Non Coding Rnas In Cardiovascular Diseases

Author : Junjie Xiao
Publisher : Springer Nature
Page : 417 pages
File Size : 45,6 Mb
Release : 2020-04-13
Category : Science
ISBN : 9789811516719

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Non-coding RNAs in Cardiovascular Diseases by Junjie Xiao Pdf

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.

Author : Thomas Thum,Stefanie Dimmeler
Publisher : Springer
Page : 101 pages
File Size : 46,7 Mb
Release : 2017-03-15
Category : Medical
ISBN : 9783319529455

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Non-coding RNAs in the Vasculature by Thomas Thum,Stefanie Dimmeler Pdf

This book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology.

Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Page : 545 pages
File Size : 46,7 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9783030447434

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The Chemical Biology of Long Noncoding RNAs by Stefan Jurga,Jan Barciszewski Pdf

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Author : En-Zhi Jia,Laiyuan Wang,Xiangming Ding,BuChun Zhang
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 51,6 Mb
Release : 2023-04-18
Category : Medical
ISBN : 9782832517307

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Non-coding RNA and coronary artery disease by En-Zhi Jia,Laiyuan Wang,Xiangming Ding,BuChun Zhang Pdf

Author : Vijay Nambi
Publisher : Saunders
Page : 0 pages
File Size : 48,5 Mb
Release : 2018-11-26
Category : Medical
ISBN : 0323548350

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Biomarkers in Cardiovascular Disease by Vijay Nambi Pdf

Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.

Author : Paul Holvoet
Publisher : Springer Nature
Page : 289 pages
File Size : 55,5 Mb
Release : 2021-03-26
Category : Medical
ISBN : 9783030688448

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Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer by Paul Holvoet Pdf

This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.

Author : Anna Zampetaki,Lars Maegdefessel
Publisher : Frontiers Media SA
Page : 98 pages
File Size : 43,7 Mb
Release : 2020-07-22
Category : Electronic
ISBN : 9782889638826

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Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System by Anna Zampetaki,Lars Maegdefessel Pdf

Author : Kevin V. Morris
Publisher : Springer
Page : 262 pages
File Size : 52,7 Mb
Release : 2016-04-13
Category : Medical
ISBN : 9783319239071

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Long Non-coding RNAs in Human Disease by Kevin V. Morris Pdf

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Author : Takahiro Ochiya
Publisher : Humana Press
Page : 0 pages
File Size : 44,5 Mb
Release : 2013-05-30
Category : Medical
ISBN : 1627034528

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Circulating MicroRNAs by Takahiro Ochiya Pdf

microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.

Author : Gordon G. Carmichael
Publisher : Humana Press
Page : 0 pages
File Size : 47,6 Mb
Release : 2014-09-20
Category : Medical
ISBN : 1493913689

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Regulatory Non-Coding RNAs by Gordon G. Carmichael Pdf

Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.

Author : Yvan Devaux,Emma Louise Robinson
Publisher : Elsevier
Page : 498 pages
File Size : 52,6 Mb
Release : 2021-03-10
Category : Medical
ISBN : 9780128222584

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Epigenetics in Cardiovascular Disease by Yvan Devaux,Emma Louise Robinson Pdf

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

Author : Syed Mudasir Andrabi,Nazir Ahmad Ganai
Publisher : Cambridge Scholars Publishing
Page : 201 pages
File Size : 42,9 Mb
Release : 2020-09-03
Category : Science
ISBN : 9781527559103

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Long Non-Coding RNA by Syed Mudasir Andrabi,Nazir Ahmad Ganai Pdf

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.

Author : Junjie Xiao,Sanda Cretoiu
Publisher : Springer
Page : 307 pages
File Size : 44,6 Mb
Release : 2017-09-19
Category : Science
ISBN : 9789811043970

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Exosomes in Cardiovascular Diseases by Junjie Xiao,Sanda Cretoiu Pdf

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 51,9 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033

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Long Non Coding RNA Biology by M.R.S. Rao Pdf

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Author : Yuan-Chuan Chen,Shiu-Jau Chen
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 50,7 Mb
Release : 2020-04-01
Category : Science
ISBN : 9781838800314

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Gene Expression and Phenotypic Traits by Yuan-Chuan Chen,Shiu-Jau Chen Pdf

Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits.