Novel Approaches For The Delivery Of Anti Hiv Drugs

Author : José das Neves
Publisher : MDPI
Page : 208 pages
File Size : 43,5 Mb
Release : 2020-05-20
Category : Medical
ISBN : 9783039219001

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Novel Approaches for the Delivery of Anti-HIV Drugs by José das Neves Pdf

HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.

Author : José das Neves
Publisher : Unknown
Page : 208 pages
File Size : 52,5 Mb
Release : 2020
Category : Technology (General)
ISBN : 3039219014

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Novel Approaches for the Delivery of Anti-HIV Drugs by José das Neves Pdf

HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.

Author : World Health Organization
Publisher : Unknown
Page : 429 pages
File Size : 52,8 Mb
Release : 2016
Category : AIDS (Disease)
ISBN : 9241549688

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Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection by World Health Organization Pdf

These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.

Author : Travis Lane Spurling
Publisher : Unknown
Page : 0 pages
File Size : 44,7 Mb
Release : 1997
Category : Electronic
ISBN : OCLC:1426860713

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Novel Approaches Towards the Treatment of HIV Infection by Travis Lane Spurling Pdf

Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 42,5 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257

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Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Author : Alireza Minagar,Paul Shapshak
Publisher : Nova Publishers
Page : 280 pages
File Size : 48,6 Mb
Release : 2006
Category : AIDS (Disease)
ISBN : 159454610X

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Neuro-AIDS by Alireza Minagar,Paul Shapshak Pdf

During the past two decades, the world scientific community has witnessed major achievements in our understanding of the pathogenesis of HIV infection of the nervous system and HIV-Associated Dementia (HAD). Despite these giant gains, nervous system involvement during AIDS remains a relentlessly progressive disease with a deadly fate in many cases. This book on NeuroAIDS provides a unique resource for both general neurologists as well as basic neuroscientists with profound interests for research on NeuroAIDS. This book has special emphasis on the mechanisms of disease development and progression of HIV-infected patients with NeuroAIDS. The contributors have provided the readers with comprehensive reviews on clinical manifestations of HAD, mechanisms of HIV entry into the central nervous system, the role of cytokines and chemokines in pathogenesis of NeuroAIDS, drug abuse and NeuroAIDS, virus load in HAD, allostasis in HIV and AIDS, stroke in AIDS patients, and neuroimaging of HIV infection of the central nervous system. In addition, there are chapters on Varicella Zoster virus infection of HIV-seropositive and AIDS patients, as well as the molecular basis for opioids and AIDS virus interactions.

Author : Anat Rosenthal
Publisher : Routledge
Page : 142 pages
File Size : 52,8 Mb
Release : 2017-07-14
Category : Social Science
ISBN : 9781351779975

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Health on Delivery by Anat Rosenthal Pdf

In 2004 Malawi began to offer antiretroviral therapy to anyone who needed it. This undertaking would have been ambitious for any nation, but it was unprecedented coming from one of the poorest countries in the world. Health on Delivery examines this introduction of state-provided antiretroviral therapy from an ethnographic perspective. Moving from World Health Organization boardrooms in Geneva to clinics held under trees in rural Malawi, it studies the patients, healthcare providers, and policy-makers involved, considering how the rollout has impacted their lives and professions. In doing so, it examines both the challenges and successes of an ambitious attempt to provide universal HIV treatment with limited money, infrastructure, and human resources. As well as an important case study, the book also offers an analytic framework to address the processes by which global policy is made and implemented. Engagingly written, Health on Delivery will be interesting reading for students and scholars of both anthropology and public health, as well as related disciplines such as geography, international politics and world development. It will also appeal to the general reader interested in global health policies and world development.

Author : Guido Silvestri,Mathias Lichterfeld
Publisher : Springer
Page : 248 pages
File Size : 42,7 Mb
Release : 2018-10-11
Category : Medical
ISBN : 9783030028169

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HIV-1 Latency by Guido Silvestri,Mathias Lichterfeld Pdf

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Author : World Health Organization. Department of Mental Health and Substance Abuse,World Health Organization
Publisher : World Health Organization
Page : 133 pages
File Size : 55,9 Mb
Release : 2009
Category : Medical
ISBN : 9789241547543

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Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence by World Health Organization. Department of Mental Health and Substance Abuse,World Health Organization Pdf

"These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv

Author : Anonim
Publisher : Unknown
Page : 1398 pages
File Size : 44,7 Mb
Release : 1987
Category : Medicine
ISBN : STANFORD:36105021766048

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Biomedical Index to PHS-supported Research by Anonim Pdf

Author : Wolfgang Jahnke,Daniel A. Erlanson
Publisher : John Wiley & Sons
Page : 391 pages
File Size : 41,7 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527608607

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Fragment-based Approaches in Drug Discovery by Wolfgang Jahnke,Daniel A. Erlanson Pdf

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Author : Prashant Kesharwani
Publisher : Academic Press
Page : 284 pages
File Size : 50,7 Mb
Release : 2020-06-10
Category : Business & Economics
ISBN : 9780128226117

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Nanotechnology Based Approaches for Tuberculosis Treatment by Prashant Kesharwani Pdf

Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers

Author : José das Neves,Bruno Sarmento
Publisher : CRC Press
Page : 709 pages
File Size : 53,7 Mb
Release : 2014-10-16
Category : Medical
ISBN : 9789814463560

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Drug Delivery and Development of Anti-HIV Microbicides by José das Neves,Bruno Sarmento Pdf

The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed. In the absence of a cure, prophylaxis represents a cornerstone in the battle against infection. One promising strategy comprises the use around the time of sexual intercourse of vaginal/rectal products containing antiviral compounds, termed microbicides. It is now recognized that specific development of drug dosage forms and/or drug delivery systems is an indispensable aspect for the success of microbicides. Different groups strived over the last decade to optimize the biophysical and technological performance of traditional dosage forms (gels, tablets, and suppositories) to fulfill the specificities of microbicides use, without neglecting users’ preferences and affordability issues. Moreover, new formulation approaches, such as vaginal rings and films, nanotechnology-based systems, stimuli-sensitive formulations, targeted drug delivery systems, among others have been proposed and are currently undergoing pre-clinical or even clinical testing.

Author : Usama Ahmad,Juber Akhtar
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 40,7 Mb
Release : 2020-02-05
Category : Medical
ISBN : 9781789856620

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Pharmaceutical Formulation Design by Usama Ahmad,Juber Akhtar Pdf

Pharmaceutical formulations have evolved from simple and traditional systems to more modern and complex novel dosage forms. Formulation development is a tedious process and requires an enormous amount of effort from many different people. Developing a stable novel dosage form and further targeting it to the desired site inside the body has always been a challenge. The purpose of this book is to bring together scholarly articles that highlight recent developments and trends in pharmaceutical formulation science. Each article has been written by authors specializing in the subject area and hailing from top institutions around the world. The book has been written in a systematic and lucid style explaining all basic concepts and fundamentals in a very simple way. This book aims to serve the need of all individuals involved at any level in the pharmaceutical dosage form development. I sincerely hope that the book will be liked by inquisitive students and learned colleagues.

Author : Farid A. Badria
Publisher : BoD – Books on Demand
Page : 236 pages
File Size : 49,7 Mb
Release : 2020-12-02
Category : Medical
ISBN : 9781839685200

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Drug Repurposing by Farid A. Badria Pdf

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.