Molecular Cellular And Metabolic Fundamentals Of Human Aging

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Molecular, Cellular, and Metabolic Fundamentals of Human Aging

Evandro Fei Fang,Linda Hildegard Bergersen,Brian C. Gilmour
Molecular Cellular and Metabolic Fundamentals of Human Aging Book PDF

Author : Evandro Fei Fang,Linda Hildegard Bergersen,Brian C. Gilmour
Publisher : Academic Press
Page : 262 pages
File Size : 42,5 Mb
Release : 2022-10-23
Category : Science
ISBN : 9780323916189

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Molecular, Cellular, and Metabolic Fundamentals of Human Aging by Evandro Fei Fang,Linda Hildegard Bergersen,Brian C. Gilmour Pdf

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer’s disease Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging Highlights recurring themes and key principles shared across the hallmarks of aging Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

J. Robin Harris,Viktor I. Korolchuk
Biochemistry and Cell Biology of Ageing Part I Biomedical Science Book PDF

Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Page : 526 pages
File Size : 40,7 Mb
Release : 2019-02-18
Category : Medical
ISBN : 9789811328350

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Biochemistry and Cell Biology of Ageing: Part I Biomedical Science by J. Robin Harris,Viktor I. Korolchuk Pdf

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Conn's Handbook of Models for Human Aging

Jeffrey L. Ram,P. Michael Conn
Conn s Handbook of Models for Human Aging Book PDF

Author : Jeffrey L. Ram,P. Michael Conn
Publisher : Academic Press
Page : 1218 pages
File Size : 42,8 Mb
Release : 2018-04-05
Category : Medical
ISBN : 9780128113547

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Conn's Handbook of Models for Human Aging by Jeffrey L. Ram,P. Michael Conn Pdf

Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Biomarkers of Human Aging

Alexey Moskalev
Biomarkers of Human Aging Book PDF

Author : Alexey Moskalev
Publisher : Springer Nature
Page : 421 pages
File Size : 41,5 Mb
Release : 2019-09-13
Category : Science
ISBN : 9783030249700

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Biomarkers of Human Aging by Alexey Moskalev Pdf

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Human Aging

Calogero Caruso,Giuseppina Candore
Human Aging Book PDF

Author : Calogero Caruso,Giuseppina Candore
Publisher : Academic Press
Page : 382 pages
File Size : 45,8 Mb
Release : 2021-05-11
Category : Science
ISBN : 9780128227374

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Human Aging by Calogero Caruso,Giuseppina Candore Pdf

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Aging at the Molecular Level

Thomas von Zglinicki
Aging at the Molecular Level Book PDF

Author : Thomas von Zglinicki
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 42,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9789401706674

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Aging at the Molecular Level by Thomas von Zglinicki Pdf

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

Models, Molecules and Mechanisms in Biogerontology

Pramod C. Rath
Models Molecules and Mechanisms in Biogerontology Book PDF

Author : Pramod C. Rath
Publisher : Springer Nature
Page : 497 pages
File Size : 43,8 Mb
Release : 2020-06-26
Category : Medical
ISBN : 9789813290051

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Models, Molecules and Mechanisms in Biogerontology by Pramod C. Rath Pdf

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Molecular Basis of Aging

Alvaro Macieira-Coelho
Molecular Basis of Aging Book PDF

Author : Alvaro Macieira-Coelho
Publisher : CRC Press
Page : 666 pages
File Size : 46,6 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351359962

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Molecular Basis of Aging by Alvaro Macieira-Coelho Pdf

Using a new, integrative approach, Molecular Basis of Aging describes the aging phenomenon within mammalian organisms from the perspective of changes in information storage and coordination between hierarchical orders of structure. This unique approach provides the reader with a thorough insight into the evolution of molecular, cellular, tissue, and organ systems and processes in mammals. This informative volume contains up-to-date reviews of:

Aging

Paulo J. Oliveira,Joao O. Malva
Aging Book PDF

Author : Paulo J. Oliveira,Joao O. Malva
Publisher : Elsevier
Page : 820 pages
File Size : 41,8 Mb
Release : 2022-09-15
Category : Medical
ISBN : 9780128237618

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Aging by Paulo J. Oliveira,Joao O. Malva Pdf

