Multiscale Mechanobiology Of Bone Remodeling And Adaptation
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Multiscale Mechanobiology of Bone Remodeling and Adaptation by Peter Pivonka Pdf
The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.
Bone Adaptation by Yoshitaka Kameo,Ken-ichi Tsubota,Taiji Adachi Pdf
This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
Bone Remodeling Process by Rabeb Ben Kahla,Abdelwahed Barkaoui Pdf
Bone Remodeling Process: Mechanics, Biology, and Numerical Modeling provides a literature review. The first part of the book discusses bones in a normal physiological condition, bringing together the involved actors and factors reported over the past two decades, and the second discusses pathological conditions, highlighting the attack vectors of each bone disease. The third part is devoted to the mathematical descriptions of bone remodeling, formulated to develop models able to provide information that is not amenable to direct measurement, while the last part focuses on models using the finite element method in investigating bone biomechanics.This book creates an overall image of the complex communication network established between the diverse remodeling actors, based on overwhelming control evidence revealed over recent years, as well as visualizes the remodeling defects and possible treatments in each case. It also regroups the models allowing readers to analyze and assess bone mechanical and biological properties. This book details the cellular mechanisms allowing the bone to adapt its microarchitecture to the requirements of the human body, which is the main issue in bone biology and presents the evolution of mathematical modeling used in a bone computer simulation. Each chapter covers a core topic in bone biomechanics Provides a multidisciplinary view that effectively links orthopaedics, cellular biology, mechanics, and computer simulation Draws an overall image about bone biology and cell interactions, for identifying cell populations that are crucial for the remodeling process
Multiscale Biomechanics by Jean-Francois Ganghoffer Pdf
Multiscale Biomechanics provides new insights on multiscale static and dynamic behavior of both soft and hard biological tissues, including bone, the intervertebral disk, biological membranes and tendons. The physiological aspects of bones and biological membranes are introduced, along with micromechanical models used to compute mechanical response. A modern account of continuum mechanics of growth and remodeling, generalized continuum models to capture internal lengths scales, and dedicated homogenization methods are provided to help the reader with the necessary theoretical foundations. Topics discussed include multiscale methods for fibrous media based on discrete homogenization, generalized continua constitutive models for bone, and a presentation of recent theoretical and numerical advances. In addition, a refresher on continuum mechanics and more advanced background related to differential geometry, configurational mechanics, mechanics of growth, thermodynamics of open systems and homogenization methods is given in separate chapters. Numerical aspects are treated in detail, and simulations are presented to illustrate models. This book is intended for graduate students and researchers in biomechanics interested in the latest research developments, as well as those who wish to gain insight into the field of biomechanics. Provides a clear exposition of multiscale methods for fibrous media based on discrete homogenization and the consideration of generalized continua constitutive models for bone Presents recent theoretical and numerical advances for bone remodeling and growth Includes the necessary theoretical background that is exposed in a clear and self-contained manner Covers continuum mechanics and more advanced background related to differential geometry, configurational mechanics, mechanics of growth, thermodynamics of open systems and homogenization methods
Encyclopedia of Biomedical Engineering by Anonim Pdf
Encyclopedia of Biomedical Engineering, Three Volume Set is a unique source for rapidly evolving updates on topics that are at the interface of the biological sciences and engineering. Biomaterials, biomedical devices and techniques play a significant role in improving the quality of health care in the developed world. The book covers an extensive range of topics related to biomedical engineering, including biomaterials, sensors, medical devices, imaging modalities and imaging processing. In addition, applications of biomedical engineering, advances in cardiology, drug delivery, gene therapy, orthopedics, ophthalmology, sensing and tissue engineering are explored. This important reference work serves many groups working at the interface of the biological sciences and engineering, including engineering students, biological science students, clinicians, and industrial researchers. Provides students with a concise description of the technologies at the interface of the biological sciences and engineering Covers all aspects of biomedical engineering, also incorporating perspectives from experts working within the domains of biomedicine, medical engineering, biology, chemistry, physics, electrical engineering, and more Contains reputable, multidisciplinary content from domain experts Presents a ‘one-stop’ resource for access to information written by world-leading scholars in the field
A Companion to Biological Anthropology by Clark Spencer Larsen Pdf
A Companion to Biological Anthropology The discipline of biological anthropology—the study of the variation and evolution of human beings and their evolutionary relationships with past and living hominin and primate relatives—has undergone enormous growth in recent years. Advances in DNA research, behavioral anthropology, nutrition science, and other fields are transforming our understanding of what makes us human. A Companion to Biological Anthropology provides a timely and comprehensive account of the foundational concepts, historical development, current trends, and future directions of the discipline. Authoritative yet accessible, this field-defining reference work brings together 37 chapters by established and younger scholars on the biological and evolutionary components of the study of human development. The authors discuss all facets of contemporary biological anthropology including systematics and taxonomy, population and molecular genetics, human biology and functional adaptation, early primate evolution, paleoanthropology, paleopathology, bioarchaeology, forensic anthropology, and paleogenetics. Updated and expanded throughout, this second edition explores new topics, revisits key issues, and examines recent innovations and discoveries in biological anthropology such as race and human variation, epidemiology and catastrophic disease outbreaks, global inequalities, migration and health, resource access and population growth, recent primate behavior research, the fossil record of primates and humans, and much more. A Companion to Biological Anthropology, Second Edition is an indispensable guide for researchers and advanced students in biological anthropology, geosciences, ancient and modern disease, bone biology, biogeochemistry, behavioral ecology, forensic anthropology, systematics and taxonomy, nutritional anthropology, and related disciplines.
Functional Inference in Paleoanthropology by David J. Daegling Pdf
In this deep examination of functional morphology, a renowned paleoanthropologist offers a new way to investigate human evolution through the fossil record. It is common for two functional anatomists to examine the exact same fossil material, yet argue over its evolutionary significance. How can this be? Traditionally, paleoanthropology has interpreted hominin fossil morphology by first considering the ecological challenges hominins faced, then drawing adaptive inferences based on the idea that skeletal morphology is largely a reflection of paleoecology. In Functional Inference in Paleoanthropology, innovative paleoanthropologist David J. Daegling suggests that researchers can resolve dichotomous interpretations of the fossil record by instead focusing on the biology and development of the bones themselves—such as measurable responses to deformations, stresses, and damage. Critically exploring how scientists probe and interpret fossil morphology for behavioral and adaptive inferences, Daegling makes the case that an intelligible science of functional morphology in the fossil record is impossible without the inclusion of this mechanobiological perspective. Drawing on historical examples from long-standing debates on the emergence of bipedality and the dietary shifts that facilitated the emergence of the hominin clade, Daegling traces the disjunctions between theoretical principles of comparative morphology and methodological practice in the paleontological context of human evolution. Sharing rich findings from recent decades of research in skeletal biomechanics, Functional Inference in Paleoanthropology examines how bone adapts over the lifespan, what environmental factors influence its quality, and how developmental constraints limit the skeleton's adaptive potential over evolutionary time.
Ortner's Identification of Pathological Conditions in Human Skeletal Remains by Jane Buikstra Pdf
Ortner's Identification of Pathological Conditions in Human Skeletal Remains, Third Edition, provides an integrated and comprehensive treatment of the pathological conditions that affect the human skeleton. As ancient skeletal remains can reveal a treasure trove of information to the modern orthopedist, pathologist, forensic anthropologist, and radiologist, this book presents a timely resource. Beautifully illustrated with over 1,100 photographs and drawings, it provides an essential text and material on bone pathology, thus helping improve the diagnostic ability of those interested in human dry bone pathology. Presents a comprehensive review of the skeletal diseases encountered in archaeological human remains Includes more than 1100 photographs and line drawings illustrating skeletal diseases, including both microscopic and gross features Based on extensive research on skeletal paleopathology in many countries Reviews important theoretical issues on how to interpret evidence of skeletal disease in archaeological human populations
Smart Multifunctional Nano-inks by Ram K. Gupta,Tuan Anh Nguyen Pdf
Smart Multifunctional Nano-inks: Fundamentals and Emerging Applications covers nano-inks and how they can be used in inkjet printers for printing complex circuitry on flexible substrates or as a paste for 3D printers. Microstructures can be 3D-printed using nano-inks in a combination of high-resolution plasma printing and subsequent rotogravure printing. In addition, smart multifunctional nano-inks are not only required for the electronic, but also in other applications, such as for secure inks, for currency, and in immigration documents. This book focuses on fundamental design concepts, promising applications, and future challenges of nano-inks in various areas, such as optoelectronics, energy, security and biomedical fields. The current challenge for the successful industrial application of nano-inks is in the preparation of a stable dispersion of advanced materials for nano-inks. The functionalization, synthesizing, and theoretical modeling provide the solution for most of the current issues, but there are still remaining challenges which are covered in this comprehensive resource. Outlines the major nanomaterials used in the manufacture of smart nano-inks Provides information on the major industrial applications of nano-inks Assesses the major challenges of using nano-inks in a cost-effective way, and on an industrial scale
Proceedings of the International Conference of Mechatronics and Cyber- MixMechatronics - 2020 by Gheorghe Ion Gheorghe Pdf
This book presents state-of-the-art research in the field of mechatronics and cyber-mixmechatronics, gathering papers from almost all continents. Featuring contributions by research scholars in both government-financed institutions and in the business environment, it offers a clear picture of the innovations emerging in the field. The book is not limited to mechatronics, but also covers all the smart technical sciences, and discusses promising medical applications based on nanotechnologies. As such, it is a valuable resource for students wanting to learn from leading scholars, as well as for researchers in all areas of engineering.
A. Mark Pollard,Ruth Ann Armitage,Cheryl A. Makarewicz
Author : A. Mark Pollard,Ruth Ann Armitage,Cheryl A. Makarewicz Publisher : John Wiley & Sons Page : 2313 pages File Size : 41,7 Mb Release : 2023-02-09 Category : Technology & Engineering ISBN : 9781119592082
Handbook of Archaeological Sciences by A. Mark Pollard,Ruth Ann Armitage,Cheryl A. Makarewicz Pdf
HANDBOOK OF ARCHAEOLOGICAL SCIENCES A modern and comprehensive introduction to methods and techniques in archaeology In the newly revised Second Edition of the Handbook of Archaeological Sciences, a team of more than 100 researchers delivers a comprehensive and accessible overview of modern methods used in the archaeological sciences. The book covers all relevant approaches to obtaining and analyzing archaeological data, including dating methods, quaternary paleoenvironments, human bioarchaeology, biomolecular archaeology and archaeogenetics, resource exploitation, archaeological prospection, and assessing the decay and conservation of specimens. Overview chapters introduce readers to the relevance of each area, followed by contributions from leading experts that provide detailed technical knowledge and application examples. Readers will also find: A thorough introduction to human bioarchaeology, including hominin evolution and paleopathology The use of biomolecular analysis to characterize past environments Novel approaches to the analysis of archaeological materials that shed new light on early human lifestyles and societies In-depth explorations of the statistical and computational methods relevant to archaeology Perfect for graduate and advanced undergraduate students of archaeology, the Handbook of Archaeological Sciences will also earn a prominent place in the libraries of researchers and professionals with an interest in the geological, biological, and genetic basis of archaeological studies.
Multiscale Modeling to Tackle the Complexity of Load-Bearing Organ and Tissue Regulation by Jerome Noailly,Stephane Avril,Peter Pivonka,Stefan Scheiner Pdf
Stem Cells and Regenerative Medicine by J.-F. Stoltz,Y. Chen,J. Magdalou Pdf
As the world’s population ages, the problem of degenerative disease is increasing. At the same time, the demand for organ transplants to repair or replace damaged tissue continues to grow. Regenerative medicine is a branch of translational medicine which promotes the repair, regeneration, or construction of tissues and organs or improves or restores their function through tissue engineering, cell biology, molecular biology and other techniques. Stem cells are one of the most important types of cells used in regenerative medicine, and stem cell research is also one of the most active research areas in the field. This book presents 20 full papers from the 8th International Symposium China-Europe “Stem Cells and Regenerative Medicine”, held in Wuhan, China from 19-21 June 2018. At this symposium, researchers in the field of stem cells and regenerative medicine from China and France discussed research from a molecular point of view and pointed out the clinical applications of mesenchymal stem cells, as well as the construction and applications of new biomaterials, the biomechanics of bone tissue engineering, and cellular immunotherapy, among other subjects. Stem cell technology could soon make possible the repair or replacement of aging and damaged tissue, as well as providing a treatment for genetic defects and malignancies,and this book will be of value to all those with an interest in regenerative medicine.
Multiscale Modelling in Biomedical Engineering by Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika Pdf
Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Multiscale Simulations and Mechanics of Biological Materials by Shaofan Li,Dong Qian Pdf
Multiscale Simulations and Mechanics of Biological Materials A compilation of recent developments in multiscale simulation and computational biomaterials written by leading specialists in the field Presenting the latest developments in multiscale mechanics and multiscale simulations, and offering a unique viewpoint on multiscale modelling of biological materials, this book outlines the latest developments in computational biological materials from atomistic and molecular scale simulation on DNA, proteins, and nano-particles, to meoscale soft matter modelling of cells, and to macroscale soft tissue and blood vessel, and bone simulations. Traditionally, computational biomaterials researchers come from biological chemistry and biomedical engineering, so this is probably the first edited book to present work from these talented computational mechanics researchers. The book has been written to honor Professor Wing Liu of Northwestern University, USA, who has made pioneering contributions in multiscale simulation and computational biomaterial in specific simulation of drag delivery at atomistic and molecular scale and computational cardiovascular fluid mechanics via immersed finite element method. Key features: Offers a unique interdisciplinary approach to multiscale biomaterial modelling aimed at both accessible introductory and advanced levels Presents a breadth of computational approaches for modelling biological materials across multiple length scales (molecular to whole-tissue scale), including solid and fluid based approaches A companion website for supplementary materials plus links to contributors’ websites (www.wiley.com/go/li/multiscale)