New Developments In The Pathogenesis Of Rheumatoid Arthritis

Author : Lazaros Sakkas
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 55,5 Mb
Release : 2017-02-22
Category : Medical
ISBN : 9789535129691

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New Developments in the Pathogenesis of Rheumatoid Arthritis by Lazaros Sakkas Pdf

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 46,9 Mb
Release : 19??
Category : Electronic
ISBN : 9535129708

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New Developments in the Pathogenesis of Rheumatoid Arthritis by Anonim Pdf

Author : Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman,Ellen M Gravallese
Publisher : Elsevier Health Sciences
Page : 1808 pages
File Size : 41,6 Mb
Release : 2018-01-08
Category : Medical
ISBN : 9780702073069

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Rheumatology E-Book by Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman,Ellen M Gravallese Pdf

Thoroughly revised and updated, the 7th Edition of Rheumatology remains a leading text in this fast-changing field, keeping you abreast of recent advances in medications, therapies, clinical trials, and much more. Dr. Mark Hochberg and his team of expert authors and editors cover everything you need to know -- from basic scientific principles to practical clinical management strategies, all in a user-friendly, accessible manner.

Author : Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman
Publisher : Elsevier Health Sciences
Page : 462 pages
File Size : 54,5 Mb
Release : 2008-11-07
Category : Medical
ISBN : 9780323071024

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Rheumatoid Arthritis E-Book by Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman Pdf

First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state-of-the-art reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It’s the guidance you need to offer optimal care to your patients with rheumatoid arthritis. Presents the work of leading international experts in rheumatoid arthritis for guidance you can trust. Provides the very latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures—disease activity, joint assessment, imaging, and more—for expert diagnosis and monitoring of disease progression. Examines evidence-based treatment options—including traditional and biologic DMARDs and combination therapies—as well as promising therapies on the horizon, placing up-to-date guidance on disease modifying or disease controlling agents at your fingertips.

Author : Paul-Peter Tak
Publisher : Springer Science & Business Media
Page : 233 pages
File Size : 44,6 Mb
Release : 2009-05-14
Category : Medical
ISBN : 9783764382384

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New Therapeutic Targets in Rheumatoid Arthritis by Paul-Peter Tak Pdf

This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.

Author : Chih-Hsin Tang
Publisher : MDPI
Page : 366 pages
File Size : 55,7 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9783038970651

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Research of Pathogenesis and Novel Therapeutics in Arthritis by Chih-Hsin Tang Pdf

Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.

Author : B. Henderson,J. G. Edwards,E. R. Pettipher
Publisher : Academic Press
Page : 548 pages
File Size : 44,9 Mb
Release : 1995-03-16
Category : Medical
ISBN : 0080536026

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Mechanisms and Models in Rheumatoid Arthritis by B. Henderson,J. G. Edwards,E. R. Pettipher Pdf

Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model. Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis. Key Features: * The book is divided into five sections: * The clinical spectrum, aetiopathogenesis, the role of microbial superantigens in pathology and the present and future therapies for rheumatoid arthritis * The pathology of rheumatoid arthritis, the development and role of synovial pannus and the use of immunohistochemistry in defining synovial pathology * Cell populations involved in synovitis with chapters on synovial cells, chondrocytes, bone cells, leukocytes and leukocyte trafficking * Mediators, with coverage of: cytokines and cytokine inhibitors, growth factors, free radicals and inflammatory lipid mediators, neuropeptides and proteases * Current studies on experimental models of rheumatoid arthritis

Author : Stefan Laufer,Steffen Gay,Kay Brune
Publisher : Georg Thieme Verlag
Page : 154 pages
File Size : 53,8 Mb
Release : 2003
Category : Medical
ISBN : 3131330910

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Inflammation and Rheumatic Diseases by Stefan Laufer,Steffen Gay,Kay Brune Pdf

This book is a useful guide for students, physicians in continuing education and practitioners who want to keep abreast of the latest developments in rheumatology. The chapters on the pathogenesis of rheumatoid arthritis and the biochemistry of inflammation present the latest research results in this field and are illustrated by a wealth of charts and tables. There follows practical and critical information on all drug groups that are currently used in the treatment of inflammatory rheumatic diseases and osteoarthritis. (Midwest).

Author : Paul Emery
Publisher : Unknown
Page : 0 pages
File Size : 55,5 Mb
Release : 2005
Category : Rheumatoid arthritis
ISBN : 141602767X

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Early Rheumatoid Arthritis by Paul Emery Pdf

This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.

