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New Therapeutics for Traumatic Brain Injury by Kim Heidenreich Pdf
New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic
Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Institute of Medicine,Board on the Health of Select Populations
Author : Institute of Medicine,Board on the Health of Select Populations Publisher : National Academies Press Page : 71 pages File Size : 44,6 Mb Release : 2013-04-25 Category : Medical ISBN : 9780309267861
Cognitive Rehabilitation Therapy for Traumatic Brain Injury by Institute of Medicine,Board on the Health of Select Populations Pdf
In October 2011, the Institute of Medicine (IOM) released the report Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence, assessing the published evidence for the effectiveness of using cognitive rehabilitation therapy (CRT) to treat people with traumatic brain injury (TBI). TBI has gained increasing attention in the past 15 years because of its status as the signature wound of American military conflicts in Iraq and Afghanistan. Growing numbers of U.S. service members are suffering traumatic brain injuries and are surviving them, given that (a) the majority of traumatic brain injuries are mild and (b) lifesaving measures for more severe injuries have significantly improved. People with any level of injury can require ongoing health care in their recovery, helping them to regain (or compensate for) their losses of function and supporting their full integration into their social structure and an improved quality of life. One form of treatment for TBI is CRT, a systematic, goal-oriented approach to helping patients overcome cognitive impairments. The Department of Defense (DoD) asked the IOM to evaluate CRT for traumatic brain injury in order to guide the DoD's use and coverage in the Military Health System. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence was the IOM's resulting study of the evidence. The report's conclusions revolved around the fact that there is little continuity among research studies of the effectiveness of different types of CRT, and there exist only small amounts of evidence (or, in many cases, none) demonstrating the effectiveness of using CRT to treat TBI-although the evidence that does exist generally indicates that CRT interventions have some effectiveness. The workshop brought together experts in health services administration, research, and clinical practice from the civilian and military arenas in order to discuss the barriers for evaluating the effectiveness of CRT care and for identifying suggested taxonomy, terminology, timing, and ways forward for CRT researchers. The workshop consisted of individuals and was not intended to constitute a comprehensive group. Select decision makers in the Military Health System and Veterans Affairs (VA) and researchers were invited to participate. The workshop was designed to spur thinking about (1) the types of research necessary to move the field forward toward evidence-based clinical guidelines, (2) what the translational pipeline looks like and what its current deficiencies are, and (3) considerations that decision makers may choose to use as they decide what research they will support and decide how they will balance the urgency of the need with the level of evidence for CRT interventions. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Model Study Protocols and Frameworks to Advance the State of the Science summarizes the happenings of the workshop.
This thoroughly revised and updated work covers numerous advances in traumatic brain injury diagnosis, evaluation, treatment, and pathophysiology. Since publication of the first edition in 2012, there has been greatly increased public awareness of the clinical consequences of even the mildest of head injuries, and the result has been a concerted effort of countries around the world to increase research funding. This second edition continues to focus on mild traumatic brain injury--or concussion--and contains updates to all the original chapters as well as adding new chapters addressing clinical sequelae, including pediatric concussion, visual changes, chronic traumatic encephalopathy, and blast-associated TBI. Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation, Second Edition, is a comprehensive resource designed for neurologists, primary care clinicians, sports physicians, and other medical providers, including psychologists and neuropsychologists, as well as athletic trainers who may evaluate and care for individuals who have sustained a TBI. The book features summaries of the most pertinent areas of diagnosis and therapy, which can be readily accessed by the busy clinician/professional. In addition, the book's treatment algorithms provide a highly practical reference to cutting edge therapies, and an updated appendix of ICD codes is included. An outstanding contribution to the literature, Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation, Second Edition, again offers an invaluable resource for all providers who treat patients with TBI.
