Neuroglia Molecular Mechanisms In Psychiatric Disorders

Author : Caterina Scuderi,Mami Noda,Alexei Verkhratsky
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 52,6 Mb
Release : 2019-01-21
Category : Electronic
ISBN : 9782889456987

Get Book

Neuroglia Molecular Mechanisms in Psychiatric Disorders by Caterina Scuderi,Mami Noda,Alexei Verkhratsky Pdf

Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 45,6 Mb
Release : 2019
Category : Electronic
ISBN : OCLC:1368445828

Get Book

Neuroglia Molecular Mechanisms in Psychiatric Disorders by Anonim Pdf

Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders.

Author : Ryan B. MacDonald,Stefanie Robel,Nathan Anthony Smith,Tim Czopka
Publisher : Frontiers Media SA
Page : 533 pages
File Size : 40,7 Mb
Release : 2023-04-11
Category : Science
ISBN : 9782832520406

Get Book

Molecular Mechanisms of Glia in Development and Disease by Ryan B. MacDonald,Stefanie Robel,Nathan Anthony Smith,Tim Czopka Pdf

Author : Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura
Publisher : Springer Nature
Page : 405 pages
File Size : 43,8 Mb
Release : 2019-10-03
Category : Medical
ISBN : 9789811399138

Get Book

Neuroglia in Neurodegenerative Diseases by Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura Pdf

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Author : Roger N. Rosenberg,Juan M. Pascual
Publisher : Academic Press
Page : 830 pages
File Size : 40,8 Mb
Release : 2020-06-24
Category : Medical
ISBN : 9780128138670

Get Book

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by Roger N. Rosenberg,Juan M. Pascual Pdf

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Provides comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease Presents detailed coverage of genomics, animal models and diagnostic methods, with new coverage on evaluating patients with biochemical abnormalities or gene mutations Includes new chapters on the pharmacogenomics of epilepsy and the most recent updates in molecular genetics, focusing on neurodegenerative and psychiatric diseases

Author : Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Publisher : Academic Press
Page : 1120 pages
File Size : 48,8 Mb
Release : 2011-11-02
Category : Science
ISBN : 9780080959016

Get Book

Basic Neurochemistry by Scott Brady,George Siegel,R. Wayne Albers,Donald Price Pdf

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Author : Marie-Ève Tremblay,Amanda Sierra
Publisher : Springer
Page : 486 pages
File Size : 47,8 Mb
Release : 2014-09-22
Category : Medical
ISBN : 9781493914296

Get Book

Microglia in Health and Disease by Marie-Ève Tremblay,Amanda Sierra Pdf

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Author : El-Mansoury, Bilal,El Hiba, Omar,Jayakumar, Arumugam Radhakrishnan
Publisher : IGI Global
Page : 613 pages
File Size : 44,6 Mb
Release : 2023-12-18
Category : Science
ISBN : 9781668496763

Get Book

Physiology and Function of Glial Cells in Health and Disease by El-Mansoury, Bilal,El Hiba, Omar,Jayakumar, Arumugam Radhakrishnan Pdf

Glial cells, including microglia, astrocytes, oligodendrocytes, and their progenitors NG2-glia, serve as key players in maintaining structural integrity and complex brain homeostasis. They actively participate in neurotransmission, energy metabolism, synaptic plasticity, neurogenesis, ion balance, immune defense, and the clearance of neuronal debris. However, the physiological functions of glial cells are often compromised in aging, neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, and multiple sclerosis, as well as in gliomas, brain tumors demanding specialized understanding for effective therapeutic interventions. Physiology and Function of Glial Cells in Health and Disease provides a comprehensive exploration of the vital role played by glial cells in maintaining neural homeostasis within the central nervous system (CNS). This book delves into the intricate interaction between glial cells and neurons, shedding light on their essential contributions to neural function and overall brain health. The book also highlights emerging research on astrocyte reprogramming for the management of neurodegenerative diseases, offering a glimpse into potential future therapies. This book is an essential resource for researchers, clinicians, and students in the field of neuroscience. Its academic tone, coupled with in-depth discussions and cutting-edge insights, makes it a valuable reference for anyone seeking a comprehensive understanding of the role of glial cells in both health and disease.

