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Author : Wenbo Zhang,Patrice E. Fort,Nan-Jie Xu
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 43,6 Mb
Release : 2020-01-23
Category : Electronic
ISBN : 9782889633456
Author : Charles E. Ribak PhD,Carlos Aramburo de la Hoz Phd,Edward G. Jones, PhD,Jorge A. Larriva Sahd, PhD,Larry W. Swanson PhD
Publisher : Oxford University Press
Page : 404 pages
File Size : 50,8 Mb
Release : 2009
Category : Medical
ISBN : 9780195369007
This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.
Author : F.W. Van Leeuwen,A. Salehi,R.J. Giger,A.J.G.D. Holtmaat,J. Verhaagen
Publisher : Elsevier
Page : 529 pages
File Size : 47,7 Mb
Release : 1998-11-09
Category : Science
ISBN : 008086242X
This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases. The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 48,8 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Author : Christopher Bell
Publisher : Unknown
Page : 128 pages
File Size : 43,8 Mb
Release : 2013-06-10
Category : Electronic
ISBN : 0444541160
This volume provides an up-to-date survey of current thinking concerning the actions of chemical factors in the regulation of neuronal behaviour under normal and pathological conditions. The book is divided into four sections, dealing with chemical factors involved with the formation of axon pathways, factors involved with neuronal survival and specialization during normal development, factors involved in normal maintenance and repair of adult neurons and, finally, factors that have been implicated as mediators of degenerative changes in neurological and neuropsychiatric disorders.
Author : Dale Purves,Jeff W. Lichtman
Publisher : Sinauer Associates, Incorporated
Page : 456 pages
File Size : 52,9 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015009519722
Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 51,5 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Author : Santiago Ramón y Cajal
Publisher : History of Neuroscience
Page : 977 pages
File Size : 47,6 Mb
Release : 1991
Category : Nervous system
ISBN : 9780195065169
This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.
Author : Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor)
Publisher : Cambridge University Press
Page : 693 pages
File Size : 49,7 Mb
Release : 2014
Category : Nervous system
ISBN : 9781107011670
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
Author : Kazuo Emoto,Rachel Wong,Eric Huang,Casper Hoogenraad
Publisher : Springer
Page : 0 pages
File Size : 51,9 Mb
Release : 2018-04-22
Category : Medical
ISBN : 443156764X
Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.
Author : Kurt Jellinger,Reinhold Schmidt,Manfred Windisch
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 53,6 Mb
Release : 2002-08-20
Category : Medical
ISBN : 3211837973
Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Author : Santiago Ramón y Cajal
Publisher : Unknown
Page : 128 pages
File Size : 48,8 Mb
Release : 1968
Category : Electronic
ISBN : OCLC:421811645
Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 52,9 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Author : Kjell Fuxe,Lars Olson,Yngve Zotterman
Publisher : Pergamon
Page : 624 pages
File Size : 52,6 Mb
Release : 1974
Category : Nervous system
ISBN : UOM:39015004417377
Dynamics of Degeneration and Growth in Neurons ...
Author : Tejbeer Kaur,Thomas Coate,Steven Haym Green
Publisher : Frontiers Media SA
Page : 246 pages
File Size : 52,9 Mb
Release : 2022-11-02
Category : Science
ISBN : 9782889746828
