Nanotechnology Based Approaches For Targeting And Delivery Of Drugs And Genes

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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes Book PDF

Author : Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
Publisher : Academic Press
Page : 552 pages
File Size : 49,7 Mb
Release : 2017-05-23
Category : Medical
ISBN : 9780128097182

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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes by Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer Pdf

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Drug Delivery Approaches and Nanosystems, Volume 2

Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Drug Delivery Approaches and Nanosystems Volume 2 Book PDF

Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 248 pages
File Size : 52,6 Mb
Release : 2017-11-15
Category : Medical
ISBN : 9781351846660

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Drug Delivery Approaches and Nanosystems, Volume 2 by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.

Drug Delivery with Targeted Nanoparticles

Yılmaz Çapan,Adem Sahin,Hayrettin Tonbul
Drug Delivery with Targeted Nanoparticles Book PDF

Author : Yılmaz Çapan,Adem Sahin,Hayrettin Tonbul
Publisher : CRC Press
Page : 790 pages
File Size : 52,9 Mb
Release : 2021-11-30
Category : Medical
ISBN : 9781000375268

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Drug Delivery with Targeted Nanoparticles by Yılmaz Çapan,Adem Sahin,Hayrettin Tonbul Pdf

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

Application of Nanotechnology in Drug Delivery

Ali Demir Sezer
Application of Nanotechnology in Drug Delivery Book PDF

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 556 pages
File Size : 40,9 Mb
Release : 2014-07-25
Category : Science
ISBN : 9789535116288

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Application of Nanotechnology in Drug Delivery by Ali Demir Sezer Pdf

This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Drug Delivery Approaches and Nanosystems, Two-Volume Set

Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Drug Delivery Approaches and Nanosystems Two Volume Set Book PDF

Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 858 pages
File Size : 42,9 Mb
Release : 2020-02-10
Category : Medical
ISBN : 9781351839358

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Drug Delivery Approaches and Nanosystems, Two-Volume Set by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

This new two-volume set, Drug Delivery Approaches and Nanosystems, Volume 1: Novel Drug Carriers and Volume 2: Drug Targeting Aspects of Nanotechnology presents a comprehensive look at the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is due to the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. These volumes address that gap. Volume 1 addresses the ubiquitous applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques, while Volume 2 focuses on drug targeting aspects of nanotechnology. Together they provide a thorough review of the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. These two volumes will provide a plethora of real-world information for the application of drug delivery approaches via nanotechnology that will be valuable to scientists and researchers as well as faculty and students. The volumes are available separately or together as a set.

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer

Prashant Kesharwani
Nanotechnology Based Targeted Drug Delivery Systems for Lung Cancer Book PDF

Author : Prashant Kesharwani
Publisher : Academic Press
Page : 340 pages
File Size : 50,8 Mb
Release : 2019-01-26
Category : Business & Economics
ISBN : 9780128163672

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Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer by Prashant Kesharwani Pdf

Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers

Nanocarriers: Drug Delivery System

Nirmal Shah
Nanocarriers Drug Delivery System Book PDF

Author : Nirmal Shah
Publisher : Springer Nature
Page : 483 pages
File Size : 54,5 Mb
Release : 2021-01-22
Category : Medical
ISBN : 9789813344976

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Nanocarriers: Drug Delivery System by Nirmal Shah Pdf

A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules. With this desirability in mind, the book unites different techniques through which extremely small-sized particles can be utilized as a successful carrier for curing chronic as well as life-threatening diseased conditions. This is a highly informative and prudently organized book, providing scientific insight for readers with an interest in nanotechnology. Beginning with an overview of nanocarriers, the book impetuses on to explore other essential ways through which these carriers can be employed for drug delivery to varieties of administrative routes. This book discusses the functional and significant features of nanotechnology in terms of Lymphatic and other drug targeting deliveries. The book is presenting depth acquaintance for various vesicular and particulate nano-drug delivery carriers, utilized successfully in Pharmaceutical as well as in Cosmeceutical industries along with brief information on their related toxicities. In addition, the work also explores the potential applications of nanocarriers in biotechnology sciences for the prompt and safe delivery of nucleic acid, protein, and peptide-based drugs. An exclusive section in the book illuminates the prominence and competent applicability of nanotechnology in the treatment of oral cancer. The persistence of this book is to provide basic to advanced information for different novel carriers which are under scale-up consideration for the extensive commercialization. The book also includes recent discoveries and the latest patents of such nanocarriers. The cutting-edge evidence of these nanocarriers available in this book is beneficial to students, research scholars, and fellows for promoting their advanced research.

