Non Coding Rnas And Epigenetic Regulation Of Gene Expression

Author : Kevin V. Morris
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 52,9 Mb
Release : 2012
Category : Epigenesis
ISBN : 1904455948

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Non-coding RNAs and Epigenetic Regulation of Gene Expression by Kevin V. Morris Pdf

Non-coding RNAs potentially play an active role in modulating gene transcription and epigenetic states. Several genes in differentiated cells may be under some form of RNA-based transcriptional and epigenetic regulatory control. This form of regulation may be controlled by selective pressures and influence the adaptability of the cell. The concept that RNA can control epigenetic states impacts our understanding of the basic fabric of the cell and may have therapeutic potential. Many studies have been carried out on the modulation of gene transcription by non-coding RNAs. This book, written by a group of distinguished scientists, represents an important overview and summary of the field to date. The 13 chapters are organized into three sections: a) Non-coding RNAs: Form, Function and Diversity; b) Non-coding RNAs: Gene Regulation and Epigenetics; and c) Non-coding RNAs: Disease and Therapeutics. This up-to-date volume is an essential book for those working in the area and represents a major information resource on current research in the fast-moving fields of epigenetics, the regulation of gene expression, and RNA research.

Author : Ahmad M. Khalil
Publisher : Springer
Page : 187 pages
File Size : 49,8 Mb
Release : 2019-06-06
Category : Medical
ISBN : 9783030170868

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Molecular Biology of Long Non-coding RNAs by Ahmad M. Khalil Pdf

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Author : Durdica Ugarkovic
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 45,5 Mb
Release : 2011-02-01
Category : Science
ISBN : 9783642165023

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Long Non-Coding RNAs by Durdica Ugarkovic Pdf

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 698 pages
File Size : 41,8 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254

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Epigenetics: Development and Disease by Tapas Kumar Kundu Pdf

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Author : Igor Kovalchuk,Olga Kovalchuk
Publisher : FT Press
Page : 609 pages
File Size : 47,6 Mb
Release : 2012-05-22
Category : Education
ISBN : 9780132599511

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Epigenetics in Health and Disease by Igor Kovalchuk,Olga Kovalchuk Pdf

This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.

Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Page : 576 pages
File Size : 50,8 Mb
Release : 2017-10-13
Category : Medical
ISBN : 9780128134375

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Cancer and Noncoding RNAs by Jayprokas Chakrabarti,Sanga Mitra Pdf

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 49,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Author : Ninuo Xia
Publisher : Unknown
Page : 268 pages
File Size : 51,9 Mb
Release : 2009
Category : Breast
ISBN : UCR:31210023258641

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Non-coding RNA's Role in Epigenetic Gene Regulation by Ninuo Xia Pdf

Author : John C. Lucchesi
Publisher : Oxford University Press
Page : 240 pages
File Size : 47,8 Mb
Release : 2018-12-19
Category : Science
ISBN : 9780192567161

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Epigenetics, Nuclear Organization & Gene Function by John C. Lucchesi Pdf

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Page : 514 pages
File Size : 49,8 Mb
Release : 2011-07-20
Category : Science
ISBN : 9783642194542

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Non Coding RNAs in Plants by Volker A. Erdmann,Jan Barciszewski Pdf

In the most recent years, each of the RNA silencing pathways of plants have appeared to generate ncRNAs with dedicated functions, specialized biological activities and specific functional scopes. RNA silencing plays a crucial role in coordinating the expression, stability, protection and inheritance of eukaryotic genomes. It compromises several mechanisms, that invariably depend on core small non coding RNAs and that achieve dedicated sequence-specific functions. RNA silencing has been recognized to carry critical developmental, stress-response and bodyguard functions be coordinating the expression, protection, stability and inheritance of virtually all eukaryotic genomes. Thus, the ncRNAs encompass a wide set of mechanisms that achieve specialized functions.

Author : Lütfi Tutar,Sumer Aras,Esen Tutar
Publisher : BoD – Books on Demand
Page : 150 pages
File Size : 52,5 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9781789856552

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Non-Coding RNAs by Lütfi Tutar,Sumer Aras,Esen Tutar Pdf

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.

Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Page : 545 pages
File Size : 54,9 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9783030447434

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The Chemical Biology of Long Noncoding RNAs by Stefan Jurga,Jan Barciszewski Pdf

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 53,9 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033

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Long Non Coding RNA Biology by M.R.S. Rao Pdf

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Author : Kasirajan Ayyanathan
Publisher : CRC Press
Page : 424 pages
File Size : 51,6 Mb
Release : 2013-11-25
Category : Science
ISBN : 9781482224825

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Epigenetics and Pathology by Kasirajan Ayyanathan Pdf

This title includes a number of Open Access chapters.This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactionscausal relationships between genes and the environmentthe effects

Author : Antonin Morillon
Publisher : Elsevier
Page : 190 pages
File Size : 44,6 Mb
Release : 2018-02-01
Category : Science
ISBN : 9780081023556

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Long Non-coding RNA by Antonin Morillon Pdf

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests