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Author : Ruidong Xiang,Hao Cheng,Lingzhao Fang,Zhe Zhang,Marie-Pierre Sanchez
Publisher : Frontiers Media SA
Page : 116 pages
File Size : 41,9 Mb
Release : 2022-04-29
Category : Science
ISBN : 9782889760473
Author : Cedric Gondro,Julius van der Werf,Ben J. Hayes
Publisher : Unknown
Page : 566 pages
File Size : 44,9 Mb
Release : 2013
Category : Bioinformatics
ISBN : 1627034471
"With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice."--
Author : Gerard Salton,Michael J. McGill
Publisher : New York ; Montreal : McGraw-Hill
Page : 470 pages
File Size : 44,7 Mb
Release : 1983
Category : Computers
ISBN : UOM:39015035282485
Examines Concepts, Functions & Processes of Information Retrieval Systems
Author : Nunzio D’Agostino,Alison Bentley,Charles Chen
Publisher : Frontiers Media SA
Page : 192 pages
File Size : 55,7 Mb
Release : 2023-05-05
Category : Science
ISBN : 9782889763382
Author : Cedric Gondro,Julius van der Werf,Ben Hayes
Publisher : Humana Press
Page : 0 pages
File Size : 47,9 Mb
Release : 2013-06-12
Category : Science
ISBN : 1627034463
With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice.
Author : Hajime Wada,Norio Murata
Publisher : Springer Science & Business Media
Page : 506 pages
File Size : 42,5 Mb
Release : 2009-11-07
Category : Science
ISBN : 9789048128631
Lipids in Photosynthesis: Essential and Regulatory Functions, provides an essential summary of an exciting decade of research on relationships between lipids and photosynthesis. The book brings together extensively cross-referenced and peer-reviewed chapters by prominent researchers. The topics covered include the structure, molecular organization and biosynthesis of fatty acids, glycerolipids and nonglycerolipids in plants, algae, lichens, mosses, and cyanobacteria, as well as in chloroplasts and mitochondria. Several chapters deal with the manipulation of the extent of unsaturation of fatty acids and the effects of such manipulation on photosynthesis and responses to various forms of stress. The final chapters focus on lipid trafficking, signaling and advanced analytical techniques. Ten years ago, Siegenthaler and Murata edited "Lipids in Photosynthesis: Structure, Function and Genetics," which became a classic in the field. "Lipids in Photosynthesis: Essential and Regulatory Functions," belongs, with its predecessor, in every plant and microbiological researcher's bookcase.
Author : R. A. Mrode
Publisher : Cab International
Page : 343 pages
File Size : 55,7 Mb
Release : 2014
Category : Technology & Engineering
ISBN : 1845939816
The prediction of producing desirable traits in offspring such as increased growth rate or superior meat, milk and wool production is a vital economic tool to the animal scientist. Summarizing the latest developments in genomics relating to animal breeding values and design of breeding programs, this new edition includes models of survival analysis, social interaction and sire and dam models, as well as advancements in the use of SNPs in the computation of genomic breeding values.
Author : Bernd Kaspers,Karel A. Schat,Thomas Göbel,Lonneke Vervelde
Publisher : Academic Press
Page : 627 pages
File Size : 45,6 Mb
Release : 2021-12-05
Category : Technology & Engineering
ISBN : 9780128190715
Avian Immunology, Third Edition contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers, include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. With contributions from the foremost international experts in the field, Avian Immunology 3rd, provides the most up-to-date crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. Avian Immunology, Third Edition, is a fascinating and growing field and surely provides new and exciting insights for mainstream immunology in the future. Reflects significant advances in the field since the second edition, particularly the explosion of knowledge on genomics including work on the chicken, turkey and zebra finch genomes Provides a single source reference ranging from the basic science to cutting edge research Provides practical information for veterinarians particularly those specialised in poultry or companion bird medicine New chapters on the impact of the microbiome on the immune system, defence mechanisms in the egg and embryo and emerging transgene technologies
Author : EAAP scientific committee
Publisher : BRILL
Page : 576 pages
File Size : 43,9 Mb
Release : 2023-09-04
Category : Technology & Engineering
ISBN : 9789086868162
This Book of Abstracts is the main publication of the 66th Annual Meeting of the European Federation for Animal Science 2015 in Warsaw, Poland. It contains abstracts of the invited papers and contributed presentations. The meeting addressed subjects relating to science and innovation. Important problems were also discussed during the sessions of EAAP's nine Commissions: Animal Genetics, Animal Nutrition, Animal Management and Health, Animal Physiology, Cattle Production, Sheep and Goat Production, Pig Production, Horse Production and Livestock Farming Systems.
Author : Fikret Isik,James Holland,Christian Maltecca
Publisher : Springer
Page : 400 pages
File Size : 41,5 Mb
Release : 2017-09-09
Category : Science
ISBN : 9783319551777
This book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this book is composed of two sections. The first section (Chapters 1 to 8) covers topics of classical phenotypic data analysis for prediction of breeding values in animal and plant breeding programs. In the second section (Chapters 9 to 13) we provide the concept and overall review of available tools for using DNA markers for predictions of genetic merits in breeding populations. With advances in DNA sequencing technologies, genomic data, especially single nucleotide polymorphism (SNP) markers, have become available for animal and plant breeding programs in recent years. Analysis of DNA markers for prediction of genetic merit is a relatively new and active research area. The algorithms and software to implement these algorithms are changing rapidly. This section represents state-of-the-art knowledge on the tools and technologies available for genetic analysis of plants and animals. However, readers should be aware that the methods or statistical packages covered here may not be available or they might be out of date in a few years. Ultimately the book is intended for professional breeders interested in utilizing these tools and approaches in their breeding programs. Lastly, we anticipate the usage of this volume for advanced level graduate courses in agricultural and breeding courses.