Nanomedicine in Drug Delivery

Arun Kumar,Heidi M. Mansour,Adam Friedman,Eric R. Blough
Nanomedicine in Drug Delivery Book PDF

Author : Arun Kumar,Heidi M. Mansour,Adam Friedman,Eric R. Blough
Publisher : CRC Press
Page : 465 pages
File Size : 40,5 Mb
Release : 2013-06-05
Category : Medical
ISBN : 9781466506169

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Nanomedicine in Drug Delivery by Arun Kumar,Heidi M. Mansour,Adam Friedman,Eric R. Blough Pdf

There is a clear need for innovative technologies to improve the delivery of therapeutic and diagnostic agents in the body. Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. Nanomedicine in Drug Delivery gives an overview of aspects of nanomedicine to help readers design and develop novel drug delivery systems and devices that build on nanoscale technologies. Featuring contributions by leading researchers from around the world, the book examines: The integration of nanoparticles with therapeutic agents The synthesis and characterization of nanoencapsulated drug particles Targeted pulmonary nanomedicine delivery using inhalation aerosols The use of biological systems—bacteria, cells, viruses, and virus-like particles—as carriers to deliver nanoparticles Nanodermatology and the role of nanotechnology in the diagnosis and treatment of skin disease Nanoparticles for the delivery of small molecules, such as for gene and vaccine delivery The use of nanotechnologies to modulate and modify wound healing Nanoparticles in bioimaging, including magnetic resonance, computed tomography, and molecular imaging Nanoparticles to enhance the efficiency of existing anticancer drugs The development of nanoparticle formulations Nanoparticles for ocular drug delivery Nanoparticle toxicity, including routes of exposure and mechanisms of toxicity The use of animal and cellular models in nanoparticles safety studies With its practical focus on the design, synthesis, and application of nanomedicine in drug delivery, this book is a valuable resource for clinical researchers and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner. It explores a wide range of promising approaches for the diagnosis and treatment of diseases using cutting-edge nanotechnologies.

Nano-Oncologicals

Maria José Alonso,Marcos Garcia-Fuentes
Nano Oncologicals Book PDF

Author : Maria José Alonso,Marcos Garcia-Fuentes
Publisher : Springer
Page : 473 pages
File Size : 52,5 Mb
Release : 2014-10-15
Category : Medical
ISBN : 9783319080840

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Nano-Oncologicals by Maria José Alonso,Marcos Garcia-Fuentes Pdf

This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines). Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Nanotechnology and Drug Delivery, Volume Two

Jose L. Arias
Nanotechnology and Drug Delivery Volume Two Book PDF

Author : Jose L. Arias
Publisher : CRC Press
Page : 487 pages
File Size : 50,8 Mb
Release : 2016-04-21
Category : Medical
ISBN : 9781482262735

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Nanotechnology and Drug Delivery, Volume Two by Jose L. Arias Pdf

The recent introduction of nanomedicines in the drug therapy arena is revolutionizing the management of severe diseases. The key advance in the field is the optimization of the biological fate of drug molecules, thus improving the therapeutic effect while keeping to a very minimum the associated toxicity. Volume one of this book series, Nanoplatforms in Drug Delivery, established the basic aspects in the development of drug-loaded nanoplatforms, the so-called nanomedicines or nanodrugs, focusing on representative materials and strategies used in their formulation. Taking advantage of the advanced conceptualizations on nanomedicine engineering that were described in volume one, volume two, Nano-Engineering Strategies and Nanomedicines against Severe Diseases, analyzes in depth special features related to the formulation of nanoplatforms for oral, dental, topical and transdermal, pulmonary and nasal, ocular and otic, vaginal, and brain drug delivery and targeting. Particular aspects of nanomedicine engineering and in vivo fate associated with the routing of drug administration are given special attention. In addition, an up-to-date view is presented on the use of nanomedicines against severe diseases, such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, and metabolic diseases. The chapters analyze the key factors that need to be controlled to achieve the optimum therapeutic effect. Attention is further given to gene delivery and the recent concept of nanotheranosis.

