Neuronal Networks In Brain Function Cns Disorders And Therapeutics

Author : Carl Faingold,Hal Blumenfeld
Publisher : Academic Press
Page : 512 pages
File Size : 47,5 Mb
Release : 2013-12-26
Category : Medical
ISBN : 9780124158641

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Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics by Carl Faingold,Hal Blumenfeld Pdf

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Author : Roger D. Traub,Richard Miles
Publisher : Cambridge University Press
Page : 0 pages
File Size : 47,8 Mb
Release : 2008-05-29
Category : Medical
ISBN : 0521063310

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Neuronal Networks of the Hippocampus by Roger D. Traub,Richard Miles Pdf

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbors. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks.

Author : António Salgado
Publisher : Elsevier
Page : 712 pages
File Size : 48,6 Mb
Release : 2020-06-10
Category : Medical
ISBN : 9780128180853

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Handbook of Innovations in Central Nervous System Regenerative Medicine by António Salgado Pdf

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Author : Claire M. Lathers,Paul L. Schraeder,Jan E. Leestma,Braxton B. Wannamaker,Richard L. Verrier F.A.C.C. Ph.D.,Steven C. Schachter MD
Publisher : CRC Press
Page : 350 pages
File Size : 52,9 Mb
Release : 2015-04-06
Category : Law
ISBN : 9781482223880

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Sudden Unexpected Death in Epilepsy by Claire M. Lathers,Paul L. Schraeder,Jan E. Leestma,Braxton B. Wannamaker,Richard L. Verrier F.A.C.C. Ph.D.,Steven C. Schachter MD Pdf

Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classificatio

Author : Kim Heidenreich
Publisher : Academic Press
Page : 352 pages
File Size : 53,9 Mb
Release : 2016-09-27
Category : Medical
ISBN : 9780128027011

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New Therapeutics for Traumatic Brain Injury by Kim Heidenreich Pdf

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 53,6 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : Brian R. Noga,Mikhail Lebedev,Ioan Opris,Gordon S. Mitchell
Publisher : Frontiers Media SA
Page : 449 pages
File Size : 41,6 Mb
Release : 2020-03-25
Category : Electronic
ISBN : 9782889635757

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Neuromodulatory Control of Brainstem Function in Health and Disease by Brian R. Noga,Mikhail Lebedev,Ioan Opris,Gordon S. Mitchell Pdf

Author : Ioan Opris,Manuel F. Casanova
Publisher : Springer
Page : 782 pages
File Size : 44,8 Mb
Release : 2017-12-01
Category : Medical
ISBN : 9783319296746

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The Physics of the Mind and Brain Disorders by Ioan Opris,Manuel F. Casanova Pdf

This book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind. It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair. The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.

Author : Prashant Raghavan,Dheeraj Gandhi
Publisher : Elsevier Health Sciences
Page : 145 pages
File Size : 55,9 Mb
Release : 2016-07-27
Category : Medical
ISBN : 9780323444743

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Tinnitus: Imaging, Endovascular and Surgical Approaches, An issue of Neuroimaging Clinics of North America, E-Book by Prashant Raghavan,Dheeraj Gandhi Pdf

This issue of Neuroimaging Clinics of North America focuses on Imaging of Tinnitus. Articles will include: Neuroscience of Tinnitus; Clinical Evaluation of the Patient with Tinnitus; Arterial Abnormalities Leading to Tinnitus; Paragangliomas and Other Vascular Skull Base Tumors; Dural AV Fistulae: Imaging and Management; Venous Abnormalities Leading to Tinnitus: Imaging Evaluation; Endovascular Intervention in Venous Tinnitus: New Horizons and Future Directions; Emerging Role of Surgical Treatments in the Treatment of Tinnitus; Role of Advanced Neuroimaging and Future Directions; Imaging Interpretation of Temporal Bone Studies in a Patient with Tinnitus: A Systematic Approach; and much more!

Author : Sandro M. Krieg
Publisher : Springer
Page : 299 pages
File Size : 55,6 Mb
Release : 2017-07-03
Category : Medical
ISBN : 9783319549187

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Navigated Transcranial Magnetic Stimulation in Neurosurgery by Sandro M. Krieg Pdf

This book is the first comprehensive work summarizing the advances that have been made in the neurosurgical use of navigated transcranial magnetic stimulation (nTMS) over the past ten years. Having increasingly gained acceptance as a presurgical mapping modality in neurosurgery, today it is widely used for preoperative mapping of cortical motor and language function, risk stratification and improving the accuracy of subcortical fiber bundle visualization. This unique work will provide neurosurgeons and neuroscientists who are starting their nTMS program essential and detailed information on the technique and protocols, as well as the current clinical evidence on and limitations of the various applications of nTMS. At the same time, more experienced nTMS users looking for deeper insights into nTMS mapping and treatment in neurosurgery will find clearly structured, accessible information. The book was prepared by an international mix of authors, each of which was chosen for their status as a respected expert on the respective subtopic, as evinced by their landmark publications on nTMS.

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 118 pages
File Size : 43,8 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
Publisher : Academic Press
Page : 1178 pages
File Size : 45,5 Mb
Release : 2017-06-14
Category : Science
ISBN : 9780128040676

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Models of Seizures and Epilepsy by Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé Pdf

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Author : Anna Esposito,Marcos Faundez-Zanuy,Francesco Carlo Morabito,Eros Pasero
Publisher : Springer Nature
Page : 525 pages
File Size : 49,6 Mb
Release : 2019-09-18
Category : Technology & Engineering
ISBN : 9789811389504

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Neural Approaches to Dynamics of Signal Exchanges by Anna Esposito,Marcos Faundez-Zanuy,Francesco Carlo Morabito,Eros Pasero Pdf

The book presents research that contributes to the development of intelligent dialog systems to simplify diverse aspects of everyday life, such as medical diagnosis and entertainment. Covering major thematic areas: machine learning and artificial neural networks; algorithms and models; and social and biometric data for applications in human–computer interfaces, it discusses processing of audio-visual signals for the detection of user-perceived states, the latest scientific discoveries in processing verbal (lexicon, syntax, and pragmatics), auditory (voice, intonation, vocal expressions) and visual signals (gestures, body language, facial expressions), as well as algorithms for detecting communication disorders, remote health-status monitoring, sentiment and affect analysis, social behaviors and engagement. Further, it examines neural and machine learning algorithms for the implementation of advanced telecommunication systems, communication with people with special needs, emotion modulation by computer contents, advanced sensors for tracking changes in real-life and automatic systems, as well as the development of advanced human–computer interfaces. The book does not focus on solving a particular problem, but instead describes the results of research that has positive effects in different fields and applications.

Author : Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian
Publisher : Oxford University Press, USA
Page : 433 pages
File Size : 40,6 Mb
Release : 2014-12-02
Category : Medical
ISBN : 9780199965243

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Cognitive Plasticity in Neurologic Disorders by Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian Pdf

This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Author : Marat Akhmet
Publisher : Springer
Page : 360 pages
File Size : 47,7 Mb
Release : 2019-06-20
Category : Technology & Engineering
ISBN : 9783030205720

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Almost Periodicity, Chaos, and Asymptotic Equivalence by Marat Akhmet Pdf

The central subject of this book is Almost Periodic Oscillations, the most common oscillations in applications and the most intricate for mathematical analysis. Prof. Akhmet's lucid and rigorous examination proves these oscillations are a "regular" component of chaotic attractors. The book focuses on almost periodic functions, first of all, as Stable (asymptotically) solutions of differential equations of different types, presumably discontinuous; and, secondly, as non-isolated oscillations in chaotic sets. Finally, the author proves the existence of Almost Periodic Oscillations (asymptotic and bi-asymptotic) by asymptotic equivalence between systems. The book brings readers' attention to contemporary methods for considering oscillations as well as to methods with strong potential for study of chaos in the future. Providing three powerful instruments for mathematical research of oscillations where dynamics are observable and applied, the book is ideal for engineers as well as specialists in electronics, computer sciences, robotics, neural networks, artificial networks, and biology. Distinctively combines results and methods of the theory of differential equations with thorough investigation of chaotic dynamics with almost periodic ingredients; Provides all necessary mathematical basics in their most developed form, negating the need for any additional sources for readers to start work in the area; Presents a unique method of investigation of discontinuous almost periodic solutions in its unified form, employed to differential equations with different types of discontinuity; Develops the equivalence method to its ultimate effective state such that most important theoretical problems and practical applications can be analyzed by the method.