Institute of Medicine,Board on the Health of Select Populations
Author : Institute of Medicine,Board on the Health of Select Populations Publisher : National Academies Press Page : 71 pages File Size : 44,7 Mb Release : 2013-03-25 Category : Medical ISBN : 9780309267892
Cognitive Rehabilitation Therapy for Traumatic Brain Injury by Institute of Medicine,Board on the Health of Select Populations Pdf
In October 2011, the Institute of Medicine (IOM) released the report Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence, assessing the published evidence for the effectiveness of using cognitive rehabilitation therapy (CRT) to treat people with traumatic brain injury (TBI). TBI has gained increasing attention in the past 15 years because of its status as the signature wound of American military conflicts in Iraq and Afghanistan. Growing numbers of U.S. service members are suffering traumatic brain injuries and are surviving them, given that (a) the majority of traumatic brain injuries are mild and (b) lifesaving measures for more severe injuries have significantly improved. People with any level of injury can require ongoing health care in their recovery, helping them to regain (or compensate for) their losses of function and supporting their full integration into their social structure and an improved quality of life. One form of treatment for TBI is CRT, a systematic, goal-oriented approach to helping patients overcome cognitive impairments. The Department of Defense (DoD) asked the IOM to evaluate CRT for traumatic brain injury in order to guide the DoD's use and coverage in the Military Health System. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence was the IOM's resulting study of the evidence. The report's conclusions revolved around the fact that there is little continuity among research studies of the effectiveness of different types of CRT, and there exist only small amounts of evidence (or, in many cases, none) demonstrating the effectiveness of using CRT to treat TBI-although the evidence that does exist generally indicates that CRT interventions have some effectiveness. The workshop brought together experts in health services administration, research, and clinical practice from the civilian and military arenas in order to discuss the barriers for evaluating the effectiveness of CRT care and for identifying suggested taxonomy, terminology, timing, and ways forward for CRT researchers. The workshop consisted of individuals and was not intended to constitute a comprehensive group. Select decision makers in the Military Health System and Veterans Affairs (VA) and researchers were invited to participate. The workshop was designed to spur thinking about (1) the types of research necessary to move the field forward toward evidence-based clinical guidelines, (2) what the translational pipeline looks like and what its current deficiencies are, and (3) considerations that decision makers may choose to use as they decide what research they will support and decide how they will balance the urgency of the need with the level of evidence for CRT interventions. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Model Study Protocols and Frameworks to Advance the State of the Science summarizes the happenings of the workshop.
Author : Jack W. Tsao Publisher : Springer Science & Business Media Page : 345 pages File Size : 52,7 Mb Release : 2012-06-13 Category : Medical ISBN : 9780387878874
Traumatic brain injury (TBI) is a major cause of disability worldwide. Each year 1.7 million new TBIs occur in the United States, and it is also considered a signature injury of the Iraq and Afghanistan conflicts. Despite the relatively high incidence-within both civilian and military populations-the diagnosis and treatment, particularly of mild TBI/concussion, remains an inexact science. Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation is a concise guide designed for neurologists, primary care, and sports physicians and other medical providers, psychologists and neuropsychologists, and athletic trainers who may evaluate and care for patients with TBI. The book features summaries of the most pertinent areas of diagnosis and therapy, which can be readily accessed by the busy clinician/professional. In addition, the book's treatment algorithms provide a highly practical reference to cutting edge therapies. A superb contribution to the literature, Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation offers a well-designed, well-written, useful resource for all providers who treat patients with TBI.
Clinical Recovery from CNS Damage by Hiroaki Naritomi,D. W. Krieger Pdf
A compilation of innovative findings and new directions in neurological recovery After decades of focusing on how to alleviate and prevent recurrence of acute CNS injuries, the emphasis has finally shifted towards repairing such devastating events and rehabilitation. This development has been made possible by substantial progress in understanding the scientific underpinnings of recovery as well as by novel diagnostic tools, and most importantly, by emerging therapies awaiting clinical trials. In this publication, several international experts introduce novel areas of neurological reorganization and repair following CNS damage. Principles and methods to monitor and augment neuroplasticity are explored in depth and supplemented by a critical appraisal of neurological repair mechanisms and possibilities to curtail disability using computer or robotic interfaces. Rather than providing a textbook approach of CNS restoration, the editors selected topics where progress is most imminent in this labyrinthine domain of medicine. Moreover, the varied background and origins of the contributors lend this book a truly global perspective on the current state of affairs in neurological recovery.
