Molecular Pathology Of Nervous System Tumors

Author : Matthias A. Karajannis,David Zagzag
Publisher : Springer
Page : 256 pages
File Size : 45,9 Mb
Release : 2014-11-21
Category : Medical
ISBN : 9781493918300

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Molecular Pathology of Nervous System Tumors by Matthias A. Karajannis,David Zagzag Pdf

This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.

Author : WHO Classification of Tumours Editorial Board
Publisher : WHO Classification of Tumours
Page : 584 pages
File Size : 48,6 Mb
Release : 2022-02-15
Category : Medical
ISBN : 9283245083

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Central Nervous System Tumours: Who Classification of Tumours by WHO Classification of Tumours Editorial Board Pdf

****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** The WHO Classification of Tumours Central Nervous System Tumours is the sixth volume in the 5th edition of the WHO series on the classification of human tumors. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumors and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. What's new in this edition? The 5th edition, guided by the WHO Classification of Tumours Editorial Board, will establish a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumor type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria. Who should read this book? Pathologists Neuro-oncologists Neuroradiologists Medical oncologists Radiation oncologists Neurosurgeons Oncology nurses Cancer researchers Epidemiologists Cancer registrars This volume Prepared by 199 authors and editors Contributors from around the world More than 1100 high-quality images More than 3600 references WHO Classification of Tumours Online The content of this renowned classification series is now also available in a convenient digital format by purchasing a subscription directly from IARC here.

Author : José Javier Otero,Aline Paixao Becker
Publisher : Springer Nature
Page : 266 pages
File Size : 55,8 Mb
Release : 2021-04-30
Category : Medical
ISBN : 9783030691707

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Precision Molecular Pathology of Glioblastoma by José Javier Otero,Aline Paixao Becker Pdf

This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.

Author : Roger McLendon,Marc Rosenblum,Darell Bigner
Publisher : CRC Press
Page : 1157 pages
File Size : 44,6 Mb
Release : 2006-07-28
Category : Medical
ISBN : 9781444113433

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Russell & Rubinstein's Pathology of Tumors of the Nervous System 7Ed by Roger McLendon,Marc Rosenblum,Darell Bigner Pdf

This is the leading international professional reference text that also serves as a bench book, describing all aspects of the pathology of brain tumours - genetics, molecular biology, epidemiology, morphology, immunohistochemistry, diagnostic criteria and prognosis. Beautifully illustrated in colour throughout and comprehensively referenc

Author : David A. Walker,Giorgio Perilongo,Roger E. Taylor,Ian F. Pollack
Publisher : CRC Press
Page : 796 pages
File Size : 45,8 Mb
Release : 2020-11-22
Category : Medical
ISBN : 9781000177947

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Brain and Spinal Tumors of Childhood by David A. Walker,Giorgio Perilongo,Roger E. Taylor,Ian F. Pollack Pdf

This second edition comes at a time of a paradigm shift in understanding of the molecular pathology and neuroscience of brain and spinal tumors of childhood and their mechanisms of growth within the developing brain. Excellent collaborative translational networks of researchers are starting to drive change in clinical practise through the need to test many ideas in trials and scientific initiatives. This text reflects the growing concern to understand the impact of the tumour and its treatment upon the full functioning of the child’s developing brain and to integrate the judgments of the risks of acquiring brain damage with the risk of death and the consequences for the quality of life for those who survive. Information on the principles of treatment has been thoroughly updated. A chapter also records the extraordinary work done by advocates. All medical and allied professionals involved in any aspect of the clinical care of these patients will find this book an invaluable resource.

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 412 pages
File Size : 46,7 Mb
Release : 2013-11-12
Category : Medical
ISBN : 9789400772175

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Tumors of the Central Nervous System, Volume 12 by M.A. Hayat Pdf

As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children’s Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.

Author : César R. Lacruz
Publisher : Springer Nature
Page : 464 pages
File Size : 46,6 Mb
Release : 2024
Category : Electronic
ISBN : 9783031510786

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CENTRAL NERVOUS SYSTEM TUMORS by César R. Lacruz Pdf

Author : Francis Ali-Osman
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 42,7 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781592598434

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Brain Tumors by Francis Ali-Osman Pdf

Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.

Author : Mark Cohen, MD,David E. Elder, MB, ChB,Bette K. Kleinschmidt-DeMasters, MD,Richard Prayson, MD
Publisher : Demos Medical Publishing
Page : 224 pages
File Size : 46,9 Mb
Release : 2009-11-24
Category : Medical
ISBN : 1935281364

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Brain Tumors by Mark Cohen, MD,David E. Elder, MB, ChB,Bette K. Kleinschmidt-DeMasters, MD,Richard Prayson, MD Pdf

Surgical neuropathology is a challenging arena for many pathologists, due in large part to a relative lack of experience of most pathologists in this area compared to other areas of surgical pathology. Brain Tumors is intended to address this need with cases drawn from the surgical neuropathology practices of the authors. This volume provides examples of over 100 brain tumors, running the gamut from the very common to the rare. Each example is presented in a case based format and the wide variety of cases presented covers the entire scope of brain tumors and offers the opportunity to review both the basics for the beginner or relatively inexperienced pathologist and also offers experienced pathologists the chance to see some of the rare entities. Each case is formatted as if it were a consult case and includes a brief clinical history, description of the pathologic findings with numerous illustrations, the line diagnosis, discussion of the entity, and the diagnostic thought process as well pertinent references for further reading. When relevant, current practical applications of immunohistochemistry and molecular pathology are discussed. The Consultant Pathology Series The Consultant Pathology series is designed to disseminate the knowledge of expert surgical pathology consultants in the analysis and diagnosis of difficult cases to the full community of pathology practitioners. The volumes are based on actual consultations and presented in a format that illustrates the expert's process of evaluating the case, including indications for consultation, the consultants findings and comment, and discussion of the entity that amplifies the case description. Each volume in the Consultant Pathology series is authored by international experts with extensive case experience in the areas covered

Author : Liam Chen,Ming-Tseh Lin,Zhaohui Zhang
Publisher : Frontiers Media SA
Page : 283 pages
File Size : 47,9 Mb
Release : 2020-12-09
Category : Medical
ISBN : 9782889661640

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Molecular Advances in Diagnosis and Treatment of CNS Tumors by Liam Chen,Ming-Tseh Lin,Zhaohui Zhang Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Thomas James Deeley,Thomas J. Deeley
Publisher : Unknown
Page : 346 pages
File Size : 42,8 Mb
Release : 1974
Category : Medical
ISBN : UOM:39015000297740

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Central Nervous System Tumours by Thomas James Deeley,Thomas J. Deeley Pdf

Author : Adekunle M. Adesina,Tarik Tihan,Christine E. Fuller,Tina Young Poussaint
Publisher : Springer
Page : 349 pages
File Size : 47,6 Mb
Release : 2016-10-03
Category : Medical
ISBN : 9783319334325

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Atlas of Pediatric Brain Tumors by Adekunle M. Adesina,Tarik Tihan,Christine E. Fuller,Tina Young Poussaint Pdf

This text was created to fill a void in the practice of pediatric neuropathology. It is a practical and well-illustrated book representing a collection of interesting, common and unusual tumors for a diagnostic exercise by the reader. The wide reception of the first edition by the pathology community is testament to its relevance and utility in the pathologic diagnosis of pediatric brain tumors. This edition covers topics ranging from neuroimaging, the use of crush and touch preps during intraoperative consultation, classic histological features of pediatric brain tumors, tumor variants, and a miscellaneous group of challenging tumors. Chapters consist of essential diagnostic information and features highlighting recognized variants and their differential diagnoses. A section on molecular pathology and electron microscopy is also included for each tumor category, along with a list of classic reviews and innovative articles on each of the tumor entities as suggested reading at the end of each chapter. Atlas of Pediatric Brain Tumors, Second Edition represents the state of the art in pediatric neuropathology with easy utility beside the microscope.

Author : Peter C. Burger,Bernd W. Scheithauer
Publisher : American Registry of Pathology
Page : 470 pages
File Size : 40,5 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015037693747

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Tumors of the Central Nervous System by Peter C. Burger,Bernd W. Scheithauer Pdf

Author : National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability
Publisher : Unknown
Page : 128 pages
File Size : 52,6 Mb
Release : 2021-09-09
Category : Electronic
ISBN : 0309683491

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Childhood Cancer and Functional Impacts Across the Care Continuum by National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability Pdf

Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 44,5 Mb
Release : 2011-09-15
Category : Medical
ISBN : 9789400717060

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Tumors of the Central Nervous System, Volume 4 by M.A. Hayat Pdf

This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. Information on pathways (e.g., hedgehog) facilitates targeted therapies in cancer. Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. For example, rat model of malignant brain tumors using implantation of doxorubicin with drug eluting beads for delivery is explained. The future of pathway-driven therapies for tumors is summarized. The importance of personalizing cancer care is emphasized. The need for supportive measures for survivors of brain cancer is pointed out, so is the quality of life monitoring. The need of rehabilitation therapy for patients with primary and metastatic brain tumors is also emphasized. Role of MicroRNA in distinguishing primary tumors from metastatic primary tumors is discussed. Advantages and limitations of chemotherapy (e.g., temozolomide and doxorubicin) are discussed. The complexity of tumor to tumor transfer is explained; examples discussed are: brain metastases from breast cancer and brain metastases fro non-small cell lung carcinoma. Identification and characterization of biomarkers, including those for metastatic brain tumors, are presented. Genomic analysis for identifying clinically relevant subtypes of glioblastoma is included. A large number of imaging modalities are detailed to study progression and invasion of gliomas