Author : Giovanni Cirillo,Andrea Beatriz Cragnolini,Livio Luongo
Publisher : Frontiers Media SA
Page : 149 pages
File Size : 48,6 Mb
Release : 2023-10-17
Category : Science
ISBN : 9782832536636

Get Book

Glial Cells, Maladaptive Plasticity and Neurodegeneration: Mechanisms, Targeted Therapies and Future Directions by Giovanni Cirillo,Andrea Beatriz Cragnolini,Livio Luongo Pdf

Author : Anonim
Publisher : Unknown
Page : 1398 pages
File Size : 49,7 Mb
Release : 1987
Category : Medicine
ISBN : STANFORD:36105021766048

Get Book

Biomedical Index to PHS-supported Research by Anonim Pdf

Author : Robert Perneczky
Publisher : Humana Press
Page : 372 pages
File Size : 50,5 Mb
Release : 2018-03-07
Category : Medical
ISBN : 1493977032

Get Book

Biomarkers for Alzheimer’s Disease Drug Development by Robert Perneczky Pdf

This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.

Author : Roger S McIntyre
Publisher : Elsevier Health Sciences
Page : 202 pages
File Size : 42,5 Mb
Release : 2019-08-25
Category : Medical
ISBN : 9780323581325

Get Book

Major Depressive Disorder by Roger S McIntyre Pdf

Get a quick, expert overview of the key issues surrounding best practices and current consensus on major depressive disorder (MDD). This concise resource by Drs. Roger S. McIntyre, Carola Rong, Mehala Subramaniapillai, and Yena Lee consolidates today’s available information on this complex topic into one convenient resource, making it an ideal, easy-to-digest reference for both psychiatrists and primary care physicians. Covers genetics and epigenetics, brain structural abnormalities, cognition, neuroendocrine alterations, and inflammatory abnormalities as they relate to MDD. Contains chapters on psychiatric comorbidity, pharmacological treatments, neuromodulatory treatments, lifestyle interventions, internet-based/technology-based interventions, and glutamate alterations.

Author : Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi
Publisher : Springer Nature
Page : 368 pages
File Size : 54,6 Mb
Release : 2021-12-09
Category : Medical
ISBN : 9783030773755

Get Book

Astrocytes in Psychiatric Disorders by Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi Pdf

This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.

Author : Chengjin Gao,Shuming Pan,Kun Xiong
Publisher : Frontiers Media SA
Page : 355 pages
File Size : 45,5 Mb
Release : 2024-03-19
Category : Medical
ISBN : 9782832546529

Get Book

Characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases by Chengjin Gao,Shuming Pan,Kun Xiong Pdf

The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and γδ T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases.

Author : Takahiro A. Kato,Aye M. Myint,Johann Steiner
Publisher : Frontiers Media SA
Page : 277 pages
File Size : 51,7 Mb
Release : 2017-05-03
Category : Electronic book
ISBN : 9782889451579

Get Book

Minding Glial Cells in the Novel Understandings of Mental Illness by Takahiro A. Kato,Aye M. Myint,Johann Steiner Pdf

Traditionally, abnormalities of neurons and neuronal networks including synaptic abnormalities and disturbance of neurotransmitters have dominantly been believed to be the main causes of psychiatric disorders. Recent cellular neuroscience has revealed various unknown roles of glial cells such as astrocytes, oligodendrocytes and microglia. These glial cells have proved to continuously contact with neurons /synapses, and have been shown to play important roles in brain development, homeostasis and various brain functions. Beyond the classic neuronal doctrine, accumulating evidence has suggested that abnormalities and disturbances of neuron-glia crosstalk may induce psychiatric disorders, while these mechanisms have not been well understood. This Research Topic of the Frontiers in Cellular Neuroscience will focus on the most recent developments and ideas in the study of glial cells (astrocytes, oligodendrocytes and microglia) focusing on psychiatric disorders such as schizophrenia, mood disorders and autism. Not only molecular, cellular and pharmacological approaches using in vitro / in vivo experimental methods but also translational research approaches are welcome. Novel translational research approaches, for example, using novel techniques such as induced pluripotent stem (iPS) cells, may lead to novel solutions. We believe that investigations to clarify the correlation between glial cells and psychiatric disorders contribute to a novel understanding of the pathophysiology of these disorders and the development of effective treatment strategies.