Natural Products And Neuroprotection

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Natural Products and Neuroprotection

Cristina Angeloni,David Vauzour
Natural Products and Neuroprotection Book PDF

Author : Cristina Angeloni,David Vauzour
Publisher : MDPI
Page : 338 pages
File Size : 46,9 Mb
Release : 2020-06-17
Category : Science
ISBN : 9783039362165

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Natural Products and Neuroprotection by Cristina Angeloni,David Vauzour Pdf

Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

Discovery and Development of Neuroprotective Agents from Natural Products

Goutam Brahmachari
Discovery and Development of Neuroprotective Agents from Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 490 pages
File Size : 55,9 Mb
Release : 2017-05-18
Category : Science
ISBN : 9780128097694

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Discovery and Development of Neuroprotective Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Natural Products and Neuroprotection

Cristina Angeloni,David Vauzour
Natural Products and Neuroprotection Book PDF

Author : Cristina Angeloni,David Vauzour
Publisher : Unknown
Page : 338 pages
File Size : 53,5 Mb
Release : 2020
Category : Electronic
ISBN : 3039362178

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Natural Products and Neuroprotection by Cristina Angeloni,David Vauzour Pdf

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

The Benefits of Natural Products for Neurodegenerative Diseases

M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
The Benefits of Natural Products for Neurodegenerative Diseases Book PDF

Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
Publisher : Springer
Page : 496 pages
File Size : 46,9 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9783319283838

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The Benefits of Natural Products for Neurodegenerative Diseases by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin Pdf

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Neuroprotective Natural Products

Goutam Brahmachari
Neuroprotective Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 51,8 Mb
Release : 2017-03-01
Category : Medical
ISBN : 9783527803804

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Neuroprotective Natural Products by Goutam Brahmachari Pdf

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Neuroprotection

Raymond Chuen-Chung Chang,Yuen-Shan Ho
Neuroprotection Book PDF

Author : Raymond Chuen-Chung Chang,Yuen-Shan Ho
Publisher : BoD – Books on Demand
Page : 104 pages
File Size : 51,7 Mb
Release : 2019-08-28
Category : Medical
ISBN : 9781789847369

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Neuroprotection by Raymond Chuen-Chung Chang,Yuen-Shan Ho Pdf

Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

Christophe Wiart
Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases Book PDF

Author : Christophe Wiart
Publisher : Academic Press
Page : 416 pages
File Size : 50,9 Mb
Release : 2013-12-16
Category : Medical
ISBN : 9780123983831

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Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases by Christophe Wiart Pdf

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Neuroprotection and Neurorestoration: Natural Medicinal Products in Preventing and Ameliorating Cognitive Impairment

Jianxun Liu,Guibo Sun,Dennis Chang,Qian Hua,Yehao Zhang
Neuroprotection and Neurorestoration Natural Medicinal Products in Preventing and Ameliorating Cognitive Impairment Book PDF

Author : Jianxun Liu,Guibo Sun,Dennis Chang,Qian Hua,Yehao Zhang
Publisher : Frontiers Media SA
Page : 215 pages
File Size : 42,7 Mb
Release : 2024-01-31
Category : Science
ISBN : 9782832543870

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Neuroprotection and Neurorestoration: Natural Medicinal Products in Preventing and Ameliorating Cognitive Impairment by Jianxun Liu,Guibo Sun,Dennis Chang,Qian Hua,Yehao Zhang Pdf

The value and therapeutic potential of medicinal plants as molecular sources has been demonstrated throughout history and remains an important resource for identifying novel drug leads. A major asset in medicinal plant drug discovery is the presence of ethnopharmacological information that provides clues to the therapeutic efficacy of compounds in humans. With the coming of an aging society, neurodegenerative conditions have arguably become the most dreaded maladies of the elderly. The latest idea is that some aspects of the aging process can be reversed at a younger age if the brain is malleable. If this idea is realized, it may also be possible to slow or reverse neurodegeneration and cognitive impairment. Natural medicines display promising neuroprotective and neuroreparatived properties in neurological diseases.

Nutraceuticals in Brain Health and Beyond

Dilip Ghosh
Nutraceuticals in Brain Health and Beyond Book PDF

Author : Dilip Ghosh
Publisher : Academic Press
Page : 476 pages
File Size : 42,6 Mb
Release : 2020-11-12
Category : Health & Fitness
ISBN : 9780128206102

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Nutraceuticals in Brain Health and Beyond by Dilip Ghosh Pdf

Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer’s, Parkinson’s, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health. Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. • Addresses nutritional psychiatry and cognitive health at all stages of the lifespan • Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients • Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders • Explores the role of genomics and epigenetics, including discussion of the gut–brain axis

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Tahira Farooqui,Akhlaq A. Farooqui
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases Book PDF

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Page : 484 pages
File Size : 55,9 Mb
Release : 2017-10-24
Category : Science
ISBN : 9780128119600

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Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease

Neurodegenerative Diseases

Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
Neurodegenerative Diseases Book PDF

Author : Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
Publisher : Springer
Page : 542 pages
File Size : 50,5 Mb
Release : 2017-07-03
Category : Medical
ISBN : 9783319571935

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Neurodegenerative Diseases by Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis Pdf

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Natural Products for Neurodegenerative Diseases

Yung Hou Wong,Joseph T. Y. Wong
Natural Products for Neurodegenerative Diseases Book PDF

Author : Yung Hou Wong,Joseph T. Y. Wong
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 48,9 Mb
Release : 2005
Category : Natural products
ISBN : 3805579330

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Natural Products for Neurodegenerative Diseases by Yung Hou Wong,Joseph T. Y. Wong Pdf

Natural products have long been used for the relief of neurological symptoms, yet their mechanisms of action remain elusive. Recent investigations have started to unveil the complex molecular events associated with the therapeutic effects of natural products in neurodegenerative diseases. In this publication, leading experts share their perspectives and latest research findings on the roles of natural products in neuroprotection and neuronal regeneration. Multifunctional properties of constituents of botanicals and their derivatives are discussed to illustrate the possibilities towards the development of effective multitarget therapeutics. Researchers in the fields of neuroscience, molecular biology, alternative medicine and pharmacology will find that this issue provides a useful overview of the various mechanisms underlying the therapeutic effects of natural products in neurodegenerative diseases.

Discovery and Development of Antidiabetic Agents from Natural Products

Goutam Brahmachari
Discovery and Development of Antidiabetic Agents from Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 332 pages
File Size : 53,9 Mb
Release : 2016-10-11
Category : Science
ISBN : 9780128096925

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Discovery and Development of Antidiabetic Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Neuroprotection

Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Neuroprotection Book PDF

Author : Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publisher : BoD – Books on Demand
Page : 350 pages
File Size : 52,6 Mb
Release : 2020-11-26
Category : Medical
ISBN : 9781838804398

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Neuroprotection by Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret Pdf

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Neuroprotective Effects of Phytochemicals in Neurological Disorders

Tahira Farooqui,Akhlaq A. Farooqui
Neuroprotective Effects of Phytochemicals in Neurological Disorders Book PDF

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 54,5 Mb
Release : 2017-01-03
Category : Medical
ISBN : 9781119155171

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Neuroprotective Effects of Phytochemicals in Neurological Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.