Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases

Author : Mohammadreza Hajjari,Seyed Javad Mowla, Mohammad Ali Faghihi
Publisher : Frontiers Media SA
Page : 73 pages
File Size : 52,8 Mb
Release : 2016-12-14
Category : Electronic book
ISBN : 9782889450022

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Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases by Mohammadreza Hajjari,Seyed Javad Mowla, Mohammad Ali Faghihi Pdf

Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 42,9 Mb
Release : 2016
Category : Electronic
ISBN : OCLC:1368446430

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Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases by Anonim Pdf

Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.

Author : Jan Barciszewski
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 41,6 Mb
Release : 2003-08-31
Category : Science
ISBN : 0306478358

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Non-Coding RNAs by Jan Barciszewski Pdf

General inspection of a role performed in the cell by RNAs allows us to distinguish three major groups of transcripts: I. protein-coding mRNAs, II. non-coding housekeeping and III. regulatory RNAs. The housekeeping RNAs include RNA classes that are generally, constitutively expressed and whose presence is required for normal function and viability of the cells. On the other hand, a group of regulatory RNAs includes RNA species that are expressed at certain stages of organism development or cell differentiation or as a response to external stimuli and can affect expression of other genes on the levels of transcription or translation. Non-coding RNA transcripts form a heterogeneous class of RNAs that can not be characterized by a single specific function. Initially, the term non-coding RNA (ncRNA) was used primarily to describe polyadenylated and a capped eukaryotic RNAs transcribed by RNA polymerase II, but lacking long open reading frames. Now, this definition can be extended to cover all RNA transcripts that do not show protein-coding capacity and is sometimes used to describe any RNA that does not encode protein, including introns. This book is an in-depth look at the function of Non-Coding RNAs and their relationship to Molecular Biology and Molecular Biology.

Author : Ahmad M. Khalil,Jeff Coller
Publisher : Springer Science & Business Media
Page : 232 pages
File Size : 49,5 Mb
Release : 2013-09-20
Category : Medical
ISBN : 9781461486213

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Molecular Biology of Long Non-coding RNAs by Ahmad M. Khalil,Jeff Coller Pdf

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Author : Syed Mudasir Andrabi,Nazir Ahmad Ganai
Publisher : Cambridge Scholars Publishing
Page : 201 pages
File Size : 43,5 Mb
Release : 2020-09-03
Category : Science
ISBN : 9781527559103

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Long Non-Coding RNA by Syed Mudasir Andrabi,Nazir Ahmad Ganai Pdf

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.

Author : Antonin Morillon
Publisher : Elsevier
Page : 190 pages
File Size : 44,8 Mb
Release : 2018-02-01
Category : Science
ISBN : 9780081023556

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Long Non-coding RNA by Antonin Morillon Pdf

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests

Author : Gordon G. Carmichael
Publisher : Unknown
Page : 181 pages
File Size : 55,7 Mb
Release : 2014
Category : Genetic regulation
ISBN : 1493913697

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Regulatory Non-Coding RNAs by Gordon G. Carmichael Pdf

Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls.Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.

Author : Junjie Xiao
Publisher : Springer
Page : 426 pages
File Size : 53,9 Mb
Release : 2021-04-28
Category : Science
ISBN : 9811516731

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Non-coding RNAs in Cardiovascular Diseases by Junjie Xiao Pdf

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.

Author : Quan Zou,Arun Kumar Sangaiah,Dariusz Mrozek
Publisher : Frontiers Media SA
Page : 485 pages
File Size : 55,9 Mb
Release : 2019-12-04
Category : Electronic
ISBN : 9782889632145

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Machine Learning Techniques on Gene Function Prediction by Quan Zou,Arun Kumar Sangaiah,Dariusz Mrozek Pdf

Author : Yun Zheng,Philipp Kapranov
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 40,9 Mb
Release : 2020-11-04
Category : Science
ISBN : 9782889660544

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Recent Progresses of Non-Coding RNAs in Biological and Medical Research, 2nd Edition by Yun Zheng,Philipp Kapranov Pdf

Publisher’s note: In this 2nd edition, the following article has been updated: Xun Y, Tang Y, Hu L, Xiao H, Long S, Gong M, Wei C, Wei K and Xiang S (2019) Purification and Identification of miRNA Target Sites in Genome Using DNA Affinity Precipitation. Front. Genet. 10:778. doi: 10.3389/fgene.2019.00778

Author : Vijay Nambi
Publisher : Saunders
Page : 0 pages
File Size : 45,5 Mb
Release : 2018-11-26
Category : Medical
ISBN : 0323548350

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Biomarkers in Cardiovascular Disease by Vijay Nambi Pdf

Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.

Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 44,6 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033

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Long Non Coding RNA Biology by M.R.S. Rao Pdf

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Author : Mathieu Rederstorff
Publisher : Humana
Page : 0 pages
File Size : 44,8 Mb
Release : 2016-10-05
Category : Medical
ISBN : 1493949039

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Small Non-Coding RNAs by Mathieu Rederstorff Pdf

This volume contains state-of-the-art methods tackling all aspects of small non-coding RNAs biology. Small Non-Coding RNAs: Methods and Protocols guides readers through customized dedicated protocols and technologies that will be of valuable help to all those willing to contribute deciphering the numerous functions of small non-coding RNAs. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubles troubleshooting and avoiding known pitfalls. Instructive and practical, Small Non-Coding RNAs: Methods and Protocols reaches out to biochemists, cellular and molecular biologists already working in the field of RNA biology and to those just starting to study small non-coding RNAs.

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 580 pages
File Size : 46,6 Mb
Release : 2009-08-20
Category : Science
ISBN : 0521118557

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MicroRNAs by Krishnarao Appasani Pdf

MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 49,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.