Neuronal Death By Accident Or By Design

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Neuronal Death by Accident or by Design

C.E. Henderson,D. Green,J. Mariani,Y. Christen
Neuronal Death by Accident or by Design Book PDF

Author : C.E. Henderson,D. Green,J. Mariani,Y. Christen
Publisher : Springer Science & Business Media
Page : 162 pages
File Size : 42,5 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662043332

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Neuronal Death by Accident or by Design by C.E. Henderson,D. Green,J. Mariani,Y. Christen Pdf

Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

Discovering the Brain

National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Discovering the Brain Book PDF

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 40,7 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

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Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Cell Death

Gerry Melino,David Vaux
Cell Death Book PDF

Author : Gerry Melino,David Vaux
Publisher : John Wiley & Sons
Page : 316 pages
File Size : 40,6 Mb
Release : 2010-02-22
Category : Science
ISBN : 9780470686577

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Cell Death by Gerry Melino,David Vaux Pdf

This book on cell death contains 29 self-contained, peer-reviewed articles written by leading scientists in each field. It features overview articles aimed at undergraduates and non-specialists, which present basic information and provide entry into the following advanced articles. These advanced articles are written for postgraduate students and research workers, containing detailed information and key references allowing the reader to investigate a specific area in more depth. The book is an essential resource for educational purposes as well as a reference work for experienced researchers in the field. The articles will also be available electronically as part of the acclaimed Encyclopedia of Life Sciences (ELS). Key features: Provides a comprehensive overview on the research of programmed cell death. Edited by leaders in the field. Clearly written and illustrated articles. Full colour throughout. A spin-on to the acclaimed reference work, the Encyclopedia of Life Science (ELS). Combines introductory information with coverage of the latest discoveries in the field. Features overview level articles for advanced students or people new to a topic and more advanced articles for those requiring more detailed information. Serves as a reference work for advanced students as well as researchers in this field. Ideal library purchase for science, medical, and technology libraries in academia, government, and industry; medical libraries; networks and consortia covering these markets.

Biomimetic Materials And Design

Angela Dillow,Anthony Lowman
Biomimetic Materials And Design Book PDF

Author : Angela Dillow,Anthony Lowman
Publisher : CRC Press
Page : 609 pages
File Size : 49,7 Mb
Release : 2002-08-28
Category : Technology & Engineering
ISBN : 9780824743802

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Biomimetic Materials And Design by Angela Dillow,Anthony Lowman Pdf

Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Translational Research in Traumatic Brain Injury

Daniel Laskowitz,Gerald Grant
Translational Research in Traumatic Brain Injury Book PDF

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 49,5 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Regulated Cell Death Part A

Avi Ashkenazi,Junying Yuan,Jim Wells
Regulated Cell Death Part A Book PDF

Author : Avi Ashkenazi,Junying Yuan,Jim Wells
Publisher : Elsevier
Page : 504 pages
File Size : 48,7 Mb
Release : 2014-06-25
Category : Science
ISBN : 9780124171756

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Regulated Cell Death Part A by Avi Ashkenazi,Junying Yuan,Jim Wells Pdf

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Cell Death Signaling in Cancer Biology and Treatment

Daniel Johnson
Cell Death Signaling in Cancer Biology and Treatment Book PDF

Author : Daniel Johnson
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 52,5 Mb
Release : 2012-11-19
Category : Science
ISBN : 9781461458470

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Cell Death Signaling in Cancer Biology and Treatment by Daniel Johnson Pdf

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Mechanisms of Cell Death and Opportunities for Therapeutic Development

Diaqing Liao
Mechanisms of Cell Death and Opportunities for Therapeutic Development Book PDF

Author : Diaqing Liao
Publisher : Academic Press
Page : 298 pages
File Size : 47,9 Mb
Release : 2021-10-26
Category : Science
ISBN : 9780128142097

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Mechanisms of Cell Death and Opportunities for Therapeutic Development by Diaqing Liao Pdf

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Multiple Action-Based Design Approaches to Antibacterials

John Bremner
Multiple Action Based Design Approaches to Antibacterials Book PDF

Author : John Bremner
Publisher : Springer Nature
Page : 193 pages
File Size : 47,9 Mb
Release : 2021-04-05
Category : Technology & Engineering
ISBN : 9789811609992

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Multiple Action-Based Design Approaches to Antibacterials by John Bremner Pdf

This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.

