Micrornas

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MicroRNAs in Plant Development and Stress Responses

Ramanjulu Sunkar
MicroRNAs in Plant Development and Stress Responses Book PDF

Author : Ramanjulu Sunkar
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 50,6 Mb
Release : 2012-02-21
Category : Science
ISBN : 9783642273841

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MicroRNAs in Plant Development and Stress Responses by Ramanjulu Sunkar Pdf

Precise regulation of gene expression in both time and space is vital to plant growth, development and adaptation to biotic and abiotic stress conditions. This is achieved by multiple mechanisms, with perhaps the most important control being exerted at the level of transcription. However, with the recent discovery of microRNAs another ubiquitous mode of gene regulation that occurs at the post-transcriptional level has been identified. MicroRNAs can silence gene expression by targeting complementary or partially complementary mRNAs for degradation or translational inhibition. Recent studies have revealed that microRNAs play fundamental roles in plant growth and development, as well as in adaptation to biotic and abiotic stresses. This book highlights the roles of individual miRNAs that control and regulate diverse aspects of plant processes.

MicroRNAs

Krishnarao Appasani
MicroRNAs Book PDF

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 580 pages
File Size : 40,9 Mb
Release : 2009-08-20
Category : Science
ISBN : 0521118557

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MicroRNAs by Krishnarao Appasani Pdf

MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

MicroRNA Cancer Regulation

Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
MicroRNA Cancer Regulation Book PDF

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 53,8 Mb
Release : 2013-02-03
Category : Medical
ISBN : 9789400755901

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MicroRNA Cancer Regulation by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera Pdf

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

MicroRNAs

Neil J. Clarke,Philippe Sanseau
MicroRNAs Book PDF

Author : Neil J. Clarke,Philippe Sanseau
Publisher : Unknown
Page : 0 pages
File Size : 43,6 Mb
Release : 2007
Category : Small interfering RNA.
ISBN : 1933255196

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MicroRNAs by Neil J. Clarke,Philippe Sanseau Pdf

Providing a comprehensive overview of a fast-emerging field, this description of the biological role of microRNAs discusses methods for identifying and characterizing their functions and looks at potential applications of microRNA research in medicine and pharmacology. First identified a decade ago, microRNAs (miRNAs) are small, noncoding RNA molecules that appear to regulate gene expression. Found in plant and animal species and possibly traceable back to ancient forms of life, miRNAs are now estimated to regulate a third or more of human genes. Neil J. Clarke, PhD, is a molecular biologist and the manager of gene interference research for GlaxoSmithKline. Philippe Sanseau, PhD, is a molecular biologist specializing in cancer and immunogenetics. He is the director of bioinformatics at GlaxoSmithKline.

Hormones, Metabolism and the Benefits of Exercise

Bruce Spiegelman
Hormones Metabolism and the Benefits of Exercise Book PDF

Author : Bruce Spiegelman
Publisher : Springer
Page : 108 pages
File Size : 52,5 Mb
Release : 2018-03-07
Category : Science
ISBN : 9783319727905

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Hormones, Metabolism and the Benefits of Exercise by Bruce Spiegelman Pdf

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

MicroRNAs

David C. Henshall
MicroRNAs Book PDF

Author : David C. Henshall
Publisher : Cambridge University Press
Page : 291 pages
File Size : 47,9 Mb
Release : 2024-06-30
Category : Medical
ISBN : 9781009466424

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MicroRNAs by David C. Henshall Pdf

Explore microRNA's fascinating story, and uncover the secrets of their discovery, purpose, and real-world applications.

Current Perspectives in microRNAs (miRNA)

Shao-Yao Ying
Current Perspectives in microRNAs miRNA Book PDF

Author : Shao-Yao Ying
Publisher : Springer Science & Business Media
Page : 461 pages
File Size : 54,9 Mb
Release : 2008-09-12
Category : Medical
ISBN : 9781402085338

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Current Perspectives in microRNAs (miRNA) by Shao-Yao Ying Pdf

Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

MicroRNAs and cardiovascular disease

Tiago Pereira-da-Silva
MicroRNAs and cardiovascular disease Book PDF

Author : Tiago Pereira-da-Silva
Publisher : Principia Editora
Page : 90 pages
File Size : 44,9 Mb
Release : 2022-10-27
Category : Medical
ISBN : 9789897163241

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MicroRNAs and cardiovascular disease by Tiago Pereira-da-Silva Pdf

According to the World Health Organization, cardiovascular diseases are the leading cause of death globally, taking an estimated 17.9 million lives each year, most of which are attributable to athero-sclerosis. Notably, the mechanisms that regulate atherosclerotic disease development and expression are not fully understood yet. MicroRNAs are small non-coding molecules of ribonucleic acid that regu-late the gene expression at the post-transcriptional level and play a key role in the pathophysiology of different cardiovascular diseases, including atherosclerosis. Moreover, circulating microRNAs have been studied as biomarkers of different diseases, and specific circulating microRNA profiles are asso-ciated with the presence of atherosclerosis of different arterial territories and multi-territorial athero-sclerosis. These issues are discussed in the book, including the core results of the translational re-search carried out by our group. Knowledge of microRNA profiles in such context provided insights into the pathophysiology of atherosclerosis and supports the potential clinical value of microRNAs as noninvasive biomarkers.

MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers

Takahiro Ochiya,Ryou-u Takahashi
MicroRNAs Novel Biomarkers and Therapeutic Targets for Human Cancers Book PDF

Author : Takahiro Ochiya,Ryou-u Takahashi
Publisher : MDPI
Page : 273 pages
File Size : 42,7 Mb
Release : 2018-10-16
Category : Electronic books
ISBN : 9783038972525

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MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers by Takahiro Ochiya,Ryou-u Takahashi Pdf

This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM

MiRNomics

Malik Yousef,Jens Allmer
MiRNomics Book PDF

Author : Malik Yousef,Jens Allmer
Publisher : Unknown
Page : 333 pages
File Size : 44,8 Mb
Release : 2014
Category : RNA
ISBN : 1627037489

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MiRNomics by Malik Yousef,Jens Allmer Pdf

In miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective. These include methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNomics: MicroRNA Biology and Computational Analysis seeks to aid scientists in the further study into miRNA research and statistics.

Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance

Peter Igaz
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance Book PDF

Author : Peter Igaz
Publisher : Springer
Page : 288 pages
File Size : 50,8 Mb
Release : 2015-11-25
Category : Medical
ISBN : 9783034809559

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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance by Peter Igaz Pdf

MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.

Translating MicroRNAs to the Clinic

Jeffrey Laurence
Translating MicroRNAs to the Clinic Book PDF

Author : Jeffrey Laurence
Publisher : Academic Press
Page : 392 pages
File Size : 55,8 Mb
Release : 2016-09-17
Category : Science
ISBN : 9780128005545

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Translating MicroRNAs to the Clinic by Jeffrey Laurence Pdf

Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply microRNA from lab to clinic“/li> Extensive pedagogical updates aiming to improve the education of translational researchers in this field Transdisciplinary approach aims to support cross-fertilization between different sub-specialties of medicine

The Role of MicroRNAs in Plants

Anthony A. Millar
The Role of MicroRNAs in Plants Book PDF

Author : Anthony A. Millar
Publisher : MDPI
Page : 174 pages
File Size : 41,5 Mb
Release : 2020-05-27
Category : Science
ISBN : 9783039287307

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The Role of MicroRNAs in Plants by Anthony A. Millar Pdf

Discovered in plants at the turn of the century, microRNAs (miRNAs) have been found to be fundamental to many aspects of plant biology. These small (20–24 nt) regulatory RNAs are derived via processing from longer imperfect double-stranded RNAs. They are then incorporated into silencing complexes, which they guide to (m)RNAs of high sequence complementarity, resulting in gene silencing outcomes, either via RNA degradation and/or translational inhibition. Some miRNAs are ancient, being present in all species of land plants and controlling fundamental processes such as phase change, organ polarity, flowering, and leaf and root development. However, there are many more miRNAs that are much less conserved and with less understood functions. This Special Issue contains seven research papers that span from understanding the function of a single miRNA family to examining how the miRNA profiles alter during abiotic stress or nutrient deficiency. The possibility of circular RNAs in plants acting as miRNA decoys to inhibit miRNA function is investigated, as was the hierarchical roles of miRNA biogenesis factors in the maintenance of phosphate homeostasis. Three reviews cover the potential of miRNAs for agronomic improvement of maize, the role of miRNA-triggered secondary small RNAs in plants, and the potential function of an ancient plant miRNA.

microRNAs in Toxicology and Medicine

Saura C. Sahu
microRNAs in Toxicology and Medicine Book PDF

Author : Saura C. Sahu
Publisher : John Wiley & Sons
Page : 537 pages
File Size : 42,7 Mb
Release : 2013-08-23
Category : Science
ISBN : 9781118696033

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microRNAs in Toxicology and Medicine by Saura C. Sahu Pdf

During the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of human diseases including cancer. microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators. It focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology. Divided into six parts, topics covered include: microRNA and toxicology – including environmental toxicants and perturbation of miRNA signaling; microRNA, and Disease States featuring microRNAs in drug-induced liver toxicity, microRNAs and Inflammation the regulatory role of microRNA in mutagenesis, microRNAs and cancer, and the role of microRNAs in tumor progression and therapy, as well as current understanding of microRNAs as therapeutic targets in cancer microRNAs and disease states microRNAs and stem cells microRNAs and genomics microRNAs and epigenomics microRNAs and biomarkers – including body fluid microRNAs as toxicological biomarkers, cell-free microRNAs as biomarkers in human diseases, and circulating microRNAs as biomarkers of drug-induced pancreatitis microRNAs in Toxicology and Medicine is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors, and regulators in academia, medical settings, industry, and government.

Regulation of microRNAs

Helge Großhans
Regulation of microRNAs Book PDF

Author : Helge Großhans
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 41,6 Mb
Release : 2010-12-10
Category : Science
ISBN : 9781441978233

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Regulation of microRNAs by Helge Großhans Pdf

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.