Selected Topics In Myasthenia Gravis

Author : Isam Jaber Al-Zwaini,Ali AL-Mayahi
Publisher : BoD – Books on Demand
Page : 96 pages
File Size : 44,7 Mb
Release : 2019-06-12
Category : Medical
ISBN : 9781838808297

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Selected Topics in Myasthenia Gravis by Isam Jaber Al-Zwaini,Ali AL-Mayahi Pdf

Myasthenia gravis is a rare potentially fatal chronic autoimmune disorder. Circulating autoantibodies directed against components of the neuromuscular junction of skeletal muscles, most commonly nicotinic acetylcholine receptor and associated protein in the postsynaptic membrane, block neuromuscular transmission resulting in muscle weakness. This muscle weakness typically worsens with continued activity, improves on rest, and is of variable severity ranging from mild ocular muscle weakness to severe generalized muscle weakness, involving the respiratory muscle with impending respiratory failure. The worldwide prevalence of myasthenia gravis is 100-200 per million population, affecting more than 700,000 people all over the world. The prevalence rate has increased since the 1950s due to improved diagnostic precision and decreased mortality rate.

Author : Ali AL-Mayahi,Isam Jaber Al-Zwaini
Publisher : Unknown
Page : 94 pages
File Size : 40,8 Mb
Release : 2019
Category : Neurology. Diseases of the nervous system
ISBN : 1838808310

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Selected Topics in Myasthenia Gravis by Ali AL-Mayahi,Isam Jaber Al-Zwaini Pdf

Myasthenia gravis is a rare potentially fatal chronic autoimmune disorder. Circulating autoantibodies directed against components of the neuromuscular junction of skeletal muscles, most commonly nicotinic acetylcholine receptor and associated protein in the postsynaptic membrane, block neuromuscular transmission resulting in muscle weakness. This muscle weakness typically worsens with continued activity, improves on rest, and is of variable severity ranging from mild ocular muscle weakness to severe generalized muscle weakness, involving the respiratory muscle with impending respiratory failure. The worldwide prevalence of myasthenia gravis is 100-200 per million population, affecting more than 700,000 people all over the world. The prevalence rate has increased since the 1950s due to improved diagnostic precision and decreased mortality rate.

Author : Premkumar Christadoss
Publisher : Springer Science & Business Media
Page : 220 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401140607

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Myasthenia Gravis by Premkumar Christadoss Pdf

Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG. This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease. To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.

Author : Andrew G. Engel
Publisher : OUP USA
Page : 305 pages
File Size : 47,5 Mb
Release : 2012-04-03
Category : Medical
ISBN : 9780199738670

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Myasthenia Gravis and Myasthenic Disorders by Andrew G. Engel Pdf

Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.

Author : Anonim
Publisher : Unknown
Page : 137 pages
File Size : 40,5 Mb
Release : 2009
Category : Neurology
ISBN : 0981888305

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Myasthenia Gravis by Anonim Pdf

Author : Rozen Le Panse,Linda L. Kusner,Sonia Berrih-Aknin,Anna Rostedt Punga
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 40,7 Mb
Release : 2020-10-27
Category : Medical
ISBN : 9782889661077

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Advances in Autoimmune Myasthenia Gravis by Rozen Le Panse,Linda L. Kusner,Sonia Berrih-Aknin,Anna Rostedt Punga Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Satish V. Khadilkar,Rakhil S. Yadav,Bhagyadhan A. Patel
Publisher : Springer
Page : 534 pages
File Size : 42,7 Mb
Release : 2017-12-28
Category : Medical
ISBN : 9789811053610

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Neuromuscular Disorders by Satish V. Khadilkar,Rakhil S. Yadav,Bhagyadhan A. Patel Pdf

This book provides a concise overview of the diagnosis and therapy of a wide variety of neuromuscular disorders, in tabulated form and with illustrative cases. Treating neuromuscular disorders calls for a sound, step-by-step clinical approach based on differential diagnosis and laboratory investigations. Yet to date, there has been no single, compact book that offers all the relevant information related to the management of these disorders. This book fills that gap, presenting the state of the art in the field and addressing practical problems together with their solutions. Each chapter covers disorder characteristics, clinical differentiating points, relevant investigations and their interpretation, available genetic testing, best management approaches and counselling. Illustrative cases provide valuable insights, while extensive tables and illustrations mean that information can be rapidly found.

Author : Webb
Publisher : Oxford University Press
Page : 1961 pages
File Size : 44,7 Mb
Release : 2020-01-10
Category : Medical
ISBN : 9780198855439

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Oxford Textbook of Critical Care by Webb Pdf

Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Author : Isam Jaber Al-Zwaini,Ban Adbul-Hameed Majeed Albadri
Publisher : BoD – Books on Demand
Page : 221 pages
File Size : 43,9 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9781789238679

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Epilepsy by Isam Jaber Al-Zwaini,Ban Adbul-Hameed Majeed Albadri Pdf

Epilepsy is the most common neurological disorder globally, affecting approximately 50 million people of all ages. It is one of the oldest diseases described in literature from remote ancient civilizations 2000-3000 years ago. Despite its long history and wide spread, epilepsy is still surrounded by myth and prejudice, which can only be overcome with great difficulty. The term epilepsy is derived from the Greek verb epilambanein, which by itself means to be seized and to be overwhelmed by surprise or attack. Therefore, epilepsy is a condition of getting over, seized, or attacked. The twelve very interesting chapters of this book cover various aspects of epileptology from the history and milestones of epilepsy as a disease entity, to the most recent advances in understanding and diagnosing epilepsy.