Nanopharmaceutics

Xing-Jie Liang
Nanopharmaceutics Book PDF

Author : Xing-Jie Liang
Publisher : World Scientific
Page : 605 pages
File Size : 54,7 Mb
Release : 2013
Category : Medical
ISBN : 9789814368667

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Nanopharmaceutics by Xing-Jie Liang Pdf

Nanomaterials, with their unique size-dependent physical and chemical properties, have shown promising advantages as drug and gene delivery vehicles, ultra-sensitive intracellular detectors and novel therapeutic drugs. Nanopharmaceutics is one of the disciplines that will benefit the most from this technology. Nanotechnology will have a revolutionary impact on cancer diagnosis and therapy due to the exceptional characteristics of nanopharmaceutics. This book provides an overview of some tools, methods, and materials of nanotechnology that offer potential applications in pharmaceutics, followed by a series of examples showing applications that are already in development. It may very well inspire researchers to develop a new generation of pharmaceutics with inventive non-traditional approach and employ nanoscale science for the benefit of the patient.

Advances in Nanotechnology-Based Drug Delivery Systems

Anupam Das Talukdar,Satyajit Dey Sarker,Jayanta Kumar Patra
Advances in Nanotechnology Based Drug Delivery Systems Book PDF

Author : Anupam Das Talukdar,Satyajit Dey Sarker,Jayanta Kumar Patra
Publisher : Elsevier
Page : 672 pages
File Size : 54,8 Mb
Release : 2022-06-06
Category : Technology & Engineering
ISBN : 9780323904148

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Advances in Nanotechnology-Based Drug Delivery Systems by Anupam Das Talukdar,Satyajit Dey Sarker,Jayanta Kumar Patra Pdf

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more

Post-genomic Approaches in Cancer and Nano Medicine

Kishore R. Sakharkar,Meena K. Sakharkar,Ramesh Chandra
Post genomic Approaches in Cancer and Nano Medicine Book PDF

Author : Kishore R. Sakharkar,Meena K. Sakharkar,Ramesh Chandra
Publisher : CRC Press
Page : 385 pages
File Size : 53,6 Mb
Release : 2022-09-01
Category : Health & Fitness
ISBN : 9781000794878

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Post-genomic Approaches in Cancer and Nano Medicine by Kishore R. Sakharkar,Meena K. Sakharkar,Ramesh Chandra Pdf

Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. A substantial proportion of human genes show alternative splicing and mis-regulation of Pre-mRNA splicing is seen in several cancers.This book further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing, and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving towards revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs. Technical topics discussed in the book include: • Alternative splicing and cancer• Cancer imaging• Nanomaterials in infectious diseases• Nanomedicine in oxidative stress and cancer• Nanoparticle based drug delivery systems

Nanoparticles in Life Sciences and Biomedicine

Ana Rute Neves,Salette Reis
Nanoparticles in Life Sciences and Biomedicine Book PDF

Author : Ana Rute Neves,Salette Reis
Publisher : CRC Press
Page : 552 pages
File Size : 52,7 Mb
Release : 2018-02-13
Category : Medical
ISBN : 9781351207348

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Nanoparticles in Life Sciences and Biomedicine by Ana Rute Neves,Salette Reis Pdf

The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles, such as nanoemulsions, liposomes, nanocrystals, and nanocomplexes, applied in the diagnosis, treatment, or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and, following a multidisciplinary approach, presents new strategies for drug delivery, including aspects from chemistry, physics, biology, and imaging methodologies and exploiting several administration routes, internalization pathways, site-specific delivery strategies, and the potential cytotoxicity of nanoparticles. Beginning with a description of the importance and application of nanotechnology for enhancing existing therapy, the book moves on to detailing oral, topical, pulmonary, brain, cancer, and anti-inflammatory drug delivery approaches; gene delivery approaches; theranostic approaches; and nanoparticle cytotoxicity. Practical and user friendly, it is suitable for advanced undergraduate, graduate, and postgraduate students of nanoscience and nanotechnology; researchers in nanoscience, nanotechnology, chemistry, biology, biochemistry, pharmaceutical sciences, medicine, and bioengineering, especially those with an interest in drug delivery or theranostics; and academia and university readership.

Nanoparticulates as Drug Carriers

V. P. Torchilin
Nanoparticulates as Drug Carriers Book PDF

Author : V. P. Torchilin
Publisher : Imperial College Press
Page : 758 pages
File Size : 48,8 Mb
Release : 2006
Category : Technology & Engineering
ISBN : 9781860949074

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Nanoparticulates as Drug Carriers by V. P. Torchilin Pdf

Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."