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Author : Henry J. Kaminski Publisher : Springer Science & Business Media Page : 397 pages File Size : 47,7 Mb Release : 2002-10-03 Category : Medical ISBN : 9781592593415
Myasthenia Gravis and Related Disorders by Henry J. Kaminski Pdf
An international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromytonia and Lambert-Eaton syndrome. For the clinician, the book describes the wide range of signs and symptoms that make these diseases difficult to diagnose, review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatments now emerging. For the basic scientist, the text illuminates neuromuscular structure and function, describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis), and illuminates the autoimmune pathogenesis.
Author : Henry J. Kaminski Publisher : Springer Science & Business Media Page : 314 pages File Size : 54,9 Mb Release : 2009-03-02 Category : Medical ISBN : 9781597451567
Myasthenia Gravis and Related Disorders by Henry J. Kaminski Pdf
Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients’ psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the “personal approach” of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.
Myasthenia Gravis and Myasthenic Disorders by Andrew G. Engel Pdf
Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.
Myasthenia Gravis and Related Disorders by Henry J. Kaminski,Richard Barohn Pdf
Basic and clinical investigators have contributed reports to this volume in which they explore new findings in myasthenia gravis and related diseases, exploring topics in basic science, translational research, and clinical science, including advances in therapies and treatment strategies. Topics covered include the following: structure and function of the neuromuscular junction; communication between nerve and muscle; structure and function of the acetylcholine receptor; neuromuscular junction pathology; autoimmunity and signaling; immunology of autoimmune disorders involving the neuron and presynaptic nerve terminal; autoimmune pathogenesis of myasthenia gravis; clinical treatments including thymectomy; myasthenia gravis due to muscle-specific kinase antibodies. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
Handbook of Myasthenia Gravis and Myasthenic Syndromes by Robert P. Lisak Pdf
This practical resource provides up-to-the-minute examinations of every aspect of myasthenia gravis and myasthenic syndromes-presenting detailed descriptions of the etiology, pathogenesis, diagnosis, and treatment. Contains nearly 1900 helpful literature citations, tables, drawings, and photographs! Exploring new and emerging therapies for difficult cases, Handbook of Myasthenia Gravis and Myasthenic Syndromes discusses neuroophthalmological features of the disorders congenital, neonatal, and juvenile myasthenia gravis and myasthenic syndromes the clinical presentation and immunology of Lambert-Eaton syndrome the myasthenic neuromuscular junction, diagnostic tests in neuromuscular junction disorders, and the involvement of sites outside the junction the genetics of myasthenia gravis electrodiagnosis, serological diagnosis, and pharmacological diagnosis the value of experimental models in understanding acquired myasthenia gravis the immunopathogenesis of acquired myasthenia gravis and much more!
Myasthenia Gravis and Related Diseases by David P. Richman Pdf
This volume of proceedings includes the latest research on the pathogenesis, diagnosis and treatment of myasthenia gravis and related diseases. It includes reports of progress in the study of the acetylcholine receptor molecule and its function as a ligand-gated ion channel. Further topics include the molecular events involved in presynaptic neurotransmitter release, postsynaptic antigens in autoimmune myasthenia gravis, the immune mechanisms involved in Lambert-Eaton myasthenic syndrome, and genetically determined abnormalities of neuromuscular transmission.
Myasthenia Gravis and Related Disorders by Mark A. Agius Pdf
Myasthenia gravis is the best-understood autoimmune disorder and its intense investigation has provided insights into the pathogenesis of autoimmune disease in general and the basic mechanisms of synaptic transmission. The papers in this volume report research findings on the mechanisms of disease, diagnosis and treatment of myasthenia gravis and related diseases. Other papers examine the advances in knowledge about the physiology, biochemistry, genetics, and the structure of the neuromuscular junction as well as advances in the immunology of pre-and post-synaptic disorders of the junction. Papers also discuss the clinical management of myasthenia gravis and related disorders.
Myasthenia Gravis and Related Disorders by Audrey S. Penn Pdf
This work on the neurosciences presents an update on normal physiological mechanisms at the neuromuscular junction, normal immune responses as these relate to auto-immunity, and pathogenic mechanisms responsible for myasthenia (the prototype human auto-immune disease), along with diagnostic and therapy information.
Author : Marc H. De Baets,Hans J. G. H. Oosterhuis Publisher : CRC Press Page : 331 pages File Size : 50,8 Mb Release : 2019-06-04 Category : Medical ISBN : 9781000013108
Myasthenia Gravis by Marc H. De Baets,Hans J. G. H. Oosterhuis Pdf
First Published in 1993, this book offers a full, comprehensive guide into Myasthenia Gravis and how it affects our muscular function. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
Attacking Myasthenia Gravis by Ronald Henderson Pdf
Using his insight as a longtime physician, Dr. Ron Henderson describes the productive life he lives despite having a rare autoimmune disease known as myasthenia gravis (MG). He also provides a forum for three other MG patients to share their inspirational stories. A disease unfamiliar to many, myasthenia gravis means "grave muscle weakness" and causes severe weakness and loss of strength in voluntary muscles in various parts of the body. Often debilitating, MG falls into the category of "autoimmune" diseases, which all involve problems related to the immune system. Explaining MG symptoms, treatments, research, and disease-management tips, this book becomes a useful guide for MG patients, their families, and their physicians. And the book goes further. Using MG as an example, Dr. Henderson and others provide tips to all who suffer from chronic health problems for which there are treatments but no cures. Forced by MG to retire eight years ago as an obstetrician-gynecologist, Dr. Henderson now enjoys improved health but realizes he can never expect to be well unless a cure is found for MG. In this book, he announces plans to expand research into MG and other autoimmune disease through his founding of the International Autoimmune Disease Research Foundation.
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG. This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease. To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.
News and Views in the Management of Myasthenia Gravis by Amelia Evoli,Nils Erik Gilhus,Jeff Guptill Pdf
Dr. Jeffrey Guptill has received research grants and contracts: from: US NIH, NINDS (K23NS085049, HHSN27100001), NIAID (HHSN272201300017I), Myasthenia Gravis Foundation of America, the Grifols Foundation, the Alzheimer’s Association, Ra Pharmaceuticals. He has also received personal compensation in the past year from Alexion, Kashiv, Argen-X, and Momenta, Inc for consulting services and from Grifols for educational activities.