Author : Charles Vacanti,Scott Segal,Pankaj Sikka,Richard Urman
Publisher : Cambridge University Press
Page : 1191 pages
File Size : 55,5 Mb
Release : 2011-07-11
Category : Medical
ISBN : 9781139498401

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Essential Clinical Anesthesia by Charles Vacanti,Scott Segal,Pankaj Sikka,Richard Urman Pdf

The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.

Author : Rahman Pourmand
Publisher : Karger Medical and Scientific Publishers
Page : 179 pages
File Size : 45,9 Mb
Release : 2009-01-01
Category : Medical
ISBN : 9783805591416

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Immune-mediated Neuromuscular Diseases by Rahman Pourmand Pdf

Neuromuscular medicine is constantly advancing in terms of accurate diagnosis, pathophysiology, and treatment. Many disorders that have been discovered within this field are either autoimmune or genetic. This publication provides the latest updates of the more common and treatable autoimmune neuromuscular diseases affecting the spinal cord, peripheral nerves, neuromuscular junction and muscles. The authors, renowned experts in the field, offer clinical presentations as well as the best diagnostic and treatment approach to the readers. The chapters are dealing with acute and chronic neuropathies, nonsystemic vasculitic neuropathy, dysimmune neuropathy and autoimmune autonomic ganglionopathy. Further, disorders such as myasthenia gravis, Lambert-Eaton myasthenic syndrome, idiopathic inflammatory myopathies and stiff person syndrome are discussed.Providing an excellent source of up-to-date information, this publication is highly recommended not only to neurologists, but also to internists, rheumatologists, allergists and immunologists.

Author : Henry J. Kaminski
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 51,5 Mb
Release : 2002-10-03
Category : Medical
ISBN : 9781592593415

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Myasthenia Gravis and Related Disorders by Henry J. Kaminski Pdf

An international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromytonia and Lambert-Eaton syndrome. For the clinician, the book describes the wide range of signs and symptoms that make these diseases difficult to diagnose, review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatments now emerging. For the basic scientist, the text illuminates neuromuscular structure and function, describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis), and illuminates the autoimmune pathogenesis.

Author : William P. Howlett
Publisher : Cambridge University Press
Page : 465 pages
File Size : 50,9 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9781107114227

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Neurology in Africa by William P. Howlett Pdf

This practical, comprehensive and highly illustrated book will be invaluable to students and doctors of neurology and internal medicine in Africa.

Author : Isam Jaber Al-Zwaini
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 44,5 Mb
Release : 2018-12-19
Category : Medical
ISBN : 9781789848304

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Cerebral Palsy by Isam Jaber Al-Zwaini Pdf

Cerebral palsy is a common pediatric problem and is the leading cause of childhood disability. It occurs at a rate of 3.6 cases per 1000 children, and represents a major social and psychological impact on both family and society. It is a group of disorders with movement difficulties being common for all affected patients. Its severity and extent are variable from one patient to another. Additionally, the impacts of cerebral palsy on daily activities, communications, and requirements are also variable. Recent advances in clinical research increase our knowledge and understanding of causal pathways, possible preventive measures, specific intervention strategies, and the value of new treatment modalities such as botulinum toxin and intrathecal baclofen in the management of cerebral palsy.

Author : George A. Mashour,Ehab Farag
Publisher : Cambridge University Press
Page : 361 pages
File Size : 50,7 Mb
Release : 2011-02-03
Category : Medical
ISBN : 9781139494083

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Case Studies in Neuroanesthesia and Neurocritical Care by George A. Mashour,Ehab Farag Pdf

The anesthetic considerations and procedures involved in the perioperative care of the neurosurgical patient are among the most complex in anesthesiology. The practice of neurosurgery and neuroanesthesiology encompasses a wide range of cases, from major spine surgery, to aneurysm clipping and awake craniotomy. Case Studies in Neuroanesthesia and Neurocritical Care provides a comprehensive view of real-world clinical practice. It contains over 90 case presentations with accompanying focussed discussions, covering the broad range of procedures and monitoring protocols involved in the care of the neurosurgical patient, including preoperative and postoperative care. The book is illustrated throughout with practical algorithms, useful tables and examples of neuroimaging. Written by leading neuroanesthesiologists, neurologists, neuroradiologists and neurosurgeons from the University of Michigan Medical School and the Cleveland Clinic, these clear, concise cases are an excellent way to prepare for specific surgical cases or to aid study for both written and oral board examinations.