Institute of Medicine,Board on the Health of Select Populations,Committee on Cognitive Rehabilitation Therapy for Traumatic Brain Injury
Author : Institute of Medicine,Board on the Health of Select Populations,Committee on Cognitive Rehabilitation Therapy for Traumatic Brain Injury Publisher : National Academies Press Page : 356 pages File Size : 41,8 Mb Release : 2012-01-28 Category : Medical ISBN : 9780309218184
Cognitive Rehabilitation Therapy for Traumatic Brain Injury by Institute of Medicine,Board on the Health of Select Populations,Committee on Cognitive Rehabilitation Therapy for Traumatic Brain Injury Pdf
Traumatic brain injury (TBI) may affect 10 million people worldwide. It is considered the "signature wound" of the conflicts in Iraq and Afghanistan. These injuries result from a bump or blow to the head, or from external forces that cause the brain to move within the head, such as whiplash or exposure to blasts. TBI can cause an array of physical and mental health concerns and is a growing problem, particularly among soldiers and veterans because of repeated exposure to violent environments. One form of treatment for TBI is cognitive rehabilitation therapy (CRT), a patient-specific, goal-oriented approach to help patients increase their ability to process and interpret information. The Department of Defense asked the IOM to conduct a study to determine the effectiveness of CRT for treatment of TBI.
Nathan D. Zasler, MD,Douglas I. Katz, MD,Ross D. Zafonte, DO
Author : Nathan D. Zasler, MD,Douglas I. Katz, MD,Ross D. Zafonte, DO Publisher : Springer Publishing Company Page : 1891 pages File Size : 45,7 Mb Release : 2021-09-01 Category : Medical ISBN : 9780826143051
Brain Injury Medicine, Third Edition by Nathan D. Zasler, MD,Douglas I. Katz, MD,Ross D. Zafonte, DO Pdf
“This updated textbook was much needed as there has been increased attention in recent years toward brain injuries. The book provides updated guidelines and clinical practice recommendations that support the intended audience of trainees and current practitioners. This update makes it the current standard text for any brain injury specialist." ---Doody's Review Service, 4 stars This revised and greatly expanded Third Edition of Brain Injury Medicine continues its reputation as the key core textbook in the field, bringing together evidence-based medicine and years of collective author clinical experience in a clear and comprehensive guide for brain injury professionals. Universally praised as the gold standard text and go-to clinical reference, the book covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomes. With 12 new chapters and expanded coverage in key areas of pathobiology and neuro-recovery, special populations, sport concussion, disorders of consciousness, neuropharmacology, and more, this "state of the science" resource promotes a multi-disciplinary approach to a complex condition with consideration of emerging topics and the latest clinical advances. Written by over 200 experts from all involved disciplines, the text runs the full gamut of practice of brain injury medicine including principles of public health and research, biomechanics and neural recovery, neuroimaging and neurodiagnostic testing, sport and military, prognosis and outcome, acute care, treatment of special populations, neurologic and other medical complications post-injury, motor and musculoskeletal problems, post-trauma pain disorders, cognitive and behavioral problems, functional mobility, neuropharmacology and alternative treatments, community reentry, and medicolegal and ethical issues. Unique in its scope of topics relevant to professionals working with patients with brain injury, this third edition offers the most complete and contemporary review of clinical practice standards in the field. Key Features: Thoroughly revised and updated Third Edition of the seminal reference on brain injury medicine Evidence-based consideration of emerging topics with new chapters covering pathobiology, biomarkers, neurorehabilitation nursing, neurodegenerative dementias, anoxic/hypoxic ischemic brain injury, infectious causes of acquired brain injury, neuropsychiatric assessment, PTSD, and capacity assessment Multi-disciplinary authorship with leading experts from a wide range of specialties including but not limited to physiatry, neurology, psychiatry, neurosurgery, neuropsychology, physical therapy, occupational therapy speech language pathology, and nursing New online chapters on survivorship, family perspectives, and resources for persons with brain injury and their caregivers Purchase includes digital access for use on most mobile devices or computers