Aging: From Fundamental Biology to Societal Impact examines the interconnection of the cellular and molecular basis of aging and societal-based challenges and innovative interventions. Sections take a societal-based angle on aging, describing several flagship initiatives for healthy living and active aging in different regions, cover the biology of aging which includes the hallmarks of aging, explain the pathophysiology of aging, describing different comorbidities associated with aging and possible interventions to decrease the impact of aging, and envision future and innovative measures to tackle aging-related morbidities. Contributions from an interdisciplinary panel of experts cover such topics as the biology of aging to physical activity, nutrition, psychology, pharmacology, health care, social care and urban planning. Provides a cross-disciplinary approach to aging at both the biological and societal level Highlights frontline scientific knowledge in the biology of aging and its translation into societal interventions Offers insights on the value of aging research and its future impact from a fundamental and translation point-of-view

Molecular and Cellular Gerontology

Olivier Toussaint
Molecular and Cellular Gerontology Book PDF

Author : Olivier Toussaint
Publisher : Unknown
Page : 0 pages
File Size : 53,5 Mb
Release : 2000
Category : Aging
ISBN : 1573312711

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Molecular and Cellular Gerontology by Olivier Toussaint Pdf

This work covers a number of relevant aspects of the molecular and cellular biology of ageing, a timely general topic highlighted by the United Nations' having declared 1999 the Year of the Elderly. The papers published here represent a wide range of complementary research areas: molecular and cellular aspects; theories of ageing; molecular basis of the loss of homeostatic maintenance mechanisms; lower and higher model organisms including transgenic animal models; the genetics of human longevity; clinical and molecular aspects of age-related diseases; and integrated systems like brain and immune system aging. It is hoped that the additions to knowledge of the molecular mechanisms of ageing provided by this volume may ultimately lead to the prevention of age-related diseases.

Sarcopenia

Dominique Meynial-Denis
Sarcopenia Book PDF

Author : Dominique Meynial-Denis
Publisher : CRC Press
Page : 432 pages
File Size : 41,6 Mb
Release : 2019-12-02
Category : Aging
ISBN : 1498765130

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Sarcopenia by Dominique Meynial-Denis Pdf

"Maintaining adequate muscle mass is crucial to healthy aging. Numerous diseases as well as deterioration of motor nerves and muscle repair mechanisms cause risks to developing sarcopenia. Sedentary lifestyles coupled with excess caloric intake among senior citizens compound the problem by creating a condition of limited muscle strength overwhelmed with body weight. This book presents biochemical, nutritional, and metabolic implications related to sarcopenia. It provides information on mechanisms regulating age-related loss of muscle mass and function as well as nutritional anti-aging strategies to fight against atrophy and support healthy aging"--

Times, Cells, and Aging

Bernard Strihler
Times Cells and Aging Book PDF

Author : Bernard Strihler
Publisher : Academic Press
Page : 480 pages
File Size : 50,9 Mb
Release : 1977-01-28
Category : Science
ISBN : UCAL:B4300046

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Times, Cells, and Aging by Bernard Strihler Pdf

Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Basic Neurochemistry

Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Basic Neurochemistry Book PDF

Author : Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Publisher : Academic Press
Page : 1120 pages
File Size : 55,8 Mb
Release : 2011-11-02
Category : Science
ISBN : 9780080959016

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Basic Neurochemistry by Scott Brady,George Siegel,R. Wayne Albers,Donald Price Pdf

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Navigating Metabolism

Navdeep Singh Chandel
Navigating Metabolism Book PDF

Author : Navdeep Singh Chandel
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2015
Category : SCIENCE
ISBN : 1621821293

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Navigating Metabolism by Navdeep Singh Chandel Pdf

"Metabolic pathways used to be "road maps" most biologists learned as undergraduates and then promptly forgot. Recent work has revealed how changes in metabolism are closely linked to many aspects of cell behavior and the development of cancer and other diseases. This book represents both a new look at metabolism and a refresher course. It surveys the major metabolic pathways, places these in biological context, and highlights the key control points that control cell behavior and can become dysregulated in disease"--

Molecular Biology of Aging

Leonard Guarente,Linda Partridge,Douglas C. Wallace
Molecular Biology of Aging Book PDF

Author : Leonard Guarente,Linda Partridge,Douglas C. Wallace
Publisher : CSHL Press
Page : 610 pages
File Size : 42,8 Mb
Release : 2008
Category : Aging
ISBN : 9780879698249

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Molecular Biology of Aging by Leonard Guarente,Linda Partridge,Douglas C. Wallace Pdf

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.