Molecular Cellular And Clinical Aspects Of Angiogenesis

Author : Michael E. Maragoudakis
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461303893

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Molecular, Cellular, and Clinical Aspects of Angiogenesis by Michael E. Maragoudakis Pdf

There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis.

Author : Michael E Maragoudakis
Publisher : Unknown
Page : 312 pages
File Size : 50,5 Mb
Release : 1996-07-31
Category : Electronic
ISBN : 1461303907

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Molecular, Cellular, and Clinical Aspects of Angiogenesis by Michael E Maragoudakis Pdf

Author : Michael E. Maragoudakis,Pietro M. Gullino,Peter I. Lelkes
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 44,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475791884

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Angiogenesis by Michael E. Maragoudakis,Pietro M. Gullino,Peter I. Lelkes Pdf

Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states and also provide the basis for developing promoters or suppressors of angiogenesis for clinical applications. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis: Molecular Biology, Oinical Aspects" held in Rhodes, Greece, from June 16-27, 1993. This meeting was a comprehensive review of the various aspects of angiogenesis such as embryonic development, endothelial cell heterogeneity and tissue specificity, molecular biology of endothelial cell, mechanisms for the regulation of angiogenesis, disease states in which angiogenesis is involved and potential application of promoters or suppressors of angiogenesis. The presentations and discussions of the meeting provided an opportunity for investigators from many different areas of basic science and medicine to exchange information, evaluate the present status and provide future research directions in the field of angiogenesis.

Author : Józef Dulak,Alicja Józkowicz,Agnieszka Łoboda
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 52,6 Mb
Release : 2014-02-10
Category : Medical
ISBN : 9783709114285

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Angiogenesis and Vascularisation by Józef Dulak,Alicja Józkowicz,Agnieszka Łoboda Pdf

The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.

Author : Gaetano Santulli
Publisher : Nova Biomedical Books
Page : 362 pages
File Size : 52,9 Mb
Release : 2014-05-14
Category : Medical
ISBN : 1626181578

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Angiogenesis by Gaetano Santulli Pdf

This book provides an overview of the scientific methods used to search, analyse, appraise and synthesize studies on angiogenesis. It is intended to serve as a comprehensive piece of literature that encompasses all aspects from the molecular features of angiogenesis to the clinical value and potential pitfalls of angiogenic-based therapies. The primary motion to write this book is to provide an overview of the current status of the research in this field, with a focus on both tumoral and non-tumoral disease. Effects of various anti-angiogenic and pro-angiogenic molecules are also addressed in detail. This book comes at an important time in the development of so-called "translational medicine". Its purpose is to explain all the molecular bases underlying the angiogenic process and apply them to the clinical world. Reviewed and addressed are the basic concepts and importance of new drugs in clinical trials to inhibit or promote angiogenesis. This book may be considered as a scholarly reference work for libraries and researchers across the world and as a supplementary text for courses in medicine, physiology, biochemistry, molecular and cellular biology. It is expected that readers, both basic researchers and clinicians, will gain a good understanding of the essential value of angiogenesis in health and disease.

Author : Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Publisher : Springer
Page : 505 pages
File Size : 40,9 Mb
Release : 2014-05-27
Category : Science
ISBN : 9782817804668

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Molecular Mechanisms of Angiogenesis by Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin Pdf

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 52,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Michael E. Maragoudakis
Publisher : Springer Science & Business Media
Page : 552 pages
File Size : 40,5 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475791853

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Angiogenesis by Michael E. Maragoudakis Pdf

Interest in angiogenesis research remains strong in recent years and exciting new discoveries, about modulators of angiogenesis, their receptors, the transduction mechanisms and the angiogenic genes involved, have contributed to our present day understanding of this complex process. This knowledge has provided the basis and broadened the scope of angiogenesis - based therapy in oncology and many other clinical conditions. This monograph contains the contributions to the NATO Advanced Study Institute on "Angiogenesis: Models, Modulators and Clinical Applications", which was held in Rhodes, Greece, from June 20-30, 1997. This was the fourth of a series of NATO supported international meetings on Angiogenesis aiming to bring together basic scientists with clinicians to exchange ideas, disseminate new knowledge and discuss the present status and potential new directions in this fast moving area of biomedical research. The International Organising Committee that included Drs. E. Dejana, C Haudenschild, M. Hackel, H. Kleinman, P. Lelkes, M. Presta, P. Polverini, D. Thompson, has provided invaluable help with their insightful suggestions in the formulation of the scientific program for which I am grateful. I wish to thank all the participants for their enthusiastic participation and their complimentary comments on the success of the conference.

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 45,5 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 260 pages
File Size : 49,8 Mb
Release : 2007-08-20
Category : Science
ISBN : 9780470319420

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Vascular Development by Derek J. Chadwick,Jamie A. Goode Pdf

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Author : Cynthia A Reinhart-King
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 47,7 Mb
Release : 2012-09-14
Category : Technology & Engineering
ISBN : 9783642308567

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Mechanical and Chemical Signaling in Angiogenesis by Cynthia A Reinhart-King Pdf

This volume describes and discusses recent advances in angiogenesis research. The chapters are organized to address all biological length scales of angiogenesis: molecular, cellular and tissue in both in vivo and in vitro settings. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

Author : John Penn
Publisher : Springer Science & Business Media
Page : 557 pages
File Size : 50,8 Mb
Release : 2008-01-19
Category : Medical
ISBN : 9781402067808

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Retinal and Choroidal Angiogenesis by John Penn Pdf

This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.

Author : Shaker Mousa,Paul Davis
Publisher : Academic Press
Page : 210 pages
File Size : 50,6 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9780128026731

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Anti-Angiogenesis Strategies in Cancer Therapies by Shaker Mousa,Paul Davis Pdf

Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Author : Domenico Ribatti,Francesco Pezzella
Publisher : Academic Press
Page : 198 pages
File Size : 44,6 Mb
Release : 2020-01-21
Category : Science
ISBN : 9780128194942

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Tumor Vascularization by Domenico Ribatti,Francesco Pezzella Pdf

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Author : David A. Cheresh
Publisher : Academic Press
Page : 400 pages
File Size : 44,8 Mb
Release : 2009-02-12
Category : Science
ISBN : 0080921655

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Angiogenesis: In Vivo Systems by David A. Cheresh Pdf

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition. * Provides the "builder's manual" for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques. * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics