Mouse Brain Development

Author : Andre M. Goffinet,Pasko Rakic
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 52,9 Mb
Release : 2012-08-10
Category : Science
ISBN : 9783540480020

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Mouse Brain Development by Andre M. Goffinet,Pasko Rakic Pdf

Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

Author : George Paxinos,Glenda Halliday,Charles Watson,Mustafa S. Kassem
Publisher : Academic Press
Page : 384 pages
File Size : 49,8 Mb
Release : 2020-03-21
Category : Science
ISBN : 9780128226469

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Atlas of the Developing Mouse Brain by George Paxinos,Glenda Halliday,Charles Watson,Mustafa S. Kassem Pdf

Atlas of the Developing Mouse Brain, Second Edition builds on the features of successful first edition, providing a comprehensive and convenient reference for all areas of the mouse brain at Fetal-Day 17.5 (E17.5), Day-of-Birth (P0), and Day-Six postnatal (P6). The book also delineates the parts of the eye, features of the skull, ganglia, nerves, arteries, veins, bones and foramina. This atlas is an essential tool for researchers and students who study the development of the mouse brain, or for those who interpret findings from genetic manipulation. Contains 176 high-resolution color scans of Nissl-stained coronal sections of the brain and skull of the fetal (E17.5), day-of-birth (P0), and day-six postnatal mouse (P6) Includes diagrams that delineate all structures of the brain, as well as peripheral nerves, ganglia, muscles, bones, veins and arteries of the head Presents approximately 5000 corrections and updates from the first edition Includes color codes of the veins, arteries, nerves and ganglions of the skull in diagrams

Author : Charles Watson,George Paxinos,Luis Puelles
Publisher : Academic Press
Page : 815 pages
File Size : 55,9 Mb
Release : 2011-11-28
Category : Science
ISBN : 9780123694973

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The Mouse Nervous System by Charles Watson,George Paxinos,Luis Puelles Pdf

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 45,5 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Author : Uta Schambra
Publisher : Springer Science & Business Media
Page : 552 pages
File Size : 42,6 Mb
Release : 2008-05-07
Category : Medical
ISBN : 9780387470931

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Prenatal Mouse Brain Atlas by Uta Schambra Pdf

This is the only book available for studies of the mouse brain before birth. It presents a complete mapping of the developing mouse brain that features imaging of whole brain sections. Users will be able to compare structure shown in the Atlas to what they see in the microscope. This new, greatly expanded edition provides an easily accessible tool for researchers in the fields of normal and abnormal brain development.

Author : David M. Jacobowitz,Louise C. Abbott
Publisher : CRC Press
Page : 304 pages
File Size : 51,6 Mb
Release : 1997-12-29
Category : Medical
ISBN : 9781466593411

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Chemoarchitectonic Atlas of the Developing Mouse Brain by David M. Jacobowitz,Louise C. Abbott Pdf

Representing the state-of-the-art in neurochemical mapping, Chemoarchitectonic Atlas of the Developing Mouse Brain provides a complete, full-color look at the developing mouse brain. Hundreds of coronal sections are presented, clearly illustrating structures at progressive stages of brain development.

Author : Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
Publisher : Academic Press
Page : 343 pages
File Size : 44,6 Mb
Release : 2015-09-23
Category : Science
ISBN : 9780128009130

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Kaufman’s Atlas of Mouse Development Supplement by Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay Pdf

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems

Author : Catherine Lambert De Rouvroit,Andre M Goffinet
Publisher : Unknown
Page : 124 pages
File Size : 41,7 Mb
Release : 1998-09-28
Category : Electronic
ISBN : 364272258X

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The Reeler Mouse As a Model of Brain Development by Catherine Lambert De Rouvroit,Andre M Goffinet Pdf

Author : Uta B. Schambra,Jerry Silver
Publisher : Academic Press
Page : 359 pages
File Size : 46,8 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483289083

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Atlas of the Prenatal Mouse Brain by Uta B. Schambra,Jerry Silver Pdf

The Atlas of the Prenatal Mouse Brain is the latest addition to Academic Press' list of atlases for neuroscientists and neuroscience students. It fills an urgent need for a comprehensive atlas of the developing mouse brain for use in studies of both normal and abnormal development. High-quality photomicrographs of brain sections are depicted in sagittal, coronal, and horizontal planes for four gestational age groups. Each photomicrograph is accompanied by a fully labeled, precision-drawn diagram for easy identification of brain structures. Researchers and students using normal, transgenic, or mutant mouse preparations in developmental neurobiology, neurotoxicology, and biotechnology will welcome this meticulously assembled and accessible guide. Presents 153 photomicrographs of serial brain sections Represents four gestational ages (GD 12 and 14 embryos; GD 16 and 18 fetuses), each depicted in sigittal, coronal, and horizontal planes Includes fully labeled diagrams identifying brain structures for each photomicrograph Provides complete alphabetical lists of brain structures and abbreviations Presents a full description of tissue preparation method Large format, 8-1/2 x 11" pages in a sturdy hardcover case

Author : Janet Rossant,Patrick P. L. Tam
Publisher : Gulf Professional Publishing
Page : 754 pages
File Size : 46,6 Mb
Release : 2002-03
Category : Medical
ISBN : 0125979517

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Mouse Development by Janet Rossant,Patrick P. L. Tam Pdf

This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference. *Broad-based overview of mouse development from fundamental to specialist levels *Extensive coverage of a wide range of developmental mutations of the mouse *Excellent benchmark illustrations of brain, craniofacial, gut and heart development *In-depth experiment-based assessment of concepts in mammalian development *Focus on models of specific relevance to human development *Comprehensive reference to key literature and electronic databases related to mouse development *High-quality full-color production

Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 368 pages
File Size : 55,5 Mb
Release : 2008-10-29
Category : Medical
ISBN : 9781420044157

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Biology of the NMDA Receptor by Antonius M. VanDongen Pdf

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Author : Catherine Lambert de Rouvroit,Andre M. Goffinet
Publisher : Springer Science & Business Media
Page : 117 pages
File Size : 40,9 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783642722578

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The Reeler Mouse as a Model of Brain Development by Catherine Lambert de Rouvroit,Andre M. Goffinet Pdf

Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.

Author : Edward D. Levin,Jerry J. Buccafusco
Publisher : CRC Press
Page : 395 pages
File Size : 49,6 Mb
Release : 2006-06-22
Category : Medical
ISBN : 9781420004335

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Animal Models of Cognitive Impairment by Edward D. Levin,Jerry J. Buccafusco Pdf

The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Author : David M. Jacobowitz,Louise C. Abbott
Publisher : CRC Press
Page : 336 pages
File Size : 41,9 Mb
Release : 1997-12-29
Category : Medical
ISBN : 0849326672

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Chemoarchitectonic Atlas of the Developing Mouse Brain by David M. Jacobowitz,Louise C. Abbott Pdf

Representing the state-of-the-art in neurochemical mapping, Chemoarchitectonic Atlas of the Developing Mouse Brain provides a complete, full-color look at the developing mouse brain. Hundreds of coronal sections are presented, clearly illustrating structures at progressive stages of brain development.

Author : George Paxinos
Publisher : Academic Press
Page : 378 pages
File Size : 46,8 Mb
Release : 2007
Category : Science
ISBN : 9780125476225

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Atlas of the Developing Mouse Brain at E17.5, P0 and P6 by George Paxinos Pdf

This atlas provides an accurate and detailed depiction of all brain structures at fetal stage E17.5, Day of birth, and Day 6 postnatal. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs. It is an indispensable guide for the interpretation of nervous system changes in gene knockout and transgenic mice. Contains: 43 photographs and drawings of Nissl-stained coronal sections of the brain of a fetal mouse at E17.5 days, 65 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse on the day of birth, and 73 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse aged 6 days postnatal. The drawings are based on the study of sections stained with Nissl and a range of neuroactive substances. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs.