Multiscale Biomechanical Modeling Of The Brain

Author : Mark F. Horstemeyer,Raj K. Prabhu
Publisher : Academic Press
Page : 278 pages
File Size : 47,9 Mb
Release : 2021-10-27
Category : Technology & Engineering
ISBN : 9780128181454

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Multiscale Biomechanical Modeling of the Brain by Mark F. Horstemeyer,Raj K. Prabhu Pdf

Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. Presents concepts in a theoretical and thermodynamic framework for each length scale Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems

Author : Soheil Mohammadi
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 47,7 Mb
Release : 2023-06-09
Category : Technology & Engineering
ISBN : 9781119033721

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Multiscale Biomechanics by Soheil Mohammadi Pdf

MULTISCALE BIOMECHANICS Model biomechanical problems at multiple scales with this cutting-edge technology Multiscale modelling is the set of techniques used to solve physical problems which exist at multiple scales either in space or time. It has been shown to have significant applications in biomechanics, the study of biological systems and their structures, which exist at scales from the macroscopic to the microscopic and beyond, and which produce a myriad of overlapping problems. The next generation of biomechanical researchers therefore has need of the latest multiscale modelling techniques. Multiscale Biomechanics offers a comprehensive introduction to these techniques and their biomechanical applications. It includes both the theory of multiscale biomechanical modelling and its practice, incorporating some of the latest research and surveying a wide range of multiscale methods. The result is a thorough yet accessible resource for researchers looking to gain an edge in their biomechanical modelling. Multiscale Biomechanics readers will find: Practical biomechanical applications for a variety of multiscale methods Detailed discussion of soft and hard tissues, and more An introduction to analysis of advanced topics ranging from stenting, drug delivery systems, and artificial intelligence in biomechanics Multiscale Biomechanics is a useful reference for researchers and scientists in any of the life sciences with an interest in biomechanics, as well as for graduate students in mechanical, biomechanical, biomedical, civil, material, and aerospace engineering.

Author : Karol Miller
Publisher : Springer
Page : 353 pages
File Size : 50,8 Mb
Release : 2019-08-08
Category : Science
ISBN : 9783030049966

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Biomechanics of the Brain by Karol Miller Pdf

This new edition presents an authoritative account of the current state of brain biomechanics research for engineers, scientists and medical professionals. Since the first edition in 2011, this topic has unquestionably entered into the mainstream of biomechanical research. The book brings together leading scientists in the diverse fields of anatomy, neuroimaging, image-guided neurosurgery, brain injury, solid and fluid mechanics, mathematical modelling and computer simulation to paint an inclusive picture of the rapidly evolving field. Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery (including the most recent applications of biomechanics to treat epilepsy), to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the comprehensive reference in the field. Experienced researchers as well as students will find this book useful.

Author : Soheil Mohammadi
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 42,5 Mb
Release : 2023-08-28
Category : Technology & Engineering
ISBN : 9781119033691

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Multiscale Biomechanics by Soheil Mohammadi Pdf

Model biomechanical problems at multiple scales with this cutting-edge technology Multiscale modelling is the set of techniques used to solve physical problems which exist at multiple scales either in space or time. It has been shown to have significant applications in biomechanics, the study of biological systems and their structures, which exist at scales from the macroscopic to the microscopic and beyond, and which produce a myriad of overlapping problems. The next generation of biomechanical researchers therefore has need of the latest multiscale modelling techniques. Multiscale Biomechanics offers a comprehensive introduction to these techniques and their biomechanical applications. It includes both the theory of multiscale biomechanical modelling and its practice, incorporating some of the latest research and surveying a wide range of multiscale methods. The result is a thorough yet accessible resource for researchers looking to gain an edge in their biomechanical modelling. Multiscale Biomechanics readers will also find: An accompanying website hosting sample codes designed to facilitate reader understanding and retention Detailed discussion of soft and hard tissues, and more Introduction to analysis of advanced topics ranging from stenting, drug delivery systems and artificial intelligence in biomechanics Multiscale Biomechanics is a useful reference for researchers and scientists in any of the life sciences with an interest in biomechanics, as well as for graduate students in mechanical, biomechanical, biomedical, civil, material and aerospace engineering.

Author : Vassilis Cutsuridis
Publisher : Springer Nature
Page : 222 pages
File Size : 42,6 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9783030188306

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Multiscale Models of Brain Disorders by Vassilis Cutsuridis Pdf

This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.

Author : Silvia Budday,Philip Bayly,Gerhard A. Holzapfel
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 41,8 Mb
Release : 2022-02-04
Category : Science
ISBN : 9782889742790

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Advances in Brain Mechanics by Silvia Budday,Philip Bayly,Gerhard A. Holzapfel Pdf

Author : Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 44,5 Mb
Release : 2023-05-05
Category : Science
ISBN : 9781119517351

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Multiscale Modelling in Biomedical Engineering by Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika Pdf

Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.

Author : Gerhard Holzapfel,Ellen Kuhl
Publisher : Springer Science & Business Media
Page : 406 pages
File Size : 53,7 Mb
Release : 2012-10-17
Category : Technology & Engineering
ISBN : 9789400754638

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Computer Models in Biomechanics by Gerhard Holzapfel,Ellen Kuhl Pdf

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Author : Guoqiang Xing,Heng-Ye Man,Yumin Zhang
Publisher : Frontiers Media SA
Page : 136 pages
File Size : 45,9 Mb
Release : 2022-03-24
Category : Medical
ISBN : 9782889719792

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Understanding the mechanism of traumatic brain injury-induced energy metabolism by Guoqiang Xing,Heng-Ye Man,Yumin Zhang Pdf

Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publisher : Springer
Page : 286 pages
File Size : 51,8 Mb
Release : 2014-10-10
Category : Technology & Engineering
ISBN : 9781447165996

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Multiscale Modeling in Biomechanics and Mechanobiology by Suvranu De,Wonmuk Hwang,Ellen Kuhl Pdf

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Author : Kent-André Mardal,Marie E. Rognes,Travis B. Thompson,Lars Magnus Valnes
Publisher : Springer Nature
Page : 129 pages
File Size : 45,7 Mb
Release : 2022-02-25
Category : Mathematics
ISBN : 9783030951368

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Mathematical Modeling of the Human Brain by Kent-André Mardal,Marie E. Rognes,Travis B. Thompson,Lars Magnus Valnes Pdf

This open access book bridges common tools in medical imaging and neuroscience with the numerical solution of brain modelling PDEs. The connection between these areas is established through the use of two existing tools, FreeSurfer and FEniCS, and one novel tool, the SVM-Tk, developed for this book. The reader will learn the basics of magnetic resonance imaging and quickly proceed to generating their first FEniCS brain meshes from T1-weighted images. The book's presentation concludes with the reader solving a simplified PDE model of gadobutrol diffusion in the brain that incorporates diffusion tensor images, of various resolution, and complex, multi-domain, variable-resolution FEniCS meshes with detailed markings of anatomical brain regions. After completing this book, the reader will have a solid foundation for performing patient-specific finite element simulations of biomechanical models of the human brain.

Author : Xiang Li,Jinglei Lv,Yuankai Huo,Bin Dong,Richard M. Leahy,Quanzheng Li
Publisher : Springer Nature
Page : 139 pages
File Size : 45,8 Mb
Release : 2022-10-13
Category : Computers
ISBN : 9783031188145

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Multiscale Multimodal Medical Imaging by Xiang Li,Jinglei Lv,Yuankai Huo,Bin Dong,Richard M. Leahy,Quanzheng Li Pdf

This book constitutes the refereed proceedings of the Third International Workshop on Multiscale Multimodal Medical Imaging, MMMI 2022, held in conjunction with MICCAI 2022 in singapore, in September 2022. The 12 papers presented were carefully reviewed and selected from 18 submissions. The MMMI workshop aims to advance the state of the art in multi-scale multi-modal medical imaging, including algorithm development, implementation of methodology, and experimental studies. The papers focus on medical image analysis and machine learning, especially on machine learning methods for data fusion and multi-score learning.

