Molecular Mechanisms Of Drug Action

Author : Christopher J. Coulson
Publisher : CRC Press
Page : 318 pages
File Size : 42,5 Mb
Release : 1994-02-03
Category : Medical
ISBN : 0748400680

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Molecular Mechanisms Of Drug Action by Christopher J. Coulson Pdf

In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.

Author : Louis Sanford Goodman
Publisher : McGraw Hill Professional
Page : 1232 pages
File Size : 51,8 Mb
Release : 2008
Category : Medical
ISBN : 9780071443432

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Goodman and Gilman's Manual of Pharmacology and Therapeutics by Louis Sanford Goodman Pdf

Put the authority of Goodman & Gilman's in the palm of your hand! 5 STAR DOODY'S REVIEW! "...the most authoritative and trusted source of pharmacological information, has now spawned a portable pocket drug guide....This manual extracts the essential core drug information from the eleventh edition of the parent book, referring the reader to the online version of the parent book for historical aspects, many chemical and clinical details, and additional figures and references. This makes G & G a very useful book. This will be of use to individuals in training or practice in the fields of pharmacy, medicine, nursing, or allied health disciplines where knowledge of drug actions are important....Each chapter provides the core essential information provided in the parent book in a very readable format. Readers can use this easy to handle and read manual for essential information along with the online version of the parent book as a reference for more in-depth specific information on drugs."--Doody's Review Service The Goodman & Gilman Manual of Pharmacology and Therapeutics offers the renowned content of Goodman & Gilman's Pharmacological Basis of Therapeutics, Eleventh Edition, condensed into an ultra-handy, streamlined reference. More than just a pocket drug guide, this indispensable resource offers: A carry-along source of essential fundamental information, with all the authority of Goodman & Gilman's Pharmacological Basis of Therapeutics, Eleventh Edition The benefits of the world's leading pharmacology text in a convenient, portable format Comprehensive, yet streamlined and clinically relevant coverage of the pharmacological basis of therapeutics High-yield overview of pharmacokinetics, pharmacodynamics, and the foundations of pharmacology Expert insights into the properties, mechanisms, and uses of all the major drug classes Considerations of vital patient-specific issues

Author : J¿nos Fischer,David P. Rotella
Publisher : John Wiley & Sons
Page : 258 pages
File Size : 45,9 Mb
Release : 2015-05-04
Category : Medical
ISBN : 9783527336852

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Successful Drug Discovery, Volume 1 by J¿nos Fischer,David P. Rotella Pdf

The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.

Author : Francesco Clementi,Guido Fumagalli
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 43,8 Mb
Release : 2015-07-01
Category : Medical
ISBN : 9781118768594

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General and Molecular Pharmacology by Francesco Clementi,Guido Fumagalli Pdf

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

Author : T. J. Franklin,G. A. Snow
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 43,6 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475745993

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Biochemistry and Molecular Biology of Antimicrobial Drug Action by T. J. Franklin,G. A. Snow Pdf

The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Author : E. A. Rekka,P. N. Kourounakis
Publisher : CRC Press
Page : 384 pages
File Size : 54,7 Mb
Release : 2008-04-28
Category : Medical
ISBN : 9781420008272

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Chemistry and Molecular Aspects of Drug Design and Action by E. A. Rekka,P. N. Kourounakis Pdf

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve

Author : Francesco Clementi,Guido Fumagalli
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 51,6 Mb
Release : 2015-08-10
Category : Medical
ISBN : 9781118768570

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General and Molecular Pharmacology by Francesco Clementi,Guido Fumagalli Pdf

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 43,6 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Richard B. Silverman
Publisher : Elsevier
Page : 650 pages
File Size : 48,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080513379

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman Pdf

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Author : J. B. Stenlake
Publisher : A&C Black
Page : 336 pages
File Size : 46,8 Mb
Release : 1979-01-01
Category : Medical
ISBN : 0485111721

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Foundations of Molecular Pharmacology by J. B. Stenlake Pdf

Author : Trevor J. Franklin,George Alan Snow
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 42,9 Mb
Release : 2006-10-31
Category : Medical
ISBN : 9780387275666

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Biochemistry and Molecular Biology of Antimicrobial Drug Action by Trevor J. Franklin,George Alan Snow Pdf

The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Author : Stefan Offermanns,Walter Rosenthal
Publisher : Unknown
Page : 1152 pages
File Size : 52,9 Mb
Release : 2004
Category : Encyclopedias and dictionaries
ISBN : UOM:39015052659656

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Encyclopedic Reference of Molecular Pharmacology by Stefan Offermanns,Walter Rosenthal Pdf

Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.

Author : Stefan Offermanns,W. Rosenthal
Publisher : Springer Science & Business Media
Page : 1515 pages
File Size : 54,6 Mb
Release : 2008-08-14
Category : Medical
ISBN : 9783540389163

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Encyclopedia of Molecular Pharmacology by Stefan Offermanns,W. Rosenthal Pdf

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Author : R. W. Ryall
Publisher : Cambridge University Press
Page : 256 pages
File Size : 46,9 Mb
Release : 1989-05-25
Category : Medical
ISBN : 0521254248

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Mechanisms of Drug Action on the Nervous System by R. W. Ryall Pdf

Drugs affecting the nerves and the brain are among the most commonly used in contemporary medicine. This study examines the mechanisms by which such substances cause their therapeutic or undesirable side-effects in relation to underlying processes and pathological phenomena. The book fills the information gap between large textbooks and highly specialized reviews and monographs. Mechanisms of drug actions are examined mainly at the cellular and subcellular levels. Molecular, neurochemical and electrophysiological approaches are used in an attempt to provide a rational study of drugs acting on the nervous system.

Author : John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam
Publisher : John Wiley & Sons
Page : 675 pages
File Size : 44,9 Mb
Release : 2012-11-30
Category : Medical
ISBN : 9781118451953

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Molecular Pharmacology by John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam Pdf

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.