Nanotherapy For Brain Tumor Drug Delivery

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Nanotherapy for Brain Tumor Drug Delivery

Vivek Agrahari,Anthony Kim,Vibhuti Agrahari

Author : Vivek Agrahari,Anthony Kim,Vibhuti Agrahari
Publisher : Humana
Page : 0 pages
File Size : 43,8 Mb
Release : 2020-12-01
Category : Medical
ISBN : 1071610511

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Nanotherapy for Brain Tumor Drug Delivery by Vivek Agrahari,Anthony Kim,Vibhuti Agrahari Pdf

This volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR/Cas9 delivery vehicle. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Nanotherapy for Brain Tumor Drug Delivery is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors.

Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications

Ram Kumar Sahu

Author : Ram Kumar Sahu
Publisher : Bentham Science Publishers
Page : 240 pages
File Size : 53,9 Mb
Release : 2023-09-02
Category : Medical
ISBN : 9789815079739

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Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications by Ram Kumar Sahu Pdf

Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications is a comprehensive reference focused on the latest advancements in nanotechnology for brain tumor therapy. With practical insights and cutting-edge research, this book equips readers with the knowledge to develop innovative drug delivery systems for effective brain tumor diagnosis and treatment. Structured into insightful chapters, this book covers the anatomy, physiology, and pathophysiology of the brain, addressing barriers to targeted drug delivery strategies. Chapters explore theranostics-based delivery systems, including polymeric nanoparticles, liposomes, dendrimers, nanoemulsions, micelles, and inorganic nanoparticles, for precise brain tumor diagnosis and treatment. This informative resource is designed for students and research scholars in pharmacology, pharmaceutical industry scientists, professors, and clinical medicine researchers. With comprehensive chapters and references for further reading, this book facilitates easy understanding of the intricate nanomedical technology, empowering researchers to make significant strides in the field of brain tumor therapy. Key Features: Structured chapters for easy understanding of nanotechnology concepts In-depth coverage of theranostics-based delivery systems for brain tumor diagnosis and treatment References for further reading and exploring new advances in drug delivery systems

Application of Nanoparticles in Brain Tumor Treatment

Gerardo Caruso

Author : Gerardo Caruso
Publisher : Momentum Press
Page : 80 pages
File Size : 40,9 Mb
Release : 2012-08-10
Category : Technology & Engineering
ISBN : 9781606504222

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Application of Nanoparticles in Brain Tumor Treatment by Gerardo Caruso Pdf

Despite progress in surgery, radiotherapy, and chemotherapy, an effective treatment of gliomas does not yet exist. This new monograph in the ASME-Momentum Press series on Biomedical & Nanomedical Technologies book shows how nanotechnology could be used both to improve the treatment efficacy and to reduce the adverse side effects. It will explain how nanotechnology-based approaches to targeted delivery of drugs across the brain-blood barrier may potentially be engineered to carry out specific functions as needed.

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors

Prashant Kesharwani,Umesh Gupta

Author : Prashant Kesharwani,Umesh Gupta
Publisher : Academic Press
Page : 478 pages
File Size : 50,8 Mb
Release : 2018-04-20
Category : Medical
ISBN : 9780128122495

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Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors by Prashant Kesharwani,Umesh Gupta Pdf

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Nanoarchitectonics for Brain Drug Delivery

Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh

Author : Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh
Publisher : CRC Press
Page : 381 pages
File Size : 52,8 Mb
Release : 2024-02-22
Category : Technology & Engineering
ISBN : 9781003851844

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Nanoarchitectonics for Brain Drug Delivery by Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh Pdf

This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoretical aspects of advanced drug-delivery systems for brain diseases including challenges and progress in nose-to-brain delivery Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.

