Neural Dynamics Of Neurological Disease

Author : Christopher A. Shaw
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 55,6 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9781118634578

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Neural Dynamics of Neurological Disease by Christopher A. Shaw Pdf

The emerging understanding of age-related neurological disorders suggests that notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders probably arise due to a unique intersection of multiple genetic and toxic factors, combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end-state disease, each is a spectrum disorder, and every individual case is therefore unique. Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how they arise and progress, and, crucially, what might be done to "cure" them. It first introduces the concept of neural dynamics of neurological disease, then examines various diseases and gives examples of the interplay of elements such as neural systems, cell types, and biochemical pathways that can contribute to disease. The concluding chapters point the way to how the emerging notion of neurological disease as a dynamic process may lead to more successful treatment options. Providing a cross-disciplinary approach to understanding the origin and progression of neurological disease, Neural Dynamics of Neurological Disease is a timely and valuable resource for neuroscientists, researchers, and clinicians.

Author : Christopher Ariel Shaw
Publisher : Unknown
Page : 128 pages
File Size : 44,6 Mb
Release : 2017
Category : Nervous system
ISBN : 1118634527

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Neural Dynamics of Neurological Disease by Christopher Ariel Shaw Pdf

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 51,7 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Author : Michel J.A.M. van Putten
Publisher : Springer Nature
Page : 259 pages
File Size : 51,8 Mb
Release : 2020-12-18
Category : Science
ISBN : 9783662611845

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Dynamics of Neural Networks by Michel J.A.M. van Putten Pdf

This book treats essentials from neurophysiology (Hodgkin–Huxley equations, synaptic transmission, prototype networks of neurons) and related mathematical concepts (dimensionality reductions, equilibria, bifurcations, limit cycles and phase plane analysis). This is subsequently applied in a clinical context, focusing on EEG generation, ischaemia, epilepsy and neurostimulation. The book is based on a graduate course taught by clinicians and mathematicians at the Institute of Technical Medicine at the University of Twente. Throughout the text, the author presents examples of neurological disorders in relation to applied mathematics to assist in disclosing various fundamental properties of the clinical reality at hand. Exercises are provided at the end of each chapter; answers are included. Basic knowledge of calculus, linear algebra, differential equations and familiarity with MATLAB or Python is assumed. Also, students should have some understanding of essentials of (clinical) neurophysiology, although most concepts are summarized in the first chapters. The audience includes advanced undergraduate or graduate students in Biomedical Engineering, Technical Medicine and Biology. Applied mathematicians may find pleasure in learning about the neurophysiology and clinic essentials applications. In addition, clinicians with an interest in dynamics of neural networks may find this book useful, too.

Author : Armin Fuchs,Viktor K. Jirsa
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 43,6 Mb
Release : 2007-12-11
Category : Technology & Engineering
ISBN : 9783540744795

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Coordination: Neural, Behavioral and Social Dynamics by Armin Fuchs,Viktor K. Jirsa Pdf

One of the most striking features of Coordination Dynamics is its interdisciplinary character. The problems we are trying to solve in this field range from behavioral phenomena of interlimb coordination and coordination between stimuli and movements (perception-action tasks) through neural activation patterns that can be observed during these tasks to clinical applications and social behavior. It is not surprising that close collaboration among scientists from different fields as psychology, kinesiology, neurology and even physics are imperative to deal with the enormous difficulties we are facing when we try to understand a system as complex as the human brain. The chapters in this volume are not simply write-ups of the lectures given by the experts at the meeting but are written in a way that they give sufficient introductory information to be comprehensible and useful for all interested scientists and students.

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 49,9 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : György Buzsáki,Yves Christen
Publisher : Springer
Page : 181 pages
File Size : 49,8 Mb
Release : 2016-05-02
Category : Medical
ISBN : 9783319288024

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Micro-, Meso- and Macro-Dynamics of the Brain by György Buzsáki,Yves Christen Pdf

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Author : Carl Faingold,Hal Blumenfeld
Publisher : Academic Press
Page : 537 pages
File Size : 51,7 Mb
Release : 2013-12-26
Category : Medical
ISBN : 9780124158641

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Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics by Carl Faingold,Hal Blumenfeld Pdf

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Author : György Buzsáki,Yves Christen
Publisher : Springer
Page : 172 pages
File Size : 55,6 Mb
Release : 2018-05-27
Category : Medical
ISBN : 3319804294

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Micro-, Meso- and Macro-Dynamics of the Brain by György Buzsáki,Yves Christen Pdf

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Author : Stefano Govoni,Pierluigi Politi,Emilio Vanoli
Publisher : Springer
Page : 0 pages
File Size : 50,6 Mb
Release : 2020-07-31
Category : Medical
ISBN : 3030280071

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Brain and Heart Dynamics by Stefano Govoni,Pierluigi Politi,Emilio Vanoli Pdf

This ambitious and comprehensive handbook represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, the book presents a variety of perspectives on the core topic: from social and philosophical to gender-related aspects. It is designed for a broad readership and includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease.

Author : Vassilis Cutsuridis
Publisher : Springer
Page : 0 pages
File Size : 40,7 Mb
Release : 2020-10-24
Category : Medical
ISBN : 3030188329

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Multiscale Models of Brain Disorders by Vassilis Cutsuridis Pdf

This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.

Author : Donald A. P. Bundy,Nilanthi de Silva,Susan Horton,Dean T. Jamison
Publisher : World Bank Publications
Page : 502 pages
File Size : 54,8 Mb
Release : 2017-11-20
Category : Medical
ISBN : 9781464804397

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Disease Control Priorities, Third Edition (Volume 8) by Donald A. P. Bundy,Nilanthi de Silva,Susan Horton,Dean T. Jamison Pdf

More children born today will survive to adulthood than at any time in history. It is now time to emphasize health and development in middle childhood and adolescence--developmental phases that are critical to health in adulthood and the next generation. Child and Adolescent Health and Development explores the benefits that accrue from sustained and targeted interventions across the first two decades of life. The volume outlines the investment case for effective, costed, and scalable interventions for low-resource settings, emphasizing the cross-sectoral role of education. This evidence base can guide policy makers in prioritizing actions to promote survival, health, cognition, and physical growth throughout childhood and adolescence.

Author : John Milton,Peter Jung
Publisher : Springer Science & Business Media
Page : 439 pages
File Size : 47,5 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662050484

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Epilepsy as a Dynamic Disease by John Milton,Peter Jung Pdf

The first book to bring together experts in epilepsy, bio-engineering and dynamical systems theory, to discuss the possibility of treating epilepsy by controlling mechanisms that cause seizures. It includes a unique reference database with more than 1000 references, including hard-to-access references in the Russian literature.

Author : Wulfram Gerstner,Werner M. Kistler,Richard Naud,Liam Paninski
Publisher : Cambridge University Press
Page : 591 pages
File Size : 41,5 Mb
Release : 2014-07-24
Category : Computers
ISBN : 9781107060838

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Neuronal Dynamics by Wulfram Gerstner,Werner M. Kistler,Richard Naud,Liam Paninski Pdf

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

Author : Institute of Medicine,Division of Biobehavioral Sciences and Mental Disorders,Division of Health Sciences Policy,Committee on a National Neural Circuitry Database
Publisher : National Academies Press
Page : 180 pages
File Size : 41,5 Mb
Release : 1991-02-01
Category : Computers
ISBN : 9780309044974

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Mapping the Brain and Its Functions by Institute of Medicine,Division of Biobehavioral Sciences and Mental Disorders,Division of Health Sciences Policy,Committee on a National Neural Circuitry Database Pdf

Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.