Author : Corina Drapaca,Siv Sivaloganathan
Publisher : Springer Nature
Page : 155 pages
File Size : 43,8 Mb
Release : 2019-09-06
Category : Mathematics
ISBN : 9781493998104

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Mathematical Modelling and Biomechanics of the Brain by Corina Drapaca,Siv Sivaloganathan Pdf

This monograph aims to provide a rigorous yet accessible presentation of some fundamental concepts used in modeling brain mechanics and give a glimpse of the insights and advances that have arisen as a result of the nascent interaction of the mathematical and neurosurgical sciences. It begins with some historical perspective and a brief synopsis of the biomedical/biological manifestations of the clinical conditions/diseases considered. Each chapter proceeds with a discussion of the various mathematical models of the problems considered, starting with the simplest models and proceeding to more complex models where necessary. A detailed list of relevant references is provided at the end of each chapter. With the beginning research student in mind, the chapters have been crafted to be as self-contained as possible while addressing different clinical conditions and diseases. The book is intended as a brief introduction to both theoreticians and experimentalists interested in brain mechanics, with directions and guidance for further reading, for those who wish to pursue particular topics in greater depth. It can also be used as a complementary textbook in a graduate level course for neuroscientists and neuroengineers.

Author : Jerzy Leszczynski,Manoj Shukla
Publisher : Springer Science & Business Media
Page : 465 pages
File Size : 52,5 Mb
Release : 2009-10-03
Category : Science
ISBN : 9789048126873

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Practical Aspects of Computational Chemistry by Jerzy Leszczynski,Manoj Shukla Pdf

"Practical Aspects of Computational Chemistry" presents contributions on a range of aspects of Computational Chemistry applied to a variety of research fields. The chapters focus on recent theoretical developments which have been used to investigate structures and properties of large systems with minimal computational resources. Studies include those in the gas phase, various solvents, various aspects of computational multiscale modeling, Monte Carlo simulations, chirality, the multiple minima problem for protein folding, the nature of binding in different species and dihydrogen bonds, carbon nanotubes and hydrogen storage, adsorption and decomposition of organophosphorus compounds, X-ray crystallography, proton transfer, structure-activity relationships, a description of the REACH programs of the European Union for chemical regulatory purposes, reactions of nucleic acid bases with endogenous and exogenous reactive oxygen species and different aspects of nucleic acid bases, base pairs and base tetrads.

Author : Ronald MacGregor
Publisher : Elsevier
Page : 656 pages
File Size : 42,9 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323143844

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Neural and Brain Modeling by Ronald MacGregor Pdf

Neural and Brain Modeling reviews models used to study neural interactions. The book also discusses 54 computer programs that simulate the dynamics of neurons and neuronal networks to illustrate between unit and systemic levels of nervous system functions. The models of neural and brain operations are composed of three sections: models of generic mechanisms; models of specific neuronal systems; and models of generic operations, networks, and systems. The text discusses the computational problems related to galvanizing a neuronal population though an activity in the multifiber input system. The investigator can use a computer technique to simulate multiple interacting neuronal populations. For example, he can investigate the case of a single local region that contains two populations of neurons: namely, a parent population of excitatory cells, and a second set of inhibitory neurons. Computer simulation models predict the various dynamic activity occurring in the complicated structure and physiology of neuronal systems. Computer models can be used in "top-down" brain/mind research where the systemic, global, and emergent properties of nervous systems are generated. The book is recommended for behavioral scientists, psychiatrists, psychologists, computer programmers, students, and professors in human behavior.