Nanoparticles for Brain Drug Delivery

Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais

Author : Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais
Publisher : CRC Press
Page : 518 pages
File Size : 51,7 Mb
Release : 2021-03-15
Category : Medical
ISBN : 9781000245592

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Nanoparticles for Brain Drug Delivery by Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais Pdf

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Nanocarriers for Brain Targeting

Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani

Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 512 pages
File Size : 45,7 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9780429877544

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Nanocarriers for Brain Targeting by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Nanocarriers for Drug-Targeting Brain Tumors

Lalit Kumar,Yashwant Pathak

Author : Lalit Kumar,Yashwant Pathak
Publisher : Elsevier
Page : 864 pages
File Size : 46,9 Mb
Release : 2022-06-21
Category : Technology & Engineering
ISBN : 9780323914710

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Nanocarriers for Drug-Targeting Brain Tumors by Lalit Kumar,Yashwant Pathak Pdf

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors

Nanoparticle Drug Delivery Systems for Cancer Treatment

Hala Gali-Muhtasib,Racha Chouaib

Author : Hala Gali-Muhtasib,Racha Chouaib
Publisher : CRC Press
Page : 342 pages
File Size : 49,7 Mb
Release : 2020-02-19
Category : Medical
ISBN : 9781000680874

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Nanoparticle Drug Delivery Systems for Cancer Treatment by Hala Gali-Muhtasib,Racha Chouaib Pdf

In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Nanotechnology Methods for Neurological Diseases and Brain Tumors

Yasemin Gürsoy Özdemir,Sibel Bozdag Pehlivan,Emine Sekerdag

Author : Yasemin Gürsoy Özdemir,Sibel Bozdag Pehlivan,Emine Sekerdag
Publisher : Academic Press
Page : 378 pages
File Size : 44,9 Mb
Release : 2017-07-14
Category : Medical
ISBN : 9780128038000

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Nanotechnology Methods for Neurological Diseases and Brain Tumors by Yasemin Gürsoy Özdemir,Sibel Bozdag Pehlivan,Emine Sekerdag Pdf

Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors. Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier Written in a language that makes it easy to understand nanotechnology drug delivery techniques Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors

Nano Drug Delivery Strategies for the Treatment of Cancers

Awesh K. Yadav,Umesh Gupta,Rajeev Sharma

Author : Awesh K. Yadav,Umesh Gupta,Rajeev Sharma
Publisher : Academic Press
Page : 374 pages
File Size : 44,9 Mb
Release : 2020-09-03
Category : Science
ISBN : 9780128197943

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Nano Drug Delivery Strategies for the Treatment of Cancers by Awesh K. Yadav,Umesh Gupta,Rajeev Sharma Pdf

Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles

Brain Tumor and Nanotechnology

Rishabha Malviya,Arun Kumar Singh,Sonali Sundram

Author : Rishabha Malviya,Arun Kumar Singh,Sonali Sundram
Publisher : CRC Press
Page : 253 pages
File Size : 41,9 Mb
Release : 2024-08-09
Category : Technology & Engineering
ISBN : 9781040120828

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Brain Tumor and Nanotechnology by Rishabha Malviya,Arun Kumar Singh,Sonali Sundram Pdf

Brain Tumors and Nanotechnology explores the complex world of brain tumors and the ground-breaking role that nanotechnology is playing in both detection and treatment. It offers comprehensive and up-to-date strategies in the treatment of brain tumors, with a special emphasis on the revolutionary impact of nanotechnology. It begins with an in-depth analysis of the anatomy of the brain and nervous system, highlighting the constituents of the central nervous system (CNS) such as neurons and glial cells. It also offers a thorough understanding of the intricate structure of the human brain, including the hemispheres, brainstem, diencephalon, and ventricular system. It then reveals the understanding of the complicated nature of brain tumors and the potential for nanotechnology to revolutionize their diagnosis and treatment. Brain Tumors and Nanotechnology will be a longstanding valuable resource for researchers, medical professionals, and students in the field.

