Neuroinflammatory Mechanisms In Alzheimer S Disease

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Neuroinflammatory Mechanisms in Alzheimer’s Disease

Author : Joseph Rogers
Publisher : Birkhäuser
Page : 266 pages
File Size : 48,5 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9783034883504

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Neuroinflammatory Mechanisms in Alzheimer’s Disease by Joseph Rogers Pdf

Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be useful to delay the onset or slow the progression of the disorder. Moreover, virtually all the major systems of the innate immune response appear to be present, and most are upregulated, in pathologically-vulnerable regions of the AD brain. These new findings are described in this volume - first in overview form, followed by chapters on topics of special interest. In many ways, to understand AD brain inflammation, one need only review a text on peripheral inflammation biology, leaving out the chapters on humoral medi ators and substituting microglia for macrophages. In several other key respects, however, AD brain inflammation is unique, due primarily to idiosyncratic interac tions of inflammatory mediators and mechanisms with classical AD pathology: amyloid ~ peptide(A~) deposits and neurofibrillary tangles (NFTs). For this reason, some key concepts about the inflammation that occurs in AD may warrant discus sion in preparation for the more detailed chapters that follow.

Neuroinflammatory Mechanisms in Alzheimer's Disease

Author : Joseph Rogers (Ph.D.)
Publisher : Birkhauser
Page : 261 pages
File Size : 44,8 Mb
Release : 2001
Category : Alzheimer's disease
ISBN : 0817660747

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Neuroinflammatory Mechanisms in Alzheimer's Disease by Joseph Rogers (Ph.D.) Pdf

Neuroinflammation

Author : Paul L. Wood
Publisher : Springer Science & Business Media
Page : 411 pages
File Size : 51,5 Mb
Release : 2002-12-18
Category : Medical
ISBN : 9781592592975

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Neuroinflammation by Paul L. Wood Pdf

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Mechanisms of Neuroinflammation

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Page : 320 pages
File Size : 42,6 Mb
Release : 2017-08-23
Category : Medical
ISBN : 9789535134510

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Mechanisms of Neuroinflammation by Gonzalo Emiliano Aranda Abreu Pdf

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Neuroinflammation and its Resolution: From Molecular Mechanisms to Therapeutic Perspectives

Author : Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes
Publisher : Frontiers Media SA
Page : 282 pages
File Size : 46,7 Mb
Release : 2020-07-14
Category : Electronic
ISBN : 9782889638543

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Neuroinflammation and its Resolution: From Molecular Mechanisms to Therapeutic Perspectives by Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes Pdf

Biomarkers of Neuroinflammation

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 89 pages
File Size : 43,9 Mb
Release : 2018-03-16
Category : Medical
ISBN : 9780309463652

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Biomarkers of Neuroinflammation by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury

Author : Arthur Liesz,Christoph Kleinschnitz
Publisher : Frontiers Media SA
Page : 286 pages
File Size : 41,8 Mb
Release : 2015-11-13
Category : Electronic book
ISBN : 9782889196913

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Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury by Arthur Liesz,Christoph Kleinschnitz Pdf

Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.

Neuroinflammation and Neurodegeneration

Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Page : 606 pages
File Size : 42,6 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9781493910717

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Neuroinflammation and Neurodegeneration by Phillip K. Peterson,Michal Toborek Pdf

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Neuroinflammation and Behaviour

Author : Luba Sominsky,Adam K. Walker,Deborah M. Hodgson
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 47,8 Mb
Release : 2015-07-21
Category : Electronic book
ISBN : 9782889196029

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Neuroinflammation and Behaviour by Luba Sominsky,Adam K. Walker,Deborah M. Hodgson Pdf

The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.

The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration

Author : Fei Yin,Jia Yao,Roberta Diaz Brinton,Enrique Cadenas
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 55,6 Mb
Release : 2017-08-16
Category : Electronic book
ISBN : 9782889452538

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The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration by Fei Yin,Jia Yao,Roberta Diaz Brinton,Enrique Cadenas Pdf

Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.

Mechanisms of Neuroinflammation

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 41,7 Mb
Release : 19??
Category : Electronic
ISBN : 9535134523

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Mechanisms of Neuroinflammation by Anonim Pdf

Neuroinflammation — From Bench to Bedside

Author : H. Kettenmann,G. Burton,U. Moenning
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 46,6 Mb
Release : 2002-05-15
Category : Medical
ISBN : 3540430903

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Neuroinflammation — From Bench to Bedside by H. Kettenmann,G. Burton,U. Moenning Pdf

This book deals with the subject of neuroinflammation and attempts to take the reader on a journey from the bench to the bedside. The microglia and their response to brain injury as well as the importance of the chemokine family are discussed. The relevance of neuroinflammation in experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and multiple sclerosis is investigated before proceeding to clinical aspects of neuroinflammation and its involvement in human disease pathophysiology. The book provides an excellent introduction to the field of neuroinflammation and its involvement in human neurodegenerative disease.

Neuro-inflammation in Neuronal Death and Repair

Author : Giacinto Bagetta,Stuart Lipton,M. Tiziana Corasaniti
Publisher : Elsevier
Page : 499 pages
File Size : 45,7 Mb
Release : 2007-07-25
Category : Medical
ISBN : 9780080550565

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Neuro-inflammation in Neuronal Death and Repair by Giacinto Bagetta,Stuart Lipton,M. Tiziana Corasaniti Pdf

Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies.

Alzheimer’s Disease: Original Mechanisms and Translational Impact

Author : Cesare Mancuso,Silvana Gaetani
Publisher : Frontiers Media SA
Page : 221 pages
File Size : 49,7 Mb
Release : 2020-04-03
Category : Electronic
ISBN : 9782889636310

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Alzheimer’s Disease: Original Mechanisms and Translational Impact by Cesare Mancuso,Silvana Gaetani Pdf

Neuroinflammation

Author : Alireza Minagar
Publisher : Elsevier
Page : 540 pages
File Size : 46,5 Mb
Release : 2010-12-17
Category : Science
ISBN : 0123849144

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Neuroinflammation by Alireza Minagar Pdf

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities