Molecular Therapeutics

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Molecular Therapeutics

Pamela Greenwell,Michelle McCulley
Molecular Therapeutics Book PDF

Author : Pamela Greenwell,Michelle McCulley
Publisher : John Wiley & Sons
Page : 264 pages
File Size : 44,7 Mb
Release : 2008-03-11
Category : Science
ISBN : 0470725141

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Molecular Therapeutics by Pamela Greenwell,Michelle McCulley Pdf

"This book should be useful to lecturers who teach senior undergraduates, graduate students, and students in the biomedical sciences in general. More globally, Greenwell and McCulley's book should encourage academicians of any stripe who for some time have been honing their lectures in a niche subject area to turn their courses into textbooks." –Biochemistry and Molecular Biology Education Molecular therapeutics refers to the developments in molecular biology that are focused on treating disease with new molecular-based drugs. By taking advantage of recent advances and increased understanding in the field of human genetics, this book provides essential background knowledge and key literature on a broad range of novel approaches and disciplines. These include making recombinant proteins, xenotransplantation gene therapy and therapeutic cloning. Molecular Therapeutics: 21st Century Medicine describes the techniques - including their associated benefits, problems, pitfalls - and discusses their applicability with respect to treating microbial, inherited, multifactoral and acquired diseases. The book also pays specific attention to the ethical issues associated with this new field. Cutting-edge topics and clinically relevant materials engage and maintain student interest Self-assessment questions are included throughout the book Features an additional web site, with a web forum, regular updates and PowerPoint slides of figures from the book Molecular Therapeutics: 21st Century Medicine is a comprehensive, accessible and engaging guide to the rapidly developing field of molecular therapeutics. It is essential reading for all students in this area of research and also of interest for health professionals involved in these novel therapies.

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

Herbert B. Newton
Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy Book PDF

Author : Herbert B. Newton
Publisher : Academic Press
Page : 848 pages
File Size : 52,6 Mb
Release : 2018-03-28
Category : Medical
ISBN : 9780128121016

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Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy by Herbert B. Newton Pdf

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Molecular and Cellular Therapeutics

David Whitehouse,Ralph Rapley
Molecular and Cellular Therapeutics Book PDF

Author : David Whitehouse,Ralph Rapley
Publisher : John Wiley & Sons
Page : 331 pages
File Size : 40,6 Mb
Release : 2012-02-17
Category : Science
ISBN : 9781119967804

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Molecular and Cellular Therapeutics by David Whitehouse,Ralph Rapley Pdf

Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.

An Introduction to Molecular Medicine and Gene Therapy

Thomas F. Kresina
An Introduction to Molecular Medicine and Gene Therapy Book PDF

Author : Thomas F. Kresina
Publisher : John Wiley & Sons
Page : 408 pages
File Size : 46,8 Mb
Release : 2004-03-24
Category : Science
ISBN : 9780471461043

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An Introduction to Molecular Medicine and Gene Therapy by Thomas F. Kresina Pdf

An Introduction to Molecular Medicine and Gene Therapy Edited by Thomas F. Kresina, Ph.D. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections - an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: * Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations * Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases * Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter * Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.

Molecular and Cell Biology of Human Gene Therapeutics

G. Dickson
Molecular and Cell Biology of Human Gene Therapeutics Book PDF

Author : G. Dickson
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401105477

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Molecular and Cell Biology of Human Gene Therapeutics by G. Dickson Pdf

advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro vides good palliation for the patient in a manner that differs essentially from chemotherapy.

Methods in Vaccines and Molecular Therapeutics: 2022

Nargis Khan,P. Bernard Fourie,Mrinmoy Sanyal,Ernesto T. A. Marques
Methods in Vaccines and Molecular Therapeutics 2022 Book PDF

Author : Nargis Khan,P. Bernard Fourie,Mrinmoy Sanyal,Ernesto T. A. Marques
Publisher : Frontiers Media SA
Page : 257 pages
File Size : 46,7 Mb
Release : 2024-02-26
Category : Medical
ISBN : 9782832545287

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Methods in Vaccines and Molecular Therapeutics: 2022 by Nargis Khan,P. Bernard Fourie,Mrinmoy Sanyal,Ernesto T. A. Marques Pdf

This Research Topic is part of the “Methods in Immunology” series. Please submit your article to the Research Topic that best suits the focus of your research. This series aims to highlight the latest experimental techniques and methods used to investigate fundamental questions in Immunology research, with a focus on Vaccines and Molecular Therapeutics. Review articles or opinions on methodologies or applications including the advantages and limitations of each are welcome. This Topic includes technologies and up-to-date methods which help advance science.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease Book PDF

Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 52,9 Mb
Release : 2007-08-06
Category : Medical
ISBN : 9780387464015

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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia Pdf

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Molecular Biology of Cancer

Lauren Pecorino
Molecular Biology of Cancer Book PDF

Author : Lauren Pecorino
Publisher : Oxford University Press
Page : 365 pages
File Size : 53,8 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780199577170

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Molecular Biology of Cancer by Lauren Pecorino Pdf

Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.

