Molecular Neurobiology Of The Mammalian Brain

Author : Patrick McGeer
Publisher : Springer Science & Business Media
Page : 646 pages
File Size : 42,6 Mb
Release : 2013-04-17
Category : Science
ISBN : 9781461574910

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Molecular Neurobiology of the Mammalian Brain by Patrick McGeer Pdf

The human brain is the inner universe through which all external events are perceived. That fact alone should ensure that neuroscience will eventually receive top priority in the list of human endeavors. The brain represents the pinnacle of sophistication in the realm of living systems. Yet it is an imperfect organ, whose failures in disease processes lead to the occupation of more than half of all hospital beds and whose variable performance in the healthy state contributes in undetermined degree to the world's social problems. Every significant advance in our understanding of the brain has yielded enormous practical dividends. There is every reason to believe the future holds even greater promise. It can be said that brain research took root near the end of the last century when Ram6n y Cajal proved beyond doubt that the neuron is the basic functioning unit of the brain and Sherrington revealed its method of transmitting impulses. But it is only in the past two decades that neuroscience has been established as a recognized discipline where the anatomical, physiological, and chemical aspects of neuronal function are treated in a unified fashion. It can be anticipated that this logical advance'will allow brain research to reach new levels of sophistication. Already it has resulted in the establishment of graduate programs at dozens of universities, and the found ing of numerous journals devoted to reports of interdisciplinary research on the brain.

Author : Patrick McGeer
Publisher : Unknown
Page : 672 pages
File Size : 42,6 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1461574927

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Molecular Neurobiology of the Mammalian Brain by Patrick McGeer Pdf

Author : Patrick L. McGeer,John C. Eccles,Edith G. McGeer
Publisher : Springer
Page : 0 pages
File Size : 44,8 Mb
Release : 1987-04-14
Category : Medical
ISBN : 1461574978

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Molecular Neurobiology of the Mammalian Brain by Patrick L. McGeer,John C. Eccles,Edith G. McGeer Pdf

The human brain is the inner universe through which all external events are perceived. That fact alone should ensure that neuroscience will eventually receive top priority in the list of human endeavors. The brain represents the pinnacle of sophistication in the realm of living systems. Yet it is an imperfect organ, whose failures in disease processes lead to the occupation of more than half of all hospital beds and whose variable performance in the healthy state contributes in undetermined degree to the world's social problems. Every significant advance in or understanding of the brain has yielded enormous practical dividends. There is every reason to believe the future holds even greater promise. In the preface to our first edition, we drew attention to the establishment of graduate programs in dozens of universities around the world and the emergence of numerous international journals devoted to interdisciplinary work on the brain. The discoveries that have flowed from this activity have required extensive updating of the details of this book, which is a testimony to the fruitfulness of neuroscience research. Yet the basics remain the same. It is more important than ever that the neuroscientist be presented with the fundamental subdisciplines that together make up the total of brain research in an integrated manner.

Author : Ian R. Brown
Publisher : Academic Press
Page : 434 pages
File Size : 43,9 Mb
Release : 2014-06-28
Category : Science
ISBN : 9781483282299

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Molecular Approaches to Neurobiology by Ian R. Brown Pdf

Molecular Approaches to Neurobiology deals with molecular approaches to the analysis of the nervous system. This book surveys the current state of knowledge in a number of areas of molecular neurobiology that includes the subcellular level of chromatin structure, complexity of RNA synthesis, role of hormones in cell differentiation, and molecular correlates between neuropeptides and behavior. A comprehensive review of procedures for the isolation of specific brain cells and their experimental use is also provided at the end of this text. This publication is useful to those working in the field of neurochemistry and those engaged in morphological and physiological approaches to the analysis of the nervous system, as well as molecular biologists and biochemists working with non-neural tissues.

Author : C. U. M. Smith
Publisher : Wiley
Page : 630 pages
File Size : 45,9 Mb
Release : 2003-06-13
Category : Medical
ISBN : 9780470857175

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Elements of Molecular Neurobiology by C. U. M. Smith Pdf

This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This "evodevo" (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology. * Well known and widely used as a text throughout the UK, good reviews from students and lecturers. * Good complement to Fundementals of Psychopharmacology by Brian Leonard. This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists. It is also a useful basic reference for university libraries. Maurice Elphick, Queen Mary, University of London "I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams."

Author : Steve Heinemann,James Patrick
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461574880

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Molecular Neurobiology by Steve Heinemann,James Patrick Pdf

This book is a collection of papers describing some of the first attempts to apply the techniques of recombinant DNA and molecular biology to studies of the nervous system. We believe this is an important new direction for brain research that will eventually lead to insights not pos sible with more traditional approaches. At first glance, the marriage of molecular biology to brain research seems an unlikely one because of the tremendous disparity in the histories of these two disciplines and the problems they face. Molecular biology is by nature a reductionist approach to biology. Molecular biologists have always tried to attack central questions in the most direct approach possible, usually in the most simple system available: a bacterium or a bacterial virus. Important experiments can usually be repeated quickly and cheaply, in many cases by the latest group of graduate students entering the field. The success of molecular biology has been so profound because the result of each important experiment has made the next critical question obvious, and usually answerable, in short order. Studies of the nervous system have a very different history. First, the human brain is what really interests us and it is the most complex structure that we know in biology. The central question is clear: How do we carry out higher functions such as learning and thinking? How ever, at present there is no widely accepted and testable theory of learn ing and no clear path to such a theory.

Author : Damir Janigro
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 45,5 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9781607612872

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Mammalian Brain Development by Damir Janigro Pdf

Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The “genetic program” for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful “book of life” metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.

Author : Alan Longstaff,Patricia Revest
Publisher : Humana Press
Page : 373 pages
File Size : 50,9 Mb
Release : 2013-08-15
Category : Medical
ISBN : 1489940197

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Protocols in Molecular Neurobiology by Alan Longstaff,Patricia Revest Pdf

Neurobiologists are bound to differ in their perceptions of what the discipline of molecular neurobiology should encompass. We have taken the view that molecular neurobiology should cover any aspect of brain science that uses the techniques of modern molecular biology, though we accept the fact that classification of a technique as a "biochemical* or "molecular biological* one is in itself somewhat arbitrary. Each chapter of this volume sets out to identify a clear problem in neurobiology and to place it in its context within the literatu- i.e., indicating how the solution of the problem will advance knowledge in the field. The core of the chapter then details the approaches taken to solve the problem, in sufficient detail that the reader can appre- ate exactly why a specific strategy was adopted and how it was executed. Each chapter also includes detailed protocols providing all the inf- mation necessary to reproduce the technique and its results in any appropriately equipped laboratory.

Author : Patricia Revest,Alan Longstaff
Publisher : Garland Science
Page : 258 pages
File Size : 53,5 Mb
Release : 1998
Category : Anatomy
ISBN : 9781859962503

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Molecular Neuroscience by Patricia Revest,Alan Longstaff Pdf

This textbook provides an introduction to neuroscience, focusing particularly on the rapidly developing molecular aspects. The techniques of molecular biology are introduced and described in the context of their role in elucidating brain function at the molecular level.

Author : Zach W. Hall
Publisher : Sinauer Associates, Incorporated
Page : 584 pages
File Size : 47,8 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015040623913

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An Introduction to Molecular Neurobiology by Zach W. Hall Pdf

An introduction to Molecular Neurobiology, is a textbook of contemporary cellular and molecular neurobiology written for advanced undergraduates, graduate students, and practising neurobiologists. This book describes the behaviour and properties of neurons and glia and how these arise from the molecules that constitute them. Major sections focus on the signals that neurons use and how they are produced, the molecular and cellular organization of neurons and glia, neuronal differentiation, synaptic plasticity, and the molecular basis of neuronal diseases. Each chapter is written by an expert in the field and gives an up-to-date account of major questions, experimental approaches, the present state of knowledge, and future directions. Boxes provide historical, technical, or biographical notes, and expand on points of particular interest to contemporary research. The book has been carefully edited to give uniformity of style and coverage, and is illustrated in two colours.

Author : Alan Longstaff,Patricia Revest
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 54,6 Mb
Release : 1992-12-17
Category : Medical
ISBN : UOM:39015029550681

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Protocols in Molecular Neurobiology by Alan Longstaff,Patricia Revest Pdf

Neurobiologists are bound to differ in their perceptions of what the discipline of molecular neurobiology should encompass. We have taken the view that molecular neurobiology should cover any aspect of brain science that uses the techniques of modern molecular biology, though we accept the fact that classification of a technique as a "biochemical* or "molecular biological* one is in itself somewhat arbitrary. Each chapter of this volume sets out to identify a clear problem in neurobiology and to place it in its context within the literatu- i.e., indicating how the solution of the problem will advance knowledge in the field. The core of the chapter then details the approaches taken to solve the problem, in sufficient detail that the reader can appre- ate exactly why a specific strategy was adopted and how it was executed. Each chapter also includes detailed protocols providing all the inf- mation necessary to reproduce the technique and its results in any appropriately equipped laboratory.

Author : Steven Zalcman,Richard Scheller,Richard W. Tsien
Publisher : DIANE Publishing
Page : 325 pages
File Size : 43,9 Mb
Release : 1994
Category : Molecular neurobiology
ISBN : 9780788126468

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Molecular Neurobiology by Steven Zalcman,Richard Scheller,Richard W. Tsien Pdf

Covers: channels; secretory vesicles and exocytosis; receptors/coupling mechanisms; synaptic plasticity; modulatory factors; and protein kinases and control of gene expression. Includes both abstracts of papers, and poster sessions. Illustrated.

Author : Abel Lajtha
Publisher : Springer
Page : 516 pages
File Size : 49,5 Mb
Release : 1982-12-01
Category : Science
ISBN : 0306409720

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Experimental Neurochemistry by Abel Lajtha Pdf

The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Author : Laurent Nguyen,Simon Hippenmeyer
Publisher : Springer
Page : 0 pages
File Size : 48,6 Mb
Release : 2013-11-28
Category : Medical
ISBN : 9400776861

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Cellular and Molecular Control of Neuronal Migration by Laurent Nguyen,Simon Hippenmeyer Pdf

Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.

Author : Gordon M. Shepherd
Publisher : Oxford University Press, USA
Page : 712 pages
File Size : 55,9 Mb
Release : 1988
Category : Architecture
ISBN : UOM:39015015091211

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Neurobiology by Gordon M. Shepherd Pdf

In this new edition, the recent discoveries of molecular neurobiology have been integrated throughout, and a chapter on molecular mechanisms added.