Advances In Pancreatic Cancer Treatment

Author : Susan Tsai,Paul S. Ritch,Beth A. Erickson,Douglas B. Evans
Publisher : Springer
Page : 205 pages
File Size : 46,9 Mb
Release : 2019-07-30
Category : Medical
ISBN : 9783319989440

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Management of Localized Pancreatic Cancer by Susan Tsai,Paul S. Ritch,Beth A. Erickson,Douglas B. Evans Pdf

This book is designed to present a comprehensive understanding for the rationale of neoadjuvant treatment sequencing for localized pancreatic cancer and to focus on accurate clinical staging and stage-specific treatment sequencing. Sections address important aspects of clinical management of localized pancreatic cancer from diagnosis to surgery. These areas include initial radiographic staging, management of obstructive jaundice, role of chemotherapy and chemoradiation in neoadjuvant therapy, assessment of treatment response, and operative considerations for complex vascular resections. A brief review of suggested readings addressing the particular topic follows in each section, as well as a summary of clinical “pearls”. Management of Localized Pancreatic Cancer: Current Treatment and Challenges provides a comprehensive resource which clearly defines the principles of neoadjuvant therapy as well as a clinical framework for successful therapy. It serves as a valuable guide to physicians of multiple disciplines who are interested in utilizing neoadjuvant therapy for localized pancreatic cancer.

Author : Helmut Friess
Publisher : Unknown
Page : 0 pages
File Size : 45,9 Mb
Release : 2011
Category : Electronic
ISBN : 1780841353

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Advances in Pancreatic Cancer Treatment by Helmut Friess Pdf

Author : Andrew M. Lowy,Steven D. Leach,Philip Philip
Publisher : Springer Science & Business Media
Page : 737 pages
File Size : 45,8 Mb
Release : 2008-07-10
Category : Medical
ISBN : 9780387692524

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Pancreatic Cancer by Andrew M. Lowy,Steven D. Leach,Philip Philip Pdf

Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. This book provides information on the recent progress and improvements. It brings to the forefront the most current advances that have been made in understanding pancreatic cancer development and successfully treating this disease.

Author : Asfar Azmi
Publisher : Elsevier
Page : 458 pages
File Size : 50,7 Mb
Release : 2014-04-14
Category : Medical
ISBN : 9780124079465

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Molecular Diagnostics and Treatment of Pancreatic Cancer by Asfar Azmi Pdf

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Author : Luis Rodrigo
Publisher : BoD – Books on Demand
Page : 226 pages
File Size : 48,5 Mb
Release : 2018-09-05
Category : Medical
ISBN : 9781789236408

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Advances in Pancreatic Cancer by Luis Rodrigo Pdf

Pancreatic cancer is a growing source of cancer-related death and has poor survival rates, which have not improved in the last few decades. Its high-mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis, and lack of standardized international guidelines in assessing the pancreatic masses. This book aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of the available diagnostic technology and therapy. The main modalities for diagnosis are imaging with HCT, MRI, USE, and PET. Some chapters review the improvements in the techniques used. Timely and accurate diagnosis of pancreatic cancer can lead to improve in the current poor outcome of this disease.

Author : Shubham Pant
Publisher : Springer Nature
Page : 197 pages
File Size : 40,6 Mb
Release : 2023-12-09
Category : Medical
ISBN : 9783031386237

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Pancreatic Cancer by Shubham Pant Pdf

Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents. This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquid biopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.

Author : Tanios Bekaii-Saab,Bassel El-Rayes
Publisher : Springer
Page : 381 pages
File Size : 52,9 Mb
Release : 2017-09-27
Category : Medical
ISBN : 9783319582566

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Current and Emerging Therapies in Pancreatic Cancer by Tanios Bekaii-Saab,Bassel El-Rayes Pdf

This book provides a comprehensive, state-of-the art review of current and new therapies in treating pancreatic cancer. In addition to discussing the current landscape for treating various stages of pancreatic cancer, the text highlights several standard and emerging approaches, with a particular emphasis on novel endoscopic, surgical, chemotherapeutic, radiotherapeutic, targeted, and immunotherapeutic strategies. The volume also features concepts on the potential economic effects associated with the development and implementation of new treatments in pancreatic cancer. Written by experts from a variety of integrative disciplines, Current and Emerging Therapies in Pancreatic Cancer is a valuable resource for oncologists, gastroenterologists, surgeons, and other professionals who treat and manage patients with pancreatic cancer.

