Nmr With Biological Macromolecules In Solution

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NMR with Biological Macromolecules in Solution

Kurt Wüthrich
NMR with Biological Macromolecules in Solution Book PDF

Author : Kurt Wüthrich
Publisher : World Scientific Publishing Company
Page : 270 pages
File Size : 44,9 Mb
Release : 2021
Category : Science
ISBN : 9811235783

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NMR with Biological Macromolecules in Solution by Kurt Wüthrich Pdf

The book provides insights into the research of the Kurt Wüthrich laboratories from 1996-2020. During this time period, the technique of nuclear magnetic resonance (NMR) spectroscopy in solution went through several breakthroughs, while maturing into a standard method of structural biology. With the introduction of TROSY (transverse relaxation-optimized spectroscopy), the range of accessible molecular sizes was extended about thirty-fold, and efficient protein structure determination resulted from the demands of the structural genomics initiative. Applications in fundamental biology and biomedicine include studies of prion proteins and prion diseases (TSEs), the SARS-Corona virus proteome, trans-membrane signalling by G protein-coupled receptors (GPCRs), and signal transfer by pheromones.Key publications from the Kurt Wüthrich laboratories are placed in perspective, providing insights into new aspects of NMR spectroscopy in structural biology. In addition to methods development, this includes applications in diverse areas of biological research, such as prion proteins and their role in transmissible spongiform encephalopathies (TSEs), trans-membrane signal transfer by G protein-coupled receptors (GPCRs), structural characterization of the SARS-Corona virus proteome, metabolic-flux profiling in bacterial cultures, and signal transfers by pheromones.

Nuclear Magnetic Resonance of Biological Macromolecules, Part B

Anonim
Nuclear Magnetic Resonance of Biological Macromolecules Part B Book PDF

Author : Anonim
Publisher : Elsevier
Page : 487 pages
File Size : 55,9 Mb
Release : 2001-07-12
Category : Science
ISBN : 9780080496894

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Nuclear Magnetic Resonance of Biological Macromolecules, Part B by Anonim Pdf

This volume and its companion, Volume 338, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.

NMR in Structural Biology

Kurt Wthrich
NMR in Structural Biology Book PDF

Author : Kurt Wthrich
Publisher : World Scientific
Page : 770 pages
File Size : 48,9 Mb
Release : 1995
Category : Science
ISBN : 9810223846

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NMR in Structural Biology by Kurt Wthrich Pdf

The volume presents a survey of the research by Kurt Wthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

NMR of Biological Macromolecules

Chariklia I. Stassinopoulou
NMR of Biological Macromolecules Book PDF

Author : Chariklia I. Stassinopoulou
Publisher : Springer Science & Business Media
Page : 367 pages
File Size : 43,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642791581

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NMR of Biological Macromolecules by Chariklia I. Stassinopoulou Pdf

Provided here are the latest techniques of NMR as applied to the study of proteins, carbohydrates and nucleic acids. The first chapters are devoted to an introduction to NMR and parameters related to molecular structure and molecular interactions. NMR experiments from basic 1D to 2D, 3D and 4D, used in combination with isotopically labelled molecules, are described and a general strategy is presented for biomacromolecular structure determination. Subsequent chapters deal with more advanced principles and techniques and their applications to structural and dynamic processes involving biomacromolecules in solution. Advanced results on peptide, protein, oligosaccharide and nucleic acid structure and recognition are presented.

Biomolecular NMR Spectroscopy

Andrew J. Dingley,A. J. Dingley,Steven M. Pascal
Biomolecular NMR Spectroscopy Book PDF

Author : Andrew J. Dingley,A. J. Dingley,Steven M. Pascal
Publisher : IOS Press
Page : 488 pages
File Size : 46,5 Mb
Release : 2011
Category : Medical
ISBN : 9781607506942

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Biomolecular NMR Spectroscopy by Andrew J. Dingley,A. J. Dingley,Steven M. Pascal Pdf

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful technique for characterization of biomolecular structures at atomic resolution in the solution state. This timely book, entitled "Biomolecular NMR Spectroscopy," focuses on the latest state-of-the-art NMR techniques for characterization of biological macromolecules in the solid and solution state. The editors, Dr. Andrew Dingley (University of Auckland, New Zealand) and Dr. Steven Pascal (Massey University, New Zealand) have organized the book into four sections, covering the following topics: sample preparation, structure and dynamics of proteins, structure and dynamics of nucleic acids and protein-nucleic acid complexes, and rapid and hybrid techniques--

Nuclear Magnetic Resonance of Biological Macromolecules, Part A

Anonim
Nuclear Magnetic Resonance of Biological Macromolecules Part A Book PDF

Author : Anonim
Publisher : Elsevier
Page : 513 pages
File Size : 45,5 Mb
Release : 2001-07-12
Category : Science
ISBN : 9780080496887

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Nuclear Magnetic Resonance of Biological Macromolecules, Part A by Anonim Pdf

This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.

Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy

Jeffrey C. Hoch
Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy Book PDF

Author : Jeffrey C. Hoch
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 40,9 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475797947

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Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy by Jeffrey C. Hoch Pdf

This volume is the scientific chronicle of the NATO Advanced Research Workshop on Computational Aspects of the Study of Biological Macro molecules by Nuclear Magnetic Resonance Spectroscopy, which was held June 3-8, 1990 at Il Ciocco, near Barga, Italy. The use of computers in the study of biological macromolecules by NMR spectroscopy is ubiquitous. The applications are diverse, including data col lection, reduction, and analysis. Furthermore, their use is rapidly evolv ing, driven by the development of new experimental methods in NMR and molecular biology and by phenomenal increases in computational perfor mance available at reasonable cost. Computers no longer merely facilitate, but are now absolutely essential in the study of biological macromolecules by NMR, due to the size and complexity of the data sets that are obtained from modern experiments. The Workshop, and this proceedings volume, provide a snapshot of the uses of computers in the NMR of biomolecules. While by no means exhaustive, the picture that emerges illustrates both the· importance and the diversity of their application.

Nuclear Magnetic Resonance of Biological Macromolecules, Part C

Anonim
Nuclear Magnetic Resonance of Biological Macromolecules Part C Book PDF

Author : Anonim
Publisher : Academic Press
Page : 670 pages
File Size : 55,6 Mb
Release : 2005-05-04
Category : Science
ISBN : 9780080549477

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Nuclear Magnetic Resonance of Biological Macromolecules, Part C by Anonim Pdf

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. Nuclear Magnetic Resonance of Biological Macromolecules, Part C is written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules. * One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences

NMR in Biological Systems

K.V.R. Chary,Girjesh Govil
NMR in Biological Systems Book PDF

Author : K.V.R. Chary,Girjesh Govil
Publisher : Springer Science & Business Media
Page : 552 pages
File Size : 48,9 Mb
Release : 2008-04-01
Category : Science
ISBN : 9781402066801

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NMR in Biological Systems by K.V.R. Chary,Girjesh Govil Pdf

During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book covers the entire area of NMR in Biological Sciences (Biomolecules, cells and tissues, animals, plants and drug design). As well as being useful to researchers, this is an excellent book for teaching a course on NMR in Biological Systems.

NMR as a Structural Tool for Macromolecules

M.D. Kemple,B.D.N. Rao
NMR as a Structural Tool for Macromolecules Book PDF

Author : M.D. Kemple,B.D.N. Rao
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461303879

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NMR as a Structural Tool for Macromolecules by M.D. Kemple,B.D.N. Rao Pdf

The contemplation of truth and beauty is the proper object for which we were created, which calls forth the most intense desires of the soul, and of which it never tires -Hazlitt In his Nobel lecture Purcell commented that when he saw snow in New England after the discovery of NMR, it appeared like "heaps of protons quietly precessing in earth's magnetic field. " If he were to make the comment in the context of how NMR is being used today, he could have conjured up an image of hydrogen, carbon, and nitrogen nuclei in proteins of an earthbound 8rganism subtly orchestrating a quiet symphony of frequencies, from 150 Hz to 2 kHz, carrying clues to the three-dimensional structure of the macromolecules. The manner in which the basic discoveries of Bloch and Purcell have led to the emergence of NMR, several decades later, as a major technique of biological and medical physics (and chemistry) is a striking example of the power of basic research. It is also a fascinating saga whereby whenever it was felt that the field had reached a plateau, new directions, new technologies, and sometimes serendipity produced new developments that revolutionized the technique and enhanced its capability. As Richard Ernst points out "NMR is intellectually attractive, . . . the practical importance of NMR is enormous, and can justify much of the playful activities of an addicted spectroscopist" (Nobel lecture).

Protein NMR Spectroscopy

Lu-Yun Lian,Gordon Roberts
Protein NMR Spectroscopy Book PDF

Author : Lu-Yun Lian,Gordon Roberts
Publisher : John Wiley & Sons
Page : 345 pages
File Size : 53,5 Mb
Release : 2011-06-09
Category : Science
ISBN : 9781119972822

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Protein NMR Spectroscopy by Lu-Yun Lian,Gordon Roberts Pdf

Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. This up-to-date volume covers NMR techniques and their application to proteins, with a focus on practical details. Providing newcomers to NMR with practical guidance to carry out successful experiments with proteins and analyze the resulting spectra, those familiar with the chemical applications of NMR will also find it useful in understanding the special requirements of protein NMR.

