Molecular Diagnostics And Treatment Of Pancreatic Cancer

Author : Asfar Azmi
Publisher : Elsevier
Page : 458 pages
File Size : 46,6 Mb
Release : 2014-04-14
Category : Medical
ISBN : 9780124079465

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Molecular Diagnostics and Treatment of Pancreatic Cancer by Asfar Azmi Pdf

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Author : Dongfeng Tan,Henry T. Lynch
Publisher : Lippincott Williams & Wilkins
Page : 2177 pages
File Size : 47,7 Mb
Release : 2012-12-07
Category : Medical
ISBN : 9781469820644

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Principles of Molecular Diagnostics and Personalized Cancer Medicine by Dongfeng Tan,Henry T. Lynch Pdf

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Author : Howard Reber
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461218104

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Pancreatic Cancer by Howard Reber Pdf

A distinguished panel of world authorities reviews the current state of today's understanding, diagnosis, and treatment of pancreatic cancer. Their cutting-edge reviews discuss both medical and surgical modalities and include numerous insights into the basic molecular processes underlying the disease. Among the key topics covered are the prospects for early diagnosis using molecular techniques, the latest diagnostic and therapeutic methods, the role of laparoscopy (diagnostic and therapeutic), and nonsurgical treatment. The reviewers also address the future possibilities for clinical advances, quality of life concerns, and the value of the Japanese "extended Whipple resection." Pancreatic Cancer will become the new standard reference for all clinicians who diagnose and treat this disease, as well as for basic scientists needing a summary of the many recent advances. i

Author : Domenico Coppola
Publisher : Springer Science & Business Media
Page : 601 pages
File Size : 48,8 Mb
Release : 2013-11-29
Category : Medical
ISBN : 9789400771925

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Molecular Pathology and Diagnostics of Cancer by Domenico Coppola Pdf

Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Author : Kamla Kant Shukla,Praveen Sharma,Sanjeev Misra
Publisher : Springer
Page : 341 pages
File Size : 47,7 Mb
Release : 2019-03-15
Category : Medical
ISBN : 9789811358777

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Molecular Diagnostics in Cancer Patients by Kamla Kant Shukla,Praveen Sharma,Sanjeev Misra Pdf

This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Author : Fazlul H. Sarkar,Michael C. Dugan
Publisher : Eaton Publishing Company/Biotechniques Books
Page : 232 pages
File Size : 42,8 Mb
Release : 1998
Category : Medical
ISBN : CHI:56383034

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Pancreatic Cancer by Fazlul H. Sarkar,Michael C. Dugan Pdf

Author : Carlos A. Vaccaro,Mev Dominguez-Valentin,Walter Hernán Pavicic
Publisher : Frontiers Media SA
Page : 108 pages
File Size : 41,6 Mb
Release : 2023-01-27
Category : Medical
ISBN : 9782832512128

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Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer by Carlos A. Vaccaro,Mev Dominguez-Valentin,Walter Hernán Pavicic Pdf

Author : Shiyang Pan,Jinhai Tang
Publisher : Springer Nature
Page : 889 pages
File Size : 53,6 Mb
Release : 2021-07-08
Category : Medical
ISBN : 9789811610370

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Clinical Molecular Diagnostics by Shiyang Pan,Jinhai Tang Pdf

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publisher : Academic Press
Page : 420 pages
File Size : 49,9 Mb
Release : 2020-01-15
Category : Electronic
ISBN : 012819457X

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Theranostic Approach for Pancreatic Cancer by Ganji Purnachandra Nagaraju,Sarfraz Ahmad Pdf

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. This book discusses several topics related to pancreatic cancer such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer Discusses treatment options available currently as well as prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Author : Helmut Friess
Publisher : Unknown
Page : 0 pages
File Size : 49,8 Mb
Release : 2011
Category : Electronic
ISBN : 1780841353

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Advances in Pancreatic Cancer Treatment by Helmut Friess Pdf

Author : P. Malfertheiner,J.E. Dominguez-Munoz,H.-U. Schulz,Hans Lippert
Publisher : Springer
Page : 0 pages
File Size : 51,9 Mb
Release : 2011-09-18
Category : Medical
ISBN : 3642644643

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Diagnostic Procedures in Pancreatic Disease by P. Malfertheiner,J.E. Dominguez-Munoz,H.-U. Schulz,Hans Lippert Pdf

These proceedings of an international meeting held as recently as December 1996 cover diagnostic procedures in pancreatic disease, together with the progress made over the last 10 years in treating acute and chronic pancreatitis as well as pancreatic cancer. The meeting also covered standards in medical and surgical treatment.

Author : Finbarr E. Cotter
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 55,7 Mb
Release : 1996
Category : Cancer
ISBN : UOM:39015037821058

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Molecular Diagnosis of Cancer by Finbarr E. Cotter Pdf

Leading clinicians and expert researchers bring together under one cover a comprehensive guide to the newest and most essential molecular techniques-particularly PCR-for diagnosing and monitoring hematological and solid tumors. These distinguished practitioners demonstrate step-by-step the use of PCR, FISH, CGH, Southern analysis, sequencing, and SSCP to assess cancer markers, to detect minimal disease and apoptosis, and to uncover particular translocations, mutations, and deletions. Their readily reproducible results offer physicians and scientists a promising entré into the powerful possibilities of using these techniques to improve the diagnosis, prognosis, and management of cancer.

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 46,6 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 846 pages
File Size : 53,6 Mb
Release : 2023-10-27
Category : Science
ISBN : 9780128229934

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Diagnostic Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Author : Ralph H. Hruban,Martha Bishop Pitman,David S. Klimstra
Publisher : American Registry of Pathology
Page : 448 pages
File Size : 43,7 Mb
Release : 2007
Category : Pancreas
ISBN : UCSD:31822030271886

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Tumors of the Pancreas by Ralph H. Hruban,Martha Bishop Pitman,David S. Klimstra Pdf

In addition to the extensive discussion, illustrations, and up-to-date referencing of the numerous pancreatic tumours and tumour-like lesions, normal gross, histologic and cytologic findings, and on pancreatic tumour staging are covered. These discussions complement the treatment of the issue of frozen section interpretation, dissection, and reporting of pancreatic resection specimens.