The Serotonin Receptors

Bryan L. Roth
The Serotonin Receptors Book PDF

Author : Bryan L. Roth
Publisher : Springer Science & Business Media
Page : 628 pages
File Size : 54,9 Mb
Release : 2008-08-17
Category : Medical
ISBN : 9781597450805

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The Serotonin Receptors by Bryan L. Roth Pdf

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Gene and Cell Therapy: Biology and Applications

Giridhara R. Jayandharan
Gene and Cell Therapy Biology and Applications Book PDF

Author : Giridhara R. Jayandharan
Publisher : Springer
Page : 305 pages
File Size : 40,7 Mb
Release : 2018-09-12
Category : Medical
ISBN : 9789811304811

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Gene and Cell Therapy: Biology and Applications by Giridhara R. Jayandharan Pdf

Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.

Molecular Biology of Cancer

Lauren Pecorino
Molecular Biology of Cancer Book PDF

Author : Lauren Pecorino
Publisher : Oxford University Press, USA
Page : 395 pages
File Size : 52,5 Mb
Release : 2016
Category : Cancer
ISBN : 9780198717348

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Molecular Biology of Cancer by Lauren Pecorino Pdf

"The most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear. -- Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an engaging and manageable route into the complex subject of cancer biology. Using the hallmarks of cancer as a foundation, the book describes the cellular and molecular mechanisms underpinning the transformation of healthy cells into cancer cells. -- after discussing a specific biological hallmark of cancer, each chapter shows how this knowledge can be directly applied to the development of new targeted therapies, giving you a clear appreciation of how the theory translated to tackling the disease. The new edition gives a contemporary account of the field, drawing on the latest research but presenting it in a manner that you will find easy to understand. -- New to this edition: *New full colour diagrams help you visualize key concepts more effectively *Separate chapters for growing areas of cancer biology: Metastasis, Angiogenesis, Infectious Agents and Inflammation, and Technology and Drug and Diagnostics Development *Coverage of range of new topics, including immune checkpoints, studying gene function by CRISPR-Ca9, newly proposed mechanisms for the role of obesity in cancer, non-coding RNAs, and the role of exosomes in intercellular communication *Latest details of newly approved therapeutics" -- from back of book.

Molecular Cancer Therapeutics

George C. Prendergast
Molecular Cancer Therapeutics Book PDF

Author : George C. Prendergast
Publisher : John Wiley & Sons
Page : 370 pages
File Size : 52,8 Mb
Release : 2004-04-02
Category : Science
ISBN : 0471432024

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Molecular Cancer Therapeutics by George C. Prendergast Pdf

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.

Molecular Medicines for Cancer

Deepak Chitkara,Anupama Mittal,Ram I. Mahato
Molecular Medicines for Cancer Book PDF

Author : Deepak Chitkara,Anupama Mittal,Ram I. Mahato
Publisher : CRC Press
Page : 610 pages
File Size : 50,6 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781351978378

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Molecular Medicines for Cancer by Deepak Chitkara,Anupama Mittal,Ram I. Mahato Pdf

The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology. Key Features: Provides current information in the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology Presents important aspects of nanotechnology in the site-specific delivery of anticancer agents Includes up to date information on oligonucleotide and gene based therapies in cancer Describes small targeted molecules, antibodies and oligonucleotides which have shown to selectively target the molecular structures thereby influencing signal transduction Facilitates discussion between researchers involved in cancer therapy and nanoscientists

Gene and Cell Therapy

Giridhara R. Jayandharan
Gene and Cell Therapy Book PDF

Author : Giridhara R. Jayandharan
Publisher : Unknown
Page : 305 pages
File Size : 55,5 Mb
Release : 2018
Category : HEALTH & FITNESS
ISBN : 9811304823

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Gene and Cell Therapy by Giridhara R. Jayandharan Pdf

Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.

RNA Therapeutics

Mouldy Sioud
RNA Therapeutics Book PDF

Author : Mouldy Sioud
Publisher : Humana Press
Page : 527 pages
File Size : 52,5 Mb
Release : 2011-03-04
Category : Science
ISBN : 1607616645

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RNA Therapeutics by Mouldy Sioud Pdf

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.