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Myasthenia Gravis and Myasthenic Disorders by Andrew G. Engel Pdf
Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.
Handbook of Myasthenia Gravis and Myasthenic Syndromes by Robert P. Lisak Pdf
This practical resource provides up-to-the-minute examinations of every aspect of myasthenia gravis and myasthenic syndromes-presenting detailed descriptions of the etiology, pathogenesis, diagnosis, and treatment. Contains nearly 1900 helpful literature citations, tables, drawings, and photographs! Exploring new and emerging therapies for difficult cases, Handbook of Myasthenia Gravis and Myasthenic Syndromes discusses neuroophthalmological features of the disorders congenital, neonatal, and juvenile myasthenia gravis and myasthenic syndromes the clinical presentation and immunology of Lambert-Eaton syndrome the myasthenic neuromuscular junction, diagnostic tests in neuromuscular junction disorders, and the involvement of sites outside the junction the genetics of myasthenia gravis electrodiagnosis, serological diagnosis, and pharmacological diagnosis the value of experimental models in understanding acquired myasthenia gravis the immunopathogenesis of acquired myasthenia gravis and much more!
Author : Henry J. Kaminski Publisher : Springer Science & Business Media Page : 396 pages File Size : 54,6 Mb Release : 2002-10-03 Category : Medical ISBN : 9781592593415
Myasthenia Gravis and Related Disorders by Henry J. Kaminski Pdf
An international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromytonia and Lambert-Eaton syndrome. For the clinician, the book describes the wide range of signs and symptoms that make these diseases difficult to diagnose, review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatments now emerging. For the basic scientist, the text illuminates neuromuscular structure and function, describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis), and illuminates the autoimmune pathogenesis.
Selected Topics in Myasthenia Gravis by Isam Jaber Al-Zwaini,Ali AL-Mayahi Pdf
Myasthenia gravis is a rare potentially fatal chronic autoimmune disorder. Circulating autoantibodies directed against components of the neuromuscular junction of skeletal muscles, most commonly nicotinic acetylcholine receptor and associated protein in the postsynaptic membrane, block neuromuscular transmission resulting in muscle weakness. This muscle weakness typically worsens with continued activity, improves on rest, and is of variable severity ranging from mild ocular muscle weakness to severe generalized muscle weakness, involving the respiratory muscle with impending respiratory failure. The worldwide prevalence of myasthenia gravis is 100-200 per million population, affecting more than 700,000 people all over the world. The prevalence rate has increased since the 1950s due to improved diagnostic precision and decreased mortality rate.
Neuromuscular Disorders in Clinical Practice by Bashar Katirji,Henry J. Kaminski,Robert L. Ruff Pdf
Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment. Mirroring the first book, this two-volume edition is divided into two parts. Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders. Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes. Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners. General neurologists as well as specialists in neuromuscular medicine and trainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused. Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.
Myasthenia Gravis and Related Diseases by David P. Richman Pdf
This volume of proceedings includes the latest research on the pathogenesis, diagnosis and treatment of myasthenia gravis and related diseases. It includes reports of progress in the study of the acetylcholine receptor molecule and its function as a ligand-gated ion channel. Further topics include the molecular events involved in presynaptic neurotransmitter release, postsynaptic antigens in autoimmune myasthenia gravis, the immune mechanisms involved in Lambert-Eaton myasthenic syndrome, and genetically determined abnormalities of neuromuscular transmission.
Myasthenia gravis and myasthenic syndrome by Sics Editore Pdf
Myasthenia gravis is arare autoimmune disease, in which the function of the myoneural junction of the voluntary muscles is impaired Annual incidence is about 2–8/1 000 000. Symptoms include variable degrees of fatigue and weakness in voluntary musculature, which is aggravated by strain and relieved by rest. Two main types: limited to the eye muscles, or ocular (ca. 15% of the cases) generalised; the symptoms are usually most prominent in the proximal muscles of the shoulder and pelvic region. Treatment is the domain of a specialist in neurology. Remember that patients with myasthenia are very sensitive to drugs: check always the compatibility with myasthenia when starting a new drug for a myasthenic patient!
Myasthenia Gravis and Related Disorders by Audrey S. Penn Pdf
This work on the neurosciences presents an update on normal physiological mechanisms at the neuromuscular junction, normal immune responses as these relate to auto-immunity, and pathogenic mechanisms responsible for myasthenia (the prototype human auto-immune disease), along with diagnostic and therapy information.
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG. This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease. To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.
Anesthesiology by Linda S. Aglio,Richard D. Urman Pdf
Divided into twelve sections that cover the entirety of anesthetic practice, this is a case-based, comprehensive review of anesthesiology that covers the basics of anesthetic management and reflects all new guidelines and recently developed standards of care. Each chapter of Anesthesiology: Clinical Case Reviews begins with a specific clinical problem or a clinical case scenario, followed by concise discussions of preoperative assessment, intraoperative management, and postoperative pain management. In addition to residents and fellows, this book is written for practicing anesthesiologists, student nurse anesthetists, and certified registered nurse anesthetists (CRNAs).
Author : Marc H. De Baets,Hans J. G. H. Oosterhuis Publisher : CRC Press Page : 331 pages File Size : 49,8 Mb Release : 2019-06-04 Category : Medical ISBN : 9781000013108
Myasthenia Gravis by Marc H. De Baets,Hans J. G. H. Oosterhuis Pdf
First Published in 1993, this book offers a full, comprehensive guide into Myasthenia Gravis and how it affects our muscular function. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
Myasthenia Gravis and Related Disorders by Mark A. Agius Pdf
Myasthenia gravis is the best-understood autoimmune disorder and its intense investigation has provided insights into the pathogenesis of autoimmune disease in general and the basic mechanisms of synaptic transmission. The papers in this volume report research findings on the mechanisms of disease, diagnosis and treatment of myasthenia gravis and related diseases. Other papers examine the advances in knowledge about the physiology, biochemistry, genetics, and the structure of the neuromuscular junction as well as advances in the immunology of pre-and post-synaptic disorders of the junction. Papers also discuss the clinical management of myasthenia gravis and related disorders.