Author : P. Miossec,W. van den Berg,G. Firestein
Publisher : Birkhäuser
Page : 236 pages
File Size : 54,6 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9783034888233

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T Cells in Arthritis by P. Miossec,W. van den Berg,G. Firestein Pdf

Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.

Author : John D. Isaacs,Larry W. Moreland
Publisher : Karger Medical and Scientific Publishers
Page : 118 pages
File Size : 44,8 Mb
Release : 2011-05-01
Category : Medical
ISBN : 9781905832910

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Fast Facts: Rheumatoid Arthritis by John D. Isaacs,Larry W. Moreland Pdf

This thoroughly updated second edition of 'Fast Facts: Rheumatoid Arthritis' provides an easy-to-read overview of how the condition is thought to develop and how it is diagnosed, monitored and treated. Written by two leading UK and US rheumatologists, it covers the many recent developments in this field, including: • Recently published classification criteria • The emerging role of anti-CCP autoantibodies • The latest developments in ultrasound and MRI • The association between RA and cardiovascular disease and lung disease • New concepts of undifferentiated arthritis and treatment to remission • The importance of early referral and new biological therapies 'Fast Facts: Rheumatoid Arthritis' provides a well-referenced international perspective on this condition. It is a 'must read' for all healthcare professionals caring for patients with this debilitating inflammatory joint disease. Contents: • The normal joint • Etiology • Pathogenesis • Epidemiology • Clinical features • Investigation • Assessment • Management - traditional measures • Management - biological therapies • Therapeutic developments

Author : David L. Scott,James Galloway,Andrew Cope,Arthur Pratt,Vibeke Strand
Publisher : Oxford University Press
Page : 576 pages
File Size : 40,7 Mb
Release : 2020-09-18
Category : Medical
ISBN : 9780192567109

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Oxford Textbook of Rheumatoid Arthritis by David L. Scott,James Galloway,Andrew Cope,Arthur Pratt,Vibeke Strand Pdf

This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA. During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments. Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.

Author : Rupesh K. Gautam,Lokesh Deb,Kamal Dua
Publisher : Bentham Science Publishers
Page : 292 pages
File Size : 53,8 Mb
Release : 2022-08-20
Category : Medical
ISBN : 9789815050783

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Natural Products for the Management of Arthritic Disorders by Rupesh K. Gautam,Lokesh Deb,Kamal Dua Pdf

Rheumatoid arthritis (RA) is the most common inflammatory complication and affects approximately 1 % of the global population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF‐α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not a cure for the complications, and antibody therapy and surgical procedures are expensive. However, in the present era, researchers and healthcare professionals have moved toward natural medicines obtained from plants and other natural sources. Research based on developments in phytomedicine has progressed steadily. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. Researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects. Natural Products for the Management of Arthritic Disorders compiles current knowledge about the bioactive compounds and herbal formulations useful in the treatment of rheumatoid arthritis. 11 chapters explain the role of natural products in the management of rheumatoid arthritis. Topics have been contributed by experts in medicinal chemistry and rheumatology. The book first introduces the reader to rheumatoid arthritis before delving into conventional and alternative therapies for the disease. The editors have also included special topics such as the biomarkers for RA, cytokines and anti-inflammatory mediators, preclinical and clinical studies. The range of topics should provide a comprehensive overview of natural remedies for arthritis and the role of natural products in anti-arthritic drug development. The information will be useful for many readers including medical and pharmacology students, multidisciplinary research scholars, scientists, pharma / herbal / food industrialists, and policy makers.

Author : Gary S. Firestein,Gabriel Stavros Panayi,Frank A. Wollheim
Publisher : Unknown
Page : 618 pages
File Size : 50,5 Mb
Release : 2000
Category : Medical
ISBN : UOM:39015050269011

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Rheumatoid Arthritis by Gary S. Firestein,Gabriel Stavros Panayi,Frank A. Wollheim Pdf

The old saying we now know all about rheumatoid arthritis except what causes it and how to cure it may still be true, but we certainly have a number of clues. This book presents the cutting edge of developments in etiology, mechanisms of inflammation, disease manifestations and management of this common, crippling disease.

Author : Philip Conaghan,Chris Denton,Helen Foster,John Isaacs
Publisher : Oxford University Press
Page : 1553 pages
File Size : 45,6 Mb
Release : 2013-10
Category : Medical
ISBN : 9780199642489

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Oxford Textbook of Rheumatology by Philip Conaghan,Chris Denton,Helen Foster,John Isaacs Pdf

A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.