Nanoparticles and Brain Tumor Treatment

Gerardo Caruso,Maria Caffo,Giuseppe Raudino,Francesco Tomasello

Author : Gerardo Caruso,Maria Caffo,Giuseppe Raudino,Francesco Tomasello
Publisher : Unknown
Page : 99 pages
File Size : 45,7 Mb
Release : 2012
Category : Brain
ISBN : OCLC:872150379

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Nanoparticles and Brain Tumor Treatment by Gerardo Caruso,Maria Caffo,Giuseppe Raudino,Francesco Tomasello Pdf

Despite progress in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of gliomas does not yet exist. Mortality is still close to 100% and the average survival of patients with GBM is less than 1 year. The efficacy of current anti-cancer strategies in brain tumors is limited by the lack of specific therapies against malignant cells. Besides, the delivery of the drugs to brain tumors is limited by the presence of the blood brain barrier. The oncogenesis of gliomas is characterized by several biological processes and genetic alterations, involved in the neoplastic transformation. The modulation of gene expression to more levels, such as DNA, mRNA, proteins and transduction signal pathways, may be the most effective modality to down-regulate or silence some specific gene functions. Gliomas are characterized by extensive microvascular proliferation and a higher degree of vasculature. In malignant gliomas targeted therapies efficacy is low. In this complex field, it seems to be very important to improve specific selective drugs delivery systems. Drugs, antisense oligonucleotides, small interference RNAs, engineered monoclonal antibodies and other therapeutic molecules may diffuse into CNS overcoming the BBB. Nanotechnology could be used both to improve the treatment efficacy and to reduce the adverse side effects. Nanotechnology-based approaches to targeted delivery of drugs across the BBB may potentially be engineered to carry out specific functions as needed. Moreover, nanoparticles show tumor-specific targeting and long blood circulation time, with consequent low-short-term toxicity. Nanotechnology deals with structures and devices that are emerging as a new field of research at the interface of science, engineering and medicine. Nanomedicine, the application of nanotechnology to healthcare, holds great promise for revolutionizing medical treatments, imaging, faster diagnosis, drug delivery and tissue regeneration.

Nanocarrier Based Targeted Drug Delivery for Treatment of Brain Tumor

Kudarha Ritu Rajkumar

Author : Kudarha Ritu Rajkumar
Publisher : Independent Author
Page : 0 pages
File Size : 48,6 Mb
Release : 2022-12-15
Category : Medical
ISBN : 6509109700

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Nanocarrier Based Targeted Drug Delivery for Treatment of Brain Tumor by Kudarha Ritu Rajkumar Pdf

Brain tumors refer to a heterogeneous group of primary and metastatic neoplasms in the central nervous system and are one of the life-threatening diseases which are characterized by low survival rate (1). According to GLOBOCAN 2018, nearly 296,851 new cases of brain and nervous system tumors and 241037 deaths are diagnosed in 2018 worldwide. In India 28142 new brain tumor cases annually are reported while deaths were 24003 in 2018 (2). The estimated incidence, mortality and 5 year prevalence of brain tumor among men in India is approximately 11855, 9574 and 17251 respectively which represents 2.5%, 2.7% and 2.6% of Indian population respectively while for women it is 6976 (1.3%), 5578 (1.7%) and 10157 (1%) respectively. More than 120 types of brain tumors are identified till date and depending on the origin of tumor, most common tumors are grouped as tumors of neuroepithelial tissue, tumors of cranial and spinal nerve, tumors of meninges, heamopoitic origin neoplasm and lymphomas, tumor of sellar region, germ cell tumors and cysts (3,4). The most prevalent brain tumors are intracranial metastases from systemic cancers, meningiomas, and gliomas, specifically, glioblastoma (1,5). Glioma is the most frequent primary brain cancer which accounts for 29% of all primary brain and CNS tumors and 80% of alignant brain tumors. These malignant gliomas are primary tumors that are derived from glial origin and account for approximately 70% of new primary brain cancer diagnosis. The classification, grading, and treatment of this diverse group of tumors have been primarily based on morphological criteria, which introduced a certain degree of interpretative subjectivity and moreover provided only suboptimal accuracy for the prediction of treatment response (6). WHO has classified glioma in three category viz. astrocytoma, oligodendrogliomas and mixed gliomas (oligoastrocyotomas). Amongst gliomas, glioblastomamultiforme (GBM) which is a grade IV astrocytoma according to the World Health Organization (WHO) classification, is the most common and aggressive form of glioma in nature (3,6). The median survival for glioblastoma is 14 months (7). The high mortality rate due to GBM can be attributed to specific properties of glioma which includes highly infiltrative nature and lack of clear margin. The existing therapy for GBM is nonspecific and almost fails to prevent reoccurrence of disease.