National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on the Review of the Department of Veterans Affairs Examinations for Traumatic Brain Injury
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on the Review of the Department of Veterans Affairs Examinations for Traumatic Brain Injury Publisher : National Academies Press Page : 211 pages File Size : 50,5 Mb Release : 2019-05-20 Category : Medical ISBN : 9780309486897
Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on the Review of the Department of Veterans Affairs Examinations for Traumatic Brain Injury Pdf
The Veterans Benefits Administration (VBA) provides disability compensation to veterans with a service-connected injury, and to receive disability compensation from the Department of Veterans Affairs (VA), a veteran must submit a claim or have a claim submitted on his or her behalf. Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans reviews the process by which the VA assesses impairments resulting from traumatic brain injury for purposes of awarding disability compensation. This report also provides recommendations for legislative or administrative action for improving the adjudication of veterans' claims seeking entitlement to compensation for all impairments arising from a traumatic brain injury.
Cell Therapy for Brain Injury by David C. Hess Pdf
Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.
New Hope for Concussions TBI and PTSD by Dr. Lawrence D. Komer,Joan Chandler Komer Pdf
If you or someone you love has had a concussion or traumatic brain injury, this book is for you. "New Hope for Concussions TBI & PTSD" is a powerful resource for the injured, the caregivers, the sporting world, the medical community, and those serving our veterans and others with PTSD. It is a book of hope for all those who have been told, "We are sorry but there is nothing more we can do."
Traumatic Brain Injury: Rehabilitative Treatment and Case Management, Second Edition provides therapists, case managers and physicians with information about the longer-term issues faced by this population. Originally titled Traumatic Brain Injury Rehabilitation, this new edition updates the clinical information and broadens the scope of the best-s
Alternate Therapies in the Treatment of Brain Injury and Neurobehavioral Disorders by Ethan B Russo,Margaret Ayers,Barbara L Wheeler,Susan Schaefer,Gregory Murrey Pdf
Get the tools to provide more effective treatment for the neurobehaviorally disordered TBI patient! As traditional treatment success rates for many persons with traumatic brain injury (TBI) are proving less than effective, clinicians search for other therapies that may be more productive. Alternate Therapies in the Treatment of Brain Injury and Neurobehavioral Disorders: A Practical Guide discusses at length various nontraditional treatment approaches such as music therapy, art therapy, EEG biofeedback, and others that may provide additional help for the neurobehaviorally disordered TBI patient. This text provides a practical, in-depth overview of a range of nontraditional interventions and therapies. Each treatment is extensively discussed with explanations on how it can be effectively applied in rehabilitation programs. Models, case samples, contacts, and lists of training programs and professional organizations are given for each therapeutic modality. Each chapter has clear, illustrative drawings, tables, and charts, as well as comprehensive references for further research. Alternate Therapies in the Treatment of Brain Injury and Neurobehavioral Disorders: A Practical Guide discusses these alternative treatments: horticulture therapy art therapy music therapy melodic intonation therapy recreational therapy chemical dependency treatment real time EEG feedback craniosacral therapy This book is a comprehensive source for nontraditional therapies essential for physicians; neuropsychologists; psychiatrists; rehabilitation specialists; hospital directors, administrators, and TBI professionals.