Author : Sanjay Srivastava
Publisher : BoD – Books on Demand
Page : 328 pages
File Size : 43,5 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9789535103943

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Pancreatic Cancer by Sanjay Srivastava Pdf

This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.

Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publisher : Academic Press
Page : 420 pages
File Size : 51,7 Mb
Release : 2020-01-15
Category : Electronic
ISBN : 012819457X

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Theranostic Approach for Pancreatic Cancer by Ganji Purnachandra Nagaraju,Sarfraz Ahmad Pdf

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. This book discusses several topics related to pancreatic cancer such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer Discusses treatment options available currently as well as prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Author : Borislav Vladimirov,Mila Kovacheva-Slavova
Publisher : BoD – Books on Demand
Page : 115 pages
File Size : 41,9 Mb
Release : 2021-12-22
Category : Medical
ISBN : 9781839629587

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Challenges in Pancreatic Cancer by Borislav Vladimirov,Mila Kovacheva-Slavova Pdf

Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance.

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 48,5 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Author : Howard Reber
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461218104

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Pancreatic Cancer by Howard Reber Pdf

A distinguished panel of world authorities reviews the current state of today's understanding, diagnosis, and treatment of pancreatic cancer. Their cutting-edge reviews discuss both medical and surgical modalities and include numerous insights into the basic molecular processes underlying the disease. Among the key topics covered are the prospects for early diagnosis using molecular techniques, the latest diagnostic and therapeutic methods, the role of laparoscopy (diagnostic and therapeutic), and nonsurgical treatment. The reviewers also address the future possibilities for clinical advances, quality of life concerns, and the value of the Japanese "extended Whipple resection." Pancreatic Cancer will become the new standard reference for all clinicians who diagnose and treat this disease, as well as for basic scientists needing a summary of the many recent advances. i

Author : Hiroki Yamaue
Publisher : Springer
Page : 260 pages
File Size : 50,9 Mb
Release : 2017-07-19
Category : Medical
ISBN : 9789811024863

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Innovation of Diagnosis and Treatment for Pancreatic Cancer by Hiroki Yamaue Pdf

This collection of chapters describes in detail the latest insights into the evaluation of resectability and neoadjuvant therapy to pancreaticoduodenectomy and distal pancreatectomy for pancreatic cancer. Shedding light on immunotherapy and gene therapy, this volume comprehensively covers treatments and procedures for the disease, allowing surgeons and trainees to gain an overview and explore innovative treatments. It also provides information on various cases using tools such as endoscopic ultrasound, MDCT, PET for diagnosis and laparoscopy and robotic resection methods. Edited and authored by pioneering professionals, Diagnosis and Treatment for Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, surgical oncologist and general surgeons interested in treatment of pancreatic cancer care.

Author : John L. Cameron
Publisher : PMPH-USA
Page : 294 pages
File Size : 52,5 Mb
Release : 2001
Category : Pancreas
ISBN : 155009131X

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Pancreatic Cancer by John L. Cameron Pdf

American Cancer Society Atlas of Clinical Oncology ACS Pancreatic Cancer At present, there are approximately 28,300 new cases of pancreatic cancer in the United States. It is the fourth leading cause of cancer death in men and women. Approximately 2 out of 10 patients with cancer of the pancreas will live at least one year after ......

Author : H. Riess,A. Goerke,H. Oettle
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 50,8 Mb
Release : 2007-11-17
Category : Medical
ISBN : 9783540712794

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Pancreatic Cancer by H. Riess,A. Goerke,H. Oettle Pdf

Although pancreatic cancer is one of the most serious forms of cancers, the lack of clinical symptoms often limits curative treatment options. This book gives insight into the current understanding of the management of pancreatic cancer and considers recent findings in cancer research. It provides answers to questions of how to know when cancer is respectable, how to proceed when the diagnosis comes too late for a curative approach, and how to assess different study results.