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Cellular Receptors for Hormones and Neurotransmitters by Dennis Schulster,Alexander Levitzki Pdf
Provides up-to-date information on the subject as a whole, with sufficient key references to pursue details in those areas of specific interest. Gives basic concepts in receptor research. Features works of authors selected for their high international reputation and research achievements. Provides a summary of the field at graduate level.
An Introduction to Neuroendocrinology by Richard E. Brown Pdf
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Author : Ian S. Zagon,Patricia J. McLaughlin Publisher : Springer Science & Business Media Page : 268 pages File Size : 49,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9789401115445
Receptors in the Developing Nervous System by Ian S. Zagon,Patricia J. McLaughlin Pdf
Receptors for cell hormones, growth factors, Fourth, alterations in the development of neu and neurotransmitters are involved in the ral receptors may have profound implications control and modulation of an enormous array for the structure and function of the of biological processes. The development of organism. As much as possible, the reper these receptors has distinct spatial and tem cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum forming the circuitry of the nervous system.
Neurotransmitters And Anterior Pituitary Function by Giuseppe Nistico,Umberto Scapagnini Pdf
Neurotransmitters and Anterior Pituitary Function discusses research findings on neurotransmitter-neurohormone interactions in the control of the anterior pituitary. This book contains five chapters that specifically tackle the most salient constituents of the neural-endocrine communication system in mammals. This book deals first with the biochemistry, physiology, and pharmacology of proved or putative neurotransmitters, as well as some of the techniques used for determining their synthesis or turnover in the central nervous system (CNS) of experimental animals or in man. These topics are followed by a discussion on the principal functions of the most well-known neurotransmitter containing neurons based on sophisticated techniques for neurotransmitter measurements. A chapter highlights both traditional and a vast series of developed drugs that affect both neurotransmitter and neuroendocrine function. Discussions then shift to the experimental evidence on pituitary function control by the brain through releasing and inhibiting hormones secreted by hypothalamic neuroendocrine cells; the chemical isolation, identification, and synthesis of hypothalamic neurohormones; and concepts of their mechanism of action at the level of the pituitary cells. This text further explores the role of specific brain neurotransmitters in controlling pituitary hormone secretions in both experimental animals and in man and the possible CNS site(s) where neurotransmitters and neurohormones interact for the control of anterior pituitary secretion. The concluding chapter describes the actual or potential application of neuropharmacologic approaches to the diagnosis of and therapy for specific disorders of neuroendocrine function. Clinical neuroendocrinologists and researchers and students in neuroendocrinology, neurobiology, neuropharmacology, neurophysiology, and psychiatry will find this book invaluable.
Receptors in the Developing Nervous System by Ian S. Zagon,McLaughlin Pdf
Receptors for cell hormones, growth factors, Fourth, alterations in the development of and neurotransmitters are involved in the neural receptors may have profound implica control and modulation of an enormous array tions for the structure and function of the of biological processes. The development of organism. As much as possible, the reper these receptors has distinct spatial and tem cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum forming the circuitry of the nervous system.
The central theme of this book is that systems of cell-cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I also believe it to be unfortunate that there is not a collective term to describe neurotransmitters, hormones, local mediators and growth factors, other than clumsy phrases such as "extracellular signal molecule". The lack of a short and distinctive word for these entities genuinely hampers people from thinking about them in an integrated way. Having decided that it was presumptuous to invent a new term, I have chosen in this book the term first messenger to cover all types of extracellular signal molecule, because of the widespread acceptance of the term second messenger to represent the intracellular signal molecules that are produced in response to many of them. I have given the book the title "biochemical messengers", which is a global term to cover both first and second messengers. The impetus for writing the book came, as must often be the case, when I had to put together a course on cell-cell signalling for biochemistry students at the University of Dundee.
CNS Neurotransmitters and Neuromodulators by Trevor W. Stone Pdf
As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference. Well-known international authors have contributed up-to-date reviews covering a wide-range of interdisciplinary aspects of neuroactive steroid function. Specifically, this volume includes chapters dealing with the expression and properties of steroid receptors in the central nervous system (CNS); steroid interactions with amino acids, amines, and growth factors; electrophysiology; hypothalamic and feeding control; and the extremely topical issue of steroid influences on sexual differentiation of the brain. Neuroactive Steroids is an indispensable reference work for any researcher involved with steroids in the CNS, particularly in the areas of physiology, anatomy, neuropharmacology, neurochemistry, psychiatry, and molecular biology. In addition, it provides the perfect one-stop introduction for students.
Author : D. de Wied,P.A. van Keep Publisher : Springer Science & Business Media Page : 333 pages File Size : 46,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9789400987098
Hormones and the Brain by D. de Wied,P.A. van Keep Pdf
During the last decade it has become evident that the brain is an important target for hormones. Although it has been discovered only recently that the brain contains numerous peptide hormones, the role of pituitary and hypo thalamic hormones in brain activity has been the subject of basic studies for quite some time. Peptide hormones are involved in mental performance. pain perception, food and water metabolism. sleep. sexual behaviour and nursing behaviour, and disturbances in the hormonal climate of the brain may be associated with psychopathology. cognitive disturbances and. possibly. addic tion. The clinical influence of neurohypophysial hormones and their frag ments is studied today on learning and memory. on inadequate behaviour and addiction, in Parkinson's disease. Lesch-Nyhan syndrome. depression and schizophrenia. Fragments of adrenocorticotrophin have been shown to affect motivation, concentration and attention. and neuropeptides derived from ~-lipotrophin are probably involved in psychopathology. Thyrotrophin releasing hormone has been implicated in depression. and lutein-releasing hormone in sexual disturbances. In spite of the impressive experimental data; clinical results to date have been controversial and. to some extent. anecdotal. In some cases they have been exciting. and in others disappointing. It was against this background that the International Health Foundation decided to organize and sponsor their workshop on 'The brain as an endo crine target organ in health and disease' at which the papers appearing in this book were presented.
Receptor Purification is a unique practical two-volume guide to the purification of most receptor types including receptors for neurotransmitters polypeptide hormones steroid hormones and a variety of other ligands involved in many biological processes. Today's methods of receptor purification have evolved from years of research on the mechanisms of receptor actions where they were needed to discover receptor properties and ultimately for use in cloning. Receptor Purification provides a comprehensive source of techniques to enable the purification of cloned receptors as well as a handy reference on purification of receptors from cells and tissues in a physiological context. Designed to give investigators the best possible selection of approaches to a purification problem alternative methods are provided where applicable. In addition Receptor Purification features chapters on specific agents-such as covalent binding ligands-that will greatly simplify some purification processes. Many of the leading laboratories whose work has led to the purification of a wide variety of receptors are represented in the contributions to these two volumes. In some chapters information has been added on the applications of purified receptors while others focus on the cloning of the receptors. The purification of receptors is group-based on functional ligands. The first volume is devoted to the purification of receptors that bind neurotransmitters and a wide variety of polypeptide hormones. Volume 2 covers the steroid receptors and associated proteins such as vitamin D-3 and retinoic acid receptors. Other polypeptide receptors such as those involved in
