Molecules Engineered Against Oncogenic Proteins And Cancer

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Molecules Engineered Against Oncogenic Proteins and Cancer

E. J. Corey,Yong-Jin Wu
Molecules Engineered Against Oncogenic Proteins and Cancer Book PDF

Author : E. J. Corey,Yong-Jin Wu
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 48,6 Mb
Release : 2023-09-06
Category : Medical
ISBN : 9781394207107

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Molecules Engineered Against Oncogenic Proteins and Cancer by E. J. Corey,Yong-Jin Wu Pdf

Molecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine’s most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.

The Human Molecule

Libb Thims
The Human Molecule Book PDF

Author : Libb Thims
Publisher : Unknown
Page : 0 pages
File Size : 55,5 Mb
Release : 2008-03-06
Category : Science
ISBN : 1435712943

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The Human Molecule by Libb Thims Pdf

The Human Molecule traces the historical development of the conception of the human being as an individual 'molecule'. The question of what is a 'human' has passed down through the ages as an unsolved riddle of curiosity? In partial solution to this query, the term "human molecule", as the definition of a person, was coined in 1869 by French philosopher Hippolyte Taine; the first rudimentary social, economic, and historical theories using the human molecule concept were developed in the early 20th century by those as Leon Walrus, Vilfredo Pareto, Henry Adams, and C. G. Darwin; and the first calculation of the molecular formula for a human being was made in 2000 by American limnologists Robert Sterner and James Elser. In modern terms, a person is defined as a 26-element reactionary molecule attached to substrate. The implications of this new philosophy point the way to a revolution in thought in areas such as life, work, free will, reactivity, marriage, purpose, and evolution.

Telomeres and Telomerase in Cancer

Keiko Hiyama
Telomeres and Telomerase in Cancer Book PDF

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 41,9 Mb
Release : 2009-03-18
Category : Medical
ISBN : 9781603278799

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Telomeres and Telomerase in Cancer by Keiko Hiyama Pdf

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

How Tobacco Smoke Causes Disease

Anonim
How Tobacco Smoke Causes Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 53,6 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

EGFR Signaling Networks in Cancer Therapy

John D. Haley,William John Gullick
EGFR Signaling Networks in Cancer Therapy Book PDF

Author : John D. Haley,William John Gullick
Publisher : Humana Press
Page : 0 pages
File Size : 41,8 Mb
Release : 2011-01-20
Category : Medical
ISBN : 1617378534

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EGFR Signaling Networks in Cancer Therapy by John D. Haley,William John Gullick Pdf

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Practical Protein Crystallography

Duncan E. McRee
Practical Protein Crystallography Book PDF

Author : Duncan E. McRee
Publisher : Academic Press
Page : 403 pages
File Size : 46,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138888

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Practical Protein Crystallography by Duncan E. McRee Pdf

Designed for easy use by both new and experienced protein crystallographers, this much-needed book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples ofactual experiments and data, including electron density maps. Computer methods and computer code samples are presented. Practical Protein Crystallography is loaded with new information on area detectors, synchrotron radiation techniques, and the latest computer methods, and features the XtalView software system. Graduate students and teachers in physical biochemistry and pharmaceutical researchers will find this text a timely and convenient aid.

Protein and Peptide Mass Spectrometry in Drug Discovery

Michael L. Gross,Guodong Chen,Birendra Pramanik
Protein and Peptide Mass Spectrometry in Drug Discovery Book PDF

Author : Michael L. Gross,Guodong Chen,Birendra Pramanik
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 44,8 Mb
Release : 2011-09-26
Category : Medical
ISBN : 9781118116548

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Protein and Peptide Mass Spectrometry in Drug Discovery by Michael L. Gross,Guodong Chen,Birendra Pramanik Pdf

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Biocatalysts and Enzyme Technology

Klaus Buchholz,Volker Kasche,Uwe Theo Bornscheuer
Biocatalysts and Enzyme Technology Book PDF

Author : Klaus Buchholz,Volker Kasche,Uwe Theo Bornscheuer
Publisher : John Wiley & Sons
Page : 609 pages
File Size : 41,9 Mb
Release : 2012-12-21
Category : Science
ISBN : 9783527672004

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Biocatalysts and Enzyme Technology by Klaus Buchholz,Volker Kasche,Uwe Theo Bornscheuer Pdf

This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.

Food Proteins and Peptides

Navam S. Hettiarachchy,Kenji Sato,Maurice R. Marshall,Arvind Kannan
Food Proteins and Peptides Book PDF

Author : Navam S. Hettiarachchy,Kenji Sato,Maurice R. Marshall,Arvind Kannan
Publisher : CRC Press
Page : 473 pages
File Size : 53,8 Mb
Release : 2012-03-19
Category : Technology & Engineering
ISBN : 9781420093414

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Food Proteins and Peptides by Navam S. Hettiarachchy,Kenji Sato,Maurice R. Marshall,Arvind Kannan Pdf

A multidisciplinary resource, Food Proteins and Peptides: Chemistry, Functionality, Interactions, and Commercialization enables researchers in biochemistry, biotechnology, food science and technology, nutrition, and medicine to understand the physicochemical and biochemical factors that govern the functionality of these food components. Following chapters on the structure and chemistry of amino acids, peptides, and proteins, the book describes modes of characterization and the functional relationships of food proteins. It examines protein solubility and insolubility and explores proteins and peptides as emulsifying and foaming agents. Specialized topics include: Factors affecting heat-induced casein–whey protein interactions in bovine milk systems The effects of protein–saccharide interactions on the properties of food components Ameliorative action of peptides on cholesterol and lipid metabolism Proteins and peptides with elements of sweetness, kokumi, umami, and bitterness A new approach for the large-scale fractionation of peptides based on their amphoteric nature The book examines the source of bioactive peptides and describes their bioavailability, including their absorption and occurrence in human blood. It also provides a database of biologically active proteins and peptides. Final chapters review current status, future industrial perspectives, and future trends of bioactive food proteins and peptides and explore the role of nanotechnology in protein research. With contributions from a panel of international scientists, this volume captures the state of the art in protein and peptide research, providing a launching pad for further inquiry and discovery.

Medicinal Chemistry of Anticancer Drugs

Carmen Avendaño,J. Carlos Menéndez
Medicinal Chemistry of Anticancer Drugs Book PDF

Author : Carmen Avendaño,J. Carlos Menéndez
Publisher : Elsevier
Page : 767 pages
File Size : 42,6 Mb
Release : 2015-06-11
Category : Science
ISBN : 9780444626677

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Medicinal Chemistry of Anticancer Drugs by Carmen Avendaño,J. Carlos Menéndez Pdf

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Enzyme Technology

Ashok Pandey
Enzyme Technology Book PDF

Author : Ashok Pandey
Publisher : Springer Science & Business Media
Page : 774 pages
File Size : 40,8 Mb
Release : 2006-04-28
Category : Medical
ISBN : 0387292942

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Enzyme Technology by Ashok Pandey Pdf

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Protein Families

Christine A. Orengo,Alex Bateman
Protein Families Book PDF

Author : Christine A. Orengo,Alex Bateman
Publisher : John Wiley & Sons
Page : 566 pages
File Size : 43,7 Mb
Release : 2014-02-03
Category : Computers
ISBN : 9780470624227

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Protein Families by Christine A. Orengo,Alex Bateman Pdf

New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover, they'll discover how these systems can be used to understand the evolution of protein families as well as understand and predict the degree to which structural and functional information are shared between relatives in a protein family. Edited and authored by leading international experts, Protein Families offers new insights into protein families that are important to medical research as well as protein families that help us understand biological systems and key biological processes such as cell signaling and the immune response. The book is divided into three sections: Section I: Concepts Underlying Protein Family Classification reviews the major strategies for identifying homologous proteins and classifying them into families. Section II: In-Depth Reviews of Protein Families focuses on some fascinating super protein families for which we have substantial amounts of sequence, structural and functional data, making it possible to trace the emergence of functionally diverse relatives. Section III: Review of Protein Families in Important Biological Systems examines protein families associated with a particular biological theme, such as the cytoskeleton. All chapters are extensively illustrated, including depictions of evolutionary relationships. References at the end of each chapter guide readers to original research papers and reviews in the field. Covering protein family classification systems alongside detailed descriptions of select protein families, this book offers biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new insight into the evolution and nature of proteins.

Protein Structure Prediction

Anna Tramontano
Protein Structure Prediction Book PDF

Author : Anna Tramontano
Publisher : John Wiley & Sons
Page : 226 pages
File Size : 53,8 Mb
Release : 2006-02-20
Category : Medical
ISBN : 9783527311675

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Protein Structure Prediction by Anna Tramontano Pdf

While most textbooks on bioinformatics focus on genetic algorithms and treat protein structure prediction only superficially, this course book assumes a novel and unique focus. Adopting a didactic approach, the author explains all the current methods in terms of their reliability, limitations and user-friendliness. She provides practical examples to help first-time users become familiar with the possibilities and pitfalls of computer-based structure prediction, making this a must-have for students and researchers.

Thermostable Proteins

Srikanta Sen,Lennart Nilsson
Thermostable Proteins Book PDF

Author : Srikanta Sen,Lennart Nilsson
Publisher : CRC Press
Page : 187 pages
File Size : 44,6 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781439839140

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Thermostable Proteins by Srikanta Sen,Lennart Nilsson Pdf

Thermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of "thermophilic life forms" at the molecular level with an emphasis on design strategies. The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers: Computing and simulation methods in current and future thermostability research, especially in nonempirical situations How rigidity theory is used to improve the thermal adaptation of mesophiles Subtilisin-like serine proteases and their significant engineering applications The state of knowledge concerning structure–function relations and the origins of their structural stability Computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or three-dimensional structures Understanding the molecular basis of how thermostable and hyperthermostable proteins gain and maintain their stability and biological function at high temperatures remains an important scientific challenge. A more detailed knowledge of protein stability not only deepens our understanding of protein structure but also helps in obtaining insights into processes that drive protein activities—folding, unfolding, and misfolding—essential to biological function.

Drug Design of Zinc-Enzyme Inhibitors

Claudiu T. Supuran,Jean-Yves Winum
Drug Design of Zinc Enzyme Inhibitors Book PDF

Author : Claudiu T. Supuran,Jean-Yves Winum
Publisher : John Wiley & Sons
Page : 1040 pages
File Size : 49,8 Mb
Release : 2009-10-22
Category : Medical
ISBN : 0470508159

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Drug Design of Zinc-Enzyme Inhibitors by Claudiu T. Supuran,Jean-Yves Winum Pdf

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.