Cell Physiology Source Book

Nicholas Sperelakis,Nick Sperelakis
Cell Physiology Source Book Book PDF

Author : Nicholas Sperelakis,Nick Sperelakis
Publisher : Gulf Professional Publishing
Page : 1272 pages
File Size : 55,7 Mb
Release : 2001-08-02
Category : Medical
ISBN : 0126569770

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Cell Physiology Source Book by Nicholas Sperelakis,Nick Sperelakis Pdf

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

Design of Multiphase Reactors

Vishwas G. Pangarkar
Design of Multiphase Reactors Book PDF

Author : Vishwas G. Pangarkar
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 48,7 Mb
Release : 2015-01-27
Category : Technology & Engineering
ISBN : 9781118807569

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Design of Multiphase Reactors by Vishwas G. Pangarkar Pdf

Details simple design methods for multiphase reactors in the chemical process industries Includes basic aspects of transport in multiphase reactors and the importance of relatively reliable and simple procedures for predicting mass transfer parameters Details of design and scale up aspects of several important types of multiphase reactors Examples illustrated through design methodologies presenting different reactors for reactions that are industrially important Includes simple spreadsheet packages rather than complex algorithms / programs or computational aid

Nonviral Vectors for Gene Therapy

Anonim
Nonviral Vectors for Gene Therapy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 428 pages
File Size : 47,7 Mb
Release : 2014-11-18
Category : Science
ISBN : 9780128003671

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Nonviral Vectors for Gene Therapy by Anonim Pdf

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes methods for testing with ethical, legal, and social implications Critically analyzes future directions Written and edited by recognized leaders in the field

Novel Designs of Early Phase Trials for Cancer Therapeutics

Shivaani Kummar,Chris Takimoto
Novel Designs of Early Phase Trials for Cancer Therapeutics Book PDF

Author : Shivaani Kummar,Chris Takimoto
Publisher : Academic Press
Page : 234 pages
File Size : 54,5 Mb
Release : 2018-05-22
Category : Medical
ISBN : 9780128125700

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Novel Designs of Early Phase Trials for Cancer Therapeutics by Shivaani Kummar,Chris Takimoto Pdf

Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development

Cell Physiology Sourcebook

Nicholas Sperelakis
Cell Physiology Sourcebook Book PDF

Author : Nicholas Sperelakis
Publisher : Elsevier
Page : 1235 pages
File Size : 40,9 Mb
Release : 2001-05-15
Category : Science
ISBN : 9780080528809

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Cell Physiology Sourcebook by Nicholas Sperelakis Pdf

This completely revised and updated source book provides comprehensive and authoritative coverage of cell physiology and membrane biophysics. Intended primarily as a text for advanced undergraduate and graduate students and as a reference for researchers, this multidisciplinary book includes several new chapters and is an invaluable aid to scientists interested in cell physiology, biophysics, cell biology, electrophysiology, and cell signaling. * Includes broad coverage of both animal and plant cells * Appendices review basics of the propagation of action potentials, electricity, and cable properties

Contemporary Experimental Design, Multivariate Analysis and Data Mining

Jianqing Fan,Jianxin Pan
Contemporary Experimental Design Multivariate Analysis and Data Mining Book PDF

Author : Jianqing Fan,Jianxin Pan
Publisher : Springer Nature
Page : 384 pages
File Size : 47,9 Mb
Release : 2020-05-22
Category : Mathematics
ISBN : 9783030461614

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Contemporary Experimental Design, Multivariate Analysis and Data Mining by Jianqing Fan,Jianxin Pan Pdf

The collection and analysis of data play an important role in many fields of science and technology, such as computational biology, quantitative finance, information engineering, machine learning, neuroscience, medicine, and the social sciences. Especially in the era of big data, researchers can easily collect data characterised by massive dimensions and complexity. In celebration of Professor Kai-Tai Fang’s 80th birthday, we present this book, which furthers new and exciting developments in modern statistical theories, methods and applications. The book features four review papers on Professor Fang’s numerous contributions to the fields of experimental design, multivariate analysis, data mining and education. It also contains twenty research articles contributed by prominent and active figures in their fields. The articles cover a wide range of important topics such as experimental design, multivariate analysis, data mining, hypothesis testing and statistical models.