Brain Tumor Targeting Drug Delivery Systems

Ram Kumar Sahu

Author : Ram Kumar Sahu
Publisher : Bentham Science Publishers
Page : 0 pages
File Size : 50,9 Mb
Release : 2023-09-02
Category : Electronic
ISBN : 9815079743

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Brain Tumor Targeting Drug Delivery Systems by Ram Kumar Sahu Pdf

Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications is a comprehensive reference focused on the latest advancements in nanotechnology for brain tumor therapy. With practical insights and cutting-edge research, this book equips readers with the knowledge to develop innovative drug delivery systems for effective brain tumor diagnosis and treatment. Structured into insightful chapters, this book covers the anatomy, physiology, and pathophysiology of the brain, addressing barriers to targeted drug delivery strategies. Chapters explore theranostics-based delivery systems, including polymeric nanoparticles, liposomes, dendrimers, nanoemulsions, micelles, and inorganic nanoparticles, for precise brain tumor diagnosis and treatment. This informative resource is designed for students and research scholars in pharmacology, pharmaceutical industry scientists, professors, and clinical medicine researchers. With comprehensive chapters and references for further reading, this book facilitates easy understanding of the intricate nanomedical technology, empowering researchers to make significant strides in the field of brain tumor therapy. Key Features: -Structured chapters for easy understanding of nanotechnology concepts. -In-depth coverage of theranostics-based delivery systems for brain tumor diagnosis and treatment. -References for further reading and exploring new advances in drug delivery systems.

Nanotherapy For Brain Tumor Drug Delivery

Nanotherapy for Brain Tumor Drug Delivery by Vivek Agrahari,Anthony Kim,Vibhuti Agrahari Pdf

Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications by Ram Kumar Sahu Pdf

Application of Nanoparticles in Brain Tumor Treatment by Gerardo Caruso Pdf

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors by Prashant Kesharwani,Umesh Gupta Pdf

Nanoarchitectonics for Brain Drug Delivery by Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh Pdf

Nanoparticles for Brain Drug Delivery by Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais Pdf

Nanocarriers for Brain Targeting by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

Nanocarriers for Drug-Targeting Brain Tumors by Lalit Kumar,Yashwant Pathak Pdf

Nanoparticle Drug Delivery Systems for Cancer Treatment by Hala Gali-Muhtasib,Racha Chouaib Pdf

Nanotechnology Methods for Neurological Diseases and Brain Tumors by Yasemin Gürsoy Özdemir,Sibel Bozdag Pehlivan,Emine Sekerdag Pdf

Nano Drug Delivery Strategies for the Treatment of Cancers by Awesh K. Yadav,Umesh Gupta,Rajeev Sharma Pdf

Brain Tumor and Nanotechnology by Rishabha Malviya,Arun Kumar Singh,Sonali Sundram Pdf

Nanoparticles and Brain Tumor Treatment by Gerardo Caruso,Maria Caffo,Giuseppe Raudino,Francesco Tomasello Pdf

Nanocarrier Based Targeted Drug Delivery for Treatment of Brain Tumor by Kudarha Ritu Rajkumar Pdf

Brain Tumor Targeting Drug Delivery Systems by Ram Kumar Sahu Pdf

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