Author : Stéphane Joost,Michael W. Bruford,Ino Curik,Juha Kantanen,Johannes A. Lenstra,Johann Sölkner,Göran Andersson,Philippe V. Baret,Nadine Buys,Jutta Roosen,Michèle Tixier-Boichard,Paolo Ajmone Marsan
Publisher : Frontiers Media SA
Page : 295 pages
File Size : 53,9 Mb
Release : 2016-01-28
Category : Biodiversity
ISBN : 9782889197354
The history of livestock started with the domestication of their wild ancestors: a restricted number of species allowed to be tamed and entered a symbiotic relationship with humans. In exchange for food, shelter and protection, they provided us with meat, eggs, hides, wool and draught power, thus contributing considerably to our economic and cultural development. Depending on the species, domestication took place in different areas and periods. After domestication, livestock spread over all inhabited regions of the earth, accompanying human migrations and becoming also trade objects. This required an adaptation to different climates and varying styles of husbandry and resulted in an enormous phenotypic diversity. Approximately 200 years ago, the situation started to change with the rise of the concept of breed. Animals were selected for the same visible characteristics, and crossing with different phenotypes was reduced. This resulted in the formation of different breeds, mostly genetically isolated from other populations. A few decades ago, selection pressure was increased again with intensive production focusing on a limited range of types and a subsequent loss of genetic diversity. For short-term economic reasons, farmers have abandoned traditional breeds. As a consequence, during the 20th century, at least 28% of farm animal breeds became extinct, rare or endangered. The situation is alarming in developing countries, where native breeds adapted to local environments and diseases are being replaced by industrial breeds. In the most marginal areas, farm animals are considered to be essential for viable land use and, in the developing world, a major pathway out of poverty. Historic documentation from the period before the breed formation is scarce. Thus, reconstruction of the history of livestock populations depends on archaeological, archeo-zoological and DNA analysis of extant populations. Scientific research into genetic diversity takes advantage of the rapid advances in molecular genetics. Studies of mitochondrial DNA, microsatellite DNA profiling and Y-chromosomes have revealed details on the process of domestication, on the diversity retained by breeds and on relationships between breeds. However, we only see a small part of the genetic information and the advent of new technologies is most timely in order to answer many essential questions. High-throughput single-nucleotide polymorphism genotyping is about to be available for all major farm animal species. The recent development of sequencing techniques calls for new methods of data management and analysis and for new ideas for the extraction of information. To make sense of this information in practical conditions, integration of geo-environmental and socio-economic data are key elements. The study and management of farm animal genomic resources (FAnGR) is indeed a major multidisciplinary issue. The goal of the present Research Topic was to collect contributions of high scientific quality relevant to biodiversity management, and applying new methods to either new genomic and bioinformatics approaches for characterization of FAnGR, to the development of FAnGR conservation methods applied ex-situ and in-situ, to socio-economic aspects of FAnGR conservation, to transfer of lessons between wildlife and livestock biodiversity conservation, and to the contribution of FAnGR to a transition in agriculture (FAnGR and agro-ecology).
Author : Kevin Morgan,Minerva M. Carrasquillo
Publisher : Springer Science & Business Media
Page : 257 pages
File Size : 40,7 Mb
Release : 2013-06-22
Category : Medical
ISBN : 9781461473091
Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities.
Author : Daniel Sorensen,Daniel Gianola
Publisher : Springer Science & Business Media
Page : 745 pages
File Size : 45,6 Mb
Release : 2007-03-22
Category : Science
ISBN : 9780387954400
This book, suitable for numerate biologists and for applied statisticians, provides the foundations of likelihood, Bayesian and MCMC methods in the context of genetic analysis of quantitative traits. Although a number of excellent texts in these areas have become available in recent years, the basic ideas and tools are typically described in a technically demanding style and contain much more detail than necessary. Here, an effort has been made to relate biological to statistical parameters throughout, and the book includes extensive examples that illustrate the developing argument.
Author : Yunpeng Cao,Hui Song,Liangsheng Zhang,Suvendu Mondal
Publisher : Frontiers Media SA
Page : 433 pages
File Size : 51,6 Mb
Release : 2023-02-28
Category : Science
ISBN : 9782832515594
Author : Kefei Chen,Li Ma
Publisher : Frontiers Media SA
Page : 147 pages
File Size : 42,7 Mb
Release : 2023-12-11
Category : Science
ISBN : 9782832540619
The advances in “omics” technologies have enabled unprecedented progress in agricultural and biological sciences. The synergy of high-performance computing, high throughput omics approaches, and high dimensional phenotyping data with high spatial and temporal resolution have demonstrated the capacity to enhance our understanding of biological mechanisms but also to provide powerful insights into dissecting the genetic basis of complex traits with agricultural and economical importance. Genome-wide association study (GWAS) has become a useful approach to identify mutations that underlie diseases and complex traits and has provided important insights in exploring genetic profiles. However, it is less suitable for quantitative traits influenced by a large number of genes with small effects. In addition, false discoveries are a major concern and can be partially attributed to population structure. Genomic selection holds the promise to overcome the limitations by using whole-genome information to predict the genetic merits of phenotypes. It has been a powerful tool for predicting the breeding values of candidates for selection in breeding populations. One of the challenges of genomic prediction of breeding values with large-p-with-small-n regressions is to develop robust and efficient approaches that accurately predict phenotypic traits as functions of genotypic and environmental inputs. In addition, the integration of multi-omics data in phenotypic prediction would offer the opportunity to understand the flow of information that underlies the phenotypic traits.