
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 50,7 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592598793

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Molecular Cardiology by Zhongjie Sun Pdf

The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Author : S. Sideman,Rafael Beyar
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461518938

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Molecular and Subcellular Cardiology by S. Sideman,Rafael Beyar Pdf

The Henry Goldberg Workshops were set up to address the following goals: (1) To foster interdisciplinary interaction between scientists and cardiologists, identify missing links, and catalyze new ideas. (2) To relate basic microscale phenomena to the global, clinically manifested cardiac function. (3) To relate conceptual modeling and quantitative analysis to experimental and clinical data. (4) To encourage international cooperation so as to disperse medical and technological knowhow and lead to better understanding of the cardiac system. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between cardiac mechanics, electrical activation, perfusion, and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University in 1986, highlighted the transformation of the microscale activation phenomena to macroscale activity and performance, relating electrophysiology, energy metabolism, and cardiac mechanics. The fourth Goldberg Workshop, in 1987, continued the effort to elucidate the interactions among the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop, held in Cambridge, UK, in 1988, dwelt on the effects of inhomogeneity of the cardiac muscle on its performance in health and disease. The sixth Workshop highlighted the role of new modem imaging techniques, that allow us to gain more insight into local and global cardiac performance in cardiac research and clinical practice.

Author : Runge
Publisher : Unknown
Page : 632 pages
File Size : 48,8 Mb
Release : 2008-08-01
Category : Electronic
ISBN : 8184890052

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Principles Of Molecular Cardiology by Runge Pdf

Author : D.H. Wang
Publisher : Springer Science & Business Media
Page : 221 pages
File Size : 55,7 Mb
Release : 2007-08-17
Category : Medical
ISBN : 9780387475301

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Molecular Sensors for Cardiovascular Homeostasis by D.H. Wang Pdf

The biomolecular basis underlying essential hypertension and end organ damage associated with hypertension is characterized as polygenic diseases with complexities such as "environment gene" and "gene-gene" interactions. Despite intensive research in this field, this molecular book is aimed at providing the state-of-the-art reviews which define how the biologic systems sense changes in environment, alter their activities or function, and cross talk with other neurohormonal systems to modulate cardiovascular/renal function and blood pressure. This title will attract scientists and investigators in both academic and industrial fields, and clinicians.

Author : Clive Rosendorff
Publisher : Springer Science & Business Media
Page : 818 pages
File Size : 53,8 Mb
Release : 2013-06-05
Category : Medical
ISBN : 9781461467052

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Essential Cardiology by Clive Rosendorff Pdf

Essential Cardiology: Principles and Practice, 3rd Edition, blends molecular, cellular, and physiologic concepts with current clinical practice and provides up-to-date information on all major aspects of cardiovascular disease. Fully revised by an international panel of leading authorities in the field, it is an authoritative resource for cardiologists, internists, residents, and students. The book presents the clinical examination of the patient, including diagnostic testing and cutting-edge radiologic imaging; pathogenesis and treatment of various types of cardiac abnormalities; the needs of special populations, including pregnant, elderly, and renal-compromised patients; cardiovascular gene and cell therapy; and preventive cardiology. It includes new chapters on cardiovascular disease in women; diabetes and the cardiovascular system; and cancer therapy-induced cardiomyopathy. The Third Edition also focuses on the substantial advances in anti-platelet and anticoagulant therapy; new modalities of cardiac imaging; new anti-arrhythmic drugs; and a sophisticated understanding of vascular biology and atherogenesis.

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 339 pages
File Size : 54,9 Mb
Release : 2013-12-23
Category : Medical
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology