Neuroinflammation And Cns Disorders

Author : Nicola Woodroofe,Sandra Amor
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 44,9 Mb
Release : 2014-04-15
Category : Medical
ISBN : 9781118406540

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Neuroinflammation and CNS Disorders by Nicola Woodroofe,Sandra Amor Pdf

The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system. Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 89 pages
File Size : 46,5 Mb
Release : 2018-03-16
Category : Medical
ISBN : 9780309463652

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Biomarkers of Neuroinflammation by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Author : Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia
Publisher : Frontiers Media SA
Page : 396 pages
File Size : 55,7 Mb
Release : 2022-01-20
Category : Science
ISBN : 9782889741076

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Targeting Neuroinflammation in Central Nervous System Disorders: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments by Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia Pdf

Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Page : 600 pages
File Size : 40,9 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9781493910717

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Neuroinflammation and Neurodegeneration by Phillip K. Peterson,Michal Toborek Pdf

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Author : Alireza Minagar,J. Steven Alexander
Publisher : Humana Press
Page : 281 pages
File Size : 50,9 Mb
Release : 2017-03-20
Category : Medical
ISBN : 9783319512204

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Inflammatory Disorders of the Nervous System by Alireza Minagar,J. Steven Alexander Pdf

This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.

Author : Nihar Jana,Anirban Basu,Prakash Narain Tandon
Publisher : Springer
Page : 345 pages
File Size : 52,6 Mb
Release : 2016-08-13
Category : Medical
ISBN : 9789811017117

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Inflammation: the Common Link in Brain Pathologies by Nihar Jana,Anirban Basu,Prakash Narain Tandon Pdf

This unifying theme of this book-with sections on mechanisms of defense and neuropathogenesis, neurological diseases, infections of the nervous system, neuropharmacology, and novel therapies-is interactions of the immune and nervous systems. It also discusses the role of inflammation as a key mediator of different brain disorders. There have been significant scientific advances in the multidisciplinary field of neuroimmunology / neuroinflammation in the past decade, and this book, edited under the guidance of Professor P. N. Tandon, fosters communication between those who share an interest in this exciting area, including neuroscientists, immunologists, cell biologists, clinicians and neuropharmacologists.

Author : Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes
Publisher : Frontiers Media SA
Page : 282 pages
File Size : 45,5 Mb
Release : 2020-07-14
Category : Electronic
ISBN : 9782889638543

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Neuroinflammation and its Resolution: From Molecular Mechanisms to Therapeutic Perspectives by Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes Pdf

Author : Paul L. Wood
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 49,7 Mb
Release : 1997-10-24
Category : Medical
ISBN : 9781592594733

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Neuroinflammation by Paul L. Wood Pdf

An unprecedented review of our current knowledge of the neuroinflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of our current concepts of which biochemical mediators are involved in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine those areas of current research involved in the design of specific pharmacological agents to inhibit at defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and disease model actions of first-generation agents, as well as the potential clinical relevance to AIDS-related dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.

Author : Alireza Minagar
Publisher : Elsevier
Page : 540 pages
File Size : 55,9 Mb
Release : 2010-12-17
Category : Science
ISBN : 0123849144

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Neuroinflammation by Alireza Minagar Pdf

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Author : Yu Tang,Xuping Li,Xiaobo Mao
Publisher : Frontiers Media SA
Page : 202 pages
File Size : 40,5 Mb
Release : 2020-01-15
Category : Electronic
ISBN : 9782889634101

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Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases by Yu Tang,Xuping Li,Xiaobo Mao Pdf

Author : Luba Sominsky,Adam K. Walker,Deborah M. Hodgson
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 54,5 Mb
Release : 2015-07-21
Category : Electronic book
ISBN : 9782889196029

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Neuroinflammation and Behaviour by Luba Sominsky,Adam K. Walker,Deborah M. Hodgson Pdf

The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 334 pages
File Size : 55,6 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9780323884617

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Neuroinflammation, Resolution, and Neuroprotection in the Brain by Akhlaq A. Farooqui Pdf

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation

Author : Ashok Kumar,Brandi K Ormerod,Yogesh Dwivedi,Jakob W Streit
Publisher : Frontiers Media SA
Page : 191 pages
File Size : 49,8 Mb
Release : 2019-03-22
Category : Electronic
ISBN : 9782889457601

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Neuroinflammation and Cognition by Ashok Kumar,Brandi K Ormerod,Yogesh Dwivedi,Jakob W Streit Pdf

Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 40,9 Mb
Release : 2016-04-11
Category : Science
ISBN : 9781118832486

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Author : Thomas E. Lane,Monica Carson,Conni Bergmann,Tony Wyss-Coray
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 52,9 Mb
Release : 2007-12-24
Category : Medical
ISBN : 9780387738949

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Central Nervous System Diseases and Inflammation by Thomas E. Lane,Monica Carson,Conni Bergmann,Tony Wyss-Coray Pdf

Edited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book’s unique organization provides a concise overview of inflammatory CNS disease.