NMR in Molecular Biology

Oleg Jardetzky,G. C. K. Roberts
NMR in Molecular Biology Book PDF

Author : Oleg Jardetzky,G. C. K. Roberts
Publisher : Academic Press
Page : 698 pages
File Size : 41,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483281858

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NMR in Molecular Biology by Oleg Jardetzky,G. C. K. Roberts Pdf

NMR in Molecular Biology provides an introduction to the basic concepts and principles of nuclear magnetic resonance (NMR) that are essential to a critical evaluation of experimental data. It also aims to acquaint readers in some detail with those prototype experiments in which a definite, biologically relevant answer has been obtained. The book opens with a chapter on the historical development of NMR technology. Separate chapters follow on the fundamental principles of NMR; paramagnetic perturbations of NMR spectra; time scales, chemical exchange, and problems of exchange; and characteristics of NMR spectra through investigations of compounds such as amino acids and peptides; and nucleic acid bases, nucleosides, and nucleotides. Subsequent chapters deal with protein NRM spectra, protein-ligand interactions, and the structure and dynamics of membranes. This book is intended for the student or practicing scientist wishing to gain a critical understanding of the applications of NMR to a wide range of problems in molecular biology.

Conformation of Biological Molecules

G. Govil,R. V. Hosur
Conformation of Biological Molecules Book PDF

Author : G. Govil,R. V. Hosur
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642680977

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Conformation of Biological Molecules by G. Govil,R. V. Hosur Pdf

The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc. ) and the oretical methods (quantum mechanical and classical potential energy calculations, Monte Carlo simulations and molecular graphics). F or several years now, X-ray diffraction [1] has served as our only source of infor mation on the three-dimensional arrangements of atoms in biopolymers. Fiber-diffrac tion of DNA led to the proposal of the DNA double helix. Fibers of long~hain polymers show ordering in the direction of the fibre-axis but not in the transverse plane. Accurate estimates of the dimensions of helical structures can be made using techniques on the basis of which models of biopolymers can be constructed.

NMR of Macromolecules

Gordon Carl Kenmure Roberts
NMR of Macromolecules Book PDF

Author : Gordon Carl Kenmure Roberts
Publisher : Oxford University Press, USA
Page : 486 pages
File Size : 40,6 Mb
Release : 1993
Category : Science
ISBN : UOM:39015045523191

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NMR of Macromolecules by Gordon Carl Kenmure Roberts Pdf

Following the enormous increase in the use of nuclear magnetic resonance to study the conformations and interactions of biological macromolecules, this book provides detailed guidance on how to choose the most appropriate protocol to obtain the required information, how to carry out theexperiment, and how to analyze the resulting spectra. Graduate students and post-doctoral researchers in biochemistry, biophysics, chemistry, and other disciplines who use NMR to study biological macromolecules will find this exemplary volume one of the few genuinely practical books on thesubject.

Protein NMR Techniques

A. Kristina Downing
Protein NMR Techniques Book PDF

Author : A. Kristina Downing
Publisher : Springer Science & Business Media
Page : 494 pages
File Size : 49,7 Mb
Release : 2008-02-03
Category : Science
ISBN : 9781592598090

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Protein NMR Techniques by A. Kristina Downing Pdf

When I was asked to edit the second edition of Protein NMR Techniques, my first thought was that the time was ripe for a new edition. The past several years have seen a surge in the development of novel methods that are truly revolutionizing our ability to characterize biological macromolecules in terms of speed, accuracy, and size limitations. I was particularly excited at the prospect of making these techniques accessible to all NMR labs and for the opportunity to ask the experts to divulge their hints and tips and to write, practically, about the methods. I commissioned 19 chapters with wide scope for Protein NMR Techniques, and the volume has been organized with numerous themes in mind. Chapters 1 and 2 deal with recombinant protein expression using two organisms, E. coli and P. pastoris, that can produce high yields of isotopically labeled protein at a reasonable cost. Staying with the idea of isotopic labeling, Chapter 3 describes methods for perdeuteration and site-specific protonation and is the first of several chapters in the book that is relevant to studies of higher molecular weight systems. A different, but equally powerful, method that uses molecular biology to “edit” the spectrum of a large molecule using segmental labeling is presented in Chapter 4. Having successfully produced a high molecular weight target for study, the next logical step is data acquisition. Hence, the final chapter on this theme, Chapter 5, describes TROSY methods for stru- ural studies.